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  1. Article ; Online: Causal inference under interference with prognostic scores for dynamic group therapy studies.

    Han, Bing / Paddock, Susan M / Burgette, Lane

    The international journal of biostatistics

    2021  Volume 18, Issue 2, Page(s) 439–453

    Abstract: Group therapy is a common treatment modality for behavioral health conditions. Patients often enter and exit groups on an ongoing basis, leading to dynamic therapy groups. Examining the effect of high versus low session attendance on patient outcomes is ... ...

    Abstract Group therapy is a common treatment modality for behavioral health conditions. Patients often enter and exit groups on an ongoing basis, leading to dynamic therapy groups. Examining the effect of high versus low session attendance on patient outcomes is a research question of interest. However, there are several challenges to identifying causal effects in this setting, including the lack of randomization, interference among patients, and the interrelatedness of patient participation. Dynamic therapy groups motivate a unique causal inference scenario, as the treatment statuses are completely defined by the patient attendance record for the therapy session, which is also the structure inducing interference. We adopt the Rubin causal model framework to define the causal effect of high versus low session attendance of group therapy at both the individual patient and peer levels. We propose a strategy to identify individual, peer, and total effects of high attendance versus low attendance on patient outcomes by the prognostic score stratification. We examine performance of our approach via simulation and apply it to data from a group cognitive behavioral therapy trial for treating depression among patients in a substance use disorders treatment setting.
    MeSH term(s) Humans ; Prognosis ; Psychotherapy, Group ; Cognitive Behavioral Therapy ; Causality
    Language English
    Publishing date 2021-08-13
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1557-4679
    ISSN (online) 1557-4679
    DOI 10.1515/ijb-2019-0126
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Demographic and Clinical Factors Associated With Health-Related Quality-of-Life Profiles Among Prostate Cancer Survivors.

    Potosky, Arnold L / Ahn, Jaeil / Xia, Yi / Lin, Li / Chen, Ronald C / Graves, Kristi D / Pan, Wei / Fall-Dickson, Jane M / Keegan, Theresa H M / Paddock, Lisa E / Wu, Xiao-Cheng / Shrestha, Anshu / Reeve, Bryce B

    JCO oncology practice

    2024  , Page(s) OP2400076

    Abstract: Purpose: Our purpose was to describe the prevalence and predictors of symptom and function clusters related to physical, emotional, and social components of general health-related quality of life (HRQOL) in a population-based sample of prostate cancer ( ... ...

    Abstract Purpose: Our purpose was to describe the prevalence and predictors of symptom and function clusters related to physical, emotional, and social components of general health-related quality of life (HRQOL) in a population-based sample of prostate cancer (PCa) survivors.
    Methods: Participants (N = 1,162) completed a baseline survey at a median of 9 months after diagnosis to ascertain the co-occurrence of eight symptom and functional domains that are common across all cancers and not treatment-specific. We used latent profile analysis (LPA) to identify subgroup profiles of survivors with low, moderate, or high HRQOL levels. Multinomial logistic regression models were used to identify clinical and sociodemographic factors associated with survivors' membership in the low versus moderate or high HRQOL profile.
    Results: The LPA identified 16% of survivors who were categorized in the low HRQOL profile at baseline, indicative of the highest symptom burden and lowest functioning. Factors related to survivors' membership in the low versus higher HRQOL profile groups included less than age 65 years at diagnosis, identifying as non-Hispanic Black race, not working, being a former versus never smoker, systemic therapy, less companionship, more comorbidities, lower health care financial well-being, or less spirituality. Several factors remained associated with remaining in the low versus higher HRQOL profiles on the follow-up survey (n = 699), including younger age, Black race, comorbidity, and lower financial and spiritual well-being.
    Conclusion: About one of six PCa survivors experienced elevated physical and psychosocial symptoms that were independent of local curative therapy, but with younger age, race, comorbidity, and lower financial and spiritual well-being as stable risk factors for poor HRQOL over time.
    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3028198-2
    ISSN 2688-1535 ; 2688-1527
    ISSN (online) 2688-1535
    ISSN 2688-1527
    DOI 10.1200/OP.24.00076
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: IV Thrombolysis for central retinal artery occlusion - Real-world experience from a comprehensive stroke center.

    Stretz, Christoph / Paddock, John E / Burton, Tina M / Bakaeva, Tatiana / Freeman, Melissa / Choudhury, Aparna / Yaghi, Shadi / Furie, Karen L / Schrag, Matthew / MacGrory, Brian C

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

    2024  Volume 33, Issue 4, Page(s) 107610

    Abstract: Objectives: Central retinal artery occlusion (CRAO) is a stroke of the retina potentially amenable to intravenous thrombolysis (IVT). We aimed to determine feasibility of an emergency treatment protocol and risk profile of IVT for CRAO in a ... ...

    Abstract Objectives: Central retinal artery occlusion (CRAO) is a stroke of the retina potentially amenable to intravenous thrombolysis (IVT). We aimed to determine feasibility of an emergency treatment protocol and risk profile of IVT for CRAO in a comprehensive stroke center (CSC).
    Methods: We performed a retrospective, observational cohort study including patients with acute CRAO admitted to a CSC over 4 years. Patients are offered IVT if they present with acute vision loss of ≤ 20/200 in the affected eye, have no other cause of vision loss (incorporating a dilated ophthalmologic exam), and meet criteria akin to acute ischemic stroke. We collected socio-demographic data, triage data, time from onset to presentation, IVT candidacy, and rates of symptomatic intracranial hemorrhage (sICH)- or extracranial hemorrhage.
    Results: 36 patients presented within the study period, mean (standard deviation (SD)) age of 70.7 (10), 52 % female, and median time (Q1, Q3) to ED presentation of 13.5 (4.3, 18.8) h. Patients within 4.5 h from onset presented more commonly directly to our ED (66.6 % vs 37.1 %, p = 0.1). Nine patients (25 %) presented within the 4.5 h window. Of those eligible, 7 (77 %) received IVT. There were no events of intracranial or extracranial hemorrhage.
    Conclusions: Our study confirmed that IVT for acute CRAO is feasible. We found a high rate of treatment with IVT of those eligible. However, because 75 % of patients presented outside the treatment window, continued educational efforts are needed to improve rapid triage to emergency departments to facilitate evaluation for possible candidacy with IVT.
    MeSH term(s) Female ; Humans ; Male ; Brain Ischemia/therapy ; Fibrinolytic Agents/adverse effects ; Intracranial Hemorrhages/chemically induced ; Ischemic Stroke/etiology ; Retinal Artery Occlusion/diagnosis ; Retinal Artery Occlusion/drug therapy ; Retrospective Studies ; Stroke/diagnosis ; Stroke/drug therapy ; Thrombolytic Therapy/adverse effects ; Thrombolytic Therapy/methods ; Treatment Outcome ; Middle Aged ; Aged ; Aged, 80 and over
    Chemical Substances Fibrinolytic Agents
    Language English
    Publishing date 2024-01-30
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 1131675-5
    ISSN 1532-8511 ; 1052-3057
    ISSN (online) 1532-8511
    ISSN 1052-3057
    DOI 10.1016/j.jstrokecerebrovasdis.2024.107610
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Misclassification Risk of Tier-Based Physician Quality Performance Systems.

    Adams, John L / Paddock, Susan M

    Health services research

    2017  Volume 52, Issue 4, Page(s) 1277–1296

    Abstract: Objective: There is increasing interest in identifying high-quality physicians, such as whether physicians perform above or below a threshold level. To evaluate whether current methods accurately distinguish above- versus below-threshold physicians, we ... ...

    Abstract Objective: There is increasing interest in identifying high-quality physicians, such as whether physicians perform above or below a threshold level. To evaluate whether current methods accurately distinguish above- versus below-threshold physicians, we estimate misclassification rates for two-category identification systems.
    Data sources: Claims data for Medicare fee-for-service beneficiaries residing in Florida or New York in 2010.
    Study design: Estimate colorectal cancer, glaucoma, and diabetes quality scores for 23,085 physicians. Use a beta-binomial model to estimate physician score reliabilities. Compute the proportion of physicians whose performance tier would be misclassified under three scoring systems.
    Principal findings: In the three scoring systems, misclassification ranges were 8.6-25.7 percent, 6.4-22.8 percent, and 4.5-21.7%. True positive rate ranges were 72.9-97.0 percent, 83.4-100.0 percent, and 34.7-88.2 percent. True negative rate ranges were 68.5-91.6 percent, 10.5-92.4 percent, and 81.1-99.9 percent. Positive predictive value ranges were 70.5-91.6 percent, 77.0-97.3 percent, and 55.2-99.1 percent.
    Conclusions: Current methods for profiling physicians on quality may produce misleading results, as the number of eligible events is typically small. Misclassification is a policy-relevant measure of the potential impact of tiering on providers, payers, and patients. Quantifying misclassification rates should inform the construction of high-performance networks and quality improvement initiatives.
    MeSH term(s) Algorithms ; Fee-for-Service Plans ; Florida ; Humans ; Insurance Claim Review ; Physicians, Primary Care/standards ; Quality of Health Care/standards ; Risk Assessment/classification
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 410435-3
    ISSN 1475-6773 ; 0017-9124
    ISSN (online) 1475-6773
    ISSN 0017-9124
    DOI 10.1111/1475-6773.12561
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Does removing financial incentives lead to declines in performance? A controlled interrupted time series analysis of Medicare Advantage Star Ratings programme performance.

    Reid, Rachel Orler / Kommareddi, Mallika / Paddock, Susan M / Damberg, Cheryl L

    BMJ quality & safety

    2020  Volume 30, Issue 2, Page(s) 167–172

    MeSH term(s) Aged ; Humans ; Interrupted Time Series Analysis ; Medicare Part C ; Motivation ; Quality Indicators, Health Care ; Reimbursement, Incentive ; United States
    Language English
    Publishing date 2020-04-28
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2592909-4
    ISSN 2044-5423 ; 2044-5415
    ISSN (online) 2044-5423
    ISSN 2044-5415
    DOI 10.1136/bmjqs-2019-010253
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Rickettsia species identified in adult, host-seeking Dermacentor occidentalis (Acari: Ixodidae) from Baja California, Mexico, and Oregon and Washington, United States.

    Paddock, Christopher D / Zambrano, Maria L / Clover, James R / Ladd-Wilson, Stephen / Dykstra, Elizabeth A / Salamone, Amy / Kangiser, David / Ayres, Bryan N / Shooter, Savannah L / Karpathy, Sandor E / Kjemtrup, Anne M / Beati, Lorenza / Levin, Michael L / Lane, Robert S / Zazueta, Oscar E

    Journal of medical entomology

    2024  

    Abstract: The Pacific Coast tick (Dermacentor occidentalis Marx, 1892) is a frequently encountered and commonly reported human-biting tick species that has been recorded from most of California and parts of southwestern Oregon, southcentral Washington, and ... ...

    Abstract The Pacific Coast tick (Dermacentor occidentalis Marx, 1892) is a frequently encountered and commonly reported human-biting tick species that has been recorded from most of California and parts of southwestern Oregon, southcentral Washington, and northwestern Mexico. Although previous investigators have surveyed populations of D. occidentalis for the presence of Rickettsia species across several regions of California, populations of this tick have not been surveyed heretofore for rickettsiae from Baja California, Oregon, or Washington. We evaluated 1,367 host-seeking, D. occidentalis adults collected from 2015 to 2022 by flagging vegetation at multiple sites in Baja California, Mexico, and Oregon and Washington, United States, using genus- and species-specific assays for spotted fever group rickettsiae. DNA of Rickettsia 364D, R. bellii, and R. tillamookensis was not detected in specimens from these regions. DNA of R. rhipicephali was detected in D. occidentalis specimens obtained from Ensenada Municipality in Baja California and southwestern Oregon, but not from Washington. All ompA sequences of R. rhipichephali that were amplified from individual ticks in southwestern Oregon were represented by a single genotype. DNA of the Ixodes pacificus rickettsial endosymbiont was amplified from specimens collected in southwestern Oregon and Klickitat County, Washington; to the best of our knowledge, this Rickettsia species has never been identified in D. occidentalis. Collectively, these data are consistent with a relatively recent introduction of Pacific Coast ticks in the northernmost extension of its recognized range.
    Language English
    Publishing date 2024-02-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 410635-0
    ISSN 1938-2928 ; 0022-2585
    ISSN (online) 1938-2928
    ISSN 0022-2585
    DOI 10.1093/jme/tjae023
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  7. Article ; Online: Reducing disparities requires multiple strategies.

    Sorbero, Melony E / Paddock, Susan M / Damberg, Cheryl L

    The American journal of managed care

    2018  Volume 24, Issue 12, Page(s) 577

    Abstract: Disparities in care are a complex issue requiring multiple strategies to solve, including approaches to improve the measurement of quality and reporting stratified performance estimates. ...

    Abstract Disparities in care are a complex issue requiring multiple strategies to solve, including approaches to improve the measurement of quality and reporting stratified performance estimates.
    MeSH term(s) Healthcare Disparities ; Humans ; Practice Guidelines as Topic ; Quality Assurance, Health Care/methods ; Reimbursement, Incentive ; Social Class ; United States
    Language English
    Publishing date 2018-12-01
    Publishing country United States
    Document type Letter ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2035781-3
    ISSN 1936-2692 ; 1088-0224 ; 1096-1860
    ISSN (online) 1936-2692
    ISSN 1088-0224 ; 1096-1860
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: IL-13 promotes functional recovery after myocardial infarction via direct signaling to macrophages.

    Alvarez-Argote, Santiago / Paddock, Samantha J / Flinn, Michael A / Moreno, Caelan W / Knas, Makenna C / Almeida, Victor A / Buday, Sydney L / Bakhshian Nik, Amirala / Patterson, Michaela / Chen, Yi-Guang / Lin, Chien-Wei / O'Meara, Caitlin C

    JCI insight

    2024  Volume 9, Issue 2

    Abstract: There is great interest in identifying signaling pathways that promote cardiac repair after myocardial infarction (MI). Prior studies suggest a beneficial role for IL-13 signaling in neonatal heart regeneration; however, the cell types mediating cardiac ... ...

    Abstract There is great interest in identifying signaling pathways that promote cardiac repair after myocardial infarction (MI). Prior studies suggest a beneficial role for IL-13 signaling in neonatal heart regeneration; however, the cell types mediating cardiac regeneration and the extent of IL-13 signaling in the adult heart after injury are unknown. We identified an abundant source of IL-13 and the related cytokine, IL-4, in neonatal cardiac type 2 innate lymphoid cells, but this phenomenon declined precipitously in adult hearts. Moreover, IL-13 receptor deletion in macrophages impaired cardiac function and resulted in larger scars early after neonatal MI. By using a combination of recombinant IL-13 administration and cell-specific IL-13 receptor genetic deletion models, we found that IL-13 signaling specifically to macrophages mediated cardiac functional recovery after MI in adult mice. Single transcriptomics revealed a subpopulation of cardiac macrophages in response to IL-13 administration. These IL-13-induced macrophages were highly efferocytotic and were identified by high IL-1R2 expression. Collectively, we elucidated a strongly proreparative role for IL-13 signaling directly to macrophages following cardiac injury. While this pathway is active in proregenerative neonatal stages, reactivation of macrophage IL-13 signaling is required to promote cardiac functional recovery in adults.
    MeSH term(s) Mice ; Animals ; Interleukin-13/metabolism ; Immunity, Innate ; Lymphocytes/metabolism ; Myocardial Infarction ; Macrophages/metabolism ; Receptors, Interleukin-13/metabolism
    Chemical Substances Interleukin-13 ; Receptors, Interleukin-13
    Language English
    Publishing date 2024-01-23
    Publishing country United States
    Document type Journal Article
    ISSN 2379-3708
    ISSN (online) 2379-3708
    DOI 10.1172/jci.insight.172702
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Theoretical design of a space bioprocessing system to produce recombinant proteins.

    Soundararajan, Mathangi / Paddock, Matthew B / Dougherty, Michael / Jones, Harry W / Hogan, John A / Donovan, Frances M / Galazka, Jonathan M / Settles, A Mark

    NPJ microgravity

    2023  Volume 9, Issue 1, Page(s) 78

    Abstract: ... encompassed biomass dewatering of 1 L Escherichia coli cultures through to recombinant protein purification ...

    Abstract Space-based biomanufacturing has the potential to improve the sustainability of deep space exploration. To advance biomanufacturing, bioprocessing systems need to be developed for space applications. Here, commercial technologies were assessed to design space bioprocessing systems to supply a liquid amine carbon dioxide scrubber with active carbonic anhydrase produced recombinantly. Design workflows encompassed biomass dewatering of 1 L Escherichia coli cultures through to recombinant protein purification. Non-crew time equivalent system mass (ESM) analyses had limited utility for selecting specific technologies. Instead, bioprocessing system designs focused on minimizing complexity and enabling system versatility. Three designs that differed in biomass dewatering and protein purification approaches had nearly equivalent ESM of 357-522 kg eq. Values from the system complexity metric (SCM), technology readiness level (TRL), integration readiness level (IRL), and degree of crew assistance metric identified a simpler, less costly, and easier to operate design for automated biomass dewatering, cell lysis, and protein affinity purification.
    Language English
    Publishing date 2023-09-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2823626-9
    ISSN 2373-8065
    ISSN 2373-8065
    DOI 10.1038/s41526-023-00324-w
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  10. Article ; Online: A mutation associated with resistance to synthetic pyrethroids is widespread in US populations of the tropical lineage of Rhipicephalus sanguineus s.l.

    Stone, Nathan E / Ballard, Rebecca / Bourgeois, Reanna M / Pemberton, Grant L / McDonough, Ryelan F / Ruby, Megan C / Backus, Laura H / López-Pérez, Andrés M / Lemmer, Darrin / Koch, Zane / Brophy, Maureen / Paddock, Christopher D / Kersh, Gilbert J / Nicholson, William L / Sahl, Jason W / Busch, Joseph D / Salzer, Johanna S / Foley, Janet E / Wagner, David M

    Ticks and tick-borne diseases

    2024  Volume 15, Issue 4, Page(s) 102344

    Abstract: The brown dog tick, Rhipicephalus sanguineus sensu lato (s.l.), is an important vector ... to this chemical class is widespread in ticks and other arthropods. Rhipicephalus sanguineus s.l. is a complex ... major lineages within Rh. sanguineus s.l., commonly referred to as temperate and tropical, have been ...

    Abstract The brown dog tick, Rhipicephalus sanguineus sensu lato (s.l.), is an important vector for Rickettsia rickettsii, causative agent of Rocky Mountain spotted fever. Current public health prevention and control efforts to protect people involve preventing tick infestations on domestic animals and in and around houses. Primary prevention tools rely on acaricides, often synthetic pyrethroids (SPs); resistance to this chemical class is widespread in ticks and other arthropods. Rhipicephalus sanguineus s.l. is a complex that likely contains multiple unique species and although the distribution of this complex is global, there are differences in morphology, ecology, and perhaps vector competence among these major lineages. Two major lineages within Rh. sanguineus s.l., commonly referred to as temperate and tropical, have been documented from multiple locations in North America, but are thought to occupy different ecological niches. To evaluate potential acaricide resistance and better define the distributions of the tropical and temperate lineages throughout the US and in northern Mexico, we employed a highly multiplexed amplicon sequencing approach to characterize sequence diversity at: 1) three loci within the voltage-gated sodium channel (VGSC) gene, which contains numerous genetic mutations associated with resistance to SPs; 2) a region of the gamma-aminobutyric acid-gated chloride channel gene (GABA-Cl) containing several mutations associated with dieldrin/fipronil resistance in other species; and 3) three mitochondrial genes (COI, 12S, and 16S). We utilized a geographically diverse set of Rh sanguineus s.l. collected from domestic pets in the US in 2013 and a smaller set of ticks collected from canines in Baja California, Mexico in 2021. We determined that a single nucleotide polymorphism (T2134C) in domain III segment 6 of the VGSC, which has previously been associated with SP resistance in Rh. sanguineus s.l., was widespread and abundant in tropical lineage ticks (>50 %) but absent from the temperate lineage, suggesting that resistance to SPs may be common in the tropical lineage. We found evidence of multiple copies of GABA-Cl in ticks from both lineages, with some copies containing mutations associated with fipronil resistance in other species, but the effects of these patterns on fipronil resistance in Rh. sanguineus s.l. are currently unknown. The tropical lineage was abundant and geographically widespread, accounting for 79 % of analyzed ticks and present at 13/14 collection sites. The temperate and tropical lineages co-occurred in four US states, and as far north as New York. None of the ticks we examined were positive for Rickettsia rickettsii or Rickettsia massiliae.
    Language English
    Publishing date 2024-04-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2541872-5
    ISSN 1877-9603 ; 1877-959X
    ISSN (online) 1877-9603
    ISSN 1877-959X
    DOI 10.1016/j.ttbdis.2024.102344
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