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  1. Article ; Online: Anti-GABAB receptor encephalitis after COVID-19 infection.

    Shen, J Y / Ng, G J / Yeo, T

    QJM : monthly journal of the Association of Physicians

    2022  Volume 115, Issue 10, Page(s) 686–688

    MeSH term(s) Humans ; Receptors, GABA-B ; COVID-19/complications ; Encephalitis/diagnosis ; Encephalitis/etiology ; Hashimoto Disease ; Autoantibodies
    Chemical Substances Receptors, GABA-B ; Autoantibodies
    Language English
    Publishing date 2022-09-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1199985-8
    ISSN 1460-2393 ; 0033-5622 ; 1460-2725
    ISSN (online) 1460-2393
    ISSN 0033-5622 ; 1460-2725
    DOI 10.1093/qjmed/hcac211
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Enhanced phylogenetic insights into the microbiome of chronic rhinosinusitis through the novel application of long read 16S rRNA gene amplicon sequencing.

    Connell, J T / Yeo, K / Bouras, G / Bassiouni, A / Fenix, K / Cooksley, C / Vreugde, S / Wormald, P J / Psaltis, A J

    Rhinology

    2024  Volume 62, Issue 2, Page(s) 152–162

    Abstract: Introduction: 16S rRNA next generation sequencing (NGS) has been the de facto standard of microbiome profiling. A limitation of this technology is the inability to accurately assign taxonomy to a species order. Long read 16S sequencing platforms, ... ...

    Abstract Introduction: 16S rRNA next generation sequencing (NGS) has been the de facto standard of microbiome profiling. A limitation of this technology is the inability to accurately assign taxonomy to a species order. Long read 16S sequencing platforms, including Oxford Nanopore Technologies (ONT), have the potential to overcome this limitation. The paranasal sinuses are an ideal niche to apply this technology, being a low biomass environment where bacteria are implicated in disease propagation. Characterising the microbiome to a species order may offer new pathophysiological insights.
    Methodology: Cohort series comparing ONT and NGS biological conclusions. Swabs obtained endoscopically from the middle meatus of 61 CRSwNP patients underwent DNA extraction, amplification and dual sequencing (Illumina Miseq (NGS) and ONT GridION). Agreement, relative abundance, prevalence, and culture correlations were compared.
    Results: Mean microbiome agreement between sequencers was 61.4%. Mean abundance correlations were strongest at a familial/genus order and declined at a species order where NGS lacked resolution. The most significant discrepancies applied to Corynebacterium and Cutibacterium, which were estimated in lower abundance by ONT. ONT accurately identified 84.2% of cultured species, which was significantly higher than NGS.
    Conclusions: ONT demonstrated superior resolution and culture correlations to NGS, but underestimated core sinonasal taxa. Future application and optimisation of this technology can advance our understanding of the sinonasal microenvironment.
    MeSH term(s) Humans ; RNA, Ribosomal, 16S/genetics ; Phylogeny ; Genes, rRNA ; Rhinosinusitis ; Microbiota/genetics ; Sinusitis/genetics ; Sinusitis/microbiology
    Chemical Substances RNA, Ribosomal, 16S
    Language English
    Publishing date 2024-01-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 80336-4
    ISSN 0300-0729
    ISSN 0300-0729
    DOI 10.4193/Rhin23.333
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  3. Article ; Online: Can a Stent Retriever Damage the JET 7 Reperfusion Catheter?

    Pearly Ti, J / Yeo, L / Anil, G

    AJNR. American journal of neuroradiology

    2020  Volume 41, Issue 12, Page(s) 2317–2319

    Abstract: We encountered 2 separate instances of damage to JET 7 reperfusion catheters when they were used in conjunction with a stent retriever during mechanical thrombectomy. On both occasions, after 1 or 2 passes with a stent retriever, we found that the distal ...

    Abstract We encountered 2 separate instances of damage to JET 7 reperfusion catheters when they were used in conjunction with a stent retriever during mechanical thrombectomy. On both occasions, after 1 or 2 passes with a stent retriever, we found that the distal end of the catheter was frayed and it ballooned up on flushing with saline. This mechanical failure could potentially lead to serious complications; hence, it should be shared with fellow neurointerventionalists.
    MeSH term(s) Aged, 80 and over ; Catheters ; Endovascular Procedures/adverse effects ; Endovascular Procedures/instrumentation ; Female ; Humans ; Reperfusion/adverse effects ; Reperfusion/instrumentation ; Stents ; Stroke/surgery ; Thrombectomy/adverse effects ; Thrombectomy/instrumentation
    Language English
    Publishing date 2020-10-15
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 603808-6
    ISSN 1936-959X ; 0195-6108
    ISSN (online) 1936-959X
    ISSN 0195-6108
    DOI 10.3174/ajnr.A6804
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  4. Article ; Online: The impact of impulsivity on weight loss after bariatric surgery: a systematic review.

    Yeo, D / Toh, A / Yeo, C / Low, G / Yeo, J Z / Aung, M O / Rao, J / Kaushal, S

    Eating and weight disorders : EWD

    2020  Volume 26, Issue 2, Page(s) 425–438

    Abstract: Background: Impulsivity has been shown to be associated with obesity through links to pathological eating behavior such as binge eating. The recent literature suggests that impulsivity is linked to poorer outcomes post-bariatric surgery. Impulsivity can ...

    Abstract Background: Impulsivity has been shown to be associated with obesity through links to pathological eating behavior such as binge eating. The recent literature suggests that impulsivity is linked to poorer outcomes post-bariatric surgery. Impulsivity can be measured in various ways and comprises of three broad domains: impulsive choice, impulsive action, and impulsive personality traits. The aim of this systematic review is to synthesize the current evidence on the impact of impulsivity on post-bariatric surgery weight loss.
    Methods: A literature review was performed in February 2020. Original studies investigating the relationship between impulsivity and weight loss post-bariatric surgery were evaluated.
    Results: Ten studies with a total of 1246 patients were analyzed. There were four case-control, four prospective observational and two retrospective observational studies. The postoperative follow-up ranged from 0.5 to 12 years. Eight studies measuring trait impulsivity did not show any association with weight loss post-bariatric surgery, although two studies reported an indirect effect of impulsivity on weight loss mediated via pathological eating behavior. Assessment of impulsive action by two studies showed that post-bariatric surgery weight loss is affected by impulsive action.
    Conclusion: Impulsivity may adversely affect postoperative outcomes after bariatric surgery. However, this may be specific to state impulsivity or impulsive action rather than trait impulsivity. Patients with a higher state impulsivity may benefit from closer follow-up post-bariatric surgery, as well as cognitive behavioral therapies targeting cognitive control over food.
    Level of evidence: Level I, systematic review.
    MeSH term(s) Bariatric Surgery ; Humans ; Impulsive Behavior ; Obesity ; Observational Studies as Topic ; Retrospective Studies ; Weight Loss
    Language English
    Publishing date 2020-03-30
    Publishing country Germany
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 2038625-4
    ISSN 1590-1262 ; 1124-4909
    ISSN (online) 1590-1262
    ISSN 1124-4909
    DOI 10.1007/s40519-020-00890-y
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  5. Article ; Online: Low resting metabolic rate and increased hunger due to β-MSH and β-endorphin deletion in a canine model.

    Dittmann, Marie T / Lakatos, Gabriella / Wainwright, Jodie F / Mokrosinski, Jacek / Cross, Eloise / Farooqi, I Sadaf / Wallis, Natalie J / Halsey, Lewis G / Wilson, Rory / O'Rahilly, Stephen / Yeo, Giles S H / Raffan, Eleanor

    Science advances

    2024  Volume 10, Issue 10, Page(s) eadj3823

    Abstract: Mutations that perturb leptin-melanocortin signaling are known to cause hyperphagia and obesity, but energy expenditure has not been well studied outside rodents. We report on a common canine mutation in pro-opiomelanocortin ( ...

    Abstract Mutations that perturb leptin-melanocortin signaling are known to cause hyperphagia and obesity, but energy expenditure has not been well studied outside rodents. We report on a common canine mutation in pro-opiomelanocortin (
    MeSH term(s) Humans ; Dogs ; Animals ; beta-Endorphin/genetics ; beta-MSH ; Basal Metabolism ; Pro-Opiomelanocortin/genetics ; Hunger ; alpha-MSH/genetics
    Chemical Substances beta-Endorphin (60617-12-1) ; beta-MSH ; Pro-Opiomelanocortin (66796-54-1) ; alpha-MSH (581-05-5)
    Language English
    Publishing date 2024-03-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adj3823
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  6. Article ; Online: Is proton beam therapy always better than photon irradiation? Lessons from two cases.

    Li, Michelle P / Yeo, Adam / Gunewardena, Roshini / Drum, Gabrielle / Wiltshire, Kirsty / Phillips, Claire / Sia, Joseph / Wheeler, Greg / Hall, Lisa

    Journal of medical radiation sciences

    2024  Volume 71 Suppl 2, Page(s) 90–98

    Abstract: Proton beam therapy (PBT) is increasingly used to treat cancers, especially in the paediatric and adolescent and young adult (AYA) population. As PBT becomes more accessible, determining when PBT should be used instead of photon irradiation can be ... ...

    Abstract Proton beam therapy (PBT) is increasingly used to treat cancers, especially in the paediatric and adolescent and young adult (AYA) population. As PBT becomes more accessible, determining when PBT should be used instead of photon irradiation can be difficult. There is a need to balance patient, tumour and treatment factors when making this decision. Comparing the dosimetry between these two modalities plays an important role in this process. PBT can reduce low to intermediate doses to organs at risk (OAR), but photon irradiation has its dosimetric advantages. We present two cases with brain tumours, one paediatric and one AYA, in which treatment plan comparison between photons and protons showed dosimetric advantages of photon irradiation. The first case was an 18-month-old child diagnosed with posterior fossa ependymoma requiring adjuvant radiotherapy. Photon irradiation using volumetric modulated arc therapy (VMAT) had lower doses to the hippocampi but higher doses to the pituitary gland. The second case was a 21-year-old with an optic pathway glioma. There was better sparing of the critical optic structures and pituitary gland using fractionated stereotactic radiation therapy over PBT. The dosimetric advantages of photon irradiation over PBT have been demonstrated in these cases. This highlights the role of proton-to-photon comparative treatment planning to better understand which patients might benefit from photon irradiation versus PBT.
    MeSH term(s) Adolescent ; Humans ; Child ; Infant ; Young Adult ; Adult ; Proton Therapy ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted ; Radiotherapy, Intensity-Modulated ; Radiosurgery
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2734841-6
    ISSN 2051-3909 ; 2051-3909
    ISSN (online) 2051-3909
    ISSN 2051-3909
    DOI 10.1002/jmrs.773
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  7. Article ; Online: Effect of Increased Depressive Feelings during the COVID-19 Pandemic on the Association between Depressive Mood and Suicidal Behavior: Using the 17th (2021) Korea Youth Risk Behavior Web-Based Survey (KYRBS).

    Yeo, Jinsu / Park, Geunhyoung / Shin, Joohyun / Seo, Kwanghyun / Ahn, Yeonsoon

    International journal of environmental research and public health

    2022  Volume 19, Issue 22

    Abstract: This study investigated the impact of increased depressive feelings during the COVID-19 pandemic on the suicidal behavior of Korean high school students using the 17th Korea Youth Risk Behavior Web-Based Survey (KYRBS). We classified the independent ... ...

    Abstract This study investigated the impact of increased depressive feelings during the COVID-19 pandemic on the suicidal behavior of Korean high school students using the 17th Korea Youth Risk Behavior Web-Based Survey (KYRBS). We classified the independent variables into four groups ("no depressive mood and no increase in depressive feelings [group A]", "no depressive mood and increase in depressive feelings [group B]", "depressive mood and no increase in depressive feelings [group C]", and "depressive mood and increase in depressive feelings [group D]"). Compared to group A, group D showed an odds ratio of 18.30 in men and 14.87 in women for suicidal behavior after accounting for demographic and health behavioral characteristics. We found that depressive mood and a relatively short-term increase in depressive feelings had a synergistic effect, rather than an additive one, on suicidal behavior. Based on this result, we claim that an appropriate intervention method is necessary to prevent adolescents' depressive mood from developing into suicidal behavior during the pandemic.
    MeSH term(s) Male ; Humans ; Adolescent ; Female ; Suicidal Ideation ; Pandemics ; COVID-19/epidemiology ; Republic of Korea/epidemiology ; Risk-Taking ; Internet
    Language English
    Publishing date 2022-11-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph192214868
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  8. Article: Alternatives to fluorinated binders: recyclable copolyester/carbonate electrolytes for high-capacity solid composite cathodes.

    Yeo, Holly / Gregory, Georgina L / Gao, Hui / Yiamsawat, Kanyapat / Rees, Gregory J / McGuire, Thomas / Pasta, Mauro / Bruce, Peter G / Williams, Charlotte K

    Chemical science

    2024  Volume 15, Issue 7, Page(s) 2371–2379

    Abstract: Optimising the composite cathode for next-generation, safe solid-state batteries with inorganic solid electrolytes remains a key challenge towards commercialisation and cell performance. Tackling this issue requires the design of suitable polymer binders ...

    Abstract Optimising the composite cathode for next-generation, safe solid-state batteries with inorganic solid electrolytes remains a key challenge towards commercialisation and cell performance. Tackling this issue requires the design of suitable polymer binders for electrode processability and long-term solid-solid interfacial stability. Here,
    Language English
    Publishing date 2024-01-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d3sc05105f
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  9. Article ; Online: Mapping oncogenic protein interactions for precision medicine.

    Sharifi Tabar, Mehdi / Francis, Habib / Yeo, Dannel / Bailey, Charles G / Rasko, John E J

    International journal of cancer

    2022  Volume 151, Issue 1, Page(s) 7–19

    Abstract: Normal protein-protein interactions (normPPIs) occur with high fidelity to regulate almost every physiological process. In cancer, this highly organised and precisely regulated network is disrupted, hijacked or reprogrammed resulting in oncogenic protein- ...

    Abstract Normal protein-protein interactions (normPPIs) occur with high fidelity to regulate almost every physiological process. In cancer, this highly organised and precisely regulated network is disrupted, hijacked or reprogrammed resulting in oncogenic protein-protein interactions (oncoPPIs). OncoPPIs, which can result from genomic alterations, are a hallmark of many types of cancers. Recent technological advances in the field of mass spectrometry (MS)-based interactomics, structural biology and drug discovery have prompted scientists to identify and characterise oncoPPIs. Disruption of oncoPPI interfaces has become a major focus of drug discovery programs and has resulted in the use of PPI-specific drugs clinically. However, due to several technical hurdles, studies to build a reference oncoPPI map for various cancer types have not been undertaken. Therefore, there is an urgent need for experimental workflows to overcome the existing challenges in studying oncoPPIs in various cancers and to build comprehensive reference maps. Here, we discuss the important hurdles for characterising oncoPPIs and propose a three-phase multidisciplinary workflow to identify and characterise oncoPPIs. Systematic identification of cancer-type-specific oncogenic interactions will spur new opportunities for PPI-focused drug discovery projects and precision medicine.
    MeSH term(s) Carcinogenesis/genetics ; Humans ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/metabolism ; Oncogenes ; Precision Medicine ; Protein Interaction Mapping
    Language English
    Publishing date 2022-02-14
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 218257-9
    ISSN 1097-0215 ; 0020-7136
    ISSN (online) 1097-0215
    ISSN 0020-7136
    DOI 10.1002/ijc.33954
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  10. Article ; Online: Probing the mechanisms underlying numerosity-to-numeral mappings and their relation to math competence.

    Yeo, Darren J / Price, Gavin R

    Psychological research

    2020  Volume 85, Issue 3, Page(s) 1248–1271

    Abstract: Numerosity estimation performance (e.g., how accurate, consistent, or proportionally spaced (linear ... numerical sets and symbolic numbers (e.g., Arabic numerals). The current study examined two hypothesized ... their roles in the estimation-and-math relation. Specifically, mappings for small numbers (e.g., 1-10) are ...

    Abstract Numerosity estimation performance (e.g., how accurate, consistent, or proportionally spaced (linear) numerosity-numeral mappings are) has previously been associated with math competence. However, the specific mechanisms that underlie such a relation is unknown. One possible mechanism is the mapping process between numerical sets and symbolic numbers (e.g., Arabic numerals). The current study examined two hypothesized mechanisms of numerosity-numeral mappings (item-based "associative" and holistic "structural" mapping) and their roles in the estimation-and-math relation. Specifically, mappings for small numbers (e.g., 1-10) are thought to be associative and resistant to calibration (e.g., feedback on accuracy of estimates), whereas holistic "structural" mapping for larger numbers (e.g., beyond 10) may be supported by flexibly aligning a numeral "response grid" (akin to a ruler) to an analog "mental number line" upon calibration. In 57 adults, we used pre- and post-calibration estimates to measure the range of continuous associative mappings among small numbers (e.g., a base range of associative mappings from 1 to 10), and obtained measures of math competence and delayed multiple-choice strategy reports. Consistent with previous research, uncalibrated estimation performance correlated with calculation competence, controlling for reading fluency and working memory. However, having a higher base range of associative mappings was not related to estimation performance or any math competence measures. Critically, discontinuity in calibration effects was typical at the individual level, which calls into question the nature of "holistic structural mapping". A parsimonious explanation to integrate previous and current findings is that estimation performance is likely optimized by dynamically constructing numerosity-numeral mappings through the use of multiple strategies from trial to trial.
    MeSH term(s) Academic Success ; Adolescent ; Adult ; Female ; Humans ; Male ; Mathematical Concepts ; Memory, Short-Term/physiology ; Mental Competency/psychology ; Students ; Universities ; Visual Perception/physiology ; Young Adult
    Language English
    Publishing date 2020-02-14
    Publishing country Germany
    Document type Comparative Study ; Journal Article
    ZDB-ID 1463034-5
    ISSN 1430-2772 ; 0340-0727
    ISSN (online) 1430-2772
    ISSN 0340-0727
    DOI 10.1007/s00426-020-01299-z
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