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Book ; Online: Therapeutic Landscapes in Colorectal Carcinoma

Scanu, Antonio M / De Miglio, Maria Rosaria

2023

Keywords	Medicine ; Oncology ; colorectal cancer ; inflammatory pathways ; NFKB ; RIPK2 ; MSI ; dMMR ; colorectal ; cancer ; immunotherapy ; Romania ; incidence ; PCR ; IHC ; drug development ; targeted therapies ; preclinical candidates ; databases ; cancer therapeutics ; TGF-b ; regorafenib ; colorectal carcinoma ; intratumor heterogeneity ; single-cell next-generation sequencing ; precision medicine ; metastatic colorectal cancer ; BRAF mutation ; triple target therapy ; colorectal cancer screening ; COVID-19 ; SARS-CoV-2 ; colon cancer ; cell line models ; dependencies ; targeted therapy ; signal transduction ; neoadjuvant chemotherapy (NAC) ; locally advanced colon cancer (LACC) ; preoperative treatment ; propensity score matching ; survival ; liver transplantation ; de novo malignancy ; immunosuppression ; uracil-tegafur ; chemotherapy ; adjuvant therapy ; stage IIA ; n/a
Language	English
Size	1 electronic resource (142 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel
Document type	Book ; Online
Note	English
HBZ-ID	HT030646168
ISBN	9783036594408 ; 303659440X
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Seasonal variation and disease distribution of cytophagocytic mononuclear cells in synovial fluid: A medical record study.

Oliviero, Francesca / Galozzi, Paola / Padoan, Andrea / Lorenzin, Mariagrazia / Scanu, Anna / Ramonda, Roberta

Experimental biology and medicine (Maywood, N.J.)

2023 Volume 248, Issue 10, Page(s) 839–842

Abstract: Cytophagocytic mononuclear (CPM) cells, previously known as Reiter's cells, are macrophages containing apoptotic polymorphonuclear leucocytes. Although they can be found in synovial fluid (SF) from different arthropathies, their role remains unclear. ... ...

Abstract	Cytophagocytic mononuclear (CPM) cells, previously known as Reiter's cells, are macrophages containing apoptotic polymorphonuclear leucocytes. Although they can be found in synovial fluid (SF) from different arthropathies, their role remains unclear. This study was performed to determine the frequency and disease distribution of CPM cells in SF in a large cohort of patients with rheumatic diseases over a 12-year period. We also investigated the seasonal variation in their incidence. This record review study included the reports pertaining to SF analyses performed between January 2010 and December 2021. Data were retrieved from the charts of inpatients and outpatients at Rheumatology and Emergency Departments of Padova. The total number of SF samples containing CPM cells was 189: 69% was from patients with seronegative spondyloarthritis (SpA), thus indicating a strong association between CPM cells and SpA. SF samples containing CPM cells were predominantly inflammatory. Our analyses demonstrated a 6-month cyclical fluctuation in concentrations of CPM cells, with an increase in spring and autumn. The presence of CPM cells in SF might offer diagnostic insight into the definition of SpA. Further studies are warranted to ascertain the link between CPM cells and the apoptotic process, shedding light on the mechanisms leading to their formation.
MeSH term(s)	Humans ; Synovial Fluid ; Seasons ; Neutrophils ; Macrophages ; Apoptosis
Language	English
Publishing date	2023-04-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	4015-0
ISSN	1535-3699 ; 1525-1373 ; 0037-9727
ISSN (online)	1535-3699 ; 1525-1373
ISSN	0037-9727
DOI	10.1177/15353702231162078
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Article ; Online: Neurophysiological Alterations of the Visual Pathway in Posterior Cortical Atrophy: Systematic Review and a Case Series.

Cotta Ramusino, Matteo / Scanu, Lucia / Gritti, Linda / Imbimbo, Camillo / Farina, Lisa Maria / Cosentino, Giuseppe / Perini, Giulia / Costa, Alfredo

Journal of Alzheimer's disease : JAD

2024 Volume 98, Issue 1, Page(s) 53–67

Abstract: Background: The clinical features of posterior cortical atrophy (PCA), a rare condition often caused by Alzheimer's disease, have been recently defined, while little is known about its neurophysiological correlates.: Objective: To describe ... ...

Abstract	Background: The clinical features of posterior cortical atrophy (PCA), a rare condition often caused by Alzheimer's disease, have been recently defined, while little is known about its neurophysiological correlates. Objective: To describe neurophysiological alterations of the visual pathway as assessed using visual field test (VF), visual evoked potentials (VEP), and electroretinogram (ERG) in PCA patients. Methods: Studies reporting VF, VEPs, and ERG in PCA patients were selected according PRISMA method. Of the 323 articles that emerged from the literature, 17 included the outcomes of interest. To these data, we added those derived from a patient cohort enrolled at our clinic. Results: The literature review included 140 patients, half of them (50%) presented with homonymous hemianopia or quadrantanopia. VEPs were available in 4 patients (2 normal findings, 1 decreased amplitude, and 1 increased latency) and ERG in 3 patients (substantially normal findings). Our case series included 6 patients, presenting with homonymous lateral hemianopia in 50% and contralateral cortical atrophy. VEPs showed normal amplitude in 66-83% according to the stimulation check, and increased latency in 67% in absence of myelin damage on MRI. Latency was increased in both eyes in 50% and only on one side in the other 50%. Such alterations were observed in patients with more severe and symmetric atrophy. ERG showed normal findings. Conclusions: Neurophysiological investigations of the visual pathway in PCA are almost absent in literature. Alterations involve both amplitude and latency and can be also monocular. A multiple-point involvement of the optical pathway can be hypothesized.
MeSH term(s)	Humans ; Visual Pathways/diagnostic imaging ; Evoked Potentials, Visual ; Neurodegenerative Diseases ; Electroretinography ; Atrophy
Language	English
Publishing date	2024-02-16
Publishing country	Netherlands
Document type	Systematic Review
ZDB-ID	1440127-7
ISSN	1875-8908 ; 1387-2877
ISSN (online)	1875-8908
ISSN	1387-2877
DOI	10.3233/JAD-231123
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Article: An Investigation of Metabolic Risk Factors and Gut Microbiota in Unexplained Syncope.

Longo, Susanna / Del Chierico, Federica / Scanu, Matteo / Toto, Francesca / Legramante, Jacopo M / Rizza, Stefano / Putignani, Lorenza / Federici, Massimo

Biomedicines

2024 Volume 12, Issue 2

Abstract: Background: The pathogenesis of many syncopal episodes remains unexplained. Intestinal dysbiosis could be involved in the pathophysiological mechanisms of syncope due to its connection with the central nervous system via the microbiota-gut-brain axis. ... ...

Abstract	Background: The pathogenesis of many syncopal episodes remains unexplained. Intestinal dysbiosis could be involved in the pathophysiological mechanisms of syncope due to its connection with the central nervous system via the microbiota-gut-brain axis. This pilot study aimed to explore the specific cardiometabolic risk factors and gut microbiota in unexplained syncope (US), compared to other types of syncope, to assess their similarity or verify their different origins. Methods: We studied 86 participants with syncope, who were divided into four groups: an orthostatic syncope group (OH, Results: The US group had a lower incidence of systolic hypertension at the first visit and a lower frequency of patients with nocturnal hypertension than the CS group. Compared to the OH and NMS groups, the US group had a higher incidence of carotid plaques and greater carotid intima-media thickness, respectively. The microbiota differed significantly between the US and CS groups, but not between the US group and the OH or NMS group. Conclusions: We observed significant differences in the gut microbiota between CS and US. Future studies are necessary to evaluate the involvement of the gut microbiota in the complex pathogenesis of syncope and whether its analysis could support the interpretation of the pathophysiological mechasnisms underlying some episodes classifiable as US.
Language	English
Publishing date	2024-01-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines12020264
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Article ; Online: An integrated approach for the benthic habitat mapping based on innovative surveying technologies and ecosystem functioning measurements.

Piazzolla, Daniele / Scanu, Sergio / Mancuso, Francesco Paolo / Bosch-Belmar, Mar / Bonamano, Simone / Madonia, Alice / Scagnoli, Elena / Tantillo, Mario Francesco / Russi, Martina / Savini, Alessandra / Fersini, Giorgio / Sarà, Gianluca / Coppini, Giovanni / Marcelli, Marco / Piermattei, Viviana

Scientific reports

2024 Volume 14, Issue 1, Page(s) 5888

Abstract: ... the depths of 8 and 10 m in the studied area and the obtained results showed similarities with other sites ...

Abstract	Among marine ecosystems globally, those in the Mediterranean Sea, are facing many threats. New technologies are crucial for enhancing our understanding of marine habitats and ecosystems, which can be complex and resource-intensive to analyse using traditional techniques. We tested, for the first time, an integrated multi-platform approach for mapping the coastal benthic habitat in the Civitavecchia (northern Latium, Italy) coastal area. This approach includes the use of an Unmanned Surface Vehicle (USV), a Remote Operated Vehicle (ROV), and in situ measurements of ecosystem functionality. The echosounder data allowed us to reconstruct the distribution of bottom types, as well as the canopy height and coverage of the seagrass Posidonia oceanica. Our study further involved assessing the respiration (Rd) and net primary production (NCP) rates of P. oceanica and its associated community through in situ benthic chamber incubation. By combining these findings with the results of USV surveys, we were able to develop a preliminary spatial distribution model for P. oceanica primary production (PP-SDM). The P. oceanica PP-SDM was applied between the depths of 8 and 10 m in the studied area and the obtained results showed similarities with other sites in the Mediterranean Sea. Though in the early stages, our results highlight the significance of multi-platform observation data for a thorough exploration of marine ecosystems, emphasizing their utility in forecasting biogeochemical processes in the marine environment.
MeSH term(s)	Ecosystem ; Alismatales ; Mediterranean Sea ; Italy
Language	English
Publishing date	2024-03-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-56662-6
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Article ; Online: Retrospective study of lameness in beef cattle in northeastern Sardinia, Italy.

Morrone, Sarah / Scanu, Antonio / Gerolamo, Masala / Crovace, Alberto Maria / Romeo, Stella Maria Teresa / Saderi, Laura / Sotgiu, Giovanni / Columbano, Nicolò

PloS one

2023 Volume 18, Issue 5, Page(s) e0285840

Abstract: Lameness is one of the most prevalent diseases affecting dairy and beef cattle, resulting in decreased animal performance, decreased animal welfare, and substantial economic loss. In extensive beef cattle farming, the risk factors for this multifactorial ...

Abstract	Lameness is one of the most prevalent diseases affecting dairy and beef cattle, resulting in decreased animal performance, decreased animal welfare, and substantial economic loss. In extensive beef cattle farming, the risk factors for this multifactorial disease are largely unexplored. This study aims to conduct a preliminary epidemiological survey of risk factors in beef cattle in extensive breeding, evaluate the farmer's perception of lameness, and determine the recurrence frequency of the pathologies under investigation in treated animals. The study was conducted in Sardinia, Italy. The population of the study consisted of 14379 cattle from 230 farms. An ad hoc questionnaire was developed to collect all the necessary data. A strong association was found between breed and the occurrence and recurrence of lameness (p < 0.0001). In addition, the Country of origin of both bulls and cows was found to be correlated with the incidence of lameness (p < 0.0001 and 0.0001, respectively). Farmers who indicated on the questionnaire that lameness was not important on their farm had more animals with recurrences (p < 0.0001) than other farmers. The veterinarian's treatment choice differed significantly by farmer concern (p = 0.007) and was associated with less disease recurrence (p < 0.0001), resulting in greater farmer satisfaction (p < 0.007). Pure cow breed, French bull origin, and farmer's age were detected as significant predictors of lameness issues, with pure cow breed and French bull origin having the strongest associations (p = 0.009). Even though the results of this study are preliminary, they indicate that breed selection is crucial in extensive beef farms to reduce lameness prevalence. In addition, it would be reasonable to train breeders to prevent and diagnose lameness early in order to collaborate with veterinarians to prevent recurrence.
MeSH term(s)	Female ; Animals ; Cattle ; Male ; Humans ; Retrospective Studies ; Italy ; Gait ; Farmers ; Farms
Language	English
Publishing date	2023-05-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0285840
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Article ; Online: Leucocyte Abnormalities in Synovial Fluid of Degenerative and Inflammatory Arthropathies.

Baggio, Chiara / Luisetto, Roberto / Boscaro, Carlotta / Scanu, Anna / Ramonda, Roberta / Albiero, Mattia / Sfriso, Paolo / Oliviero, Francesca

International journal of molecular sciences

2023 Volume 24, Issue 6

Abstract: Genome damage has been related to the induction of autoimmune processes, chronic inflammation, and apoptosis. Recent studies suggest that some rheumatological diseases are associated with overall genomic instability in the T cell compartment. However, no ...

Abstract	Genome damage has been related to the induction of autoimmune processes, chronic inflammation, and apoptosis. Recent studies suggest that some rheumatological diseases are associated with overall genomic instability in the T cell compartment. However, no data regarding leucocyte abnormalities in synovial fluid (SF) and their relationship with inflammation are available. The aim of this study was to investigate cellular phenotypes in SF collected from patients with different inflammatory arthropathies, including rhematoid arthritis (RA), psoriatic arthritis (PsA), crystal-induced arthritis (CIA), and non-inflammatory arthropathies, such as osteoarthritis (OA). We found high percentage of micronuclei in SF from CIA compared to the other groups and a high frequency of pyknotic cell in RA and CIA patients. A correlation between pyknosis and immature polymorphonuclear cells with local inflammatory indices was observed. The study of the apoptosis process revealed an increased BAX expression in CIA and RA compared to OA and PsA, while Bcl-2 was higher in CIA. Caspase-3 activity was increased in SF from RA patients and correlates with inflammatory and anti-inflammatory cytokines. In conclusion, our results showed that inflammatory SF is associated with genomic instability and abnormal cell subsets.
MeSH term(s)	Humans ; Synovial Fluid/metabolism ; Arthritis, Rheumatoid/metabolism ; Arthritis, Psoriatic/metabolism ; Osteoarthritis/metabolism ; Inflammation/metabolism
Language	English
Publishing date	2023-03-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24065450
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Article ; Online: The ultrasonographic pseudo-double contour sign in calcium pyrophosphate deposition disease: an anatomic explanation and how to distinguish it from gout.

Filippou, Georgios / Miguel-Pérez, Maribel / Coronel, Luis / Sirotti, Silvia / Pacini, Giovanni / Scanu, Anna / Bong, David / Möller, Ingrid

Arthritis & rheumatology (Hoboken, N.J.)

2023 Volume 75, Issue 4, Page(s) 639–640

MeSH term(s)	Humans ; Chondrocalcinosis/diagnostic imaging ; Gout/diagnostic imaging ; Uric Acid ; Ultrasonography
Chemical Substances	Uric Acid (268B43MJ25)
Language	English
Publishing date	2023-02-14
Publishing country	United States
Document type	Letter
ZDB-ID	2756371-6
ISSN	2326-5205 ; 2326-5191
ISSN (online)	2326-5205
ISSN	2326-5191
DOI	10.1002/art.42397
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Article: From in vitro research to real life studies: an extensive narrative review of the effects of balneotherapy on human immune response.

Maccarone, M C / Magro, G / Solimene, U / Scanu, A / Masiero, S

Sport sciences for health

2021 Volume 17, Issue 4, Page(s) 817–835

Abstract: Purpose: The biologic mechanisms by which balneotherapy (BT) alleviates symptoms of different diseases are still poorly understood. Recently, preclinical models and clinical trials have been developed to study the effects of BT on the immune system. ... ...

Abstract	Purpose: The biologic mechanisms by which balneotherapy (BT) alleviates symptoms of different diseases are still poorly understood. Recently, preclinical models and clinical trials have been developed to study the effects of BT on the immune system. This review summarizes the currently available evidence regarding the effects of spa therapy on the immune response, to confirm the role of BT in the enhancement of immune system and open interesting research fields. Methods: PubMed and Google Scholar were searched from 1997 up to June 2020, with search criteria including terms related to BT and immune system. We selected only in vitro research, randomized controlled trials (RCTs) or clinical trials. Results: In vitro studies on human and animal samples have demonstrated that thermal waters exert anti-inflammatory and immunomodulatory effects. In particular, H Conclusion: Further preclinical studies and RCTs could help to exploit BT in real life for preventive and therapeutic treatments.
Language	English
Publishing date	2021-05-20
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	2244652-7
ISSN	1825-1234 ; 1824-7490
ISSN (online)	1825-1234
ISSN	1824-7490
DOI	10.1007/s11332-021-00778-z
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Article ; Online: Current management of incidental gallbladder cancer: A review.

Feo, Claudio F / Ginesu, Giorgio C / Fancellu, Alessandro / Perra, Teresa / Ninniri, Chiara / Deiana, Giulia / Scanu, Antonio M / Porcu, Alberto

International journal of surgery (London, England)

2022 Volume 98, Page(s) 106234

Abstract: Early-stage gallbladder cancer (GBC) is mostly discovered incidentally by the pathologist after cholecystectomy for a presumed benign disease. It is the most common malignancy of the biliary tract with a variable incidence rate all over the World. The ... ...

Abstract	Early-stage gallbladder cancer (GBC) is mostly discovered incidentally by the pathologist after cholecystectomy for a presumed benign disease. It is the most common malignancy of the biliary tract with a variable incidence rate all over the World. The majority of patients with GBC remain asymptomatic for a long time and diagnosis is usually late when the disease is at an advanced stage. Radical surgery consisting in resection of the gallbladder liver bed and regional lymph nodes seems to be the best treatment option for incidental GBC. However, recurrence rates after salvage surgery are still high and the addition of neoadjuvant/adjuvant chemotherapy may improve outcomes. The aim of the present review is to evaluate current literature for advances in management of incidental GBC, with particular focus on staging techniques and surgical options.
MeSH term(s)	Cholecystectomy ; Gallbladder Neoplasms/diagnosis ; Gallbladder Neoplasms/epidemiology ; Gallbladder Neoplasms/surgery ; Humans ; Incidental Findings ; Lymph Node Excision ; Neoplasm Staging
Language	English
Publishing date	2022-01-21
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2212038-5
ISSN	1743-9159 ; 1743-9191
ISSN (online)	1743-9159
ISSN	1743-9191
DOI	10.1016/j.ijsu.2022.106234
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