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Article ; Online: Scientific Advances in Understanding the Pathogenesis, Diagnosis, and Prevention of Urinary Tract Infection in the Past 10 Years.

Engel, Daniel R / Wagenlehner, Florian M E / Shevchuk, Olga

Infectious disease clinics of North America

2024

Abstract: Urinary tract infection (UTI) is a very common disease that is accompanied by various complications in the affected person. UTI triggers diverse inflammatory reactions locally in the infected urinary bladder and kidney, causing tissue destruction and ... ...

Abstract	Urinary tract infection (UTI) is a very common disease that is accompanied by various complications in the affected person. UTI triggers diverse inflammatory reactions locally in the infected urinary bladder and kidney, causing tissue destruction and organ failure. Moreover, systemic responses in the entire body carry the risk of urosepsis with far-reaching consequences. Understanding the cell-, organ-, and systemic mechanisms in UTI are crucial for prevention, early intervention, and current therapeutic approaches. This review summarizes the scientific advances over the last 10 years concerning pathogenesis, prevention, rapid diagnosis, and new treatment approaches. We also highlight the impact of the immune system and potential new therapies to reduce progressive and recurrent UTI.
Language	English
Publishing date	2024-04-03
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1077676-x
ISSN	1557-9824 ; 0891-5520
ISSN (online)	1557-9824
ISSN	0891-5520
DOI	10.1016/j.idc.2024.03.002
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Article ; Online: Complex of Aphidophagous Predators of Mealy Plum Aphid Hyalopterus pruni Geoffr. and Their Efficiency in Pest Control

Igor Shevchuk / Olga Shevchuk

Biology and Life Sciences Forum, Vol 15, Iss 20, p

2022 Volume 20

Abstract: Aphids are the dominant pests in the complex of harmful fauna of stone fruits in Ukraine. In plum orchards mealy plum aphid Hyalopterus pruni Geoffr. (Hemiptera: Aphidinae) causes serious economic damage. Insect predators have an important role in the ... ...

Abstract	Aphids are the dominant pests in the complex of harmful fauna of stone fruits in Ukraine. In plum orchards mealy plum aphid Hyalopterus pruni Geoffr. (Hemiptera: Aphidinae) causes serious economic damage. Insect predators have an important role in the regulation of agricultural pests. Our goal was to determine the role of predation in the dynamics of the mealy-plum-aphid population. Investigations were carried out during the period of mass development of the mealy plum aphid in the experimental plum-orchard garden of the Institute of Horticulture of the National Academy of Agrarian Sciences of Ukraine. For this purpose, model trees were selected and isolators were installed on four branches of each tree with aphid-infested leaves. Different species of entomophagous predators were placed in the isolators and assessments were performed on a daily basis. According to our observations, Adalia bipunctata L., A. decempunctata L., Syrphus ribesii L., S. balteatus Deg, Chrysopa perla L., and Ch. carnea Steph. dominated among aphidophagous predators. Coccinella septempunctata L., Calvia quatuordecimguttata L., and Propylaea quatuordecimpunctata L. were less common. Syrphus and Chrysopa larvae had the highest predation activity. The influence of weather conditions on the efficiency of aphidophagous predators was analyzed. Optimal conditions for A. bipunctata , A. decempunctata , S. ribesii , S. balteatus , Ch. perla , and Ch. carnea during June–July were as follows: mean daily temperature, 17–20 °C, precipitation 0.1–1.5 mm, and relative air humidity 57–67%. The threshold ratios of dominant aphidophagous predators were determined. The high predation activity of Syrphus and Chrysopa larvae and coccinellids indicated that the ratio of entomophages to aphids must be taken into account when making decisions about control measures
Keywords	plum ; mealy plum aphid ; entomophages ; predation activity ; threshold ratio ; Plant ecology ; QK900-989 ; Animal biochemistry ; QP501-801 ; Biology (General) ; QH301-705.5
Subject code	590
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Outcome of clinical experience of introducing a patient with secondary systemic AL-amyloidosis associated with multiple myeloma.

Novosad, Olga / Rudiuk, Tymur / Shevchuk, Lesya / Kundina, Viktoriia / Schmidt, Anna

Carcinogenesis

2023 Volume 44, Issue 1, Page(s) 46–53

Abstract: This research is relevant, as AL-amyloidosis refers to a systemic type of disease characterized by aggregation of an improperly folded light chain of an immunoglobulin, mainly in the heart and kidneys, causing organ failure. This study describes the ... ...

Abstract	This research is relevant, as AL-amyloidosis refers to a systemic type of disease characterized by aggregation of an improperly folded light chain of an immunoglobulin, mainly in the heart and kidneys, causing organ failure. This study describes the clinical experience of introducing a patient with cardiac amyloidosis associated with multiple myeloma (MM). A clinical case of a patient diagnozed with amyloidosis was considered. Magnetic resonance imaging signs of cardiac amyloidosis were confirmed due to the presence of concentric biventricular hypertrophy without dilation, atrial septal hypertrophy, a tendency to atrial dilation, thickening of valve flaps and atrial walls. Upon admission to the research institute, the patient had an anasarca. More accurate recognition of AL-amyloidosis by cardiologists allows for prescribing earlier treatment and improving results. Conventional treatment of MM and AL-amyloidosis includes a combination of dexamethasone with bortezomib and endoxan. Haematopoietic stem cell transplantation after taking high doses of melphalan has become another treatment option and has led to remission in some patients. The novelty of the study is that an example of a timely complete diagnosis and treatment of a combination of these two diseases was presented, as a result of which the patient has achieved a complete haematological and partial organ response to the underlying disease.
MeSH term(s)	Humans ; Multiple Myeloma/complications ; Multiple Myeloma/drug therapy ; Atrial Fibrillation/complications ; Amyloidosis/complications ; Amyloidosis/diagnosis ; Amyloidosis/drug therapy ; Immunoglobulin Light-chain Amyloidosis/complications ; Hypertrophy/complications ; Treatment Outcome
Language	English
Publishing date	2023-01-16
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	603134-1
ISSN	1460-2180 ; 0143-3334
ISSN (online)	1460-2180
ISSN	0143-3334
DOI	10.1093/carcin/bgad004
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Article ; Online: Complex of Barley Leaf Spots in Ukraine

Sergiy Retman / Fedir Melnichuk / Tetiana Kyslykh / Olga Shevchuk

Chemistry Proceedings, Vol 10, Iss 1, p

2022 Volume 1

Abstract: Barley is one of the most important cereal crops globally. In Ukraine, it is grown on an area of 2.4–2.8 million hectares annually and is the second largest grain crop in Ukraine after wheat. Barley grain export is about 4.3 million tons p.a. At the same ...

Abstract	Barley is one of the most important cereal crops globally. In Ukraine, it is grown on an area of 2.4–2.8 million hectares annually and is the second largest grain crop in Ukraine after wheat. Barley grain export is about 4.3 million tons p.a. At the same time, one of the limiting factors for obtaining a high-quality yield is diseases, in particular leaf spots. In recent decades, there have been significant changes in the technology of cultivation, the composition of varieties and the pathogenic complex. Net blotch ( Pyrenophora teres Drechsler) in net and spot forms and spot blotch ( Bipolaris sorokiniana Shoem.) remain the most common among the diseases of barley leaves. They occur in all regions where barley is grown. Barley scald ( Rhynchosporium secalis (Oudem.) Davis) is distributed mainly in the forest zone and western part of the forest-steppe zone and has become more widespread in recent years with rainy summers. Outbreaks of stripe spot ( Pyrenophora graminea S. Ito & Kurib.) occur sporadically. Ascochyta leaf spot ( Ascochyta spp.) was found in the Lviv and Dnipropetrovsk regions in 2020, and in the Lviv, Donetsk and Zaporizhia regions in 2021. In the field, spots can be misdiagnosed as barley scald, so their prevalence may be much higher. In 2021, during the seed ripening period, ramularia leaf spot was found in the Kherson and Vinnytsia regions. The disease was diagnosed in the laboratory by obtaining a typical conidial sporulation of the fungus Ramularia collo-cygni B. Sutton & J.M. Waller on affected tissues (wet chamber). Therefore, in recent years, the composition of the barley leaf spot pathogens has become wider and requires further investigation.
Keywords	barley ; leaf disease complex ; emerging pathogens ; Chemistry ; QD1-999
Subject code	580
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Restrictions on grain exports during COVID-19

Olga Khodakivska / Tetiana Kolesnyk / Oksana Samborska / Hanna Shevchuk / Natalia Germaniuk

Наукові горизонти, Vol 25, Iss 9, Pp 117-

Features and solutions

2022 Volume 125

Abstract: The world export of agricultural and of food products has been a relevant topic at all times, because it regulated the issue of economic and social development of many countries. However, this issue became even more urgent after the start of the COVID-19 ...

Abstract	The world export of agricultural and of food products has been a relevant topic at all times, because it regulated the issue of economic and social development of many countries. However, this issue became even more urgent after the start of the COVID-19 pandemic, when the situation in this sector got very complicated. The aim of the study is to look at the features of grain export restrictions during the COVID-19 pandemic and how they can be addressed. The socio-economic method was applied to compare the economy with the market and take into account the multiplicity of economic behaviour. Using the functional method, the theoretical foundations of functional economics were established, focusing on the evolution of terminology to denote certain combinations of restrictions on the export of grain products and services during the COVID-19 pandemic. The method of institutional analysis was used to assess the quality of the institutional basis of the economy and political structures. It was determined that changes in the trade sphere stimulated the development of production in deficit areas. It was defined that the removal of tariff barriers to trade could be useful in overcoming the crisis caused by the pandemic and also an efficient link to reducing the costs of international trade. Another conclusion is that it is worth preserving access to food, rather than restricting exports in countries where people may suffer from hunger. The practical relevance lies in identifying the features of appropriate restrictions on grain exports during a pandemic and highlighting the main ways in which this problem can be addressed
Keywords	sustainable development ; pandemic ; food security ; macroeconomic environment ; Agriculture ; S
Subject code	381
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	Zhytomyr National Agroecological University
Document type	Article ; Online
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Article ; Online: Targeted Proteomics Reveals Quantitative Differences in Low-Abundance Glycosyltransferases of Patients with Congenital Disorders of Glycosylation.

Sakson, Roman / Beedgen, Lars / Bernhard, Patrick / Alp, K Merve / Lübbehusen, Nicole / Röth, Ralph / Niesler, Beate / Luzarowski, Marcin / Shevchuk, Olga / Mayer, Matthias P / Thiel, Christian / Ruppert, Thomas

International journal of molecular sciences

2024 Volume 25, Issue 2

Abstract: Protein glycosylation is an essential post-translational modification in all domains of life. Its impairment in humans can result in severe diseases named congenital disorders of glycosylation (CDGs). Most of the glycosyltransferases (GTs) responsible ... ...

Abstract	Protein glycosylation is an essential post-translational modification in all domains of life. Its impairment in humans can result in severe diseases named congenital disorders of glycosylation (CDGs). Most of the glycosyltransferases (GTs) responsible for proper glycosylation are polytopic membrane proteins that represent challenging targets in proteomics. We established a multiple reaction monitoring (MRM) assay to comprehensively quantify GTs involved in the processes of
MeSH term(s)	Humans ; Glycosylation ; Glycosyltransferases/genetics ; Congenital Disorders of Glycosylation/genetics ; Proteomics ; Protein Processing, Post-Translational ; Membrane Proteins/genetics ; Mannosyltransferases
Chemical Substances	Glycosyltransferases (EC 2.4.-) ; Membrane Proteins ; ALG11 protein, human (EC 2.4.1.-) ; Mannosyltransferases (EC 2.4.1.-)
Language	English
Publishing date	2024-01-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25021191
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Article: EBV-ENCEPHALITIS IN CHILDREN: DIAGNOSTIC CRITERIA.

Rzhevska, Olga O / Khodak, Larisa A / Butenko, Antonina I / Kvaratskheliya, Tamara M / Shtrakh, Kateryna V / Shevchuk, Anatolii M / Yashchenko, Yurii B

Wiadomosci lekarskie (Warsaw, Poland : 1960)

2023 Volume 76, Issue 10, Page(s) 2263–2268

Abstract: Objective: The aim: To investigate the clinical characteristics of EBV infection in the pediatric nervous system using laboratory methods and brain MRI data.: Patients and methods: Materials and methods: We observed 41 children with EBV encephalitis ... ...

Abstract	Objective: The aim: To investigate the clinical characteristics of EBV infection in the pediatric nervous system using laboratory methods and brain MRI data. Patients and methods: Materials and methods: We observed 41 children with EBV encephalitis ranging from 8 months to 17 years old. The diagnosis of EBV-encephalitis was established on the basis of clinical and medical history, laboratory and instrumental (brain MRI) data. The main thing in the diagnosis was clinical symptoms, combining general infection, cerebral syndromes and focal neurological symptoms. The etiology of Epstein-Barr virus was determined using ELISA and PCR. Results: Results: EBV-encephalitis can be as a manifestation of reactivation of persistent EBV infection (85%), much less often - acute primary EBV infection (15%). By nature, the duration of EBV encephalitis has distinguished two forms of its course: acute (63%) and chronioc (37%). The criteria of differential diagnosis of acute and chronic forms of EBV-encephalitis are proposed, which include the most common anamnesis data, clinical manifestations and changes in brain MRI. Conclusion: Conclusions: The proposed criteria specifically for acute and chronic forms of EBV-encephalitis can contribute to the timely and more accurate diagnosis of this disease in children.
MeSH term(s)	Humans ; Child ; Epstein-Barr Virus Infections/complications ; Epstein-Barr Virus Infections/diagnosis ; Herpesvirus 4, Human ; Magnetic Resonance Imaging ; Syndrome ; Encephalitis/diagnosis
Language	English
Publishing date	2023-11-01
Publishing country	Poland
Document type	Journal Article
ZDB-ID	414731-5
ISSN	0043-5147 ; 1895-0485 ; 0860-8865
ISSN	0043-5147 ; 1895-0485 ; 0860-8865
DOI	10.36740/WLek202310120
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Article ; Online: The global burden of antimicrobial resistance - urinary tract infections.

Von Vietinghoff, Sibylle / Shevchuk, Olga / Dobrindt, Ulrich / Engel, Daniel Robert / Jorch, Selina K / Kurts, Christian / Miethke, Thomas / Wagenlehner, Florian

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

2023 Volume 39, Issue 4, Page(s) 581–588

Abstract: Antimicrobial resistance (AMR) has emerged as a significant global healthcare problem. Antibiotic use has accelerated the physiologic process of AMR, particularly in Gram-negative pathogens. Urinary tract infections (UTIs) are predominantly of a Gram- ... ...

Abstract	Antimicrobial resistance (AMR) has emerged as a significant global healthcare problem. Antibiotic use has accelerated the physiologic process of AMR, particularly in Gram-negative pathogens. Urinary tract infections (UTIs) are predominantly of a Gram-negative nature. Uropathogens are evolutionarily highly adapted and selected strains with specific virulence factors, suggesting common mechanisms in how bacterial cells acquire virulence and AMR factors. The simultaneous increase in resistance and virulence is a complex and context-dependent phenomenon. Among known AMR mechanisms, the plenitude of different β-lactamases is especially prominent. The risk for AMR in UTIs varies in different patient populations. A history of antibiotic consumption and the physiology of urinary flow are major factors that shape AMR prevalence. The urinary tract is in close crosstalk with the microbiome of other compartments, including the gut and genital tracts. In addition, pharmacokinetic properties and the physiochemical composition of urinary compartments can contribute to the emergence of AMR. Alternatives to antibiotic treatment and a broader approach to address bacterial infections are needed. Among the various alternatives studied, antimicrobial peptides and bacteriophage treatment appear to be highly promising approaches. We herein summarize the present knowledge of clinical and microbiological AMR in UTIs and discuss innovative approaches, namely new risk prediction tools and the use of non-antibiotic approaches to defend against uropathogenic microbes.
MeSH term(s)	Humans ; Anti-Bacterial Agents/therapeutic use ; Drug Resistance, Bacterial ; Urinary Tract Infections/drug therapy ; Urinary Tract
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2023-10-27
Publishing country	England
Document type	Journal Article
ZDB-ID	90594-x
ISSN	1460-2385 ; 0931-0509
ISSN (online)	1460-2385
ISSN	0931-0509
DOI	10.1093/ndt/gfad233
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Article ; Conference proceedings: Interactions of myeloid cells with tumor microenvironment as a therapeutic target in head and neck cancer

Pylaeva, Ekaterina / Shevchuk, Olga / Özel, Irem / Thiel, Ilona / Antczak, Joanna / Kürten, Cornelius / Arefieva, Tatiana / Sidorova, Maria / Engel, Daniel / Lang, Stephan / Jablonska, Jadwiga

Laryngo-Rhino-Otologie

2024 Volume 103, Issue S 02

Event/congress	95th Annual Meeting German Society of Oto-Rhino-Laryngology, Head and Neck Surgery e. V., Bonn, Messe Essen, 2024-05-08
Language	English
Publishing date	2024-04-19
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	96005-6
ISSN	1438-8685 ; 0935-8943 ; 0340-1588
ISSN (online)	1438-8685
ISSN	0935-8943 ; 0340-1588
DOI	10.1055/s-0044-1784766
Database	Thieme publisher's database

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Article ; Online: Usage of Worked Clay Absorbent as a Manifestation of an Ecologically Oriented Lifestyle

Olga Palamarchuk / Halyna Sakalova / Tamara Vasylinych / Lyudmila Lyubchak / Oksana Shevchuk / Oleksandr Matviichuk / Olena Khodanaitska

Ecological Engineering & Environmental Technology, Vol 23, Iss 2, Pp 90-

2022 Volume 96

Abstract: The article deals with the development of new eco-innovative technologies, evaluation of their effectiveness and the widest possible awareness of those categories of people who could effectively use the proposed technologies. It was found that the ... ...

Abstract	The article deals with the development of new eco-innovative technologies, evaluation of their effectiveness and the widest possible awareness of those categories of people who could effectively use the proposed technologies. It was found that the personal position of economic entities is the core of the structural organization of psychological readiness for ecologically oriented innovation and is manifested in the forms of free ecologically oriented will. The paper discusses the main methods of removal of nutrients from wastewater, presents promising technologies and techniques. It contains recommendations for optimal conditions for the precipitation of ammonia nitrogen from an ion exchange regenerator for further use as an ammonium fertilizer. The maximum efficiency of ammonium nitrogen removal has been established According to the results of the best options, the deposition of real ion exchange concentrates was carried out. The humidity level was set during the drying of mineral fertilizers. The moisture content determined the content of sediment, which is close to the number of water molecules to the formula of the fertilizer MgNH4PO4 ∙ 5H2O. Complex phosphate fertilizer struvit is characterized. A comparative agronomic evaluation of synthetic struvite was performed. The influence of struvite on the processes of germination of cultivated plants is carried out. The results show that the method of obtaining struvite does not significantly affect the processes of wheat germination, and the determining factor in the effectiveness of fertilizers is the method of its application and dosage.
Keywords	adsorption ; bioindication ; natural clay sorbents ; agroecological assessment ; Ecology ; QH540-549.5
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Polish Society of Ecological Engineering (PTIE)
Document type	Article ; Online
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