LIVIVO - Search results -

Search results

Result 1 - 10 of total 440

Search options

Article: MicroRNA-centered theranostics for pulmoprotection in critical COVID-19.

Perez-Pons, Manel / Molinero, Marta / Benítez, Iván D / García-Hidalgo, María C / Chatterjee, Shambhabi / Bär, Christian / González, Jessica / Torres, Antoni / Barbé, Ferran / de Gonzalo-Calvo, David

Molecular therapy. Nucleic acids

2024 Volume 35, Issue 1, Page(s) 102118

Abstract: Elucidating the pathobiological mechanisms underlying post-acute pulmonary sequelae following SARS-CoV-2 infection is essential for early interventions and patient stratification. Here, we investigated the potential of microRNAs (miRNAs) as theranostic ... ...

Abstract	Elucidating the pathobiological mechanisms underlying post-acute pulmonary sequelae following SARS-CoV-2 infection is essential for early interventions and patient stratification. Here, we investigated the potential of microRNAs (miRNAs) as theranostic agents for pulmoprotection in critical illness survivors. Multicenter study including 172 ICU survivors. Diffusion impairment was defined as a lung-diffusing capacity for carbon monoxide (D
Language	English
Publishing date	2024-01-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2662631-7
ISSN	2162-2531
ISSN	2162-2531
DOI	10.1016/j.omtn.2024.102118
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: MicroRNA-guided drug discovery for mitigating persistent pulmonary complications in critical COVID-19 survivors: A longitudinal pilot study.

British journal of pharmacology

2024

Abstract: Background and purpose: The post-acute sequelae of SARS-CoV-2 infection pose a significant global challenge, with nearly 50% of critical COVID-19 survivors manifesting persistent lung abnormalities. The lack of understanding about the molecular ... ...

Abstract	Background and purpose: The post-acute sequelae of SARS-CoV-2 infection pose a significant global challenge, with nearly 50% of critical COVID-19 survivors manifesting persistent lung abnormalities. The lack of understanding about the molecular mechanisms and effective treatments hampers their management. Here, we employed microRNA (miRNA) profiling to decipher the systemic molecular underpinnings of the persistent pulmonary complications. Experimental approach: We conducted a longitudinal investigation including 119 critical COVID-19 survivors. A comprehensive pulmonary evaluation was performed in the short-term (median = 94.0 days after hospital discharge) and long-term (median = 358 days after hospital discharge). Plasma miRNAs were quantified at the short-term evaluation using the gold-standard technique, RT-qPCR. The analyses combined machine learning feature selection techniques with bioinformatic investigations. Two additional datasets were incorporated for validation. Key results: In the short-term, 84% of the survivors exhibited impaired lung diffusion (D Conclusion and implications: Our study reveals early mechanistic pathways contributing to persistent lung dysfunction in critical COVID-19 survivors, offering a promising approach for the development of targeted disease-modifying agents.
Language	English
Publishing date	2024-02-15
Publishing country	England
Document type	Journal Article
ZDB-ID	80081-8
ISSN	1476-5381 ; 0007-1188
ISSN (online)	1476-5381
ISSN	0007-1188
DOI	10.1111/bph.16330
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uf I Zs.146: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Addressing the unsolved challenges in microRNA-based biomarker development: Suitable endogenous reference microRNAs for SARS-CoV-2 infection severity.

Belmonte, Thalia / Perez-Pons, Manel / Benítez, Iván D / Molinero, Marta / García-Hidalgo, María C / Rodríguez-Muñoz, Carlos / Gort-Paniello, Clara / Moncusí-Moix, Anna / Madè, Alisia / Devaux, Yvan / Martelli, Fabio / Ortega, Alicia / González, Jessica / Torres, Gerard / Barbé, Ferrán / de Gonzalo-Calvo, David

International journal of biological macromolecules

2024 , Page(s) 131926

Abstract: Circulating cell-free microRNAs (miRNAs) are promising biomarkers for medical decision-making. Suitable endogenous controls are essential to ensure reproducibility. We aimed to identify and validate endogenous reference miRNAs for qPCR data normalization ...

Abstract	Circulating cell-free microRNAs (miRNAs) are promising biomarkers for medical decision-making. Suitable endogenous controls are essential to ensure reproducibility. We aimed to identify and validate endogenous reference miRNAs for qPCR data normalization in samples from SARS-CoV-2-infected hospitalized patients. We used plasma samples (n = 170) from COVID-19 patients collected at hospital admission (COVID-Ponent project, www.clinicaltrials.gov/NCT04824677). First, 179 miRNAs were profiled using RT-qPCR. After stability assessment, candidates were validated using the same methodology. miRNA stability was analyzed using the geNorm, NormFinder and BestKeeper algorithms. Stability was further evaluated using an RNA-seq dataset derived from COVID-19 hospitalized patients, along with plasma samples from patients with critical COVID-19 profiled using RT-qPCR. In the screening phase, after strict control of expression levels, stability assessment selected eleven candidates (miR-17-5p, miR-20a-5p, miR-30e-5p, miR-106a-5p, miR-151a-5p, miR-185-5p, miR-191-5p, miR-423-3p, miR-425-5p, miR-484 and miR-625-5p). In the validation phase, all algorithms identified miR-106a-5p and miR-484 as top endogenous controls. No association was observed between these miRNAs and clinical or sociodemographic characteristics. Both miRNAs were stably detected and showed low variability in the additional analyses. In conclusion, a 2-miRNA panel composed of miR-106a-5p and miR-484 constitutes a first-line normalizer for miRNA-based biomarker development using qPCR in hospitalized patients infected with SARS-CoV-2.
Language	English
Publishing date	2024-04-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2024.131926
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 2374: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Haplotypes in the

Fernández-Araque, Ana / Giaquinta-Aranda, Andrea / Moreno-Sainz, Carmelo / Martínez-Martínez, María Cruz / Velasco-González, Verónica / Sainz-Gil, María / Martín-Arias, Luis H / Carretero-Molinero, Silvia / García-Hidalgo, Miguel / Verde, Zoraida

Nutrients

2022 Volume 14, Issue 2

Abstract: Candidate gene studies have analyzed the effect of specific vitamin D pathway genes on vitamin D availability; however, it is not clear whether genetic variants also affect overall bone metabolism. This study evaluated the association between genetic ... ...

Abstract	Candidate gene studies have analyzed the effect of specific vitamin D pathway genes on vitamin D availability; however, it is not clear whether genetic variants also affect overall bone metabolism. This study evaluated the association between genetic polymorphisms in
MeSH term(s)	Aged ; Aged, 80 and over ; Bone Density/genetics ; Calcium/blood ; Cholestanetriol 26-Monooxygenase/genetics ; Creatinine/blood ; Cross-Sectional Studies ; Cytochrome P450 Family 2/genetics ; Female ; Haplotypes ; Humans ; Male ; Parathyroid Hormone/blood ; Phosphorus/blood ; Polymorphism, Single Nucleotide ; Serum Albumin/analysis ; Sex Factors ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D-Binding Protein/genetics ; Vitamin D3 24-Hydroxylase/genetics ; White People
Chemical Substances	Parathyroid Hormone ; Serum Albumin ; Vitamin D-Binding Protein ; Vitamin D (1406-16-2) ; Phosphorus (27YLU75U4W) ; 25-hydroxyvitamin D (A288AR3C9H) ; Creatinine (AYI8EX34EU) ; Cytochrome P450 Family 2 (EC 1.14.14.1) ; CYP2R1 protein, human (EC 1.14.14.24) ; Cholestanetriol 26-Monooxygenase (EC 1.14.15.15) ; CYP24A1 protein, human (EC 1.14.15.16) ; Vitamin D3 24-Hydroxylase (EC 1.14.15.16) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2022-01-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14020259
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Mycoplasma genitalium: Using a commercial molecular technique that facilitates rapid detection of mutations associated with resistance to macrolides.

Borrego-Jiménez, Jaime / Foronda Garcia-Hidalgo, Carla / Navarro-Marí, José María / Gutiérrez-Fernández, José

Enfermedades infecciosas y microbiologia clinica (English ed.)

2019 Volume 38, Issue 2, Page(s) 91–92

Title translation	Mycoplasma genitalium: utilización de una técnica molecular comercial que facilita el análisis rápido de mutaciones asociadas con resistencia a macrólidos.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Drug Resistance, Bacterial/genetics ; Humans ; Macrolides/pharmacology ; Mutation ; Mycoplasma genitalium/cytology ; Mycoplasma genitalium/drug effects
Chemical Substances	Anti-Bacterial Agents ; Macrolides
Language	Spanish
Publishing date	2019-04-20
Document type	Case Reports ; Journal Article
ISSN	2529-993X
ISSN (online)	2529-993X
DOI	10.1016/j.eimc.2019.03.005
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Depth of Invasion: Influence of the Latest TNM Classification on the Prognosis of Clinical Early Stages of Oral Tongue Squamous Cell Carcinoma and Its Association with Other Histological Risk Factors.

Navarro Cuéllar, Ignacio / Espías Alonso, Samuel / Alijo Serrano, Francisco / Herrera Herrera, Isabel / Zamorano León, José Javier / Del Castillo Pardo de Vera, José Luis / López López, Ana María / Maza Muela, Cristina / Arenas de Frutos, Gema / Ochandiano Caicoya, Santiago / Tousidonis Rial, Manuel / García Sevilla, Alba / Antúnez-Conde, Raúl / Cebrián Carretero, José Luis / García-Hidalgo Alonso, María Isabel / Salmerón Escobar, José Ignacio / Burgueño García, Miguel / Navarro Vila, Carlos / Navarro Cuéllar, Carlos

Cancers

2023 Volume 15, Issue 19

Abstract: Background: The American Joint Committee on Cancer (AJCC), in its 8th edition, introduces modifications to the previous TNM classification, incorporating tumour depth of invasion (DOI). The aim of this research is to analyse the prognosis (in terms of ... ...

Abstract	Background: The American Joint Committee on Cancer (AJCC), in its 8th edition, introduces modifications to the previous TNM classification, incorporating tumour depth of invasion (DOI). The aim of this research is to analyse the prognosis (in terms of disease-free survival and overall survival) of clinical early stage (I and II) squamous cell carcinomas of the oral tongue according to the DOI levels established by the AJCC in its latest TNM classification to assess changes to the T category and global staging system and to evaluate the association between DOI and other histological risk factors. Methods: A retrospective longitudinal observational study of a series of cases was designed. All patients were treated with upfront surgery at our institution between 2010 and 2019. The variables of interest were defined and classified into four groups: demographic, clinical, histological and evolutive control. Univariate and multivariate analyses were carried out and survival functions were calculated using the Kaplan-Meier method. Statistical significance was established for Results: Sixty-one patients were included. The average follow-up time was 47.42 months. Fifteen patients presented a loco-regional relapse (24.59%) and five developed distant disease (8.19%). Twelve patients died (19.67%). Statistically significant differences were observed, with respect to disease-free survival ( Conclusions: Depth of invasion is a histological risk factor in early clinical stages of oral tongue squamous cell carcinoma. Depth of invasion impacts negatively on patient prognosis, is capable per se of modifying the T category and the global tumour staging, and is associated with the presence of cervical metastatic disease, perineural invasion and tumoural differentiation grade.
Language	English
Publishing date	2023-10-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15194882
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: A blood microRNA classifier for the prediction of ICU mortality in COVID-19 patients: a multicenter validation study.

de Gonzalo-Calvo, David / Molinero, Marta / Benítez, Iván D / Perez-Pons, Manel / García-Mateo, Nadia / Ortega, Alicia / Postigo, Tamara / García-Hidalgo, María C / Belmonte, Thalia / Rodríguez-Muñoz, Carlos / González, Jessica / Torres, Gerard / Gort-Paniello, Clara / Moncusí-Moix, Anna / Estella, Ángel / Tamayo Lomas, Luis / Martínez de la Gándara, Amalia / Socias, Lorenzo / Peñasco, Yhivian /

de la Torre, Maria Del Carmen / Bustamante-Munguira, Elena / Gallego Curto, Elena / Martínez Varela, Ignacio / Martin Delgado, María Cruz / Vidal-Cortés, Pablo / López Messa, Juan / Pérez-García, Felipe / Caballero, Jesús / Añón, José M / Loza-Vázquez, Ana / Carbonell, Nieves / Marin-Corral, Judith / Jorge García, Ruth Noemí / Barberà, Carmen / Ceccato, Adrián / Fernández-Barat, Laia / Ferrer, Ricard / Garcia-Gasulla, Dario / Lorente-Balanza, Jose Ángel / Menéndez, Rosario / Motos, Ana / Peñuelas, Oscar / Riera, Jordi / Bermejo-Martin, Jesús F / Torres, Antoni / Barbé, Ferran

Respiratory research

2023 Volume 24, Issue 1, Page(s) 159

Abstract: ... of conventional scores, APACHE-II (C-index 0.71, DeLong test p-value 0.055) and SOFA (C-index 0.67, DeLong test p ... value 0.001), and a risk model based on clinical predictors (C-index 0.74, DeLong test-p-value 0.035 ...

Abstract	Background: The identification of critically ill COVID-19 patients at risk of fatal outcomes remains a challenge. Here, we first validated candidate microRNAs (miRNAs) as biomarkers for clinical decision-making in critically ill patients. Second, we constructed a blood miRNA classifier for the early prediction of adverse outcomes in the ICU. Methods: This was a multicenter, observational and retrospective/prospective study including 503 critically ill patients admitted to the ICU from 19 hospitals. qPCR assays were performed in plasma samples collected within the first 48 h upon admission. A 16-miRNA panel was designed based on recently published data from our group. Results: Nine miRNAs were validated as biomarkers of all-cause in-ICU mortality in the independent cohort of critically ill patients (FDR < 0.05). Cox regression analysis revealed that low expression levels of eight miRNAs were associated with a higher risk of death (HR from 1.56 to 2.61). LASSO regression for variable selection was used to construct a miRNA classifier. A 4-blood miRNA signature composed of miR-16-5p, miR-192-5p, miR-323a-3p and miR-451a predicts the risk of all-cause in-ICU mortality (HR 2.5). Kaplan‒Meier analysis confirmed these findings. The miRNA signature provides a significant increase in the prognostic capacity of conventional scores, APACHE-II (C-index 0.71, DeLong test p-value 0.055) and SOFA (C-index 0.67, DeLong test p-value 0.001), and a risk model based on clinical predictors (C-index 0.74, DeLong test-p-value 0.035). For 28-day and 90-day mortality, the classifier also improved the prognostic value of APACHE-II, SOFA and the clinical model. The association between the classifier and mortality persisted even after multivariable adjustment. The functional analysis reported biological pathways involved in SARS-CoV infection and inflammatory, fibrotic and transcriptional pathways. Conclusions: A blood miRNA classifier improves the early prediction of fatal outcomes in critically ill COVID-19 patients.
MeSH term(s)	Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Prospective Studies ; Retrospective Studies ; COVID-19/diagnosis ; COVID-19/genetics ; Critical Illness ; Biomarkers ; Intensive Care Units
Chemical Substances	MicroRNAs ; Biomarkers
Language	English
Publishing date	2023-06-17
Publishing country	England
Document type	Observational Study ; Multicenter Study ; Journal Article
ZDB-ID	2041675-1
ISSN	1465-993X ; 1465-993X
ISSN (online)	1465-993X
ISSN	1465-993X
DOI	10.1186/s12931-023-02462-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Clinical and Surgical Outcomes in Extensive Scalp Reconstruction after Oncologic Resection: A Comparison of Anterolateral Thigh, Latissimus Dorsi and Omental Free Flaps.

Del Castillo Pardo de Vera, José Luis / Navarro Cuéllar, Carlos / Navarro Cuéllar, Ignacio / Cebrián Carretero, José Luis / Bacián Martínez, Sandra / García-Hidalgo Alonso, María Isabel / Sánchez-Pérez, Arturo / Zamorano-León, Jose J / López-Farré, Antonio J / Navarro Vila, Carlos

Journal of clinical medicine

2021 Volume 10, Issue 17

Abstract: Microsurgical scalp reconstruction is indicated in patients with large scalp defects. The aim of this study was to compare the outcomes of scalp reconstruction in oncologic patients reconstructed with latissimus dorsi (LD), anterolateral thigh (ALT), and ...

Abstract	Microsurgical scalp reconstruction is indicated in patients with large scalp defects. The aim of this study was to compare the outcomes of scalp reconstruction in oncologic patients reconstructed with latissimus dorsi (LD), anterolateral thigh (ALT), and omental (OM) free flaps. Thirty oncologic patients underwent scalp reconstruction with LD (10), ALT (11), and OM (9) flaps. The length of the vascular pedicle, the operation time, the possibility of a two-team approach, the length of hospital stays, the complications, and the aesthetic results were evaluated. The OM flap was the flap with the shortest vascular pedicle length with a mean of 6.26 ± 0.16 cm, compared to the LD flap, which was 12.34 ± 0.55 cm and the ALT flap with 13.20 ± 0.26 cm (
Language	English
Publishing date	2021-08-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm10173863
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Three to Six Months Evolution of Pulmonary Function and Radiological Features in Critical COVID-19 Patients: A Prospective Cohort.

Cabo-Gambin, Ramón / Benítez, Iván D / Carmona, Paola / Santiesteve, Sally / Mínguez, Olga / Vaca, Rafaela / Moncusí-Moix, Anna / Gort-Paniello, Clara / García-Hidalgo, María C / de Gonzalo-Calvo, David / de Batlle, Jordi / Torres, Gerard / Torres, Antoni / Barbé, Ferran / González, Jessica

Archivos de bronconeumologia

2021

Language	Spanish
Publishing date	2021-07-27
Publishing country	Spain
Document type	Case Reports
ZDB-ID	733126-5
ISSN	1579-2129 ; 0300-2896
ISSN (online)	1579-2129
ISSN	0300-2896
DOI	10.1016/j.arbres.2021.07.005
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 2655: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Virtual Surgical Planning, Stereolitographic Models and CAD/CAM Titanium Mesh for Three-Dimensional Reconstruction of Fibula Flap with Iliac Crest Graft and Dental Implants.

Navarro Cuéllar, Carlos / Tousidonis Rial, Manuel / Antúnez-Conde, Raúl / Ochandiano Caicoya, Santiago / Navarro Cuéllar, Ignacio / Arenas de Frutos, Gema / Sada Urmeneta, Ángela / García-Hidalgo Alonso, María Isabel / Navarro Vila, Carlos / Salmerón Escobar, José Ignacio

Journal of clinical medicine

2021 Volume 10, Issue 9

Abstract: Mandibular reconstruction with fibula flap shows a 3D discrepancy between the fibula and the remnant mandible. Eight patients underwent three-dimensional reconstruction of the fibula flap with iliac crest graft and dental implants through virtual ... ...

Abstract	Mandibular reconstruction with fibula flap shows a 3D discrepancy between the fibula and the remnant mandible. Eight patients underwent three-dimensional reconstruction of the fibula flap with iliac crest graft and dental implants through virtual surgical planning (VSP), stereolitographic models (STL) and CAD/CAM titanium mesh. Vertical ridge augmentation and horizontal dimensions of the fibula, peri-implant bone resorption of the iliac crest graft, implant success rate and functional and aesthetic results were evaluated. Vertical reconstruction ranged from 13.4 mm to 10.1 mm, with an average of 12.22 mm. Iliac crest graft and titanium mesh were able to preserve the width of the fibula, which ranged from 8.9 mm to 11.7 mm, with an average of 10.1 mm. A total of 38 implants were placed in the new mandible, with an average of 4.75 ± 0.4 implants per patient and an osseointegration success rate of 94.7%. Two implants were lost during the osseointegration period (5.3%). Bone resorption was measured as peri-implant bone resorption at the mesial and distal level of each implant, with a variation between 0.5 mm and 2.4 mm, and with a mean of 1.43 mm. All patients were rehabilitated with a fixed implant prosthesis with good aesthetic and functional results.
Language	English
Publishing date	2021-04-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm10091922
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito