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Article ; Online: Determination of serum aflatoxin B

Di Gregorio, Mayra Carraro / Jager, Alessandra Vincenzi / Souto, Pollyana Cristina Maggio Castro / Costa, Aline Alves / Rottinghaus, George Edwin / Passarelli, Danielle / Budiño, Fabio Enrique Lemos / Corassin, Carlos Humberto / Oliveira, Carlos Augusto Fernandes

Mycotoxin research

2017 Volume 33, Issue 2, Page(s) 93–102

Abstract: In this study, serum aflatoxin B ...

Abstract	In this study, serum aflatoxin B
MeSH term(s)	Adsorption ; Aflatoxin B1/blood ; Aflatoxin B1/isolation & purification ; Aluminum Silicates ; Animal Feed ; Animals ; Diet/methods ; Food Additives ; Food Contamination ; Lysine/blood ; Mycotoxins/blood ; Mycotoxins/isolation & purification ; Serum/chemistry ; Swine
Chemical Substances	Aluminum Silicates ; Food Additives ; Mycotoxins ; sodium calcium aluminosilicate, hydrated (1344-01-0) ; Aflatoxin B1 (9N2N2Y55MH) ; Lysine (K3Z4F929H6)
Language	English
Publishing date	2017-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	14500-2
ISSN	1867-1632 ; 0178-7888
ISSN (online)	1867-1632
ISSN	0178-7888
DOI	10.1007/s12550-016-0267-5
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Article ; Online: NF-kappa-B essential modulator (NEMO) gene polymorphism in an adult woman with systemic lupus erythematosus and recurrent non-tuberculous mycobacterial disseminated infections.

Thomas, Konstantinos / Tsioulos, Georgios / Kotsogianni, Christina / Banos, Agellos / Niemela, Julie E / Cheng, Aristine / DiMaggio, Tom / Holland, Steven / Rosenzweig, Sergio D / Tziolos, Nikolaos / Papadopoulos, Antonios / Lionakis, Michail S / Boumpas, Dimitrios T

RMD open

2023 Volume 9, Issue 2

Abstract: ... interferon-γ, whole exome sequencing revealed a homozygous polymorphism in the NF-kappa-B essential modulator ...

Abstract	Infections are among the most serious complications in patients with systemic lupus erythematosus (SLE), with bacterial and viral infections being the most common. Non-tuberculous mycobacterial (NTM) infections are quite rare and are typically seen in older patients with SLE with longstanding disease duration treated with corticosteroids. Here, we describe a 39-year-old woman with SLE and an unusual pattern of recurrent NTM disseminated infections. After excluding the presence of autoantibodies against interferon-γ, whole exome sequencing revealed a homozygous polymorphism in the NF-kappa-B essential modulator (NEMO) gene. Primary immunodeficiencies should be included in the differential diagnosis of patients with recurrent opportunistic infections, even in those with iatrogenic immunosuppression.
MeSH term(s)	Adult ; Female ; Humans ; Autoantibodies ; Immunosuppression Therapy ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/drug therapy ; Nontuberculous Mycobacteria ; Polymorphism, Genetic
Chemical Substances	Autoantibodies
Language	English
Publishing date	2023-06-25
Publishing country	England
Document type	Case Reports ; Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	2812592-7
ISSN	2056-5933 ; 2056-5933
ISSN (online)	2056-5933
ISSN	2056-5933
DOI	10.1136/rmdopen-2023-003149
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Article ; Online: NF-kappa-B essential modulator (NEMO) gene polymorphism in an adult woman with systemic lupus erythematosus and recurrent non-tuberculous mycobacterial disseminated infections

Antonios Papadopoulos / Nikolaos Tziolos / Aristine Cheng / Georgios Tsioulos / Konstantinos Thomas / Christina Kotsogianni / Agellos Banos / Julie E. Niemela / Tom DiMaggio / Steven Holland / Sergio D. Rosenzweig / Michail S. Lionakis / Dimitrios T. Boumpas

RMD Open, Vol 9, Iss

2023 Volume 2

Abstract: ... interferon-γ, whole exome sequencing revealed a homozygous polymorphism in the NF-kappa-B essential modulator ...

Abstract	Infections are among the most serious complications in patients with systemic lupus erythematosus (SLE), with bacterial and viral infections being the most common. Non-tuberculous mycobacterial (NTM) infections are quite rare and are typically seen in older patients with SLE with longstanding disease duration treated with corticosteroids. Here, we describe a 39-year-old woman with SLE and an unusual pattern of recurrent NTM disseminated infections. After excluding the presence of autoantibodies against interferon-γ, whole exome sequencing revealed a homozygous polymorphism in the NF-kappa-B essential modulator (NEMO) gene. Primary immunodeficiencies should be included in the differential diagnosis of patients with recurrent opportunistic infections, even in those with iatrogenic immunosuppression.
Keywords	Medicine ; R
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The place of allogeneic stem cell transplantation in aggressive B-cell non-Hodgkin lymphoma in the era of CAR-T-cell therapy

Luca Castagna / Roberto Bono / Stefania Tringali / Giuseppe Sapienza / Alessandra Santoro / Alessandro Indovina / Vittoria Tarantino / Laura Di Noto / Aurelio Maggio / Caterina Patti

Frontiers in Medicine, Vol

2022 Volume 9

Abstract: ... large B-cell lymphoma (DLBCL), mantle cell lymphoma (MCL), follicular lymphoma (FL), and ... ALLO-SCT and CAR-T-cell therapy in patients with aggressive lymphomas (large B-cell lymphoma and MCL ...

Abstract	Chimeric antigen receptor T (CAR-T) cells are a treatment option for patients with relapse/refractory (R/R) non-Hodgkin lymphoma (NHL), acute lymphoid leukemia and multiple myeloma. To date, diffuse large B-cell lymphoma (DLBCL), mantle cell lymphoma (MCL), follicular lymphoma (FL), and chronic lymphocytic leukemia (CLL) have been successfully treated with CAR-T cells directed against the CD19 antigen. However, when R/R disease persists after several treatment lines, patients with these diseases are often referred to transplantation centres to receive allogeneic stem cell transplantation (ALLO-SCT). ALLO-SCT and CAR-T cells share mechanism of actions, inducing immune effects of T-cells (and other cells after transplantation) against lymphoma cells, but they differ in several other characteristics. These differences justify unique positioning of each therapy within treatment algorithms. In this paper, we analyzed the results obtained after ALLO-SCT and CAR-T-cell therapy in patients with aggressive lymphomas (large B-cell lymphoma and MCL) to identify the ideal scenarios in which these 2 immunological therapies should be employed.
Keywords	allogeneic stem cell transplantation ; CAR-T cells therapy ; non-Hodgkin lymphoma ; refractory ; toxicity ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: UV light absorption parameters of the pathobiologically implicated bilirubin oxidation products, MVM, BOX A, and BOX B.

Harris, Nathaniel A / Rapoport, Robert M / Zuccarello, Mario / Maggio, John E

Data in brief

2018 Volume 18, Page(s) 1400–1409

Abstract: ... dihydropyrrol-2-ylidene)acetamide]) and BOX B (3-methyl-5-oxo-4-vinyl-(1,5-dihydropyrrol-2-ylidene)acetamide ...

Abstract	The formation of the bilirubin oxidation products (BOXes), BOX A ([4-methyl-5-oxo-3-vinyl-(1,5-dihydropyrrol-2-ylidene)acetamide]) and BOX B (3-methyl-5-oxo-4-vinyl-(1,5-dihydropyrrol-2-ylidene)acetamide), as well as MVM (4-methyl-3-vinylmaleimide) were synthesized by oxidation of bilirubin with H
Language	English
Publishing date	2018-04-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2786545-9
ISSN	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2018.04.010
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Murine norovirus inhibits B cell development in the bone marrow of STAT1-deficient mice.

Hsu, Charlie C / Meeker, Stacey M / Escobar, Sabine / Brabb, Thea L / Paik, Jisun / Park, Heon / Iritani, Brian M / Maggio-Price, Lillian

Virology

2017 Volume 515, Page(s) 123–133

Abstract: ... that noroviruses can infect B cells. We demonstrate that murine norovirus (MNV) infection can significantly impair ... B cell development in the bone marrow in a signal transducer and activator of transcription 1 (STAT1 ... in the absence of STAT1 in ex vivo cultured B cells. Interestingly, using bone marrow transplantation studies ...

Abstract	Noroviruses are a leading cause of gastroenteritis in humans and it was recently revealed that noroviruses can infect B cells. We demonstrate that murine norovirus (MNV) infection can significantly impair B cell development in the bone marrow in a signal transducer and activator of transcription 1 (STAT1) dependent, but interferon signaling independent manner. We also show that MNV replication is more pronounced in the absence of STAT1 in ex vivo cultured B cells. Interestingly, using bone marrow transplantation studies, we found that impaired B cell development requires Stat1
MeSH term(s)	Animals ; B-Lymphocytes/metabolism ; B-Lymphocytes/virology ; Bone Marrow/metabolism ; Bone Marrow/virology ; Caliciviridae Infections/metabolism ; Caliciviridae Infections/virology ; Female ; Gastroenteritis/metabolism ; Gastroenteritis/virology ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Norovirus/genetics ; Norovirus/physiology ; STAT1 Transcription Factor/deficiency ; STAT1 Transcription Factor/genetics ; Virus Replication
Chemical Substances	STAT1 Transcription Factor ; Stat1 protein, mouse
Keywords	covid19
Language	English
Publishing date	2017-12-26
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	200425-2
ISSN	1096-0341 ; 0042-6822
ISSN (online)	1096-0341
ISSN	0042-6822
DOI	10.1016/j.virol.2017.12.013
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Article ; Online: Fibrin-associated diffuse large B-cell lymphoma in a hemorrhagic cranial arachnoid cyst.

Kirschenbaum, Daniel / Prömmel, Peter / Vasella, Flavio / Haralambieva, Eugenia / Marques Maggio, Ewerton / Reisch, Robert / Beer, Marc / Camenisch, Ulrike / Rushing, Elisabeth J

Acta neuropathologica communications

2017 Volume 5, Issue 1, Page(s) 60

Language	English
Publishing date	2017--07
Publishing country	England
Document type	Letter
ZDB-ID	2715589-4
ISSN	2051-5960 ; 2051-5960
ISSN (online)	2051-5960
ISSN	2051-5960
DOI	10.1186/s40478-017-0463-3
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Article ; Online: The efficacy of ginkgolide B in the acute treatment of migraine aura: an open preliminary trial.

Allais, Gianni / D'Andrea, Giovanni / Maggio, Maurizio / Benedetto, Chiara

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

2013 Volume 34 Suppl 1, Page(s) S161–3

Abstract: In this open trial we evaluated the possible efficacy of Ginkgolide B in the treatment of acute ...

Abstract	In this open trial we evaluated the possible efficacy of Ginkgolide B in the treatment of acute aura in a group of patients suffering from migraine with aura, considering in particular the effect of the treatment on aura duration. Twenty-five patients (16 females, 9 males, mean age 39.7 ± 13.5 years, range 18-65) suffering from migraine with aura were enrolled in the study. The diagnosis was made according to the diagnostic criteria of the international classification of headache disorders, second edition (ICHD-II), for typical aura with migraine headache (n = 19) or typical aura without headache (n = 6). Patients were asked to use a diary card to register the exact duration of the aura symptoms in two consecutive attacks of aura. In the first one, they only took note of the duration of neurological symptoms in minutes. In the following attack, they were instructed to take orally, immediately at the onset of the first symptoms of aura, two capsules of a combination of 60 mg Ginkgo biloba terpenes phytosome, 11 mg coenzyme Q 10 and 8.7 mg vitamin B2 (Migrasoll). Aura duration (expressed in minutes) was significantly (p < 0.001) reduced by Migrasoll intake, being 33.6 ± 11.5 in the first untreated attack and 21.9 ± 11.8 during the second attack. In general, there was a marked amelioration of the features of the neurological symptoms of aura in the treated attack. In four patients (18.1 %) suffering from typical aura with migraine, the pain phase disappeared. Among the patients who completed the study no serious adverse events were reported.
MeSH term(s)	Adolescent ; Adult ; Aged ; Female ; Fibrinolytic Agents/therapeutic use ; Ginkgolides/therapeutic use ; Humans ; Lactones/therapeutic use ; Male ; Middle Aged ; Migraine with Aura/drug therapy ; Young Adult
Chemical Substances	Fibrinolytic Agents ; Ginkgolides ; Lactones ; ginkgolide B (DF149B9460)
Language	English
Publishing date	2013-05-22
Publishing country	Italy
Document type	Clinical Trial ; Journal Article
ZDB-ID	2016546-8
ISSN	1590-3478 ; 1590-1874
ISSN (online)	1590-3478
ISSN	1590-1874
DOI	10.1007/s10072-013-1413-x
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Article ; Online: Identification and quantification of bisphenol A and bisphenol B in polyvinylchloride and polycarbonate medical devices by gas chromatography with mass spectrometry.

Gimeno, Pascal / Spinau, Coline / Lassu, Nelly / Maggio, Annie-Françoise / Brenier, Charlotte / Lempereur, Laurent

Journal of separation science

2015 Volume 38, Issue 21, Page(s) 3727–3734

Abstract: ... medical devices. In order to assay, in addition to plasticizers, bisphenols A and B possibly present ... for the polyvinylchloride sample was tested and validated for the assay of bisphenols A and B in polycarbonate ... medical devices. The separation of all compounds, including bisphenols A and B, is obtained on a cross-linked 5 ...

Abstract	A gas chromatography with mass spectrometry method has already been developed and published for the identification and quantification of 14 phthalates and five nonphthalate plasticizers in polyvinylchloride medical devices. In order to assay, in addition to plasticizers, bisphenols A and B possibly present in polyvinylchloride samples, this previous method was extended to the assay of these additional potential endocrine disruptors. Furthermore, as bisphenol A could also be present in polycarbonate samples, the method used for the polyvinylchloride sample was tested and validated for the assay of bisphenols A and B in polycarbonate medical devices. The separation of all compounds, including bisphenols A and B, is obtained on a cross-linked 5%-phenyl/95%-dimethylpolysiloxane capillary column using a temperature gradient. For both plastics, samples are dissolved in tetrahydrofuran followed by a precipitation of the plastic by addition of ethanol. Results obtained point out residual bisphenol A amounts for polycarbonate samples ranging from 0.6 to 0.8% and for polyvinylchloride samples less or equal to 5 ppm. No bisphenol B was detected in the samples tested. For bisphenols A and B, mean recoveries obtained on spiked polyvinylchloride or polycarbonate sample preparations ranged from 87 to 108% in accordance with in-house specification (80-110%).
MeSH term(s)	Benzhydryl Compounds/analysis ; Chromatography, High Pressure Liquid/methods ; Diterpenes, Abietane/analysis ; Equipment and Supplies ; Gas Chromatography-Mass Spectrometry ; Ginsenosides/analysis ; Lignin/analysis ; Phenols/analysis ; Polycarboxylate Cement/chemistry ; Polyvinyl Chloride/chemistry ; Tandem Mass Spectrometry/methods
Chemical Substances	Benzhydryl Compounds ; Diterpenes, Abietane ; Ginsenosides ; Phenols ; Polycarboxylate Cement ; tanshinone (03UUH3J385) ; bisphenol B (1RC731TJJA) ; polycarbonate (25766-59-0) ; Polyvinyl Chloride (9002-86-2) ; Lignin (9005-53-2) ; bisphenol A (MLT3645I99)
Language	English
Publishing date	2015-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2047990-6
ISSN	1615-9314 ; 1615-9306
ISSN (online)	1615-9314
ISSN	1615-9306
DOI	10.1002/jssc.201500552
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Article ; Online: UV light absorption parameters of the pathobiologically implicated bilirubin oxidation products, MVM, BOX A, and BOX B

Nathaniel A. Harris / Robert M. Rapoport / Mario Zuccarello / John E. Maggio

Data in Brief, Vol 18, Iss , Pp 1400-

2018 Volume 1409

Abstract: ... dihydropyrrol-2-ylidene)acetamide]) and BOX B (3-methyl-5-oxo-4-vinyl-(1,5-dihydropyrrol-2-ylidene)acetamide ... estimated using NMR) for BOX A, BOX B, and MVM in H2O, 15% CH3CN plus 10 mM CF3CO2H, CH3CN, CHCl3, CH2Cl2 ... by the solvent, ranging from 295–297 nm; 2) BOX B, less polar solvent yielded λmax's of lower wavelength ...

Abstract	The formation of the bilirubin oxidation products (BOXes), BOX A ([4-methyl-5-oxo-3-vinyl-(1,5-dihydropyrrol-2-ylidene)acetamide]) and BOX B (3-methyl-5-oxo-4-vinyl-(1,5-dihydropyrrol-2-ylidene)acetamide), as well as MVM (4-methyl-3-vinylmaleimide) were synthesized by oxidation of bilirubin with H2O2 without and with FeCl3, respectively. Compound identity was confirmed with NMR and mass spectrometry (MS; less than 1 ppm, tandem MS up to MS4). UV absorption profiles, including λmax, and extinction coefficient (ε; estimated using NMR) for BOX A, BOX B, and MVM in H2O, 15% CH3CN plus 10 mM CF3CO2H, CH3CN, CHCl3, CH2Cl2, and 0.9% NaCl were determined. At longer wavelengths, λmax's for 1) BOX A were little affected by the solvent, ranging from 295–297 nm; 2) BOX B, less polar solvent yielded λmax's of lower wavelength, with values ranging from 308–313 nm, and 3) MVM, less polar solvent yielded λmax's of higher wavelength, with values ranging from 318–327 nm. Estimated ε’s for BOX A and BOX B were approximately 5- to 10-fold greater than for MVM. Keywords: Bilirubin oxidation products, BOX A, BOX B, MVM, λmax, Extinction coefficient, Synthesis
Keywords	Computer applications to medicine. Medical informatics ; R858-859.7 ; Science (General) ; Q1-390
Subject code	660
Language	English
Publishing date	2018-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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