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Article ; Online: The electrochemically enabled α-C(sp

Fang, Songlin / Zhong, Kaihui / Zeng, Shaogao / Hu, Xinwei / Sun, Pinghua / Ruan, Zhixiong

Chemical communications (Cambridge, England)

2023 Volume 59, Issue 76, Page(s) 11425–11428

Abstract: C-H/N-H cross-coupling has become a key technology for the selective conjugation of azole drug molecules. However, the development of new synthetic models and green chemical methods is imperative to enhance the construction of multi-functional compounds ... ...

Abstract	C-H/N-H cross-coupling has become a key technology for the selective conjugation of azole drug molecules. However, the development of new synthetic models and green chemical methods is imperative to enhance the construction of multi-functional compounds and compounds with unique functional groups. We herein reported an electrochemical synthesis of α-tetrazolyl ketones with excellent yields and broad substrate scope, encompassing electron-donating and electron-withdrawing groups of aryl ketones, heterocycles, and alkyl and various ketone drugs. It was further proved that α-iodoketone was involved in this transformation of the reaction as a critical intermediate.
Language	English
Publishing date	2023-09-21
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d3cc02852f
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Strontium Attenuates Hippocampal Damage via Suppressing Neuroinflammation in High-Fat Diet-Induced NAFLD Mice.

Wang, Shuai / Zeng, Fangyuan / Ma, Yue / Yu, Jiaojiao / Xiang, Chenyao / Feng, Xiao / Wang, Songlin / Wang, Jianguo / Zhao, Shanting / Zhu, Xiaoyan

International journal of molecular sciences

2023 Volume 24, Issue 12

Abstract: Non-alcoholic fatty liver disease (NAFLD) leads to hippocampal damage and causes a variety of physiopathological responses, including the induction of endoplasmic reticulum stress (ERS), neuroinflammation, and alterations in synaptic plasticity. As an ... ...

Abstract	Non-alcoholic fatty liver disease (NAFLD) leads to hippocampal damage and causes a variety of physiopathological responses, including the induction of endoplasmic reticulum stress (ERS), neuroinflammation, and alterations in synaptic plasticity. As an important trace element, strontium (Sr) has been reported to have antioxidant effects, to have anti-inflammatory effects, and to cause the inhibition of adipogenesis. The present study was undertaken to investigate the protective effects of Sr on hippocampal damage in NAFLD mice in order to elucidate the underlying mechanism of Sr in NAFLD. The mouse model of NAFLD was established by feeding mice a high-fat diet (HFD), and the mice were treated with Sr. In the NAFLD mice, we found that treatment with Sr significantly increased the density of c-Fos
MeSH term(s)	Mice ; Animals ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/etiology ; Non-alcoholic Fatty Liver Disease/metabolism ; Neuroinflammatory Diseases ; Diet, High-Fat/adverse effects ; Hippocampus/metabolism ; Neuronal Plasticity ; Mice, Inbred C57BL ; Liver/metabolism
Language	English
Publishing date	2023-06-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241210248
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Article ; Online: Strontium Attenuates Hippocampal Damage via Suppressing Neuroinflammation in High-Fat Diet-Induced NAFLD Mice

Shuai Wang / Fangyuan Zeng / Yue Ma / Jiaojiao Yu / Chenyao Xiang / Xiao Feng / Songlin Wang / Jianguo Wang / Shanting Zhao / Xiaoyan Zhu

International Journal of Molecular Sciences, Vol 24, Iss 10248, p

2023 Volume 10248

Abstract	Non-alcoholic fatty liver disease (NAFLD) leads to hippocampal damage and causes a variety of physiopathological responses, including the induction of endoplasmic reticulum stress (ERS), neuroinflammation, and alterations in synaptic plasticity. As an important trace element, strontium (Sr) has been reported to have antioxidant effects, to have anti-inflammatory effects, and to cause the inhibition of adipogenesis. The present study was undertaken to investigate the protective effects of Sr on hippocampal damage in NAFLD mice in order to elucidate the underlying mechanism of Sr in NAFLD. The mouse model of NAFLD was established by feeding mice a high-fat diet (HFD), and the mice were treated with Sr. In the NAFLD mice, we found that treatment with Sr significantly increased the density of c-Fos + cells in the hippocampus and inhibited the expression of caspase-3 by suppressing ERS. Surprisingly, the induction of neuroinflammation and the increased expression of inflammatory cytokines in the hippocampus following an HFD were attenuated by Sr treatment. Sr significantly attenuated the activation of microglia and astrocytes induced by an HFD. The expression of phospho- p38 , ERK , and NF-κB was consistently significantly increased in the HFD group, and treatment with Sr decreased their expression. Moreover, Sr prevented HFD-induced damage to the ultra-structural synaptic architecture. This study implies that Sr has beneficial effects on repairing the damage to the hippocampus induced by an HFD, revealing that Sr could be a potential candidate for protection from neural damage caused by NAFLD.
Keywords	strontium ; hippocampal damage ; neuroinflammation ; non-alcoholic fatty liver disease ; endoplasmic reticulum stress ; hippocampal synaptic plasticity ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Aging-related increases in serum sex hormone-binding globulin levels in men might be related to increased synthesis.

Xu, Pei / Zeng, Rong / Wan, Qiyou / Xie, Yan / Liu, Xingyan / An, Songlin / Jiang, Jing / Yang, Jing / Zhou, Yuanzhong / Shen, Xubo

Experimental gerontology

2023 Volume 179, Page(s) 112249

Abstract: Background: Previous studies have indicated that serum sex hormone-binding globulin (SHBG) levels increase with age; however, the causes remain unknown. The present study aimed to clarify whether the increase in SHBG levels is attributable to aging- ... ...

Abstract	Background: Previous studies have indicated that serum sex hormone-binding globulin (SHBG) levels increase with age; however, the causes remain unknown. The present study aimed to clarify whether the increase in SHBG levels is attributable to aging-related increases in SHBG synthesis. Methods: We examined and evaluated the association of serum SHBG levels with synthesis-related factors in men aged 18-80 years. Additionally, we examined the serum and liver levels of SHBG, hepatic nuclear factor 4α (HNF-4α), and peroxisome proliferator-activated receptor γ (PPAR-γ) in young, middle-aged, and old Sprague-Dawley rats. Results: The study included 209 men in the young group (median age, 33 ± 10 years), 174 men in the middle-aged group (median age, 53 ± 8 years), and 98 men in the elderly group (median age, 71 ± 8 years). Serum SHBG levels increased with age (P < 0.05), whereas HNF-4α and PPAR-γ levels decreased with age (both P < 0.05). Compared with the findings in the young group, the average decline in HNF-4α levels was 2.61 % and 18.46 % in the middle-aged and elderly groups, respectively; the average decreases in PPAR-γ levels in these groups were 12.86 % and 20.76 %, respectively. The results in rats illustrated that liver SHBG and HNF-4α levels increased with age, whereas PPAR-γ and chicken ovalbumin upstream promoter-transcription factor (COUP-TF) levels decreased with age (all P < 0.05). Serum SHBG levels increased in rats with age, whereas HNF-4α and PPAR-γ levels decreased with age (all P < 0.05). Conclusions: The aging-related increased liver levels of the SHBG synthesis promoter HNF-4α and decreased levels of the SHBG inhibitory factors PPAR-γ and COUP-TF suggest that the aging-related increases in SHBG levels are associated with increased SHBG synthesis.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Animals ; Humans ; Male ; Middle Aged ; Rats ; Young Adult ; Aging ; Peroxisome Proliferator-Activated Receptors ; Promoter Regions, Genetic ; Rats, Sprague-Dawley ; Sex Hormone-Binding Globulin/genetics ; Sex Hormone-Binding Globulin/metabolism ; Testosterone
Chemical Substances	Peroxisome Proliferator-Activated Receptors ; Sex Hormone-Binding Globulin ; SHBG protein, human ; Testosterone (3XMK78S47O) ; Shbg protein, rat
Language	English
Publishing date	2023-07-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	390992-x
ISSN	1873-6815 ; 0531-5565
ISSN (online)	1873-6815
ISSN	0531-5565
DOI	10.1016/j.exger.2023.112249
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Article ; Online: Aging-related increases in serum sex hormone-binding globulin levels in men might be related to increased synthesis

Pei Xu / Rong Zeng / Qiyou Wan / Yan Xie / Xingyan Liu / Songlin An / Jing Jiang / Jing Yang / Yuanzhong Zhou / Xubo Shen

Experimental Gerontology, Vol 179, Iss , Pp 112249- (2023)

2023

Abstract	Background: Previous studies have indicated that serum sex hormone-binding globulin (SHBG) levels increase with age; however, the causes remain unknown. The present study aimed to clarify whether the increase in SHBG levels is attributable to aging-related increases in SHBG synthesis. Methods: We examined and evaluated the association of serum SHBG levels with synthesis-related factors in men aged 18–80 years. Additionally, we examined the serum and liver levels of SHBG, hepatic nuclear factor 4α (HNF-4α), and peroxisome proliferator-activated receptor γ (PPAR-γ) in young, middle-aged, and old Sprague–Dawley rats. Results: The study included 209 men in the young group (median age, 33 ± 10 years), 174 men in the middle-aged group (median age, 53 ± 8 years), and 98 men in the elderly group (median age, 71 ± 8 years). Serum SHBG levels increased with age (P < 0.05), whereas HNF-4α and PPAR-γ levels decreased with age (both P < 0.05). Compared with the findings in the young group, the average decline in HNF-4α levels was 2.61 % and 18.46 % in the middle-aged and elderly groups, respectively; the average decreases in PPAR-γ levels in these groups were 12.86 % and 20.76 %, respectively. The results in rats illustrated that liver SHBG and HNF-4α levels increased with age, whereas PPAR-γ and chicken ovalbumin upstream promoter-transcription factor (COUP-TF) levels decreased with age (all P < 0.05). Serum SHBG levels increased in rats with age, whereas HNF-4α and PPAR-γ levels decreased with age (all P < 0.05). Conclusions: The aging-related increased liver levels of the SHBG synthesis promoter HNF-4α and decreased levels of the SHBG inhibitory factors PPAR-γ and COUP-TF suggest that the aging-related increases in SHBG levels are associated with increased SHBG synthesis.
Keywords	Sex hormone-binding globulin ; Men ; Reproductive ; Testosterone ; Aging ; Medicine ; R ; Biology (General) ; QH301-705.5
Subject code	333
Language	English
Publishing date	2023-08-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Selenium-Electrocatalytic Cyclization of 2-Vinylanilides towards Indoles of Peptide Labeling.

Zeng, Shaogao / Fang, Songlin / Cai, Haiping / Wang, Dong / Liu, Weiliang / Hu, Xinwei / Sun, Pinghua / Ruan, Zhixiong

Chemistry, an Asian journal

2022 Volume 17, Issue 20, Page(s) e202200762

Abstract: A novel selenium-electrocatalytic intramolecular cyclization of 2-vinylanilides for synthesis of functionalized indoles and azaindoles has been developed. In contrast to the previous synthetic methods, this sustainable protocol enabled unparalleled broad ...

Abstract	A novel selenium-electrocatalytic intramolecular cyclization of 2-vinylanilides for synthesis of functionalized indoles and azaindoles has been developed. In contrast to the previous synthetic methods, this sustainable protocol enabled unparalleled broad substrates scope for viable indoles with highly functional and sensitive groups by employing recyclable selenium catalyst, under mild, metal- and external-oxidant-free conditions. The approach can be used to the late-stage modification of complex bioactive molecular system, thereby setting the stage for versatile syntheses of decorated indoles with peptide labeling. A plausible catalytic pathway was proposed.
MeSH term(s)	Cyclization ; Indoles/chemistry ; Selenium ; Catalysis ; Peptides ; Molecular Structure
Chemical Substances	Indoles ; Selenium (H6241UJ22B) ; Peptides
Language	English
Publishing date	2022-09-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2233006-9
ISSN	1861-471X ; 1861-4728
ISSN (online)	1861-471X
ISSN	1861-4728
DOI	10.1002/asia.202200762
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Article ; Online: Removal of chemical oxygen demand and ammonia nitrogen from high salinity tungsten smelting wastewater by one-step electrochemical oxidation: From bench-scale test, pilot-scale test, to industrial test.

Meng, Xiangsong / Zeng, Ping / Lin, Shangyong / Bao, Huanjun / Wu, Meirong / Yang, Lei / Jing, Gaogui / Han, Haisheng / Zhang, Chenyang / Jiang, Xiaoyun / Wang, Songlin / Ding, Wei / Sun, Wei

Journal of environmental management

2023 Volume 340, Page(s) 117983

Abstract: In recent years, electrochemical oxidation (EO) shows the characteristics of green and high efficiency in removing chemical oxygen demand (COD) and ammonia nitrogen ( ... ...

Abstract	In recent years, electrochemical oxidation (EO) shows the characteristics of green and high efficiency in removing chemical oxygen demand (COD) and ammonia nitrogen (NH
MeSH term(s)	Wastewater ; Ammonia/analysis ; Tungsten ; Biological Oxygen Demand Analysis ; Salinity ; Nitrogen/analysis ; Waste Disposal, Fluid/methods
Chemical Substances	Wastewater ; Ammonia (7664-41-7) ; Tungsten (V9306CXO6G) ; Nitrogen (N762921K75)
Language	English
Publishing date	2023-04-26
Publishing country	England
Document type	Journal Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2023.117983
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Article ; Online: Thermal tuning nanoprinting based on liquid crystal tunable dual-layered metasurfaces for optical information encryption.

Zhang, Shijie / Wang, Qi / Zeng, Ruimei / Chang, Chenliang / Zhang, Dawei / Zhuang, Songlin

Optics express

2021 Volume 32, Issue 3, Page(s) 4639–4649

Abstract: Dynamic tuning metasurfaces represent a significant advancement in optical encryption techniques, enabling highly secure multichannel responses. This paper proposes a liquid crystal (LC) tunable dual-layered metasurface to establish a thermal-encrypted ... ...

Abstract	Dynamic tuning metasurfaces represent a significant advancement in optical encryption techniques, enabling highly secure multichannel responses. This paper proposes a liquid crystal (LC) tunable dual-layered metasurface to establish a thermal-encrypted optical platform for information storage. Through the screening of unit cells and coupling of characteristics, a dynamic polarization-dependent beam-steering metasurface is vertically cascaded with an angular multiplexing nanoprinting metasurface, separated by a dielectric layer. By integrating high-birefringence LCs into dual-layered metasurfaces, the cascaded meta-system can achieve dynamic thermal-switching for pre-encoded nanoprinting images. This work provides a promising solution for developing compact dynamic meta-systems for customized optical storage and information encryption.
Language	English
Publishing date	2021-10-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.514603
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Article ; Online: Mesoscale visualization of three-dimensional microvascular architecture and immunocyte distribution in intact mouse liver lobes.

Liu, Zheng / Xu, Mengli / Huang, Songlin / Pan, Qi / Liu, Chong / Zeng, Fanxin / Fan, Zhan / Lu, Yafang / Wang, Jialu / Liu, Jinxin / Li, Xinlin / Luo, Qingming / Zhang, Zhihong

Theranostics

2022 Volume 12, Issue 12, Page(s) 5418–5433

Abstract: Rational: ...

Abstract	Rational:
MeSH term(s)	Animals ; Colorectal Neoplasms/pathology ; Liver/pathology ; Liver Cirrhosis/pathology ; Liver Neoplasms/pathology ; Macrophages/pathology ; Mice
Language	English
Publishing date	2022-07-11
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592097-2
ISSN	1838-7640 ; 1838-7640
ISSN (online)	1838-7640
ISSN	1838-7640
DOI	10.7150/thno.71718
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Article ; Online: Safety and efficacy of Endovascular Management of high-grade blunt renal injury.

Wang, Bin / Wen, Chongpei / Song, Songlin / Li, Guilian / Yan, Yanggang / Cheng, Shoucai / Zeng, Junmei / Lin, Zhidong / Wang, Yong

Journal of interventional medicine

2022 Volume 5, Issue 1, Page(s) 23–27

Abstract: Objectives: To provide data on the safety and efficacy of renal arterial embolization (RAE) in patients with high-grade blunt renal injury.: Materials and methods: Fifteen patients with high-grade blunt renal injury (AAST grades IV-V) admitted to our ...

Abstract	Objectives: To provide data on the safety and efficacy of renal arterial embolization (RAE) in patients with high-grade blunt renal injury. Materials and methods: Fifteen patients with high-grade blunt renal injury (AAST grades IV-V) admitted to our hospital from July 2014 to December 2019 were retrospectively reviewed in this study. Their clinical success rate and complications were investigated accordingly. Results: Fifteen patients with high-grade blunt renal injury, 13 men and 2 women with an average age of 41.6 years, including 11 hemodynamically unstable patients and 4 stable patients, were treated with RAE. Among these patients, 73.3% (11 of 15) had grade IV, and 26.7% (4 of 15) had grade V injuries, while 53.3% (8 of 15) patients had concomitant injuries. One patient received main RAE and 14 patients received selective RAE. The clinical success rate after the first embolization was 93.3% (14 of 15). RAE was repeated and was successfully performed in one patient with sustained hematuria. No significant difference in creatinine levels was found before and after embolization. During the follow-up period of 2-82 months, two patients required tube drainage due to urine leaks, one patient developed renal failure requiring renal replacement therapy, and one patient developed secondary hypertension. Conclusions: RAE can provide a high success rate of hemostasis for both hemodynamically stable and unstable patients with high-grade blunt renal injury, and only minor complications are observed with this procedure.
Language	English
Publishing date	2022-02-26
Publishing country	China
Document type	Journal Article
ZDB-ID	3008114-2
ISSN	2590-0293 ; 2096-3602
ISSN (online)	2590-0293
ISSN	2096-3602
DOI	10.1016/j.jimed.2021.12.003
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