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  1. Book: Skin cancer

    Baldi, Alfonso / Pasquali, Paola / Spugnini, Enrico P.

    a practical approach

    (Current clinical pathology)

    2014  

    Author's details Alfonso Baldi ; Paola Pasquali ; Enrico P. Spugnini ed
    Series title Current clinical pathology
    Language English
    Size XIV, 569 S. : zahlr. Ill., graph. Darst.
    Publisher Humana Press
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT017772916
    ISBN 978-1-46147-356-5 ; 1-46147-356-X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2013 A 2553 available for loan (reading room) Lesesaal EG

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  2. Article: Electroporation in Translational Medicine: From Veterinary Experience to Human Oncology.

    Spugnini, Enrico P / Condello, Maria / Crispi, Stefania / Baldi, Alfonso

    Cancers

    2024  Volume 16, Issue 5

    Abstract: Electroporation (EP) is a broadly accepted procedure that, through the application of electric pulses with appropriate amplitudes and waveforms, promotes the delivery of anticancer molecules in various oncology therapies. EP considerably boosts the ... ...

    Abstract Electroporation (EP) is a broadly accepted procedure that, through the application of electric pulses with appropriate amplitudes and waveforms, promotes the delivery of anticancer molecules in various oncology therapies. EP considerably boosts the absorptivity of targeted cells to anticancer molecules of different natures, thus upgrading their effectiveness. Its use in veterinary oncology has been widely explored, and some applications, such as electrochemotherapy (ECT), are currently approved as first-line treatments for several neoplastic conditions. Other applications include irreversible electroporation and EP-based cancer vaccines. In human oncology, EP is still mostly restricted to therapies for cutaneous tumors and the palliation of cutaneous and visceral metastases of malignant tumors. Fields where veterinary experience could help smooth the clinical transition to humans include intraoperative EP, interventional medicine and cancer vaccines. This article recapitulates the state of the art of EP in veterinary and human oncology, recounting the most relevant results to date.
    Language English
    Publishing date 2024-03-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16051067
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Electrochemotherapy in Translational Medicine: From Veterinary Experience to Human Oncology.

    Spugnini, Enrico P / Menditti, Dardo / De Luca, Antonio / Baldi, Alfonso

    Critical reviews in eukaryotic gene expression

    2022  Volume 33, Issue 1, Page(s) 79–90

    Abstract: Electrochemotherapy (ECT) is a tumor treatment that, through the application of electric pulses with suitable amplitude and waveforms, favors the systemic or local delivery of chemotherapy agents. This procedure significantly increases the permeability ... ...

    Abstract Electrochemotherapy (ECT) is a tumor treatment that, through the application of electric pulses with suitable amplitude and waveforms, favors the systemic or local delivery of chemotherapy agents. This procedure significantly increases the permeability of cancer cells to anticancer drugs, making them more effective and allowing their use at lower doses with less morbidity for patients. Its use in veterinary oncology is consolidated and it is currently adopted as first-line treatment for different cancers with successful results. In human oncology, ECT use is mainly in the treatment of cutaneous tumors and for the palliation of cutaneous metastases of malignant tumors. A standard operating procedure has been formulated. Currently, several preclinical and phase I and II studies are under way involving various cancers in humans to better define the efficacy and tolerability of this therapy. This review summarizes the state of the art of ECT in veterinary and human oncology, describing the most significant results achieved to date.
    MeSH term(s) Humans ; Electrochemotherapy/adverse effects ; Electrochemotherapy/methods ; Electrochemotherapy/veterinary ; Translational Science, Biomedical ; Antineoplastic Agents/therapeutic use ; Skin Neoplasms/etiology
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2022-11-14
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1071345-1
    ISSN 1045-4403
    ISSN 1045-4403
    DOI 10.1615/CritRevEukaryotGeneExpr.2022043966
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3226: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Electrochemotherapy for the treatment of cutaneous solid tumors in equids: A retrospective study.

    Spugnini, Enrico P / Scacco, Licia / Bolaffio, Carlo / Baldi, Alfonso

    Open veterinary journal

    2021  Volume 11, Issue 3, Page(s) 385–389

    Abstract: Background: Electrochemotherapy (ECT) promotes the increased uptake of antitumor agents through the administration of permeabilizing electric pulses, thus enhancing chemotherapy effectiveness.: Aim: Our study aimed to describe the tolerability and ... ...

    Abstract Background: Electrochemotherapy (ECT) promotes the increased uptake of antitumor agents through the administration of permeabilizing electric pulses, thus enhancing chemotherapy effectiveness.
    Aim: Our study aimed to describe the tolerability and efficacy of ECT alone or in association with surgery to manage solid neoplasms in equids.
    Methods: Medical records of equids with a diagnosis of malignant tumors treated with ECT alone or in combination with surgery were retrospectively evaluated. Each equid received local treatment within the tumors or the tumors' bed with cisplatin at the dose of 0.5 mg/cm
    Results: Sixteen equids were enrolled in this study. There were nine melanoma cases, four fibrosarcoma, and three squamous cell carcinoma. Of those 16 equids, 7 received ECT for treatment of intraoperative local disease, while in 9 cases, ECT was the only treatment modality. The seven equids treated with the combination of ECT and surgery still have no evidence of disease at different times ranging from 9 to 60 months. The remaining nine had the following responses: two complete remissions, five partial responses, one stable disease, and one progressive disease. The treatment was well-tolerated, and local side effects were minimal. No systemic effects were documented.
    Conclusion: This retrospective study suggests that ECT may be beneficial for equids with solid neoplasms and could be a useful addition to the current therapeutic options considering its low cost, limited toxicity, and ease of administration.
    MeSH term(s) Animals ; Electrochemotherapy/veterinary ; Neoplasms/drug therapy ; Neoplasms/veterinary ; Retrospective Studies
    Language English
    Publishing date 2021-07-29
    Publishing country Libya
    Document type Journal Article
    ZDB-ID 2651664-0
    ISSN 2218-6050 ; 2226-4485
    ISSN (online) 2218-6050
    ISSN 2226-4485
    DOI 10.5455/OVJ.2021.v11.i3.8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Electrochemotherapy for the treatment of cutaneous solid tumors in Equids

    Enrico P. Spugnini / Licia Scacco / Carlo Bolaffio / Alfonso Baldi

    Open Veterinary Journal, Vol 11, Iss 3, Pp 385-

    a retrospective study

    2021  Volume 389

    Abstract: Background: Electrochemotherapy (ECT) promotes the increased uptake of antitumor agents through the administration of permeabilizing electric pulses, thus enhancing chemotherapy effectiveness. Aim: Our study aimed to describe the tolerability and ... ...

    Abstract Background: Electrochemotherapy (ECT) promotes the increased uptake of antitumor agents through the administration of permeabilizing electric pulses, thus enhancing chemotherapy effectiveness. Aim: Our study aimed to describe the tolerability and efficacy of ECT alone or in association with surgery to manage solid neoplasms in equids. Methods: Medical records of equids with a diagnosis of malignant tumors treated with ECT alone or in combination with surgery were retrospectively evaluated. Each equid received local treatment within the tumors or the tumors’ bed with cisplatin at the dose of 0.5 mg/cm². Trains of permeabilizing biphasic electric pulses were then applied under spinal or general anesthesia. Results: Sixteen equids were enrolled in the study. There were nine melanoma cases, four fibrosarcoma (FSA), and three squamous cell carcinoma (SCC). Of those sixteen equids, seven received ECT for treatment of intraoperative local disease, while in 9 cases, ECT was the only treatment modality. The seven equids treated with the combination of ECT and surgery still have no evidence of disease at different times ranging from 9 to 60 months. The remaining 9 had the following responses: two complete remissions (CR), five partial responses (PR), one stable disease (SD), and one progressive disease (PD). The treatment was well-tolerated, and local side effects were minimal. No systemic effects were documented. Conclusion: This retrospective study suggests that ECT may be beneficial for equids with solid neoplasms and could be a useful addition to the current therapeutic options considering its low cost, limited toxicity, and ease of administration.
    Keywords cisplatin ; fibrosarcoma ; horse ; melanoma ; squamous cell carcinoma ; Zoology ; QL1-991
    Subject code 630
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher Tripoli University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Successful Treatment of a Keratoacanthoma with Electrochemotherapy: A Case Report.

    Pasquali, Paola / Spugnini, Enrico P / Baldi, Alfonso

    Dermatology and therapy

    2018  Volume 8, Issue 1, Page(s) 143–146

    Abstract: Introduction: Few studies have evaluated the efficacy of intralesional bleomycin injection combined with electroporation for the treatment of cutaneous tumors. However, the phenomenon that electroporation can enhance the cytotoxicity of bleomycin in ... ...

    Abstract Introduction: Few studies have evaluated the efficacy of intralesional bleomycin injection combined with electroporation for the treatment of cutaneous tumors. However, the phenomenon that electroporation can enhance the cytotoxicity of bleomycin in vivo by 300-700 fold has been intensely investigated.
    Case presentation: Keratoacanthoma in an 86-year-old patient was treated with intralesional bleomycin combined with electroporation. Treatment consisted of local application of shorty and intense electric pulses followed by local injection of bleomycin. Electroporation was always well tolerated by the patient, with no significant complaints, and the tumor had completely regressed by day 71 of the follow-up.
    Conclusion: The results suggest that intralesional bleomycin injection combined with electroporation could represent a valid alternative therapeutic approach for the treatment of keratoacanthomas.
    Language English
    Publishing date 2018-01-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2680284-3
    ISSN 2190-9172 ; 2193-8210
    ISSN (online) 2190-9172
    ISSN 2193-8210
    DOI 10.1007/s13555-018-0222-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Publisher Correction: Comparison of two different doses of bleomycin in electrochemotherapy protocols for feline cutaneous squamous cell carcinoma nonsegregated from ultraviolet light exposure.

    Dos Anjos, Denner S / Sierra, Oscar R / Spugnini, Enrico P / De Nardi, Andrigo B / Fonseca-Alves, Carlos E

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 9759

    Language English
    Publishing date 2021-05-03
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-88998-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Adjuvant electrochemotherapy with bleomycin and cisplatin combination for canine soft tissue sarcomas: A study of 30 cases.

    Spugnini, Enrico P / Vincenzi, Bruno / Amadio, Bruno / Baldi, Alfonso

    Open veterinary journal

    2019  Volume 9, Issue 1, Page(s) 88–93

    Abstract: Electrochemotherapy (ECT) couples the administration of anticancer drugs with the delivery of electric pulses that increase the drug uptake through the cell membranes, thus resulting in an improved efficacy. This study has evaluated the tolerability and ... ...

    Abstract Electrochemotherapy (ECT) couples the administration of anticancer drugs with the delivery of electric pulses that increase the drug uptake through the cell membranes, thus resulting in an improved efficacy. This study has evaluated the tolerability and efficacy of the combination of systemic bleomycin and local cisplatin as ECT agents for incompletely excised canine soft tissue sarcoma (STS). Thirty dogs with incompletely excised STSs were enrolled. The dogs received intravenous 20 mg/m
    MeSH term(s) Adjuvants, Pharmaceutic/administration & dosage ; Animals ; Antineoplastic Agents/administration & dosage ; Bleomycin/administration & dosage ; Cisplatin/administration & dosage ; Combined Modality Therapy/veterinary ; Dog Diseases/therapy ; Dogs ; Electrochemotherapy/veterinary ; Sarcoma/therapy ; Sarcoma/veterinary
    Chemical Substances Adjuvants, Pharmaceutic ; Antineoplastic Agents ; Bleomycin (11056-06-7) ; Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 2019-03-25
    Publishing country Libya
    Document type Journal Article
    ZDB-ID 2651664-0
    ISSN 2218-6050 ; 2226-4485
    ISSN (online) 2218-6050
    ISSN 2226-4485
    DOI 10.4314/ovj.v9i1.15
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Electrochemotherapy in veterinary oncology: from rescue to first line therapy.

    Spugnini, Enrico P / Baldi, Alfonso

    Methods in molecular biology (Clifton, N.J.)

    2014  Volume 1121, Page(s) 247–256

    Abstract: Electroporation is a delivery technique that is gaining popularity among the veterinary community due to its low cost, ease of application, and flexibility. It combines the administration of pharmaceutical compounds such as chemotherapy agents, antisense, ...

    Abstract Electroporation is a delivery technique that is gaining popularity among the veterinary community due to its low cost, ease of application, and flexibility. It combines the administration of pharmaceutical compounds such as chemotherapy agents, antisense, and plasmids to the application of permeabilizing pulses. This chapter reviews the veterinary results obtained through the delivery of anticancer drugs (electrochemotherapy) and genes (electro-gene therapy).
    MeSH term(s) Animals ; Antineoplastic Agents/metabolism ; Antineoplastic Agents/therapeutic use ; Electrochemotherapy/methods ; Genetic Therapy ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/veterinary ; Pets ; Veterinary Medicine/methods
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2014
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4614-9632-8_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Combination of bleomycin and cisplatin as adjuvant electrochemotherapy protocol for the treatment of incompletely excised feline injection-site sarcomas: A retrospective study.

    Spugnini, Enrico P / Vincenzi, Bruno / Carocci, Francesca / Bonichi, Chiara / Menicagli, Francesco / Baldi, Alfonso

    Open veterinary journal

    2020  Volume 10, Issue 3, Page(s) 267–271

    Abstract: Background: fFeline injection-site sarcomas (FISSs) are mesenchymal tumors that can occur in cats after injections of different medical agents and are easily prone to recurrence.: Aim: The aims of this study were to report treatment outcomes for cats ...

    Abstract Background: fFeline injection-site sarcomas (FISSs) are mesenchymal tumors that can occur in cats after injections of different medical agents and are easily prone to recurrence.
    Aim: The aims of this study were to report treatment outcomes for cats with feline injection-site sarcomas (FISSs) treated with both bleomycin and cisplatin, per adjuvant electrochemotherapy (ECT) protocol.
    Methods: The medical records of cats with a diagnosis of FISS that were treated with ECT using both bleomycin and cisplatin were retrospectively evaluated. A total of 27 cats were available for statistical evaluation of their response. The cats received intravenous 20 mg/m2 bleomycin, and the tumor bed and margins were infiltrated with cisplatin at the dose of 0.5 mg/cm2. Then, the trains of permeabilizing biphasic electric pulses lasting 50 + 50 µseconds each were delivered in bursts of 1,300 V/cm using caliper electrodes under sedation. A second session was performed 2 weeks later.
    Results: Side effects were limited to local inflammation in three cats. Three cats developed local tumor recurrence at days 180, 180, and 545 after surgery, two cats developed recurrence and metastases at 100 and 505 days after surgery, and two cats experienced distant metastases. A median time to recurrence could not be calculated as over 80% of the study population remained disease free or were censored due to death from other causes. Mean survival time was 985 days, and median cumulative survival for all cases was 1,000 days.
    Conclusion: When compared to historical controls, the results of this study demonstrate the superior rates of tumor-free survival and disease-free interval. This adjuvant therapy could be a useful addition to the current options for FISS in consideration of its efficacy, limited toxicity, and ease of administration.
    MeSH term(s) Animals ; Antibiotics, Antineoplastic/administration & dosage ; Antineoplastic Agents/administration & dosage ; Bleomycin/administration & dosage ; Cat Diseases/therapy ; Cats ; Chemotherapy, Adjuvant/veterinary ; Cisplatin/administration & dosage ; Electrochemotherapy/veterinary ; Female ; Injection Site Reaction/therapy ; Injection Site Reaction/veterinary ; Male ; Sarcoma/therapy ; Sarcoma/veterinary ; Skin Neoplasms/therapy ; Skin Neoplasms/veterinary ; Soft Tissue Neoplasms/therapy ; Soft Tissue Neoplasms/veterinary ; Treatment Outcome
    Chemical Substances Antibiotics, Antineoplastic ; Antineoplastic Agents ; Bleomycin (11056-06-7) ; Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 2020-07-31
    Publishing country Libya
    Document type Journal Article
    ZDB-ID 2651664-0
    ISSN 2218-6050 ; 2226-4485
    ISSN (online) 2218-6050
    ISSN 2226-4485
    DOI 10.4314/ovj.v10i3.4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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