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  1. Article ; Online: Alternative sunitinib schedules in metastatic renal cell carcinoma and the RAINBOW study.

    Bracarda, S

    Annals of oncology : official journal of the European Society for Medical Oncology

    2015  Volume 26, Issue 7, Page(s) 1512–1513

    MeSH term(s) Angiogenesis Inhibitors/therapeutic use ; Carcinoma, Renal Cell/drug therapy ; Humans ; Indoles/therapeutic use ; Kidney Neoplasms/drug therapy ; Protein Kinase Inhibitors/therapeutic use ; Pyrroles/therapeutic use
    Chemical Substances Angiogenesis Inhibitors ; Indoles ; Protein Kinase Inhibitors ; Pyrroles
    Language English
    Publishing date 2015-04-06
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1025984-3
    ISSN 1569-8041 ; 0923-7534
    ISSN (online) 1569-8041
    ISSN 0923-7534
    DOI 10.1093/annonc/mdv168
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2862: Show issues Location:
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  2. Article ; Online: More colors to the palette.

    Bracarda, S

    Annals of oncology : official journal of the European Society for Medical Oncology

    2015  Volume 27, Issue 2, Page(s) 363

    MeSH term(s) Bone Neoplasms/drug therapy ; Carcinoma, Papillary/drug therapy ; Carcinoma, Renal Cell/drug therapy ; Female ; Humans ; Indoles/therapeutic use ; Kidney Neoplasms/drug therapy ; Liver Neoplasms/drug therapy ; Lung Neoplasms/drug therapy ; Male ; Pyrroles/therapeutic use
    Chemical Substances Indoles ; Pyrroles
    Language English
    Publishing date 2015-11-29
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 1025984-3
    ISSN 1569-8041 ; 0923-7534
    ISSN (online) 1569-8041
    ISSN 0923-7534
    DOI 10.1093/annonc/mdv555
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2862: Show issues Location:
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  3. Article ; Online: Ad hoc afatinib in an eldery lung cancer patient with EGFR exon 19 deletion L747-A750>P.

    Guida, Annalisa / Tassi, Valentina / Facchinetti, Francesco / Marchetti, Giovanni / Caprera, Cecilia / Ragusa, Mark / Tiseo, Marcello / Bracarda, Sergio / Bracarda, Sergio

    Advances in respiratory medicine

    2022  Volume 90, Issue 3, Page(s) 234–235

    MeSH term(s) Afatinib/therapeutic use ; ErbB Receptors/genetics ; Exons/genetics ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics
    Chemical Substances Afatinib (41UD74L59M) ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1)
    Language English
    Publishing date 2022-06-22
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2893877-X
    ISSN 2543-6031 ; 2451-4934
    ISSN (online) 2543-6031
    ISSN 2451-4934
    DOI 10.5603/ARM.a2022.0034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Terapia ormonale, assetto cardio-metabolico e cardiotossicità. Il lato ancora oscuro della cardioncologia – Parte 2: Tumore della prostata.

    Tarantini, Luigi / Di Girolamo, Stefania / Masini, Cristina / Cioffi, Giovanni / Foglietta, Jennifer / Bracarda, Sergio / Pinto, Carmine / Navazio, Alessandro

    Giornale italiano di cardiologia (2006)

    2023  Volume 24, Issue 10, Page(s) 781–791

    Abstract: Hormone therapies (HTs) with anti-androgenic properties are a cornerstone for the treatment of prostate cancer (PC) and have significantly improved the survival of patients, though exposing them to a higher risk of cardiovascular diseases (CVDs), which ... ...

    Title translation Hormone therapy, cardio-metabolic profile, and cardiotoxicity. Still a dark side of cardio-oncology - Part 2: Prostate cancer.
    Abstract Hormone therapies (HTs) with anti-androgenic properties are a cornerstone for the treatment of prostate cancer (PC) and have significantly improved the survival of patients, though exposing them to a higher risk of cardiovascular diseases (CVDs), which represent a major cause of morbidity and mortality. This occurs due to the high average age of patients undergoing HT for PC, an age group in which CVDs have a high prevalence and incidence, and due to the type and duration of HTs that are increasingly effective but at the same time more aggressive towards cardiovascular health. Recent evidence from the real world suggests, however, that the cardiometabolic risk is widely underestimated and undertreated with significant impact also on the oncological prognosis. In the light of the results of the PRONOUNCE study, in this review it is emphasized the need for a multidisciplinary management of patients with PC who are candidate for or treated with HT by implementing a personalized treatment program in accordance with the current European guidelines on CVD prevention.
    MeSH term(s) Male ; Humans ; Cardiotoxicity/etiology ; Cardiotoxicity/prevention & control ; Neoplasms/complications ; Medical Oncology ; Cardiovascular Diseases/chemically induced ; Cardiovascular Diseases/prevention & control ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/chemically induced ; Hormones/therapeutic use ; Antineoplastic Agents/adverse effects
    Chemical Substances Hormones ; Antineoplastic Agents
    Language Italian
    Publishing date 2023-10-23
    Publishing country Italy
    Document type Review ; English Abstract ; Journal Article
    ZDB-ID 2272414-X
    ISSN 1972-6481 ; 1827-6806
    ISSN (online) 1972-6481
    ISSN 1827-6806
    DOI 10.1714/4100.40978
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6738: Show issues Location:
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  5. Article ; Online: SIUrO best practice recommendations to optimize BRCA 1/2 gene testing from DNA extracted from bone biopsy in mCRPC patients (BRCA Optimal Bone Biopsy Procedure: BOP).

    Cimadamore, Alessia / Rescigno, Pasquale / Conteduca, Vincenza / Caliò, Anna / Allegritti, Massimiliano / Calò, Valentina / Montagnani, Ilaria / Lucianò, Roberta / Patruno, Margherita / Bracarda, Sergio

    Virchows Archiv : an international journal of pathology

    2023  Volume 483, Issue 5, Page(s) 579–589

    Abstract: The main guidelines and recommendations for the implementation of the BRCA1/2 somatic test do not focus on the clinical application of predictive testing on bone metastases, a frequent condition in metastatic prostate cancer, by analyzing the critical ... ...

    Abstract The main guidelines and recommendations for the implementation of the BRCA1/2 somatic test do not focus on the clinical application of predictive testing on bone metastases, a frequent condition in metastatic prostate cancer, by analyzing the critical issues encountered by laboratory practice. Our goal is to produce a document (protocol) deriving from a multidisciplinary team approach to obtain high quality nucleic acids from biopsy of bone metastases. This document aims to compose an operational check-list of three phases: the pre-analytical phase concerns tumor cellularity, tissue processing, sample preservation (blood/FFPE), fixation and staining, but above all the decalcification process, the most critical phase because of its key role in allowing the extraction of somatic DNA with a good yield and high quality. The analytical phase involves the preparation of the libraries that can be analyzed in various NGS genetic sequencing platforms and with various bioinformatics software for the interpretation of sequence variants. Finally, the post-analytical phase that allows to report the variants of the BRCA1/2 genes in a clear and usable way to the clinician who will use these data to manage cancer therapy with PARP Inhibitors.
    MeSH term(s) Male ; Humans ; BRCA1 Protein/genetics ; Mutation ; BRCA2 Protein/genetics ; Prostatic Neoplasms, Castration-Resistant/diagnosis ; Prostatic Neoplasms, Castration-Resistant/genetics ; DNA ; Biopsy
    Chemical Substances BRCA1 protein, human ; BRCA1 Protein ; BRCA2 protein, human ; BRCA2 Protein ; DNA (9007-49-2)
    Language English
    Publishing date 2023-10-05
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1184867-4
    ISSN 1432-2307 ; 0945-6317
    ISSN (online) 1432-2307
    ISSN 0945-6317
    DOI 10.1007/s00428-023-03660-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud III Zs.10: Show issues Location:
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  6. Article ; Online: Theranostics revolution in prostate cancer: Basics, clinical applications, open issues and future perspectives.

    Bauckneht, Matteo / Ciccarese, Chiara / Laudicella, Riccardo / Mosillo, Claudia / D'Amico, Francesca / Anghelone, Annunziato / Strusi, Alessandro / Beccia, Viria / Bracarda, Sergio / Fornarini, Giuseppe / Tortora, Giampaolo / Iacovelli, Roberto

    Cancer treatment reviews

    2024  Volume 124, Page(s) 102698

    Abstract: In the last years, theranostics has expanded the therapeutic options available for prostate cancer patients. In this review, we explore this dynamic field and its potential to revolutionize precision medicine for prostate cancer. We delve into the ... ...

    Abstract In the last years, theranostics has expanded the therapeutic options available for prostate cancer patients. In this review, we explore this dynamic field and its potential to revolutionize precision medicine for prostate cancer. We delve into the foundational principles, clinical applications, and emerging opportunities, emphasizing the potential synergy between radioligand therapy and other systemic treatments. Additionally, we address the ongoing challenges, including optimizing patient selection, assessing treatment responses, and determining the role of theranostics within the broader landscape of prostate cancer treatment.
    MeSH term(s) Male ; Humans ; Precision Medicine ; Theranostic Nanomedicine ; Prostatic Neoplasms/therapy
    Language English
    Publishing date 2024-02-11
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 125102-8
    ISSN 1532-1967 ; 0305-7372
    ISSN (online) 1532-1967
    ISSN 0305-7372
    DOI 10.1016/j.ctrv.2024.102698
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1022: Show issues Location:
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    Zs.MO 611: Show issues

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  7. Article: Editorial comment on: prognostic and predictive factors in patients with androgen-independent prostate cancer treated with docetaxel and estramustine: a single institution experience.

    Bracarda, Sergio

    European urology

    2008  Volume 53, Issue 2, Page(s) 331

    MeSH term(s) Aged ; Androgens/metabolism ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Biomarkers, Tumor/analysis ; Estramustine/administration & dosage ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; Prognosis ; Proportional Hazards Models ; Prostate-Specific Antigen/analysis ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/surgery ; Survival Analysis ; Taxoids/administration & dosage ; Treatment Outcome
    Chemical Substances Androgens ; Biomarkers, Tumor ; Taxoids ; docetaxel (15H5577CQD) ; Estramustine (35LT29625A) ; Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2008-02
    Publishing country Switzerland
    Document type Comment ; Editorial
    ZDB-ID 193790-x
    ISSN 1421-993X ; 0302-2838
    ISSN (online) 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2007.03.073
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1247: Show issues Location:
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    Zs.MO 294: Show issues

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  8. Article: Editorial comment on: Weekly docetaxel and prednisolone versus prednisolone alone in androgen-independent prostate cancer: a randomized phase II study.

    Bracarda, Sergio

    European urology

    2007  Volume 52, Issue 6, Page(s) 1698–1699

    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Humans ; Male ; Prednisolone/administration & dosage ; Prednisolone/therapeutic use ; Prostatic Neoplasms/drug therapy ; Taxoids/administration & dosage
    Chemical Substances Taxoids ; docetaxel (15H5577CQD) ; Prednisolone (9PHQ9Y1OLM)
    Language English
    Publishing date 2007-12
    Publishing country Switzerland
    Document type Comment ; Editorial
    ZDB-ID 193790-x
    ISSN 1421-993X ; 0302-2838
    ISSN (online) 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2007.01.105
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1247: Show issues Location:
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  9. Article ; Online: Angiogenic and immunological pathways in metastatic renal cell carcinoma: A counteracting paradigm or two faces of the same medal? The GIANUS Review.

    Bracarda, Sergio / Porta, Camillo / Sabbatini, Roberto / Rivoltini, Licia

    Critical reviews in oncology/hematology

    2018  Volume 139, Page(s) 149–157

    Abstract: In the so-called "antiangiogenic era" of recent years, a number of targeted therapies have been approved for the treatment of metastatic renal cell carcinoma (mRCC). Emerging information about the immunological features of mRCC and the immunomodulating ... ...

    Abstract In the so-called "antiangiogenic era" of recent years, a number of targeted therapies have been approved for the treatment of metastatic renal cell carcinoma (mRCC). Emerging information about the immunological features of mRCC and the immunomodulating properties of antiangiogenic agents, one of the standard treatments for mRCC, indicates that a more rational design of potentially synergistic combinations should be pursued. Indeed, immunotherapy has undergone a resurgence in clinical practice. In this narrative review, we discuss the immunological features of mRCC and the potential interactions that antiangiogenic agents may also exert on host immunity and tumor immunogenicity, possibly working on both sides of this complex cross-talk. Hence, the recall to Gianus, the ancient two-faced Roman God who was looking both at the future and the past. Treatment strategies will be also critically discussed.
    MeSH term(s) Angiogenesis Inhibitors/therapeutic use ; Carcinoma, Renal Cell/blood supply ; Carcinoma, Renal Cell/drug therapy ; Carcinoma, Renal Cell/pathology ; Humans ; Immunologic Factors/therapeutic use ; Immunomodulation ; Immunotherapy/methods ; Kidney Neoplasms/blood supply ; Kidney Neoplasms/drug therapy ; Kidney Neoplasms/secondary ; Neovascularization, Pathologic/prevention & control
    Chemical Substances Angiogenesis Inhibitors ; Immunologic Factors
    Language English
    Publishing date 2018-08-01
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 605680-5
    ISSN 1879-0461 ; 0737-9587 ; 1040-8428
    ISSN (online) 1879-0461
    ISSN 0737-9587 ; 1040-8428
    DOI 10.1016/j.critrevonc.2018.07.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1931: Show issues Location:
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  10. Article ; Online: "To Cut or Not to Cut", a Biomolecular Approach to Metastasectomy in Metastatic Clear Cell Renal Cell Carcinoma.

    Bracarda, Sergio / Guida, Annalisa / Caserta, Claudia

    European urology

    2018  Volume 74, Issue 4, Page(s) 481–482

    MeSH term(s) Carcinoma, Renal Cell/surgery ; Humans ; Kidney Neoplasms/surgery ; Metastasectomy ; Nephrectomy ; Prognosis
    Language English
    Publishing date 2018-07-17
    Publishing country Switzerland
    Document type Editorial ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2018.06.039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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