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Article ; Online: Inferring microplastics origins in the Mediterranean Sea by coupling modelling and in-situ measurements.

Ourmieres, Yann / Arnaud, Maxime / Deixonne, Patrick / Ghiglione, Jean-François / Albignac, Magali / Poulain-Zarcos, Marie / Mercier, Matthieu / Ter Halle, Alexandra

Marine pollution bulletin

2023 Volume 195, Page(s) 115333

Abstract: This work focuses on the dynamics and retention of microplastics (MP) in the Mediterranean. MP manta-net trawls were performed in autumn 2019 north of the Balearic Islands and along the Balearic Front (BF). Lagrangian modelling was used to find the MP ... ...

Abstract	This work focuses on the dynamics and retention of microplastics (MP) in the Mediterranean. MP manta-net trawls were performed in autumn 2019 north of the Balearic Islands and along the Balearic Front (BF). Lagrangian modelling was used to find the MP collected origin during the campaign. These combined results show that North of Mallorca is a temporary retention zone of 3 months variability, with MP origin being the Northern Current (NC) and the Gulf of Lion (GOL). Retention processes were less clear along the BF, due to frontal dynamics together with the strong northerly winds. However, it appears that the origin can differ between the North (i.e. the large North-Westerly basin, including the GOL and the NC path) and the South (short distances around the zone) of this front. In both areas, the wind and the current variability are strongly conditioning the existence and position of the MP concentration zones.
MeSH term(s)	Microplastics ; Plastics/analysis ; Mediterranean Sea ; Environmental Monitoring/methods ; Wind ; Water Pollutants, Chemical/analysis
Chemical Substances	Microplastics ; Plastics ; Water Pollutants, Chemical
Language	English
Publishing date	2023-08-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2001296-2
ISSN	1879-3363 ; 0025-326X
ISSN (online)	1879-3363
ISSN	0025-326X
DOI	10.1016/j.marpolbul.2023.115333
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Article ; Online: Tracing MYC Expression for Small Molecule Discovery.

Steinberger, Jutta / Robert, Francis / Hallé, Maxime / Williams, David E / Cencic, Regina / Sawhney, Neha / Pelletier, Dylan / Williams, Philip / Igarashi, Yasuhiro / Porco, John A / Rodriguez, Abimael D / Kopp, Brigitte / Bachmann, Brian / Andersen, Raymond J / Pelletier, Jerry

Cell chemical biology

2019 Volume 26, Issue 5, Page(s) 699–710.e6

Abstract: Our inability to effectively "drug" targets such as MYC for therapeutic purposes requires the development of new approaches. We report on the implementation of a phenotype-based assay for monitoring MYC expression in multiple myeloma cells. The open ... ...

Abstract	Our inability to effectively "drug" targets such as MYC for therapeutic purposes requires the development of new approaches. We report on the implementation of a phenotype-based assay for monitoring MYC expression in multiple myeloma cells. The open reading frame (ORF) encoding an unstable variant of GFP was engineered immediately downstream of the MYC ORF using CRISPR/Cas9, resulting in co-expression of both proteins from the endogenous MYC locus. Using fluorescence readout as a surrogate for MYC expression, we implemented a pilot screen in which ∼10,000 compounds were prosecuted. Among known MYC expression inhibitors, we identified cardiac glycosides and cytoskeletal disruptors to be quite potent. We demonstrate the power of CRISPR/Cas9 engineering in establishing phenotype-based assays to identify gene expression modulators.
MeSH term(s)	Bufanolides/pharmacology ; CRISPR-Cas Systems/genetics ; Cardiac Glycosides/pharmacology ; Cell Line, Tumor ; Cell Survival/drug effects ; Cytoskeleton/drug effects ; Cytoskeleton/metabolism ; Eukaryotic Initiation Factor-2/genetics ; Eukaryotic Initiation Factor-2/metabolism ; Humans ; Proto-Oncogene Proteins c-myc/antagonists & inhibitors ; Proto-Oncogene Proteins c-myc/genetics ; Proto-Oncogene Proteins c-myc/metabolism ; RNA Interference ; RNA, Small Interfering/metabolism ; Small Molecule Libraries/pharmacology ; Transcription, Genetic/drug effects
Chemical Substances	Bufanolides ; Cardiac Glycosides ; Eukaryotic Initiation Factor-2 ; Proto-Oncogene Proteins c-myc ; RNA, Small Interfering ; Small Molecule Libraries ; bufalin (U549S98QLW)
Language	English
Publishing date	2019-03-14
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2451-9448
ISSN (online)	2451-9448
DOI	10.1016/j.chembiol.2019.02.007
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Article ; Online: PTP-PEST controls EphA3 activation and ephrin-induced cytoskeletal remodelling.

Mansour, Mariam / Nievergall, Eva / Gegenbauer, Kristina / Llerena, Carmen / Atapattu, Lakmali / Hallé, Maxime / Tremblay, Michel L / Janes, Peter W / Lackmann, Martin

Journal of cell science

2016 Volume 129, Issue 2, Page(s) 277–289

Abstract: Eph receptors and their corresponding membrane-bound ephrin ligands regulate cell positioning and establish tissue patterns during embryonic and oncogenic development. Emerging evidence suggests that assembly of polymeric Eph signalling clusters relies ... ...

Abstract	Eph receptors and their corresponding membrane-bound ephrin ligands regulate cell positioning and establish tissue patterns during embryonic and oncogenic development. Emerging evidence suggests that assembly of polymeric Eph signalling clusters relies on cytoskeletal reorganisation and underlies regulation by protein tyrosine phosphatases (PTPs). PTP-PEST (also known as PTPN12) is a central regulator of actin cytoskeletal dynamics. Here, we demonstrate that an N-terminal fragment of PTP-PEST, generated through an ephrinA5-triggered and spatially confined cleavage mediated by caspase-3, attenuates EphA3 receptor activation and its internalisation. Isolation of EphA3 receptor signalling clusters within intact plasma membrane fragments obtained by detergent-free cell fractionation reveals that stimulation of cells with ephrin triggers effective recruitment of this catalytically active truncated form of PTP-PEST together with key cytoskeletal and focal adhesion proteins. Importantly, modulation of actin polymerisation using pharmacological and dominant-negative approaches affects EphA3 phosphorylation in a similar manner to overexpression of PTP-PEST. We conclude that PTP-PEST regulates EphA3 activation both by affecting cytoskeletal remodelling and through its direct action as a PTP controlling EphA3 phosphorylation, indicating its multifaceted regulation of Eph signalling.
MeSH term(s)	Animals ; COS Cells ; Caspase 3/metabolism ; Cell Membrane/metabolism ; Cercopithecus aethiops ; Cytoskeleton/metabolism ; Ephrin-A5/physiology ; HEK293 Cells ; Humans ; Phosphorylation ; Protein Binding ; Protein Processing, Post-Translational ; Protein Transport ; Protein Tyrosine Phosphatase, Non-Receptor Type 12/physiology ; Receptor Protein-Tyrosine Kinases/metabolism
Chemical Substances	Ephrin-A5 ; EPHA3 protein, human (EC 2.7.10.1) ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1) ; PTPN12 protein, human (EC 3.1.3.48) ; Protein Tyrosine Phosphatase, Non-Receptor Type 12 (EC 3.1.3.48) ; CASP3 protein, human (EC 3.4.22.-) ; Caspase 3 (EC 3.4.22.-)
Language	English
Publishing date	2016-01-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2993-2
ISSN	1477-9137 ; 0021-9533
ISSN (online)	1477-9137
ISSN	0021-9533
DOI	10.1242/jcs.174490
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Article ; Online: Protein tyrosine phosphatases: emerging regulators of apoptosis.

Hallé, Maxime / Tremblay, Michel L / Meng, Tzu-Ching

Cell cycle (Georgetown, Tex.)

2007 Volume 6, Issue 22, Page(s) 2773–2781

Abstract: Apoptosis is a precisely controlled physiological mechanism that is required for the elimination of cells during embryonic development, in response to stress and infection as well as in the maintenance of homeostasis. Since the outcome of several of ... ...

Abstract	Apoptosis is a precisely controlled physiological mechanism that is required for the elimination of cells during embryonic development, in response to stress and infection as well as in the maintenance of homeostasis. Since the outcome of several of these biological processes is regulated by signaling events involving tyrosine phosphorylation, members of the protein tyrosine phosphatase (PTP) gene family are expected to be of primary importance. Here, we summarize the current literature linking the activities of classical PTPs with the regulation of apoptosis. The recent discovery of caspase-cleavage mediated modulation of a member of this family, PTP-PEST, indicates that other PTPs could be modulated in a similar manner. In light of this, we present an analysis of all murine and human PTPs gene for the presence of putative caspase cleavage motifs. Additional studies linking the activity of PTPs to their own regulation during programmed cell death initiation should provide important insight into the understanding of this fundamental physiological phenomenon.
MeSH term(s)	Animals ; Apoptosis/physiology ; Cell Survival/physiology ; Humans ; Protein Tyrosine Phosphatases/physiology ; Signal Transduction/physiology
Chemical Substances	Protein Tyrosine Phosphatases (EC 3.1.3.48)
Language	English
Publishing date	2007-08-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2146183-1
ISSN	1551-4005 ; 1538-4101 ; 1554-8627
ISSN (online)	1551-4005
ISSN	1538-4101 ; 1554-8627
DOI	10.4161/cc.6.22.4926
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Zs.A 5881: Show issues

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Article ; Online: Blood pressure response to maximal dynamic exercise testing in an athletic population.

Pressler, Axel / Jähnig, Angelika / Halle, Martin / Haller, Bernhard

Journal of hypertension

2018 Volume 36, Issue 9, Page(s) 1803–1809

Abstract: ... maximal heart rate >85% predicted, lactate ≥7 mmol/l, rate of perceived exertion ≥17) was required ... Echocardiography was also performed.: Results: Maximal workload was 305 ± 59 W (mean ± SD) in men and 218 ± 40 ... limits of maximal SBP were exceeded in 43% in men (>210 mmHg) and 28% in women (>190 mmHg). SBP response ...

Abstract	Objective: Exaggerated blood pressure (BP) response to exercise testing has been linked to left ventricular hypertrophy and myocardial fibrosis in competitive athletes. Due to frequent training, athletes are particularly exposed to high BP levels, but data on the magnitude and distribution of BP response to exercise in athletic populations is scarce. Methods: Cycle ergometry was performed in 2419 healthy competitive adolescent, professional and master athletes (age 26 ± 12 years, range 9-74, 27% women, 84 disciplines) for preparticipation screening. Fulfilling both subjective and at least two out of three objective exhaustion criteria (maximal heart rate >85% predicted, lactate ≥7 mmol/l, rate of perceived exertion ≥17) was required. Echocardiography was also performed. Results: Maximal workload was 305 ± 59 W (mean ± SD) in men and 218 ± 40 in women. SBP increased significantly (men, Δ80 ± 20; women, Δ67 ± 16 mmHg; P < 0.001) to 204 ± 22 (men) and 180 ± 17 mmHg (women). DBP changed minimally (men: Δ0 ± 9, women: Δ2 ± 8 mmHg). The upper normative limit of SBP in men was 247 [95% CI 245-249; women: 214 (212-216) mmHg]. ESC guidelines of upper limits of maximal SBP were exceeded in 43% in men (>210 mmHg) and 28% in women (>190 mmHg). SBP response was more pronounced in endurance athletes, whereas DBP was slightly higher in strength athletes. Among cardiac dimensions, the strongest association for maximal SBP was found for left ventricular mass (r = 0.489; P < 0.001). Conclusion: SBP response to exercise testing is markedly exaggerated particularly in male endurance athletes. The prognostic significance of these findings regarding long-term cardiovascular alterations requires further clarification.
MeSH term(s)	Adolescent ; Adult ; Aged ; Athletes ; Blood Pressure/physiology ; Child ; Cohort Studies ; Exercise/physiology ; Exercise Test ; Female ; Humans ; Hypertension/physiopathology ; Hypertrophy, Left Ventricular/physiopathology ; Male ; Middle Aged ; Sports/physiology ; Young Adult
Language	English
Publishing date	2018-05-22
Publishing country	England
Document type	Journal Article
ZDB-ID	605532-1
ISSN	1473-5598 ; 0263-6352 ; 0952-1178
ISSN (online)	1473-5598
ISSN	0263-6352 ; 0952-1178
DOI	10.1097/HJH.0000000000001791
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Zs.A 1885: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 614: Show issues

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Article ; Online: Regulation of the Src kinase-associated phosphoprotein 55 homologue by the protein tyrosine phosphatase PTP-PEST in the control of cell motility.

Ayoub, Emily / Hall, Anita / Scott, Adam M / Chagnon, Mélanie J / Miquel, Géraldine / Hallé, Maxime / Noda, Masaharu / Bikfalvi, Andreas / Tremblay, Michel L

The Journal of biological chemistry

2013 Volume 288, Issue 36, Page(s) 25739–25748

Abstract: PTP-PEST is a cytosolic ubiquitous protein tyrosine phosphatase (PTP) that contains, in addition to its catalytic domain, several protein-protein interaction domains that allow it to interface with several signaling pathways. Among others, PTP-PEST is a ... ...

Abstract	PTP-PEST is a cytosolic ubiquitous protein tyrosine phosphatase (PTP) that contains, in addition to its catalytic domain, several protein-protein interaction domains that allow it to interface with several signaling pathways. Among others, PTP-PEST is a key regulator of cellular motility and cytoskeleton dynamics. The complexity of the PTP-PEST interactome underscores the necessity to identify its interacting partners and physiological substrates in order to further understand its role in focal adhesion complex turnover and actin organization. Using a modified yeast substrate trapping two-hybrid system, we identified a cytosolic adaptor protein named Src kinase-associated phosphoprotein 55 homologue (SKAP-Hom) as a novel substrate of PTP-PEST. To confirm PTP-PEST interaction with SKAP-Hom, in vitro pull down assays were performed demonstrating that the PTP catalytic domain and Proline-rich 1 (P1) domain are respectively binding to the SKAP-Hom Y260 and Y297 residues and its SH3 domain. Subsequently, we generated and rescued SKAP-Hom-deficient mouse embryonic fibroblasts (MEFs) with WT SKAP-Hom, SKAP-Hom tyrosine mutants (Y260F, Y260F/Y297F), or SKAP-Hom SH3 domain mutant (W335K). Given the role of PTP-PEST, wound-healing and trans-well migration assays were performed using the generated lines. Indeed, SKAP-Hom-deficient MEFs showed a defect in migration compared with WT-rescued MEFs. Interestingly, the SH3 domain mutant-rescued MEFs showed an enhanced cell migration corresponding potentially with higher tyrosine phosphorylation levels of SKAP-Hom. These findings suggest a novel role of SKAP-Hom and its phosphorylation in the regulation of cellular motility. Moreover, these results open new avenues by which PTP-PEST regulates cellular migration, a hallmark of metastasis.
MeSH term(s)	Amino Acid Substitution ; Animals ; Cell Movement/physiology ; Cells, Cultured ; Embryo, Mammalian/cytology ; Embryo, Mammalian/metabolism ; Fibroblasts/cytology ; Fibroblasts/metabolism ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Mice, Knockout ; Mutation, Missense ; Protein Tyrosine Phosphatase, Non-Receptor Type 12/genetics ; Protein Tyrosine Phosphatase, Non-Receptor Type 12/metabolism ; Two-Hybrid System Techniques ; src Homology Domains
Chemical Substances	Intracellular Signaling Peptides and Proteins ; src kinase associated phosphoprotein 2 ; Protein Tyrosine Phosphatase, Non-Receptor Type 12 (EC 3.1.3.48) ; Ptpn12 protein, mouse (EC 3.1.3.48)
Language	English
Publishing date	2013-07-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.M113.501007
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Article: Occupational life-style programme over 12 months and changes of metabolic risk profile, vascular function, and physical fitness in blue-collar workers.

Schaller, Nina / Blume, Katharina / Hornig, Markus / Senker, Ludger / Wolfarth, Bernd / Schuster, Tibor / Halle, Martin / Esefeld, Katrin

Journal of occupational medicine and toxicology (London, England)

2023 Volume 18, Issue 1, Page(s) 4

Abstract: ... in maximal exercise capacity (202 ± 39.6 to 210 ± 38.9 Watt; 95% CI: + 5.1 to + 10.9 Watt). Metabolic and ...

Abstract	Purpose: Occupational health programmes have been successfully implemented to improve body composition, physical fitness and cardiovascular risk. However, most programmes have been small and have not included long-term evaluation. Therefore, we evaluated a twelve-month life-style change programme in a German refinery. Methods: We offered a supervised six-week endurance exercise programme (2 × 90 min/week), starting after a two-day life-style seminar. After the active intervention and a half-day refresher seminar, employees were encouraged to continue exercising over one year on their own, with monthly supervised sessions to maintain adherence. Anthropometry, bicycle ergometry, cardio-metabolic risk profile, inflammatory parameters, and vascular function e.g. endothelial function was studied at baseline, after three and after twelve months. Results: Of 550 employees, n = 327 (age 40.8 ± 9.7 years, 88% males) participated in the study. Twelve-month intervention was associated with a reduced waist circumference (92.6 ± 12.2 to 90.8 ± 11.7 cm, 95% confidence interval for the mean change (CI): -2.5 to -1.1 cm) and a gain in maximal exercise capacity (202 ± 39.6 to 210 ± 38.9 Watt; 95% CI: + 5.1 to + 10.9 Watt). Metabolic and inflammatory parameters likewise HbA Conclusion: Health education added by a six-week supervised exercise programme was associated with minor long-term twelve-month improvements of body composition as well as physical fitness and a concomitant improvement of inflammatory state. These changes were, however, not clinically relevant and not accompanied by statistically robust improvements of vascular function. Trial registration: ClinTrialsGov: NCT01919632; date of registration: August 9, 2013; retrospectively registered.
Language	English
Publishing date	2023-03-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2223190-0
ISSN	1745-6673
ISSN	1745-6673
DOI	10.1186/s12995-023-00370-w
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Article ; Online: Exercise in Heart Failure-What Is the Optimal Dose to Improve Pathophysiology and Exercise Capacity?

Schindler, Michael Johannes / Adams, Volker / Halle, Martin

Current heart failure reports

2019 Volume 16, Issue 4, Page(s) 98–107

Abstract: ... for HFrEF. The overall concept of training is to maximally strain the periphery without straining ...

Abstract	Purpose of review: In this review, our aim is to summarize the evidence of exercise interventions in heart failure. Addressing pathophysiology, we discuss training modalities and optimal dose finding in exercising patients with reduced (HFrEF) and preserved ejection fraction (HFpEF). Recent findings: While smaller studies showed a trend towards improved exercise capacity by high-intensity interval training in comparison with moderate continuous training in HFrEF, recent multicenter randomized trials were unable to confirm these findings. Considering the lack of effective drug therapies in HFpEF, exercise training plays an even more important role in this particular population. Exercise training in heart failure is beneficial in addition to medical and device therapy. Data are still mostly limited to HFrEF. Intensity should primarily be moderate at a daily base. The concept of "the higher the better" could not be confirmed for HFrEF. The overall concept of training is to maximally strain the periphery without straining the myocardium.
MeSH term(s)	Exercise ; Exercise Tolerance ; Heart Failure/physiopathology ; Heart Failure/rehabilitation ; Humans ; Oxygen/metabolism ; Oxygen Consumption ; Quality of Life ; Randomized Controlled Trials as Topic ; Stroke Volume ; Ventricular Function, Left
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2019-06-03
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2151202-4
ISSN	1546-9549 ; 1546-9530
ISSN (online)	1546-9549
ISSN	1546-9530
DOI	10.1007/s11897-019-00428-z
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Article ; Online: A multifaceted continuing professional development intervention to move stroke rehabilitation guidelines into professional practice: A feasibility study.

Luconi, Francesca / Rochette, Annie / Grad, Roland / Hallé, Marie-Christine / Chin, Diana / Habib, Bettina / Thomas, Aliki

Topics in stroke rehabilitation

2020 Volume 27, Issue 6, Page(s) 401–441

Abstract: Introduction: Rehabilitation post-stroke is critical for maximizing patient outcomes. This study ...

Abstract	Introduction: Rehabilitation post-stroke is critical for maximizing patient outcomes. This study assessed the feasibility of implementing and evaluating a continuing professional development (CPD) intervention aimed at increasing the uptake of stroke best practice guidelines among physiotherapists (PTs), occupational therapists (OTs) and speech-language pathologists (SLPs) in six university-affiliated stroke rehabilitation centers in Quebec, Canada. Method: Twelve stroke best practice recommendations with reflective tools were sent weekly by e-mail. Participants' eligibility criteria included: a) profession; b) practicing more than 1 year in a stroke rehabilitation program; c) fluency in French or English; and d) basic computer literacy. Feasibility (operationalized via participation, satisfaction and relevance), cognitive impact, perceived application in practice and expected patient outcomes were measured over 24 weeks using three questionnaires and analyzed using descriptive statistics. Results: The sample totaled 62 of 133 eligible (47%) clinicians. Satisfaction, relevance and cognitive impact of delivered information varied across disciplines and recommendations. Agreement with the recommendations was high across disciplines. On average, three-interdisciplinary recommendations (related to post-stoke depression, post-stoke fatigue and patients' and caregivers' learning needs) were rated as the most relevant for at least one patient. The majority of clinicians would use the recommendations for a specific patient and expected health benefits by applying those recommendations. Conclusion: This study demonstrated the feasibility of assessing the impact of a CPD intervention in stroke rehabilitation uptake and informed the design of a research program aimed at increasing the use of stroke evidence-based rehabilitation interventions.
MeSH term(s)	Adult ; Canada ; Feasibility Studies ; Guideline Adherence ; Humans ; Learning ; Occupational Therapists ; Physical Therapists ; Practice Guidelines as Topic ; Professional Practice ; Quebec ; Rehabilitation Centers ; Stroke/psychology ; Stroke Rehabilitation ; Surveys and Questionnaires
Language	English
Publishing date	2020-01-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1213112-x
ISSN	1945-5119 ; 1074-9357
ISSN (online)	1945-5119
ISSN	1074-9357
DOI	10.1080/10749357.2019.1711339
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Zs.A 4139: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 454: Show issues

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Article ; Online: Cardiopulmonary exercise performance of cancer survivors and patients with stable coronary artery disease with preserved ejection fraction compared to healthy controls

S Wernhart / M Halle

Cogent Medicine, Vol 6, Iss

2019 Volume 1

Abstract: ... to perform cardiopulmonary exercise testing (CPET) in our outpatient sports medical centre. Results: Maximal ...

Abstract	Purpose: Cardiorespiratory fitness (CRF) is a predictor of lower mortality in patients with coronary artery disease (CAD) and cancer patients. Whether cancer survivors with preserved ejection fraction (EF) have a higher fitness level than patients with stable CAD and heart failure with preserved EF (HFpEF) is unknown. Methods: We enrolled 61 cancer survivors with an EF >50% (mean age 56.9 years ± 12.4), 60 patients with HFpEF and stable CAD (mean age 58.9 years ±8.1) and 60 healthy control subjects (mean age 61.2 years±9.9) to perform cardiopulmonary exercise testing (CPET) in our outpatient sports medical centre. Results: Maximal power [W] was inferior in cancer survivors (mean: 141.52W ± 67.43; CI: 124.26–158.79 W) than in HFpEF patients (mean: 157.90W ± 58.31; CI: 142.84W-172.96W) and healthy controls (mean: 196.58 W ± 79.37; CI: 176.08–217.09W). Performance at the individual anaerobic threshold (IAT; p = .033) and ventilatory compensation point (VCP, p = .003) were worse in the cancer and HFpEF groups than in the controls. Conclusion: CRF is significantly inferior in stable CAD patients with preserved EF and in cancer patients than in matched controls. There is a trend that cancer survivors even perform worse than HFpEF patients. Regular follow-up of CRF in these two groups is crucial for early detection of health deterioration in these seemingly stable patients.
Keywords	cardiopulmonary exercise testing ; cancer survivors ; stable cardiovascular disease ; exercise response ; vo2peak ; Medicine ; R
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
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