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  1. Article ; Online: Renal Malakoplakia.

    Bagnasco, Serena / Gautam, Samir C

    The New England journal of medicine

    2024  Volume 390, Issue 8, Page(s) 746

    MeSH term(s) Humans ; Kidney/diagnostic imaging ; Kidney/pathology ; Kidney Transplantation ; Malacoplakia/complications ; Malacoplakia/diagnosis ; Malacoplakia/diagnostic imaging ; Malacoplakia/pathology ; Kidney Diseases/diagnosis ; Kidney Diseases/diagnostic imaging ; Kidney Diseases/pathology
    Language English
    Publishing date 2024-02-17
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMicm2301676
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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Rash and Nephrotic Syndrome in a Patient with Rheumatoid Arthritis.

    Hannouneh, Zein Alabdin / Bagnasco, Serena / Hanouneh, Mohamad

    Kidney360

    2022  Volume 4, Issue 6, Page(s) e863–e864

    MeSH term(s) Humans ; Nephrotic Syndrome/complications ; Nephrotic Syndrome/diagnosis ; Exanthema/etiology ; Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/drug therapy ; Patients
    Language English
    Publishing date 2022-09-20
    Publishing country United States
    Document type Journal Article
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0000000000000102
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  3. Article ; Online: Beyond the microscope: interpreting renal biopsy findings in the era of precision medicine.

    Bagnasco, Serena M

    American journal of physiology. Renal physiology

    2018  Volume 315, Issue 6, Page(s) F1652–F1655

    Abstract: As rapid progress in science and biotechnology is affecting the practice of renal medicine, increasingly precise diagnostic assessment is needed to select the most effective therapeutic approach for individual patients. The kidney biopsy remains the gold ...

    Abstract As rapid progress in science and biotechnology is affecting the practice of renal medicine, increasingly precise diagnostic assessment is needed to select the most effective therapeutic approach for individual patients. The kidney biopsy remains the gold standard for the diagnosis of renal disease, but the field of renal pathology is evolving, classification of renal parenchyma lesions and histopathological diagnostic criteria are undergoing more validation and updates, and new technologies and assays are sought to improve efficiency and accuracy of the diagnostic process. How new knowledge and scientific advances may potentially affect renal pathology is discussed.
    MeSH term(s) Biopsy ; Clinical Decision-Making ; Genetic Markers ; Genetic Predisposition to Disease ; Humans ; Image Interpretation, Computer-Assisted ; Kidney/pathology ; Kidney Diseases/genetics ; Kidney Diseases/pathology ; Kidney Diseases/therapy ; Microscopy/trends ; Patient-Centered Care/trends ; Phenotype ; Precision Medicine/trends ; Predictive Value of Tests ; Prognosis
    Chemical Substances Genetic Markers
    Language English
    Publishing date 2018-10-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00407.2018
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  4. Article: Renal Involvement of CD20-Negative Intravascular Large B Cell Lymphoma with Neurological Manifestations.

    Aqeel, Faten / Bagnasco, Serena M / Geetha, Duvuru

    Case reports in nephrology

    2022  Volume 2022, Page(s) 8613965

    Abstract: The involvement of hematological tumors such as lymphoma in the kidneys is a well-recognized phenomenon. Some of the distinct reported pathological processes resulting in kidney dysfunction include minimal change disease, lymphocytic invasion of the ... ...

    Abstract The involvement of hematological tumors such as lymphoma in the kidneys is a well-recognized phenomenon. Some of the distinct reported pathological processes resulting in kidney dysfunction include minimal change disease, lymphocytic invasion of the parenchyma, immune complex disposition, immunotactoid glomerulopathy, membranous glomerulopathy, and acute tubular injury. We report a rare case of CD20-negative intravascular lymphoma found on a kidney biopsy in a male with primary angiitis of the central nervous system (CNS) who presented with acute kidney injury and proteinuria. After the initiation of rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone (R-CHOP), kidney function improved and proteinuria resolved.
    Language English
    Publishing date 2022-09-10
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2627652-5
    ISSN 2090-665X ; 2090-6641
    ISSN (online) 2090-665X
    ISSN 2090-6641
    DOI 10.1155/2022/8613965
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  5. Article ; Online: BK Virus Nephropathy in Kidney Transplantation: A State-of-the-Art Review.

    Kant, Sam / Dasgupta, Alana / Bagnasco, Serena / Brennan, Daniel C

    Viruses

    2022  Volume 14, Issue 8

    Abstract: BK virus maintains a latent infection that is ubiquitous in humans. It has a propensity for reactivation in the setting of a dysfunctional cellular immune response and is frequently encountered in kidney transplant recipients. Screening for the virus has ...

    Abstract BK virus maintains a latent infection that is ubiquitous in humans. It has a propensity for reactivation in the setting of a dysfunctional cellular immune response and is frequently encountered in kidney transplant recipients. Screening for the virus has been effective in preventing progression to nephropathy and graft loss. However, it can be a diagnostic and therapeutic challenge. In this in-depth state-of-the-art review, we will discuss the history of the virus, virology, epidemiology, cellular response, pathogenesis, methods of screening and diagnosis, evidence-based treatment strategies, and upcoming therapeutics, along with the issue of re-transplantation in patients.
    MeSH term(s) BK Virus/physiology ; Humans ; Kidney Transplantation/adverse effects ; Polyomavirus Infections ; Tumor Virus Infections ; Viremia
    Language English
    Publishing date 2022-07-25
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14081616
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  6. Article ; Online: Hyperspectral Raman Imaging for Automated Recognition of Human Renal Amyloid.

    Kim, Jeong Hee / Zhang, Chi / Sperati, C John / Barman, Ishan / Bagnasco, Serena M

    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

    2023  Volume 71, Issue 11, Page(s) 643–652

    Abstract: ... chain amyloid (AL) and serum amyloid A (AA), is based on histochemical staining; rarer types of amyloid ...

    Abstract In the clinical setting, routine identification of the main types of tissue amyloid deposits, light-chain amyloid (AL) and serum amyloid A (AA), is based on histochemical staining; rarer types of amyloid require mass spectrometry analysis. Raman spectroscopic imaging is an analytical tool, which can be used to chemically map, and thus characterize, the molecular composition of fluid and solid tissue. In this proof-of-concept study, we tested the feasibility of applying Raman spectroscopy combined with artificial intelligence to detect and characterize amyloid deposits in unstained frozen tissue sections from kidney biopsies with pathologic diagnosis of AL and AA amyloidosis and control biopsies with no amyloidosis (NA). Raman hyperspectral images, mapped in a 2D grid-like fashion over the tissue sections, were obtained. Three machine learning-assisted analysis models of the hyperspectral images could accurately distinguish AL (types λ and κ), AA, and NA 93-100% of the time. Although very preliminary, these findings illustrate the potential of Raman spectroscopy as a technique to identify, and possibly, subtype renal amyloidosis.
    MeSH term(s) Humans ; Plaque, Amyloid/pathology ; Artificial Intelligence ; Amyloid/analysis ; Amyloidosis/diagnostic imaging ; Amyloidosis/pathology ; Kidney/pathology
    Chemical Substances Amyloid
    Language English
    Publishing date 2023-10-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 218208-7
    ISSN 1551-5044 ; 0022-1554
    ISSN (online) 1551-5044
    ISSN 0022-1554
    DOI 10.1369/00221554231206858
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  7. Article ; Online: Non-Perturbative Identification and Subtyping of Amyloidosis in Human Kidney Tissue with Raman Spectroscopy and Machine Learning.

    Kim, Jeong Hee / Zhang, Chi / Sperati, Christopher John / Bagnasco, Serena M / Barman, Ishan

    Biosensors

    2023  Volume 13, Issue 4

    Abstract: Amyloids are proteins with characteristic beta-sheet secondary structures that display fibrillary ultrastructural configurations. They can result in pathologic lesions when deposited in human organs. Various types of amyloid protein can be routinely ... ...

    Abstract Amyloids are proteins with characteristic beta-sheet secondary structures that display fibrillary ultrastructural configurations. They can result in pathologic lesions when deposited in human organs. Various types of amyloid protein can be routinely identified in human tissue specimens by special stains, immunolabeling, and electron microscopy, and, for certain forms of amyloidosis, mass spectrometry is required. In this study, we applied Raman spectroscopy to identify immunoglobulin light chain and amyloid A amyloidosis in human renal tissue biopsies and compared the results with a normal kidney biopsy as a control case. Raman spectra of amyloid fibrils within unstained, frozen, human kidney tissue demonstrated changes in conformation of protein secondary structures. By using t-distributed stochastic neighbor embedding (t-SNE) and density-based spatial clustering of applications with noise (DBSCAN), Raman spectroscopic data were accurately classified with respect to each amyloid type and deposition site. To the best of our knowledge, this is the first time Raman spectroscopy has been used for amyloid characterization of ex vivo human kidney tissue samples. Our approach, using Raman spectroscopy with machine learning algorithms, shows the potential for the identification of amyloid in pathologic lesions.
    MeSH term(s) Humans ; Spectrum Analysis, Raman ; Amyloidosis/diagnosis ; Amyloidosis/metabolism ; Amyloidosis/pathology ; Kidney/chemistry ; Amyloid/chemistry ; Amyloid/metabolism ; Immunoglobulin Light Chains/analysis ; Immunoglobulin Light Chains/metabolism
    Chemical Substances Amyloid ; Immunoglobulin Light Chains
    Language English
    Publishing date 2023-04-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662125-3
    ISSN 2079-6374 ; 2079-6374
    ISSN (online) 2079-6374
    ISSN 2079-6374
    DOI 10.3390/bios13040466
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  8. Article ; Online: Biomarkers of Chronic Renal Tubulointerstitial Injury.

    Bagnasco, Serena M / Rosenberg, Avi Z

    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

    2019  Volume 67, Issue 9, Page(s) 633–641

    Abstract: Progression of renal parenchyma injury is characterized by increasing interstitial fibrosis and tubular atrophy, irrespective of the cause. Histopathologic assessment of renal tissue obtained by biopsy remains the gold standard for determining the ... ...

    Abstract Progression of renal parenchyma injury is characterized by increasing interstitial fibrosis and tubular atrophy, irrespective of the cause. Histopathologic assessment of renal tissue obtained by biopsy remains the gold standard for determining the presence and extent of tubulointerstitial scarring. Discovery of robust non-invasive means for capturing a snapshot and for longitudinal monitoring of parenchymal deterioration has been the focus of intense multimodal effort by investigators within the renal community and beyond. Research in this field has included the use of in vitro and in vivo experimental models and has fostered the development and evaluation of tissue and biofluid assays for novel analytes with potential translation to the diagnosis and prognosis of kidney disease. Here, we examine recent advances in the search of "biomarkers" for detection of renal tubulointerstitial scarring and prediction of renal outcome in human renal disease.
    MeSH term(s) Animals ; Biomarkers/analysis ; Biomarkers/blood ; Biomarkers/urine ; Biopsy ; Disease Progression ; Exosomes/pathology ; Extracellular Matrix/pathology ; Fibrosis ; Humans ; Kidney Tubules/pathology ; Renal Insufficiency, Chronic/blood ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/pathology ; Renal Insufficiency, Chronic/urine
    Chemical Substances Biomarkers
    Language English
    Publishing date 2019-06-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 218208-7
    ISSN 1551-5044 ; 0022-1554
    ISSN (online) 1551-5044
    ISSN 0022-1554
    DOI 10.1369/0022155419861092
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  9. Article ; Online: Acute Kidney Injury in a Patient with Trisomy 21.

    Kim, Hannah S / Costigliolo, Francesca / Bagnasco, Serena / Fadrowski, Jeffrey / Ruebner, Rebecca L

    Pediatrics in review

    2021  Volume 42, Issue 5, Page(s) 266–269

    MeSH term(s) Acute Kidney Injury/diagnosis ; Acute Kidney Injury/etiology ; Acute Kidney Injury/therapy ; Down Syndrome/complications ; Down Syndrome/diagnosis ; Humans ; Kidney ; Leukemia, Myeloid, Acute ; Trisomy
    Language English
    Publishing date 2021-04-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 774515-1
    ISSN 1526-3347 ; 0191-9601
    ISSN (online) 1526-3347
    ISSN 0191-9601
    DOI 10.1542/pir.2020-0012
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  10. Article ; Online: Protein kinase C-α comes to the rescue of aquaporin-2.

    Bagnasco, Serena M

    American journal of physiology. Renal physiology

    2012  Volume 303, Issue 1, Page(s) F35–6

    MeSH term(s) Angiotensin II/toxicity ; Animals ; Aquaporin 2/metabolism ; Hypertension/metabolism ; Kidney/metabolism ; Kidney Concentrating Ability/genetics ; Membrane Transport Proteins/metabolism ; Protein Kinase C-alpha/genetics ; Urea Transporters
    Chemical Substances Aquaporin 2 ; Membrane Transport Proteins ; Angiotensin II (11128-99-7) ; Protein Kinase C-alpha (EC 2.7.11.13)
    Language English
    Publishing date 2012-04-25
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00225.2012
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