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  1. Article ; Online: Opioid Stewardship in Surgical Ophthalmology: Implications for Public Health.

    Lanier, William L / Berge, Keith H

    Ophthalmology

    2021  Volume 128, Issue 9, Page(s) 1274–1275

    MeSH term(s) Analgesics, Opioid ; Humans ; Ophthalmology ; Practice Patterns, Physicians' ; Public Health
    Chemical Substances Analgesics, Opioid
    Language English
    Publishing date 2021-09-16
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 392083-5
    ISSN 1549-4713 ; 0161-6420
    ISSN (online) 1549-4713
    ISSN 0161-6420
    DOI 10.1016/j.ophtha.2021.06.006
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    Ul II Zs.83: Show issues Location:
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  2. Article ; Online: The Law of Unintended Consequences Can Never Be Repealed: The Hazards of Random Urine Drug Screening of Anesthesia Providers.

    Berge, Keith H / McGlinch, Brian P

    Anesthesia and analgesia

    2017  Volume 124, Issue 5, Page(s) 1397–1399

    Language English
    Publishing date 2017-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000001972
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 149: Show issues

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  3. Article ; Online: Opioid overdose: when good drugs break bad.

    Berge, Keith H / Burkle, Christopher M

    Mayo Clinic proceedings

    2014  Volume 89, Issue 4, Page(s) 437–439

    MeSH term(s) Analgesics, Opioid/adverse effects ; Cause of Death ; Emergency Service, Hospital/utilization ; Female ; Humans ; Male ; Opioid-Related Disorders/diagnosis ; Opioid-Related Disorders/epidemiology
    Chemical Substances Analgesics, Opioid
    Language English
    Publishing date 2014-04
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2014.02.007
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  4. Article ; Online: In reply--The contribution of patient satisfaction to the opiate abuse epidemic.

    Berge, Keith H / Burkle, Christopher M

    Mayo Clinic proceedings

    2014  Volume 89, Issue 8, Page(s) 1168

    MeSH term(s) Analgesics, Opioid/adverse effects ; Cause of Death ; Emergency Service, Hospital/utilization ; Female ; Humans ; Male ; Opioid-Related Disorders/diagnosis ; Opioid-Related Disorders/epidemiology
    Chemical Substances Analgesics, Opioid
    Language English
    Publishing date 2014-08
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2014.06.007
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  5. Article ; Online: Bloodstream infection outbreaks related to opioid-diverting health care workers: a cost-benefit analysis of prevention and detection programs.

    Berge, Keith H / Lanier, William L

    Mayo Clinic proceedings

    2014  Volume 89, Issue 7, Page(s) 866–868

    MeSH term(s) Cross Infection/transmission ; Disease Outbreaks/statistics & numerical data ; Female ; Humans ; Infectious Disease Transmission, Professional-to-Patient/statistics & numerical data ; Male ; Personnel, Hospital ; Prescription Drug Diversion/statistics & numerical data
    Language English
    Publishing date 2014-07
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2014.04.010
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    Ua VI Zs.183: Show issues Location:
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  6. Article ; Online: Ten common questions (and their answers) on medical futility.

    Swetz, Keith M / Burkle, Christopher M / Berge, Keith H / Lanier, William L

    Mayo Clinic proceedings

    2014  Volume 89, Issue 7, Page(s) 943–959

    Abstract: The term medical futility is frequently used when discussing complex clinical scenarios and throughout the medical, legal, and ethics literature. However, we propose that health care professionals and others often use this term inaccurately and ... ...

    Abstract The term medical futility is frequently used when discussing complex clinical scenarios and throughout the medical, legal, and ethics literature. However, we propose that health care professionals and others often use this term inaccurately and imprecisely, without fully appreciating the powerful, often visceral, response that the term can evoke. This article introduces and answers 10 common questions regarding medical futility in an effort to define, clarify, and explore the implications of the term. We discuss multiple domains related to futility, including the biological, ethical, legal, societal, and financial considerations that have a bearing on definitions and actions. Finally, we encourage empathetic communication among clinicians, patients, and families and emphasize how dialogue that seeks an understanding of multiple points of view is critically important in preventing or attenuating conflict among the involved parties.
    MeSH term(s) Health Care Costs ; Health Services Misuse/economics ; Health Services Misuse/legislation & jurisprudence ; Humans ; Medical Futility/ethics ; Medical Futility/legislation & jurisprudence ; Medical Futility/psychology ; Physician-Patient Relations/ethics ; Professional-Family Relations/ethics ; Terminology as Topic ; United States ; Withholding Treatment/ethics
    Language English
    Publishing date 2014-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2014.02.005
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  7. Article: The subversion of urine drug testing.

    Berge, Keith H / Bush, Donna M

    Minnesota medicine

    2010  Volume 93, Issue 8, Page(s) 45–47

    Abstract: Since government and private industry have instituted urine drug testing to ensure a drug-free work force, an industry dedicated to subverting the results of those tests has developed. This article describes that industry, the types of products it ... ...

    Abstract Since government and private industry have instituted urine drug testing to ensure a drug-free work force, an industry dedicated to subverting the results of those tests has developed. This article describes that industry, the types of products it markets, and efforts to curb the sale of those products.
    MeSH term(s) Doping in Sports/legislation & jurisprudence ; Doping in Sports/prevention & control ; Female ; Fraud/legislation & jurisprudence ; Humans ; Male ; Minnesota ; Privacy/legislation & jurisprudence ; Street Drugs/urine ; Substance Abuse Detection/legislation & jurisprudence ; United States ; Workplace
    Chemical Substances Street Drugs
    Language English
    Publishing date 2010-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391068-4
    ISSN 1945-3051 ; 0026-556X
    ISSN (online) 1945-3051
    ISSN 0026-556X
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    Zs.A 218: Show issues Location:
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  8. Article: The addicted physician. A rational response to an irrational disease.

    Seppala, Marvin D / Berge, Keith H

    Minnesota medicine

    2010  Volume 93, Issue 2, Page(s) 46–49

    Abstract: Physicians are as likely to experience drug and alcohol addiction as anyone in the general population. They are more likely than others, however, to abuse prescription medications. Dealing with an impaired colleague is a difficult, emotionally charged ... ...

    Abstract Physicians are as likely to experience drug and alcohol addiction as anyone in the general population. They are more likely than others, however, to abuse prescription medications. Dealing with an impaired colleague is a difficult, emotionally charged job for physician leaders and hospital administrators, who've often had little training on how to handle such a situation. In addition to describing a case of an addicted physician, this article reviews data about the incidence of addiction among physicians and the challenges associated with confronting such a problem. It also describes the legal reporting requirements and resources such as the Minnesota Health Professionals Services Program and Physicians Serving Physicians that can help physicians get into treatment programs designed specifically for health care professionals. Physicians who go through such treatment programs and subsequent monitoring have been found to have remarkable recovery rates.
    MeSH term(s) Adult ; Buprenorphine/therapeutic use ; Combined Modality Therapy ; Denial (Psychology) ; Fentanyl ; Humans ; Male ; Mandatory Reporting ; Minnesota ; Narcotic Antagonists/therapeutic use ; Peer Group ; Physician Impairment/legislation & jurisprudence ; Psychotherapy, Group ; Substance Abuse Treatment Centers ; Substance Abuse, Intravenous/diagnosis ; Substance Abuse, Intravenous/rehabilitation ; Substance Withdrawal Syndrome/diagnosis ; Substance Withdrawal Syndrome/rehabilitation ; Substance-Related Disorders/diagnosis ; Substance-Related Disorders/rehabilitation
    Chemical Substances Narcotic Antagonists ; Buprenorphine (40D3SCR4GZ) ; Fentanyl (UF599785JZ)
    Language English
    Publishing date 2010-02
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 391068-4
    ISSN 1945-3051 ; 0026-556X
    ISSN (online) 1945-3051
    ISSN 0026-556X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Protocol-driven treatment of alcohol withdrawal in a general hospital: when theory meets practice.

    Berge, Keith H / Morse, Robert M

    Mayo Clinic proceedings

    2008  Volume 83, Issue 3, Page(s) 270–271

    MeSH term(s) Central Nervous System Depressants/adverse effects ; Clinical Protocols/standards ; Ethanol/adverse effects ; Hospitals, General ; Humans ; Inpatients ; Minnesota ; Practice Guidelines as Topic/standards ; Substance Withdrawal Syndrome/therapy
    Chemical Substances Central Nervous System Depressants ; Ethanol (3K9958V90M)
    Language English
    Publishing date 2008-03
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.4065/83.3.270
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  10. Article ; Online: Multiscale networks in multiple sclerosis.

    Kennedy, Keith E / Kerlero de Rosbo, Nicole / Uccelli, Antonio / Cellerino, Maria / Ivaldi, Federico / Contini, Paola / De Palma, Raffaele / Harbo, Hanne F / Berge, Tone / Bos, Steffan D / Høgestøl, Einar A / Brune-Ingebretsen, Synne / de Rodez Benavent, Sigrid A / Paul, Friedemann / Brandt, Alexander U / Bäcker-Koduah, Priscilla / Behrens, Janina / Kuchling, Joseph / Asseyer, Susanna /
    Scheel, Michael / Chien, Claudia / Zimmermann, Hanna / Motamedi, Seyedamirhosein / Kauer-Bonin, Josef / Saez-Rodriguez, Julio / Rinas, Melanie / Alexopoulos, Leonidas G / Andorra, Magi / Llufriu, Sara / Saiz, Albert / Blanco, Yolanda / Martinez-Heras, Eloy / Solana, Elisabeth / Pulido-Valdeolivas, Irene / Martinez-Lapiscina, Elena H / Garcia-Ojalvo, Jordi / Villoslada, Pablo

    PLoS computational biology

    2024  Volume 20, Issue 2, Page(s) e1010980

    Abstract: Complex diseases such as Multiple Sclerosis (MS) cover a wide range of biological scales, from genes and proteins to cells and tissues, up to the full organism. In fact, any phenotype for an organism is dictated by the interplay among these scales. We ... ...

    Abstract Complex diseases such as Multiple Sclerosis (MS) cover a wide range of biological scales, from genes and proteins to cells and tissues, up to the full organism. In fact, any phenotype for an organism is dictated by the interplay among these scales. We conducted a multilayer network analysis and deep phenotyping with multi-omics data (genomics, phosphoproteomics and cytomics), brain and retinal imaging, and clinical data, obtained from a multicenter prospective cohort of 328 patients and 90 healthy controls. Multilayer networks were constructed using mutual information for topological analysis, and Boolean simulations were constructed using Pearson correlation to identified paths within and among all layers. The path more commonly found from the Boolean simulations connects protein MK03, with total T cells, the thickness of the retinal nerve fiber layer (RNFL), and the walking speed. This path contains nodes involved in protein phosphorylation, glial cell differentiation, and regulation of stress-activated MAPK cascade, among others. Specific paths identified were subsequently analyzed by flow cytometry at the single-cell level. Combinations of several proteins (GSK3AB, HSBP1 or RS6) and immune cells (Th17, Th1 non-classic, CD8, CD8 Treg, CD56 neg, and B memory) were part of the paths explaining the clinical phenotype. The advantage of the path identified from the Boolean simulations is that it connects information about these known biological pathways with the layers at higher scales (retina damage and disability). Overall, the identified paths provide a means to connect the molecular aspects of MS with the overall phenotype.
    MeSH term(s) Humans ; Multiple Sclerosis ; Prospective Studies ; Tomography, Optical Coherence/methods ; Retina ; Brain ; Heat-Shock Proteins
    Chemical Substances HSBP1 protein, human ; Heat-Shock Proteins
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ZDB-ID 2193340-6
    ISSN 1553-7358 ; 1553-734X
    ISSN (online) 1553-7358
    ISSN 1553-734X
    DOI 10.1371/journal.pcbi.1010980
    Database MEDical Literature Analysis and Retrieval System OnLINE

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