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  1. Book: Protein structure

    Creighton, Thomas E.

    a practical approach

    (The practical approach series ; 174)

    1997  

    Author's details ed. by T. E. Creighton
    Series title The practical approach series ; 174
    Collection
    Keywords Proteins / physiology ; Proteins / ultrastructure ; Structure-Activity Relationship ; Proteine ; Struktur
    Subject Eiweiss ; Protein
    Language English
    Size XXIII, 383 S. : Ill., graph. Darst.
    Edition 2. ed.
    Publisher IRL Press
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT007616724
    ISBN 0-19-963619-2 ; 0-19-963618-4 ; 978-0-19-963619-8 ; 978-0-19-963618-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1997 A 6284 order for loan Magazin

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  2. Book: Protein function

    Creighton, Thomas E.

    a practical approach

    (The practical approach series ; 175)

    1997  

    Author's details ed. by T. E. Creighton
    Series title The practical approach series ; 175
    Collection
    Keywords Proteins / physiology ; Proteine ; Chemische Analyse
    Subject Analyse ; Analytik ; Eiweiss ; Protein
    Language English
    Size XXI, 334 S. : Ill., graph. Darst.
    Edition 2. ed.
    Publisher IRL Press at Oxford Univ. Press
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT007921315
    ISBN 0-19-963616-8 ; 0-19-963615-X ; 0-19-963617-6 ; 0-19-963620-6 ; 978-0-19-963616-7 ; 978-0-19-963615-0 ; 978-0-19-963617-4 ; 978-0-19-963620-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1998 A 807 order for loan Magazin

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  3. Book: Protein folding

    Creighton, Thomas E.

    1992  

    Author's details Thomas E. Creighton, ed
    Keywords Protein Folding ; Proteinfaltung
    Subject Peptidfaltung ; Proteine
    Language English
    Size XIX, 547 S. : Ill., graph. Darst.
    Publisher Freeman
    Publishing place New York
    Publishing country United States
    Document type Book
    HBZ-ID HT004447436
    ISBN 0-7167-7027-X ; 978-0-7167-7027-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1993 A 2732 order for loan Magazin

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  4. Book: Protein structure

    Creighton, Thomas E.

    a practical approach

    (The practical approach series ; [45])

    1990  

    Author's details ed. by T. E. Creighton
    Series title The practical approach series ; [45]
    Collection
    Keywords Proteins / analysis ; Proteine ; Chemische Struktur
    Subject Strukturformel ; Eiweiss ; Protein
    Language English
    Size XVIII, 355 S. : Ill., graph. Darst.
    Edition Reprint. (with corr.)
    Publisher IRL Press at Oxford Univ. Press
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT003546381
    ISBN 0-19-963000-3 ; 0-19-963001-1 ; 978-0-19-963000-4 ; 978-0-19-963001-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1990 A 3934 order for loan Magazin

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  5. Book: Protein function

    Creighton, Thomas E.

    a practical approach

    (Practical approach series ; [46])

    1989  

    Author's details ed. by T. E. Creighton
    Series title Practical approach series ; [46]
    The practical approach series
    Collection The practical approach series
    Keywords Proteins / physiology ; Proteine ; Chemische Analyse
    Subject Analyse ; Analytik ; Eiweiss ; Protein
    Language English
    Size XX, 306 S. : Ill., graph. Darst.
    Publisher IRL Pr
    Publishing place Oxford u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT003397877
    ISBN 0-19-963006-2 ; 0-19-963007-0 ; 978-0-19-963006-6 ; 978-0-19-963007-3
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1989 A 5200 order for loan Magazin

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  6. Book: Protein structure

    Creighton, Thomas E.

    a practical approach

    (Practical approach series ; [45])

    1989  

    Author's details ed. by T. E. Creighton
    Series title Practical approach series ; [45]
    The practical approach series
    Collection The practical approach series
    Keywords Proteins / analysis ; Proteine ; Chemische Analyse ; Chemische Struktur
    Subject Strukturformel ; Eiweiss ; Protein ; Analyse ; Analytik
    Language English
    Size XVIII, 355 S. : Ill., graph. Darst.
    Publisher IRL Pr
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT003367526
    ISBN 1-85221-137-7 ; 0-19-963000-3 ; 0-19-963001-1 ; 1-85221-138-5 ; 978-1-85221-137-0 ; 978-0-19-963000-4 ; 978-0-19-963001-1 ; 978-1-85221-138-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1990 A 953 order for loan Magazin

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  7. Article ; Online: Augmented Reality in Otology/Neurotology: A Scoping Review with Implications for Practice and Education.

    Chen, Jenny X / Yu, Sophie E / Ding, Andy S / Lee, Daniel J / Welling, D Brad / Carey, John P / Gray, Stacey T / Creighton, Francis X

    The Laryngoscope

    2022  Volume 133, Issue 8, Page(s) 1786–1795

    Abstract: Objective: To determine how augmented reality (AR) has been applied to the field of otology/neurotology, examine trends and gaps in research, and provide an assessment of the future potential of this technology within surgical practice and education.: ...

    Abstract Objective: To determine how augmented reality (AR) has been applied to the field of otology/neurotology, examine trends and gaps in research, and provide an assessment of the future potential of this technology within surgical practice and education.
    Data sources: PubMed, EMBASE, and Cochrane Library were assessed from their inceptions through October 2022. A manual bibliography search was also conducted.
    Review methods: A scoping review was conducted and reported according to PRISMA-ScR guidelines. Data from studies describing the application of AR to the field of otology/neurotology were evaluated, according to a priori inclusion/exclusion criteria. Exclusion criteria included non-English language articles, abstracts, letters/commentaries, conference papers, and review articles.
    Results: Eighteen articles covering a diverse range of AR platforms were included. Publication dates spanned from 2007 to 2022 and the rate of publication increased over this time. Six of 18 studies were case series in human patients although the remaining were proof of concepts in cadaveric/artificial/animal models. The most common application of AR was for surgical navigation (14 of 18 studies). Computed tomography was the most common source of input data. Few studies noted potential applications to surgical training.
    Conclusion: Interest in the application of AR to otology/neurotology is growing based on the number of recent publications that use a broad range of hardware, software, and AR platforms. Large gaps in research such as the need for submillimeter registration error must be addressed prior to adoption in the operating room and for educational purposes.
    Level of evidence: N/A Laryngoscope, 133:1786-1795, 2023.
    MeSH term(s) Humans ; Augmented Reality ; Neurotology ; Surgery, Computer-Assisted/methods ; Otolaryngology ; Software
    Language English
    Publishing date 2022-12-15
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.30515
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ul II Zs.82: Show issues Location:
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  8. Book: Proteins

    Creighton, Thomas E.

    structures and molecular principles

    1983  

    Keywords PROTEINS ; Proteine
    Subject Eiweiss ; Protein
    Size XI, 515 S. : ZAHLR. GRAPH. DARST.
    Publisher Freeman
    Publishing place New York
    Document type Book
    HBZ-ID HT002736845
    ISBN 0-7167-1566-X ; 978-0-7167-1566-5
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1985 A 2319 order for loan Magazin

    Order via subito

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  9. Article ; Online: Experiences of People Living with Parkinson's Disease in Care Homes: A Qualitative Systematic Review.

    Copeland, Shannon / Anderson, Tara / Carter, Gillian / Brown Wilson, Christine / Stark, Patrick / Doumas, Mihalis / Rodger, Matthew / O'Shea, Emma / Creighton, Laura / Craig, Stephanie / McMahon, James / Gillis, Arnelle / Crooks, Sophie / Mitchell, Gary

    Nursing reports (Pavia, Italy)

    2024  Volume 14, Issue 1, Page(s) 428–443

    Abstract: Background: Incidence of disability secondary to Parkinson's disease is increasing faster globally than any other neurological condition. The diverse appearance of symptomatology associated with Parkinson's, and the degenerative nature and subsequent ... ...

    Abstract Background: Incidence of disability secondary to Parkinson's disease is increasing faster globally than any other neurological condition. The diverse appearance of symptomatology associated with Parkinson's, and the degenerative nature and subsequent functional decline, often increase dependence on caregivers for assistance with daily living, most commonly within a care home setting. Yet, primary literature and evidence synthesis surrounding these unique and complex care needs, challenges and the lived experiences of this population living in long-term nursing or residential facilities remains sparce. The aim of this review is to synthesize qualitative literature about the lived experience of people with Parkinson's disease living in care home settings.
    Methods: A systematic search of the literature was conducted in October 2023 across six different databases (CINAHL, Medline, EMBASE, PsycINFO, Scopus and Cochrane Library). The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) was used to guide this review.
    Results: Five articles met the inclusion criteria. Four themes were identified following evidence synthesis: (1) Unique pharmacological challenges. (2) Transitioning and adapting to care home life and routines. (3) Dignified care within care homes. (4) Multidisciplinary care vacuum in care homes.
    Conclusion: This review revealed the significant and unique challenges for people with Parkinson's disease when transitioning into care homes. These are exacerbated by wider social care challenges such as staffing levels, skill mixes and attitudes as well as a lack of disease-specific knowledge surrounding symptomatology and pharmacology. The lack of multi-disciplinary working and risk-adverse practice inhibited person-centred care and autonomy and reduced the quality of life of people living with Parkinson's disease in care homes. Recommendations for practice highlight training gaps, the need for consistent and improved interdisciplinary working and better person-centred assessment and care delivery.
    Language English
    Publishing date 2024-02-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2039-4403
    ISSN (online) 2039-4403
    DOI 10.3390/nursrep14010033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Inhibition of CSF1R and KIT With Pexidartinib Reduces Inflammatory Signaling and Cell Viability in Endometriosis.

    Dunn, Timothy N / Cope, Dominique I / Tang, Suni / Sirupangi, Tirupataiah / Parks, Sydney E / Liao, Zian / Yuan, Fei / Creighton, Chad J / Masand, Ramya P / Alpuing Radilla, Linda / Guan, Xiaoming / Detti, Laura / Monsivais, Diana / Matzuk, Martin M

    Endocrinology

    2024  Volume 165, Issue 4

    Abstract: Endometriosis is a common and debilitating disease, affecting ∼170 million women worldwide. Affected patients have limited therapeutic options such as hormonal suppression or surgical excision of the lesions, though therapies are often not completely ... ...

    Abstract Endometriosis is a common and debilitating disease, affecting ∼170 million women worldwide. Affected patients have limited therapeutic options such as hormonal suppression or surgical excision of the lesions, though therapies are often not completely curative. Targeting receptor tyrosine kinases (RTKs) could provide a nonhormonal treatment option for endometriosis. We determined that 2 RTKs, macrophage-colony stimulating factor 1 receptor (CSF1R) and mast/stem cell growth factor receptor KIT (KIT), are overexpressed in endometriotic lesions and could be novel nonhormonal therapeutic targets for endometriosis. The kinase activity of CSF1R and KIT is suppressed by pexidartinib, a small molecule inhibitor that was recently approved by the US Food and Drug Administration. Using immunohistochemistry, we detected CSF1R and KIT in endometriotic tissues obtained from peritoneal lesions, colorectal lesions, and endometriomas. Specifically, we show that KIT is localized to the epithelium of the lesions, while CSF1R is expressed in the stroma and macrophages of the endometriotic lesions. Given the high epithelial expression of CSF1R and KIT, 12Z endometriotic epithelial cells were used to evaluate the efficacy of dual CSF1R and KIT inhibition with pexidartinib. We found that pexidartinib suppressed activation in 12Z cells of JNK, STAT3, and AKT signaling pathways, which control key proinflammatory and survival networks within the cell. Using quantitative real-time polymerase chain reaction, we determined that pexidartinib suppressed interleukin 8 (IL8) and cyclin D1 (CCND1) expression. Lastly, we demonstrated that pexidartinib decreased cell growth and viability. Overall, these results indicate that pexidartinib-mediated CSF1R and KIT inhibition reduces proinflammatory signaling and cell viability in endometriosis.
    MeSH term(s) Humans ; Female ; Endometriosis/metabolism ; Cell Survival ; Signal Transduction ; Receptor Protein-Tyrosine Kinases/metabolism ; Aminopyridines ; Pyrroles
    Chemical Substances pexidartinib (6783M2LV5X) ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1) ; Aminopyridines ; Pyrroles
    Language English
    Publishing date 2024-01-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 427856-2
    ISSN 1945-7170 ; 0013-7227
    ISSN (online) 1945-7170
    ISSN 0013-7227
    DOI 10.1210/endocr/bqae003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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