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Article: P.W.J. Bartrip's attack on Irving J. Selikoff.

Egilman, David / Tweedale, Geoffrey / McCulloch, Jock / Kovarik, William / Castleman, Barry / Longo, William / Levin, Stephen / Bohme, Susanna Rankin

American journal of industrial medicine

2004 Volume 46, Issue 2, Page(s) 151–155

MeSH term(s)	Asbestosis/history ; Deception ; Education, Medical/history ; History, 20th Century ; Humans ; Occupational Health/history ; United States
Language	English
Publishing date	2004-08
Publishing country	United States
Document type	Biography ; Historical Article ; Letter
ZDB-ID	604538-8
ISSN	1097-0274 ; 0271-3586
ISSN (online)	1097-0274
ISSN	0271-3586
DOI	10.1002/ajim.20047
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Book ; Online ; E-Book: ACT in steps

Twohig, Michael P. / Levin, Michael E. / Ong, Clarissa W.

a transdiagnostic manual for learning acceptance and commitment therapy

2021

Abstract: This book is a guide for new therapists on the use of acceptance and commitment therapy (ACT) for any psychological disorder that involves some level of struggle with inner experiences, but it is not targeted to any particular diagnosis. It is suitable ... ...

Author's details	Michael P. Twohig, Michael E. Levin, and Clarissa W. Ong
Abstract	"This book is a guide for new therapists on the use of acceptance and commitment therapy (ACT) for any psychological disorder that involves some level of struggle with inner experiences, but it is not targeted to any particular diagnosis. It is suitable for graduate students who are seeing their first client, clinicians with years of experience who have never done ACT or are just learning about ACT, and anyone who is interested in applying ACT across a range of presentations. The book also includes exercises and worksheets that will continue to be useful for sessions after the therapist is competent in ACT. The chapters walk therapists through a recommended sequence of ACT sessions, including creative hopelessness, control as the problem, acceptance, defusion, mindfulness, values, and committed action, and provide accompanying materials for clients. It also provides information on assessment, case conceptualization, treatment planning, and intervention that therapists can use as a starting point for practicing ACT. The book is intended to serve as a more structured framework from which therapists can learn and experiment with ACT concepts as they begin to learn more about the therapy"--
Keywords	Acceptance and commitment therapy ; Psychotherapy
Subject code	616.89/1425
Language	English
Dates of publication	2021-2021
Size	1 online resource (201 pages) :, illustrations
Publisher	Oxford University Press
Publishing place	New York
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	0-19-066899-7 ; 0-19-062994-0 ; 0-19-062993-2 ; 0-19-062992-4 ; 978-0-19-066899-0 ; 978-0-19-062994-6 ; 978-0-19-062993-9 ; 978-0-19-062992-2
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Endocan: A biomarker for endothelial dysfunction and inflammation, linking maternal obesity and pediatric obesity in a cohort of preterm neonates.

Holthaus, E / O'Neill, M / Jeske, W / DeChristopher, P / Goodman, J / Glynn, L / Levin, S / Muraskas, J

European journal of obstetrics, gynecology, and reproductive biology

2024 Volume 297, Page(s) 132–137

Abstract: ... compared to neonates born to non-obese mothers (299 ng/L [205-586] vs. 251 ng/L [164-339], p = 0.045 ... association (p = 0.021). Higher mean serum endocan level at birth was associated with pediatric obesity ... between 24 and 36 months (obese vs. non-obese offspring; 574 ng/L (222) vs. 321 ng/L (166), p = 0.005 ...

Abstract	Objectives: Numerous animal and epidemiologic studies have demonstrated a positive association between maternal obesity in pregnancy and obesity in offspring. The biologic mechanisms of this association remain under investigation. One proposed mechanism includes fetoplacental endothelial dysfunction secondary to inflammation. Endocan is a relatively new biomarker for endothelial dysfunction and inflammation. Our objectives were to examine (1) the association between maternal obesity and neonatal serum endocan at birth, and (2) the association between neonatal serum endocan at birth and pediatric obesity at 24-36 months of age. Study design: This was a secondary analysis of a prospective cohort of neonates born < 33 weeks gestation. Serum endocan was collected within 48 hours of birth. Serum endocan levels were compared in neonates born to obese mothers vs. those born to non-obese mothers. BMI data were retrospectively collected from cohort neonates between 24 and 36 months of age. Results: The analysis included 120 mother/neonate dyads. Neonates born to obese mothers had higher median serum endocan at birth compared to neonates born to non-obese mothers (299 ng/L [205-586] vs. 251 ng/L [164-339], p = 0.045). In a linear regression modeled on neonatal serum endocan level, maternal obesity had a statistically significant positive association (p = 0.021). Higher mean serum endocan level at birth was associated with pediatric obesity between 24 and 36 months (obese vs. non-obese offspring; 574 ng/L (222) vs. 321 ng/L (166), p = 0.005). Conclusions: In our cohort of preterm neonates, elevated serum endocan at birth was associated with both maternal obesity and downstream pediatric obesity. More research is needed to understand intergenerational transmission of obesity. A large focus has been on epigenetic modification. Endothelial dysfunction and inflammation may play important roles in these pathways. Effective biomarkers, including endocan, may also serve as intermediate outcomes in future pregnancy research.
Language	English
Publishing date	2024-04-12
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	190605-7
ISSN	1872-7654 ; 0301-2115 ; 0028-2243
ISSN (online)	1872-7654
ISSN	0301-2115 ; 0028-2243
DOI	10.1016/j.ejogrb.2024.04.013
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Article ; Online: Evidence for long-term efficacy of a membrane filtration device in rural villages in Ghana.

Boaheng, Joseph Marfo / Raimann, Jochen G / Narh, Philip / Johnson, Seth / Donald, Linda L / Mati, Harrison Kwame / Port, Friedrich K / Levin, Nathan W

Scientific reports

2024 Volume 14, Issue 1, Page(s) 5271

Abstract: ... from an earlier study that reported 17.8 p100pm rates before the devices were installed in 2018, (all p-values < 0 ...

Abstract	Drinking water contaminated by pathogenic micro-organisms increases the risk of infectious gastrointestinal disease which could potentially lead to acute kidney injury and even death, particularly amongst the young and the elderly. Earlier studies have shown a substantial reduction in the incidence of diarrheal disease over a period of one year using a polysulfone membrane water gravity-powered water filtration device. The current report is a continuation of these studies to assess the long-term effects of the innovative method on diarrheal incidence rates over a 4-year follow-up period. This follow-up study monitored the trend of self-reported diarrheal events in all households in the previously studied villages for 5 months, in the last half of each study year, using the same questionnaire utilized in the earlier study. Three villages that had no device yet installed served as controls. We computed monthly diarrheal incidence rates for all study years (standardized to per 100 person-months) and compared these to the pre-device incidence rate in 2018 and in the control group, using the Wilcoxon rank sum exact test. The average diarrheal incidence rates of 1.5 p100pm in 2019, 2.19 p100pm in 2021, and 0.54p100pm in 2022 were significantly different from an earlier study that reported 17.8 p100pm rates before the devices were installed in 2018, (all p-values < 0.05). Concomitantly, self-reported diarrheal infections were substantially higher in the "control villages" not yet having the filtration device installed (80.9, 77.6, and 21.5 per 100 pm). The consistent and large reduction in diarrhea incidence documents the long-term efficacy of the use of the membrane filtration device. This simple water purification method using gravity flow improves public health in remote regions with limited resources.
MeSH term(s)	Aged ; Humans ; Ghana/epidemiology ; Follow-Up Studies ; Diarrhea/epidemiology ; Diarrhea/prevention & control ; Self Report ; Water
Chemical Substances	Water (059QF0KO0R)
Language	English
Publishing date	2024-03-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-55977-8
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Article ; Online: Effect of Laser and Energy-based Device Therapies to Minimize Surgical Scar Formation: A Systematic Review and Network Meta-analysis.

Yenyuwadee, Sasitorn / Achavanuntakul, Petchlada / Phisalprapa, Pochamana / Levin, Melissa / Saokaew, Surasak / Kanchanasurakit, Sukrit / Manuskiatti, Woraphong

Acta dermato-venereologica

2024 Volume 104, Page(s) adv18477

Abstract: Utilization of lasers and energy-based devices for surgical scar minimization has been substantially evaluated in placebo-controlled trials. The aim of this study was to compare reported measures of efficacy of lasers and energy-based devices in clinical ...

Abstract	Utilization of lasers and energy-based devices for surgical scar minimization has been substantially evaluated in placebo-controlled trials. The aim of this study was to compare reported measures of efficacy of lasers and energy-based devices in clinical trials in preventing surgical scar formation in a systematic review and network meta-analyses. Five electronic databases, PubMed, Scopus, Embase, ClinicalTrials.gov, and the Cochrane Library, were searched to retrieve relevant articles. The search was limited to randomized controlled trials that reported on clinical outcomes of surgical scars with treatment initiation no later than 6 months after surgery and a follow-up period of at least 3 months. A total of 18 randomized controlled trials involving 482 participants and 671 postsurgical wounds were included in the network meta-analyses. The results showed that the most efficacious treatments were achieved using low-level laser therapy) (weighted mean difference -3.78; 95% confidence interval (95% CI) -6.32, -1.24) and pulsed dye laser (weighted mean difference -2.46; 95% CI -4.53, -0.38). Nevertheless, low-level laser therapy and pulsed dye laser demonstrated comparable outcomes in surgical scar minimization (weighted mean difference -1.32, 95% CI -3.53, 0.89). The findings of this network meta-analyses suggest that low-level laser therapy and pulsed dye laser are both effective treatments for minimization of scar formation following primary closure of surgical wounds with comparable treatment outcomes.
MeSH term(s)	Humans ; Network Meta-Analysis ; Cicatrix/diagnosis ; Cicatrix/etiology ; Cicatrix/prevention & control ; Lasers, Dye ; Databases, Factual ; Low-Level Light Therapy
Language	English
Publishing date	2024-01-08
Publishing country	Sweden
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	80007-7
ISSN	1651-2057 ; 0001-5555
ISSN (online)	1651-2057
ISSN	0001-5555
DOI	10.2340/actadv.v104.18477
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Article ; Online: Online process-based training for perfectionism: A randomized trial.

Ong, Clarissa W / Lee, Eric B / Levin, Michael E / Twohig, Michael P

Behaviour research and therapy

2022 Volume 156, Page(s) 104152

Abstract: Process-based therapy (PBT) is model of psychotherapy designed to improve people's ability to use a variety of skills from evidence-based treatments to match environmental needs and personal goals in the moment. This randomized trial tested the effect of ...

Abstract	Process-based therapy (PBT) is model of psychotherapy designed to improve people's ability to use a variety of skills from evidence-based treatments to match environmental needs and personal goals in the moment. This randomized trial tested the effect of an online self-help intervention modeled after PBT principles for participants with perfectionism (N = 77). The intervention comprised two four-session trainings teaching skills from different evidence-based treatments (e.g., cognitive-behavioral therapy, acceptance and commitment therapy) and targeting cognitive and motivational processes: (1) cognitive training and (2) motivational training respectively. Participants completed 17 assessments throughout the intervention and at 3- and 6-month follow-up. Results indicated that the full intervention led to improvement in perfectionism, self-compassion, psychological distress, and cognitive skills targeted by the cognitive intervention (e.g., cognitive defusion; absolute βs = 0.02 to 0.66). In addition, the second four-session training (i.e., training after first four-session training) was associated with improvements in perfectionism, self-compassion, quality of life, and psychological distress (absolute βs = 0.09 to 2.90), suggesting it had incremental benefit. Whereas the cognitive training appeared to specifically impact cognitive processes, the motivational training increased both cognitive and motivational processes. These findings provide initial support for the feasibility and efficacy of a process-based approach, because they show that participants can benefit from learning skills from different orientations and applying them with reference to their goals. However, specific aspects of the PBT model, including whether interventions can precisely improve targeted skills, still need to be empirically tested in larger and more diverse clinical samples.
MeSH term(s)	Acceptance and Commitment Therapy ; Cognitive Behavioral Therapy ; Humans ; Internet-Based Intervention ; Perfectionism ; Quality of Life
Language	English
Publishing date	2022-06-15
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	211997-3
ISSN	1873-622X ; 0005-7967
ISSN (online)	1873-622X
ISSN	0005-7967
DOI	10.1016/j.brat.2022.104152
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Article ; Online: Somatosensory and motor representations following bilateral transplants of the hands: A 6-year longitudinal case report on the first pediatric bilateral hand transplant patient.

Gaetz, W / Dockstader, C / Furlong, P L / Amaral, S / Vossough, A / Schwartz, E S / Roberts, T P L / Scott Levin, L

Brain research

2023 Volume 1804, Page(s) 148262

Abstract: A vascularized composite tissue allotransplantation (VCA) was performed at the Children's Hospital of Philadelphia (CHOP), on an 8-year-old patient in 2015, six years after bilateral hand and foot amputation. Hand VCA resulted in reafferentation of the ... ...

Abstract	A vascularized composite tissue allotransplantation (VCA) was performed at the Children's Hospital of Philadelphia (CHOP), on an 8-year-old patient in 2015, six years after bilateral hand and foot amputation. Hand VCA resulted in reafferentation of the medial, ulnar, and radial nerves serving hand somatosensation and motor function. We used magnetoencephalography (MEG) to assess somatosensory cortical plasticity following the post-transplantation recovery of the peripheral sensory nerves of the hands. Our 2-year postoperative MEG showed that somatosensory lip representations, initially observed at "hand areas", reverted to canonical, orthotopic lip locations with recovery of post-transplant hand function. Here, we continue the assessment of motor and somatosensory responses up to 6-years post-transplant. Magnetoencephalographic somatosensory responses were recorded eight times over a six-year period following hand transplantation, using a 275-channel MEG system. Somatosensory tactile stimuli were presented to the right lower lip (all 8 visits) as well as right and left index fingers (visits 3-8) and fifth digits (visits 4-8). In addition, left and right-hand motor responses were also recorded for left index finger and right thumb (visit 8 only).During the acute recovery phase (visits 3 and 4), somatosensory responses of the digits were observed to be significantly larger and more phasic (i.e., smoother) than controls. Subsequent measures showed that digit responses maintain this atypical response profile (evoked-response magnitudes typically exceed 1 picoTesla). Orthotopic somatosensory localization of the lip, D2, and D5 was preserved. Motor beta-band desynchrony was age-typical in localization and response magnitude; however, the motor gamma-band response was significantly larger than that observed in a reference population.These novel findings show that the restoration of somatosensory input of the hands resulted in persistent and atypically large cortical responses to digit stimulation, which remain atypically large at 6 years post-transplant; there is no known perceptual correlate, and no reports of phantom pain. Normal somatosensory organization of the lip, D2, and D5 representation remain stable following post-recovery reorganization of the lip's somatosensory response.
MeSH term(s)	Humans ; Child ; Neuronal Plasticity/physiology ; Hand Transplantation ; Somatosensory Cortex/physiology ; Hand/physiology ; Fingers/physiology ; Magnetoencephalography ; Brain Mapping
Language	English
Publishing date	2023-01-24
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	1200-2
ISSN	1872-6240 ; 0006-8993
ISSN (online)	1872-6240
ISSN	0006-8993
DOI	10.1016/j.brainres.2023.148262
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Article ; Online: Examining Excess Mortality Among Critical Workers in Minnesota During 2020-2021: An Occupational Analysis.

Karnik, Harshada / Wrigley-Field, Elizabeth / Levin, Zachary / Chen, Yea-Hung / Zabel, Erik W / Ramirez, Marizen / Leider, Jonathon P

American journal of public health

2023 Volume 113, Issue 11, Page(s) 1219–1222

Abstract: Objectives. ...

Abstract	Objectives.
MeSH term(s)	Humans ; Minnesota/epidemiology ; Pandemics ; Occupations ; COVID-19 ; Vaccines
Chemical Substances	Vaccines
Language	English
Publishing date	2023-10-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	121100-6
ISSN	1541-0048 ; 0090-0036 ; 0002-9572
ISSN (online)	1541-0048
ISSN	0090-0036 ; 0002-9572
DOI	10.2105/AJPH.2023.307395
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Article ; Online: Examining the feasibility and effectiveness of online acceptance and commitment therapy self-help in a quasi-stepped care model: A pilot study.

Ong, Clarissa W / Terry, Carina L / Levin, Michael E / Twohig, Michael P

Psychological services

2021 Volume 20, Issue 1, Page(s) 166–177

Abstract: The global burden of mental illness and limited resources make increasing the efficiency of available mental healthcare resources especially crucial. One way this can be done is a stepped care approach to treatment. To test the viability of using ... ...

Abstract	The global burden of mental illness and limited resources make increasing the efficiency of available mental healthcare resources especially crucial. One way this can be done is a stepped care approach to treatment. To test the viability of using internet-based self-help in a stepped care model, we examined the feasibility, acceptability, and effectiveness of an online self-help acceptance and commitment (ACT) program prior to starting in-person therapy at a university community clinic (
MeSH term(s)	Humans ; Acceptance and Commitment Therapy ; Pilot Projects ; Feasibility Studies ; Mental Disorders/therapy ; Health Behavior
Language	English
Publishing date	2021-11-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2156662-8
ISSN	1939-148X ; 1541-1559
ISSN (online)	1939-148X
ISSN	1541-1559
DOI	10.1037/ser0000596
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Article ; Online: A systematic review and psychometric evaluation of self-report measures for hoarding disorder.

Ong, Clarissa W / Krafft, Jennifer / Levin, Michael E / Twohig, Michael P

Journal of affective disorders

2021 Volume 290, Page(s) 136–148

Abstract: Background: Hoarding disorder (HD) affects approximately 2.5% of the general population, leads to significant distress and impairment, and is notoriously difficult to treat. The crux of developing effective treatments for HD is our ability to reliably ... ...

Abstract	Background: Hoarding disorder (HD) affects approximately 2.5% of the general population, leads to significant distress and impairment, and is notoriously difficult to treat. The crux of developing effective treatments for HD is our ability to reliably and validly measure relevant constructs in HD to better understand its presentation and, subsequently, formulate appropriate interventions. Methods: We identified measures specific to HD and evaluated their psychometric properties using rating criteria formulated by the Consensus-based Standards for the selection of health Measurement INstruments (COSMIN) group. Results: The 17 included measures were developed to assess adult and pediatric hoarding severity, functional impairment, and maladaptive processes (e.g., material scrupulosity). The Saving Inventory-Revised, the most widely used measure of HD severity showed the strongest psychometric properties. However, psychometric investigations were generally of poor quality across all measures and results indicated unsatisfactory performance of measures. Limitations: The current review excluded non-English measures and ratings inherently contain some element of subjectivity despite use of predetermined criteria and two independent reviewers. Conclusions: We suggest that clinical researchers continue to develop and modify measures used to conceptualize and, ultimately, improve treatment for HD.
MeSH term(s)	Adult ; Child ; Consensus ; Hoarding ; Hoarding Disorder/diagnosis ; Hoarding Disorder/therapy ; Humans ; Psychometrics ; Self Report
Language	English
Publishing date	2021-05-01
Publishing country	Netherlands
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2021.04.082
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