Article ; Online: α-Glucan-type exopolysaccharides with varied linkage patterns: Mitigating post-prandial glucose spike and prolonging the glycemic response.
2024 Volume 331, Page(s) 121898
Abstract: Microbial exopolysaccharides (EPSs) are traditionally known as prebiotics that foster colon health by serving as microbiota nutrients, while remaining undigested in the small intestine. However, recent findings suggest that α-glucan structures in EPS, ... ...
| Abstract | Microbial exopolysaccharides (EPSs) are traditionally known as prebiotics that foster colon health by serving as microbiota nutrients, while remaining undigested in the small intestine. However, recent findings suggest that α-glucan structures in EPS, with their varied α-linkage types, can be hydrolyzed by mammalian α-glucosidases at differing rates. This study explores α-glucan-type EPSs, including dextran, alternan, and reuteran, assessing their digestive properties both in vitro and in vivo. Notably, while fungal amyloglucosidase - a common in vitro tool for carbohydrate digestibility analysis - shows limited efficacy in breaking down these structures, mammalian intestinal α-glucosidases can partially degrade them into glucose, albeit slowly. In vivo experiments with mice revealed that various EPSs elicited a significantly lower glycemic response (p < 0.05) than glucose, indicating their nature as carbohydrates that are digested slowly. This leads to the conclusion that different α-glucan-type EPSs may serve as ingredients that attenuate post-prandial glycemic responses. Furthermore, rather than serving as mere dietary fibers, they hold the potential for blood glucose regulation, offering new avenues for managing obesity, Type 2 diabetes, and other related-chronic diseases. |
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| MeSH term(s) | Mice ; Animals ; Glucose/chemistry ; alpha-Glucosidases/metabolism ; Diabetes Mellitus, Type 2 ; Blood Glucose/metabolism ; Glucans ; Mammals/metabolism |
| Chemical Substances | Glucose (IY9XDZ35W2) ; alpha-Glucosidases (EC 3.2.1.20) ; Blood Glucose ; Glucans |
| Language | English |
| Publishing date | 2024-02-01 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 1501516-6 |
| ISSN | 1879-1344 ; 0144-8617 |
| ISSN (online) | 1879-1344 |
| ISSN | 0144-8617 |
| DOI | 10.1016/j.carbpol.2024.121898 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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