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  1. Book: Toxoplasma gondii

    Tonkin, Christopher J.

    methods and protocols

    (Methods in molecular biology ; 2071 ; Springer protocols)

    2020  

    Author's details edited by Christopher J. Tonkin
    Series title Methods in molecular biology ; 2071
    Springer protocols
    Collection
    Language English
    Size xi, 470 Seiten, Illustrationen
    Publisher Humana Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT020306045
    ISBN 978-1-4939-9856-2 ; 9781493998579 ; 1-4939-9856-0 ; 1493998579
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 7042 -2071- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Toxoplasma protein export and effector function.

    Seizova, Simona / Ferrel, Abel / Boothroyd, John / Tonkin, Christopher J

    Nature microbiology

    2024  Volume 9, Issue 1, Page(s) 17–28

    Abstract: Toxoplasma gondii is a single-celled eukaryotic parasite with a considerable host range that must invade the cells of warm-blooded hosts to survive and replicate. The challenges and opportunities that such a strategy represent have been met by the ... ...

    Abstract Toxoplasma gondii is a single-celled eukaryotic parasite with a considerable host range that must invade the cells of warm-blooded hosts to survive and replicate. The challenges and opportunities that such a strategy represent have been met by the evolution of effectors that are delivered into host cells, counter host defences and co-opt host cell functions for their own purposes. These effectors are delivered in two waves using distinct machinery for each. In this Review, we focus on understanding the architecture of these protein-export systems and how their protein cargo is recognized and selected. We discuss the recent findings on the role that host manipulation has in latent Toxoplasma infections. We also discuss how these recent findings compare to protein export in the related Plasmodium spp. (the causative agent of malaria) and how this can inform our understanding of host manipulation in the larger Apicomplexa phylum and its evolution.
    MeSH term(s) Toxoplasma/metabolism ; Protozoan Proteins/genetics ; Protozoan Proteins/metabolism ; Vacuoles/metabolism ; Plasmodium/metabolism ; Cells, Cultured
    Chemical Substances Protozoan Proteins
    Language English
    Publishing date 2024-01-03
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2058-5276
    ISSN (online) 2058-5276
    DOI 10.1038/s41564-023-01563-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: 3, 2, 1, go! Cryptosporidium counts down to sex.

    Jex, Aaron R / Tonkin, Christopher J / Ralph, Stuart A

    PLoS biology

    2022  Volume 20, Issue 5, Page(s) e3001638

    Abstract: Cryptosporidium is a leading cause of death from childhood diarrhea, but its biology is poorly understood. A recent study in PLOS Biology reveals hitherto unknown aspects of the parasite's life cycle that may lead to improvements in ex vivo culture. ...

    Abstract Cryptosporidium is a leading cause of death from childhood diarrhea, but its biology is poorly understood. A recent study in PLOS Biology reveals hitherto unknown aspects of the parasite's life cycle that may lead to improvements in ex vivo culture.
    MeSH term(s) Animals ; Cryptosporidiosis ; Cryptosporidium/genetics ; Cryptosporidium parvum ; Female ; Germ Cells ; Life Cycle Stages ; Male
    Language English
    Publishing date 2022-05-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2126776-5
    ISSN 1545-7885 ; 1544-9173
    ISSN (online) 1545-7885
    ISSN 1544-9173
    DOI 10.1371/journal.pbio.3001638
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6193: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: A CRISPR upgrade unlocks Toxoplasma gene function.

    Tsee Dawson, Aurelie / Tonkin, Christopher J

    Trends in parasitology

    2022  Volume 38, Issue 10, Page(s) 826–828

    Abstract: Forward genetic screens are invaluable in describing gene function. CRISPR has reinvigorated phenotypic screens in Toxoplasma - a model apicomplexan parasite. Two recent papers by Smith et al. and Li et al. take the next big leap in performing forward ... ...

    Abstract Forward genetic screens are invaluable in describing gene function. CRISPR has reinvigorated phenotypic screens in Toxoplasma - a model apicomplexan parasite. Two recent papers by Smith et al. and Li et al. take the next big leap in performing forward genetic screens in Toxoplasma by combining conditional gene regulation with CRISPR.
    MeSH term(s) CRISPR-Cas Systems ; Clustered Regularly Interspaced Short Palindromic Repeats/genetics ; Genetic Testing ; Toxoplasma/genetics
    Language English
    Publishing date 2022-08-13
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2022.07.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2898: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 16: Show issues
    Zs.MO 251: Show issues

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  5. Article: A CRISPR upgrade unlocks Toxoplasma gene function

    Dawson, Aurelie / Tonkin, Christopher J.

    Trends in parasitology. 2022,

    2022  

    Abstract: Forward genetic screens are invaluable in describing gene function. CRISPR has reinvigorated phenotypic screens in Toxoplasma - a model apicomplexan parasite. Two recent papers by Smith et al. and Li et al. take the next big leap in performing forward ... ...

    Abstract Forward genetic screens are invaluable in describing gene function. CRISPR has reinvigorated phenotypic screens in Toxoplasma - a model apicomplexan parasite. Two recent papers by Smith et al. and Li et al. take the next big leap in performing forward genetic screens in Toxoplasma by combining conditional gene regulation with CRISPR.
    Keywords Toxoplasma ; genes ; parasitology ; phenotype
    Language English
    Publishing place Elsevier Ltd
    Document type Article
    Note Pre-press version
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2022.07.007
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2898: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 16: Show issues
    Zs.MO 251: Show issues

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  6. Article ; Online: Modification of Polysulfide Surfaces with Low-Power Lasers.

    Mann, Abigail K / Lisboa, Lynn S / Tonkin, Samuel J / Gascooke, Jason R / Chalker, Justin M / Gibson, Christopher T

    Angewandte Chemie (International ed. in English)

    2024  , Page(s) e202404802

    Abstract: The modification of polymer surfaces using laser light is important for many applications in the nano-, bio- and chemical sciences. Such capabilities have supported advances in biomedical devices, electronics, information storage, microfluidics, and ... ...

    Abstract The modification of polymer surfaces using laser light is important for many applications in the nano-, bio- and chemical sciences. Such capabilities have supported advances in biomedical devices, electronics, information storage, microfluidics, and other applications. In most cases, these modifications require high power lasers that are expensive and require specialized equipment and facilities to minimize risk of hazardous radiation. Additionally, polymer systems that can be easily modified by lasers are often complex and costly to prepare. In this report, these challenges are addressed with the discovery of low-cost sulfur copolymers that can be rapidly modified with lasers emitting low-power infrared and visible light. The featured copolymers are made from elemental sulfur and either cyclopentadiene or dicyclopentadiene. Using a suite of lasers with discreet wavelengths (532, 638 and 786 nm) and powers, a variety of surface modifications could be made on the polymers such as controlled swelling or etching via ablation. The facile synthesis and laser modification of these polymer systems were exploited in applications such as direct laser lithography and erasable information storage.
    Language English
    Publishing date 2024-03-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202404802
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A Unit-Concentration Method to Quantify Source Contribution.

    Bedekar, Vivek / Neville, Christopher / Tonkin, Matthew J / Bartlett, R Douglas / Plato, Paul

    Ground water

    2023  Volume 62, Issue 2, Page(s) 303–309

    Abstract: Solute migration is typically simulated to describe and estimate the fate and transport of contaminants in groundwater. The unit-concentration approach is investigated here as a method to enable solute transport simulations to expand the capabilities of ... ...

    Abstract Solute migration is typically simulated to describe and estimate the fate and transport of contaminants in groundwater. The unit-concentration approach is investigated here as a method to enable solute transport simulations to expand the capabilities of groundwater flow modeling. The unit-concentration method uses a concentration value of one to identify sources of water to be assessed and a concentration of zero for all other water sources. The distribution of concentration thus obtained, unlike particle tracking methods, provides a more intuitive and direct quantification of the contribution of sources reaching various sinks. The unit-concentration approach can be applied readily with existing solute transport software for a range of analyses including source allocation, well capture analysis, and mixing/dilution calculations. This paper presents the theory, method, and example applications of the unit-concentration approach for source quantification.
    MeSH term(s) Groundwater ; Models, Theoretical ; Water Pollutants, Chemical/analysis ; Water Movements ; Water/analysis
    Chemical Substances Water Pollutants, Chemical ; Water (059QF0KO0R)
    Language English
    Publishing date 2023-06-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 246212-6
    ISSN 1745-6584 ; 0017-467X
    ISSN (online) 1745-6584
    ISSN 0017-467X
    DOI 10.1111/gwat.13333
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 4456: Show issues

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  8. Article ; Online: 3, 2, 1, go! Cryptosporidium counts down to sex.

    Aaron R Jex / Christopher J Tonkin / Stuart A Ralph

    PLoS Biology, Vol 20, Iss 5, p e

    2022  Volume 3001638

    Abstract: Cryptosporidium is a leading cause of death from childhood diarrhea, but its biology is poorly understood. A recent study in PLOS Biology reveals hitherto unknown aspects of the parasite's life cycle that may lead to improvements in ex vivo culture. ...

    Abstract Cryptosporidium is a leading cause of death from childhood diarrhea, but its biology is poorly understood. A recent study in PLOS Biology reveals hitherto unknown aspects of the parasite's life cycle that may lead to improvements in ex vivo culture.
    Keywords Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Pathogenic Infection in Male Mice Changes Sperm Small RNA Profiles and Transgenerationally Alters Offspring Behavior.

    Tyebji, Shiraz / Hannan, Anthony J / Tonkin, Christopher J

    Cell reports

    2020  Volume 31, Issue 4, Page(s) 107573

    Abstract: Germline epigenetic factors influence transgenerational inheritance of behavioral traits upon changes in experience and environment. Immune activation due to infection can also modulate brain function, but whether this experience can be passed down to ... ...

    Abstract Germline epigenetic factors influence transgenerational inheritance of behavioral traits upon changes in experience and environment. Immune activation due to infection can also modulate brain function, but whether this experience can be passed down to offspring remains unknown. Here, we show that infection of the male lineage with the common human parasite Toxoplasma results in transgenerational behavioral changes in offspring in a sex-dependent manner. Small RNA sequencing of sperm reveals significant transcriptional differences of infected animals compared to controls. Zygote microinjection of total small RNA from sperm of infected mice partially recapitulates the behavioral phenotype of naturally born offspring, suggesting an epigenetic mechanism of behavioral inheritance in the first generation. Our results demonstrate that sperm epigenetic factors can contribute to intergenerational inheritance of behavioral changes after pathogenic infection, which could have major public health implications.
    MeSH term(s) Animals ; Behavior, Animal/physiology ; Disease Models, Animal ; Epigenomics/methods ; Infections/complications ; Male ; Mice ; RNA/metabolism ; Spermatozoa/metabolism ; Toxoplasmosis/physiopathology
    Chemical Substances RNA (63231-63-0)
    Language English
    Publishing date 2020-04-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2020.107573
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Characterisation of the OTU domain deubiquitinase complement of

    Wilde, Mary-Louise / Ruparel, Ushma / Klemm, Theresa / Lee, V Vern / Calleja, Dale J / Komander, David / Tonkin, Christopher J

    Life science alliance

    2023  Volume 6, Issue 6

    Abstract: The phylum Apicomplexa contains several parasitic species of medical and agricultural importance. The ubiquitination machinery remains, for the most part, uncharacterised in apicomplexan parasites, despite the important roles that it plays in eukaryotic ... ...

    Abstract The phylum Apicomplexa contains several parasitic species of medical and agricultural importance. The ubiquitination machinery remains, for the most part, uncharacterised in apicomplexan parasites, despite the important roles that it plays in eukaryotic biology. Bioinformatic analysis of the ubiquitination machinery in apicomplexan parasites revealed an expanded ovarian tumour domain-containing (OTU) deubiquitinase (DUB) family in
    MeSH term(s) Toxoplasma/genetics ; Toxoplasma/metabolism ; Ubiquitin/genetics ; Ubiquitin/metabolism ; Ubiquitination ; Plasmodium ; Deubiquitinating Enzymes/genetics ; Deubiquitinating Enzymes/metabolism
    Chemical Substances Ubiquitin ; Deubiquitinating Enzymes (EC 3.4.19.12)
    Language English
    Publishing date 2023-03-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2575-1077
    ISSN (online) 2575-1077
    DOI 10.26508/lsa.202201710
    Database MEDical Literature Analysis and Retrieval System OnLINE

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