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  1. Article ; Online: Hidden harms of indoor air pollution - five steps to expose them.

    Lewis, Alastair C / Jenkins, Deborah / Whitty, Christopher J M

    Nature

    2023  Volume 614, Issue 7947, Page(s) 220–223

    MeSH term(s) Air Pollutants/adverse effects ; Air Pollutants/analysis ; Air Pollution, Indoor/adverse effects ; Air Pollution, Indoor/analysis ; Environmental Monitoring ; Humans ; Research
    Chemical Substances Air Pollutants
    Language English
    Publishing date 2023-02-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-023-00287-8
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  2. Article ; Online: Biological and functional multimorbidity-from mechanisms to management.

    Langenberg, Claudia / Hingorani, Aroon D / Whitty, Christopher J M

    Nature medicine

    2023  Volume 29, Issue 7, Page(s) 1649–1657

    Abstract: Globally, the number of people with multiple co-occurring diseases will increase substantially over the coming decades, with important consequences for patients, carers, healthcare systems and society. Addressing this challenge requires a shift in the ... ...

    Abstract Globally, the number of people with multiple co-occurring diseases will increase substantially over the coming decades, with important consequences for patients, carers, healthcare systems and society. Addressing this challenge requires a shift in the prevailing clinical, educational and scientific thinking and organization-with a strong emphasis on the maintenance of generalist skills to balance the specialization trends of medical education and research. Multimorbidity is not a single entity but differs quantitively and qualitatively across life stages, ethnicities, sexes, socioeconomic groups and geographies. Data-driven science that quantifies the impact of disease co-occurrence-beyond the small number of currently well-studied long-term conditions (such as cardiometabolic diseases)-can help illuminate the pathological diversity of multimorbidity and identify common, mechanistically related, and prognostically relevant clusters. Broader access to data opportunities across modalities and disciplines will catalyze vertical and horizontal integration of multimorbidity research, to enable reconfiguring of medical services, clinical trials, guidelines and research in a way that accounts for the complexity of multimorbidity-and provides efficient, joined-up services for patients.
    MeSH term(s) Humans ; Multimorbidity ; Delivery of Health Care ; Education, Medical ; Ethnicity
    Language English
    Publishing date 2023-07-18
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-023-02420-6
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  3. Article ; Online: Antimicrobial resistance: learning lessons from antiparasitic, antibacterial and antimycobacterial drug resistance in low-income settings.

    Whitty, Christopher J M

    Transactions of the Royal Society of Tropical Medicine and Hygiene

    2019  Volume 113, Issue 3, Page(s) 105–107

    MeSH term(s) Developing Countries ; Drug Resistance ; Drug Resistance, Bacterial ; Drug Resistance, Fungal ; Humans ; Infections/diagnosis ; Infections/drug therapy ; Poverty
    Language English
    Publishing date 2019-02-04
    Publishing country England
    Document type Editorial
    ZDB-ID 441375-1
    ISSN 1878-3503 ; 0035-9203
    ISSN (online) 1878-3503
    ISSN 0035-9203
    DOI 10.1093/trstmh/try146
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  4. Article ; Online: Building UK infrastructure for research that benefits infants, children and young people.

    Whitty, Christopher J M

    Archives of disease in childhood

    2018  Volume 104, Issue 9, Page(s) 825–826

    MeSH term(s) Adolescent ; Adolescent Health Services/organization & administration ; Adolescent Health Services/statistics & numerical data ; Child ; Child Health Services/organization & administration ; Child Health Services/statistics & numerical data ; Child, Preschool ; Delivery of Health Care/organization & administration ; Health Services Needs and Demand ; Health Services Research ; Humans ; Infant ; Infant, Newborn ; National Health Programs/organization & administration ; Quality of Health Care ; United Kingdom/epidemiology
    Language English
    Publishing date 2018-07-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/archdischild-2017-314334
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  5. Article ; Online: Malaria control stalls in high incidence areas.

    Whitty, Christopher J M / Ansah, Evelyn

    BMJ (Clinical research ed.)

    2019  Volume 365, Page(s) l2216

    MeSH term(s) Communicable Disease Control/organization & administration ; Communicable Disease Control/statistics & numerical data ; Communicable Disease Control/trends ; Endemic Diseases/prevention & control ; Endemic Diseases/statistics & numerical data ; Global Health/trends ; Humans ; Malaria/epidemiology ; Malaria/prevention & control
    Language English
    Publishing date 2019-05-21
    Publishing country England
    Document type Editorial
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.l2216
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  6. Article: Formal and informal science advice in emergencies: COVID-19 in the UK.

    Whitty, Christopher J M / Collet-Fenson, Luke B

    Interface focus

    2021  Volume 11, Issue 6, Page(s) 20210059

    Abstract: The importance of scientific advice to government gains greater recognition in emergencies but inevitably has to be done in an environment of uncertainty, with limited data and at high speed. Adapting existing structures is more effective than creating ... ...

    Abstract The importance of scientific advice to government gains greater recognition in emergencies but inevitably has to be done in an environment of uncertainty, with limited data and at high speed. Adapting existing structures is more effective than creating new ones in an emergency. Between emergencies, the UK has a structured scientific advice system, including Chief Scientific Advisers, scientists in government, regulatory bodies and independent expert committees, which were adapted to COVID-19 under the umbrella of the Scientific Advisory Group for Emergencies. These worked alongside networks of informal scientific advice, including internationally. Multiple sciences were needed, including from the social sciences and engineering in addition to clinical science and epidemiology, and these had to be integrated. A centrally directed clinical research programme helped provide practitioners robust evidence, with observational and interventional trials providing data for policy and testing treatments and vaccines. The scale of the emergency meant unavoidable tension between detailed work and speed, and between an integrated scientific view usable in decision-making and constructive challenge. While a final judgement of the UK scientific response will take time, everyone should be grateful to the thousands of scientists involved for the research, synthesis and advice, which improved outcomes for the public.
    Language English
    Publishing date 2021-10-12
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2042-8898
    ISSN 2042-8898
    DOI 10.1098/rsfs.2021.0059
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  7. Article ; Online: Restoring and extending secondary prevention.

    Whitty, Christopher J M / Smith, Gregor / McBride, Michael / Atherton, Frank / Powis, Stephen H / Stokes-Lampard, Helen

    BMJ (Clinical research ed.)

    2023  Volume 380, Page(s) 201

    MeSH term(s) Humans ; Secondary Prevention
    Language English
    Publishing date 2023-02-01
    Publishing country England
    Document type Editorial
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.p201
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  8. Article ; Online: The contribution of biological, mathematical, clinical, engineering and social sciences to combatting the West African Ebola epidemic.

    Whitty, Christopher J M

    Philosophical transactions of the Royal Society of London. Series B, Biological sciences

    2017  Volume 372, Issue 1721

    Abstract: The tragic West African Ebola epidemic claimed many lives, but would have been worse still if scientific insights from many disciplines had not been integrated to create a strong technical response. Epidemiology and modelling triggered the international ... ...

    Abstract The tragic West African Ebola epidemic claimed many lives, but would have been worse still if scientific insights from many disciplines had not been integrated to create a strong technical response. Epidemiology and modelling triggered the international response and guided where response efforts were directed; virology, engineering and clinical science helped reduce deaths and transmission in and from hospitals and treatment centres; social sciences were key to reducing deaths from funerals and in the community; diagnostic and operational research made the response more efficient; immunology and vaccine research contributed to the final stages of the epidemic and will help prevent future epidemics. These varied scientific contributions had to be integrated into a combined narrative, communicated to policymakers to inform decisions, and used by courageous local and international responders in the field in real time. Not every area of science was optimal, and in particular, clinical trials of simple interventions such as fluid management were slow to be adopted and sharing of data was initially poor. This Ebola epidemic demonstrated how science can respond to a major emergency, but also has lessons for better responses in future infectious emergencies.This article is part of the themed issue 'The 2013-2016 West African Ebola epidemic: data, decision-making and disease control'.
    MeSH term(s) Africa, Western/epidemiology ; Epidemics/prevention & control ; Hemorrhagic Fever, Ebola/epidemiology ; Hemorrhagic Fever, Ebola/prevention & control ; Hemorrhagic Fever, Ebola/virology ; Humans
    Language English
    Publishing date 2017-04-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 208382-6
    ISSN 1471-2970 ; 0080-4622 ; 0264-3839 ; 0962-8436
    ISSN (online) 1471-2970
    ISSN 0080-4622 ; 0264-3839 ; 0962-8436
    DOI 10.1098/rstb.2016.0293
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    Einzelsignatur: Show issues

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  9. Article ; Online: Map clusters of diseases to tackle multimorbidity.

    Whitty, Christopher J M / Watt, Fiona M

    Nature

    2020  Volume 579, Issue 7800, Page(s) 494–496

    MeSH term(s) Age Distribution ; Aging/pathology ; Biomedical Research/economics ; Biomedical Research/education ; Biomedical Research/trends ; Cluster Analysis ; Developed Countries/economics ; Developing Countries/economics ; Educational Status ; Epidemiological Monitoring ; Financing, Organized/economics ; Geographic Mapping ; Health Services Needs and Demand ; History, 19th Century ; Humans ; Incidence ; Multimorbidity/trends ; Polypharmacy ; Prevalence ; Research Support as Topic ; Sanitation/statistics & numerical data ; Smoking/epidemiology ; Smoking/pathology ; Socioeconomic Factors
    Language English
    Publishing date 2020-03-24
    Publishing country England
    Document type Historical Article ; Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-020-00837-4
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  10. Article ; Online: Coronavirus: global solutions to prevent a pandemic.

    Watts, Charlotte H / Vallance, Patrick / Whitty, Christopher J M

    Nature

    2020  Volume 578, Issue 7795, Page(s) 363

    MeSH term(s) Age Distribution ; Biomedical Research ; COVID-19 ; COVID-19 Testing ; COVID-19 Vaccines ; Clinical Laboratory Techniques ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Disease Susceptibility ; Epidemiological Monitoring ; Health Education ; Humans ; International Cooperation ; Pandemics/prevention & control ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; Seasons ; Survival Rate ; Viral Vaccines/supply & distribution ; World Health Organization/organization & administration
    Chemical Substances COVID-19 Vaccines ; Viral Vaccines
    Keywords covid19
    Language English
    Publishing date 2020-02-18
    Publishing country England
    Document type Letter
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-020-00457-y
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