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Article ; Online: Catalytic Cascade: Efficient Synthesis of Cyclohepta[b]indoles and Cyclohepta[b]indole-Indoline Conjugates via RCM, Hydrogenation, and Acid-Catalyzed Ring Expansion.

Parui, Nabin / Mandal, Tirtha / Maiti, Sandip / Dash, Jyotirmayee

Chemistry (Weinheim an der Bergstrasse, Germany)

2024 , Page(s) e202401059

Abstract: Cyclohepta[b]indoles, prevalent in natural products and pharmaceuticals, are conventionally accessed via metal or Lewis acid-mediated cycloadditions with prefunctionalized substrates. Our study introduces an innovative sequential catalytic assembly for ... ...

Abstract	Cyclohepta[b]indoles, prevalent in natural products and pharmaceuticals, are conventionally accessed via metal or Lewis acid-mediated cycloadditions with prefunctionalized substrates. Our study introduces an innovative sequential catalytic assembly for synthesizing cyclohepta[b]indoles from readily available isatin derivatives. The process involves three catalytic sequences: ring-closing metathesis, catalytic hydrogenation, and acid-catalyzed ring expansion. The RCM of 2,2-dialkene-3-oxindoles, formed by butenyl Grignard addition to 3-allyl-3-hydroxy-2-oxindoles, yields versatile spirocyclohexene-3-oxindole derivatives. These derivatives undergo further transformations, including dibromination, dihydroxylation, epoxidation, Wacker oxidation at the double bond. Hydrogenation of spirocyclohexene-3-oxindole yields spirocyclohexane-3-oxindoles. Their subsequent acid-catalyzed ring expansion/aromatization, dependent on the acid catalyst, results in either cyclohepta[b]indoles or cyclohepta[b]indole-indoline conjugates, adding a unique synthetic dimension. The utility of this methodology is exemplified through the synthesis of an A-FABP inhibitor, showcasing its potential in pharmaceutical applications.
Language	English
Publishing date	2024-04-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202401059
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: From fuzzy-TOPSIS to machine learning: A holistic approach to understanding groundwater fluoride contamination.

Nandi, Rupsha / Mondal, Sandip / Mandal, Jajati / Bhattacharyya, Pradip

The Science of the total environment

2023 Volume 912, Page(s) 169323

Abstract: Fluoride ( ... ...

Abstract	Fluoride (F
Language	English
Publishing date	2023-12-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.169323
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Article: Anthocyanins: Potential phytochemical candidates for the amelioration of non-alcoholic fatty liver disease.

Mandal, Bitasta / Das, Rakesh / Mondal, Sandip

Annales pharmaceutiques francaises

2024 Volume 82, Issue 3, Page(s) 373–391

Abstract: Nonalcoholic fatty liver disease (NAFLD) is described by too much hepatic fat deposition causing steatosis, which further develops into nonalcoholic steatohepatitis (NASH), defined by necroinflammation and fibrosis, progressing further to hepatic ... ...

Abstract	Nonalcoholic fatty liver disease (NAFLD) is described by too much hepatic fat deposition causing steatosis, which further develops into nonalcoholic steatohepatitis (NASH), defined by necroinflammation and fibrosis, progressing further to hepatic cirrhosis, hepatocellular carcinoma, and liver failure. NAFLD is linked to different aspects of the metabolic syndrome like obesity, insulin resistance, hypertension, and dyslipidemia, and its pathogenesis involves several elements including diet, obesity, disruption of lipid homeostasis, and a high buildup of triglycerides and other lipids in liver cells. It is therefore linked to an increase in the susceptibility to developing diabetes mellitus and cardiovascular diseases. Several interventions exist regarding its management, but the availability of natural sources through diet will be a benefit in dealing with the disorder due to the immensely growing dependence of the population worldwide on natural sources owing to their ability to treat the root cause of the disease. Anthocyanins (ACNs) are naturally occurring polyphenolic pigments that exist in the form of glycosides, which are the glucosides of anthocyanidins and are produced from flavonoids via the phenyl propanoid pathway. To understand their mode of action in NAFLD and their therapeutic potential, the literature on in vitro, in vivo, and clinical trials on naturally occurring ACN-rich sources was exhaustively reviewed. It was concluded that ACNs show their potential in the treatment of NAFLD through their antioxidant properties and their efficacy to control lipid metabolism, glucose homeostasis, transcription factors, and inflammation. This led to the conclusion that ACNs possess efficacy in the amelioration of NAFLD and the various features associated with it. However, additional clinical trials are required to justify the potential of ACNs in NAFLD.
MeSH term(s)	Humans ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/epidemiology ; Non-alcoholic Fatty Liver Disease/metabolism ; Anthocyanins/pharmacology ; Anthocyanins/therapeutic use ; Anthocyanins/metabolism ; Obesity/complications ; Obesity/metabolism ; Obesity/pathology ; Insulin Resistance ; Phytochemicals/pharmacology ; Phytochemicals/therapeutic use ; Phytochemicals/metabolism ; Liver/metabolism ; Liver/pathology
Chemical Substances	Anthocyanins ; Phytochemicals
Language	English
Publishing date	2024-02-13
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	307-4
ISSN	0003-4509
ISSN	0003-4509
DOI	10.1016/j.pharma.2024.02.005
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Article ; Online: Genomic dataset of a multiple-drug resistant

Mondal, Rittick / Dam, Paulami / Chakraborty, Joydeep / Shaw, Shubhajit / Pradhan, Sayantan / Das, Sandip / Nesa, Jannatun / Meena, Khemraj / Ghati, Amit / Chaudhuri, Sandip Dev / Bhattacharjee, Debjoy / Mandal, Vivekananda / Sarkar, Biraj / Mandal, Amit Kumar

Data in brief

2024 Volume 54, Page(s) 110293

Abstract: Species belonging to the ... ...

Abstract	Species belonging to the genus
Language	English
Publishing date	2024-03-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2786545-9
ISSN	2352-3409 ; 2352-3409
ISSN (online)	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2024.110293
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Article ; Online: Role of site-site interaction on the phase equilibria of multiple-site associating fluids in a functionalized slit pore.

Mandal, Sashanka Sekhar / Singh, Sudhir Kumar / Khan, Sandip

Journal of physics. Condensed matter : an Institute of Physics journal

2023 Volume 35, Issue 47

Abstract: Vapor-liquid phase equilibria for multiple sites associating fluids with different associating strengths are investigated in a slit pore using grand-canonical transition matrix Monte Carlo method. The increase of critical temperature from two-site to ... ...

Abstract	Vapor-liquid phase equilibria for multiple sites associating fluids with different associating strengths are investigated in a slit pore using grand-canonical transition matrix Monte Carlo method. The increase of critical temperature from two-site to four-site associating fluids at constant site strength is quite significant as compared to that of the one-site to two-site associating fluids, which is more pronounced at higher associating strength (
Language	English
Publishing date	2023-08-29
Publishing country	England
Document type	Journal Article
ZDB-ID	1472968-4
ISSN	1361-648X ; 0953-8984
ISSN (online)	1361-648X
ISSN	0953-8984
DOI	10.1088/1361-648X/acede1
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Article ; Online: Image-Based Longitudinal Characterization of Corneal Wound to Understand the Role of Sphingosine-1-Phosphate.

Basu, Sandip K / Mandal, Nawajes

Methods in molecular biology (Clifton, N.J.)

2022 Volume 2625, Page(s) 337–345

Abstract: Since its discovery, the bioactive sphingolipid sphingosine 1-phosphate (S1P) has been shown to involve in a myriad of cellular and physiological processes. In the process of tissue healing, S1P plays an important role in both normal and pathological ... ...

Abstract	Since its discovery, the bioactive sphingolipid sphingosine 1-phosphate (S1P) has been shown to involve in a myriad of cellular and physiological processes. In the process of tissue healing, S1P plays an important role in both normal and pathological healing, leading to fibrosis in multiple tissues including the cornea. Cornea covers the anterior portion of the eye and is responsible for the refraction of light. Corneal transparency is essential to obtain a clear vision, and a proper wound healing process is necessary for a clear cornea. Even though S1P is indicated to be a critical player in corneal fibrosis, we lack a detailed understanding of the role of S1P signaling in corneal wound healing and fibrosis. Herein, we describe a methodology to characterize the in-vivo wound healing process of the cornea using an easy and affordable imaging-based assay. This gives a consistent and easy way to characterize the wound and also the longitudinal healing process.
MeSH term(s)	Humans ; Sphingosine ; Lysophospholipids ; Cornea ; Corneal Injuries ; Fibrosis
Chemical Substances	sphingosine 1-phosphate (26993-30-6) ; Sphingosine (NGZ37HRE42) ; Lysophospholipids
Language	English
Publishing date	2022-12-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-2966-6_28
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Article: Estimating the Burden of Tuberculosis in India: A Modelling Study.

Mandal, Sandip / Rao, Raghuram / Joshi, Rajendra

Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine

2023 Volume 48, Issue 3, Page(s) 436–442

Abstract: Background: Measurements TB incidence and mortality are crucial for monitoring progress towards SDG goals for TB. Until recently, WHO estimated TB burden in India with applied simple, transparent equilibrium models to data from Gujarat, an Indian state ... ...

Abstract	Background: Measurements TB incidence and mortality are crucial for monitoring progress towards SDG goals for TB. Until recently, WHO estimated TB burden in India with applied simple, transparent equilibrium models to data from Gujarat, an Indian state where the first state-level prevalence survey was conducted in 2011. However, since then there has been several interventions in India including national TB prevalence survey, infection survey, sub-national survey & certification which gives opportunity for national and sub-national estimates for TB incidence and mortality. Methods: We developed a model is a compartmental, deterministic framework, taking account of TB natural history, as well as India's healthcare system including health care seeking from public and private sector. To address changes in TB burden owing to COVID disruptions, we followed same model that used by WHO in the global TB Report 2022 with additional impact of delta wave in 2021. Major sources of data included National TB Prevalence survey, trends in caseloads in public and private sector including their contribution and mortality information. Results: We estimated total TB incidence of 2.77 million in the year 2022 as against 2.97 in the year 2015 and corresponding TB mortality of 0.32 and 0.36 million respectively. In terms of rate per 1,00,000 TB incidence in 2022 was 196 as compared to 225 in the year 2015 and mortality was 23 and 27 respectively. TB incidence estimates are similar to what was estimated by WHO, while mortality estimates appear different in our estimates due to different calibration targets depending on in-country published data. Conclusion: Even if TB burden is infeasible to measure directly, a range of data can nonetheless offer indirect evidence for its estimation: mathematical modelling can be a helpful tool for bringing together these diverse sources of evidence, and deriving estimates that are consistent with them all. While the RGI reported mortality is an important source of information, its quality and coverage for medically certified cause of deaths requires improvement in India.
Language	English
Publishing date	2023-03-24
Publishing country	India
Document type	Journal Article
ZDB-ID	2085330-0
ISSN	1998-3581 ; 0970-0218
ISSN (online)	1998-3581
ISSN	0970-0218
DOI	10.4103/ijcm.ijcm_160_23
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Article ; Online: Floquet scattering of quadratic band-touching semimetals through a time-periodic potential well.

Bera, Sandip / Mandal, Ipsita

Journal of physics. Condensed matter : an Institute of Physics journal

2021 Volume 33, Issue 29

Abstract: We consider tunneling of quasiparticles through a rectangular quantum well, subject to periodic driving. The quasiparticles are the itinerant charges in two-dimensional and three-dimensional semimetals having a quadratic bandtouching (QBT) point in the ... ...

Abstract	We consider tunneling of quasiparticles through a rectangular quantum well, subject to periodic driving. The quasiparticles are the itinerant charges in two-dimensional and three-dimensional semimetals having a quadratic bandtouching (QBT) point in the Brillouin zone. To analyze the time-periodic Hamiltonian, we assume a non-adiabatic limit where the Floquet theorem is applicable. By deriving the Floquet scattering matrices, we chalk out the transmission and shot noise spectra of the QBT semimetals. The spectra show Fano resonances, which we identify with the (quasi)bound states of the systems.
Language	English
Publishing date	2021-06-09
Publishing country	England
Document type	Journal Article
ZDB-ID	1472968-4
ISSN	1361-648X ; 0953-8984
ISSN (online)	1361-648X
ISSN	0953-8984
DOI	10.1088/1361-648X/ac020a
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Article ; Online: A comparison between axillary brachial plexus block and elbow block using ultrasound in patients undergoing surgeries of wrist and hand

Amit Kumar Biswas / Debojyoti Das / Sarfraaz Rahman / Sandip Maji / Sandip Sinha / Mohanchandra Mandal

Asian Journal of Medical Sciences, Vol 14, Iss 6, Pp 37-

2023 Volume 43

Abstract: Background: Both the axillary brachial block and elbow block are easy to learn and perform. Elbow block was previously used to as a rescue block to supplement the inadequacy of proximal nerve plexus block. Recently, elbow block is emerging as a primary ... ...

Abstract	Background: Both the axillary brachial block and elbow block are easy to learn and perform. Elbow block was previously used to as a rescue block to supplement the inadequacy of proximal nerve plexus block. Recently, elbow block is emerging as a primary anesthetic technique for wrist and hand surgeries. However, no such study in Indian scenario exists comparing axillary brachial plexus block and elbow block using ultrasound (US) guidance during wrist and hand surgeries. Aims and Objectives: The present study was designed to compare axillary brachial plexus block and elbow block for hand and wrist surgery in terms of duration of post-operative analgesia (Primary outcome), procedure times, other characteristics of block, patient satisfaction, and adverse events. Materials and Methods: This open-label parallel-group randomized study was performed in 78 adults, aged 18–70 years, ASA I-II, undergoing elective surgeries of wrist and hand. The patients were randomly allocated into two equal groups to receive either axillary brachial plexus block (Group A, n=39) or elbow block (Group B, n=39), both under US guidance. The time to first rescue analgesia was the primary outcome measure. Other outcome measures were different characteristics of nerve blocks, procedure duration, 24-h analgesic consumption, patient’s satisfaction score, and adverse events. Results: The time to first analgesic administration was considerably higher in axillary block compared with elbow block (15 vs. 14 h, P<0.001). However, the post-operative analgesia with elbow block was not clinically insignificant. The onset of blocks was faster with axillary block compared with elbow block (sensory block 15 vs. 24 min, P<0.001; motor block 20 vs. 30 min, P<0.001). Overall, a higher number of patients were more satisfied with elbow block. Conclusion: Using US, elbow block can be a better alternative to axillary block for hand surgeries in terms of sufficient post-operative analgesia, comparatively shorter motor block, and better patient satisfaction.
Keywords	axillary block ; brachial plexus block ; distal peripheral nerve blocks ; elbow block ; ultrasound guidance ; Medicine ; R
Subject code	616
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Manipal College of Medical Sciences, Pokhara
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Estimating the burden of tuberculosis in India

Sandip Mandal / Raghuram Rao / Rajendra Joshi

Indian Journal of Community Medicine, Vol 48, Iss 3, Pp 436-

A modelling study

2023 Volume 442

Abstract	Background: Measurements TB incidence and mortality are crucial for monitoring progress towards SDG goals for TB. Until recently, WHO estimated TB burden in India with applied simple, transparent equilibrium models to data from Gujarat, an Indian state where the first state-level prevalence survey was conducted in 2011. However, since then there has been several interventions in India including national TB prevalence survey, infection survey, sub-national survey & certification which gives opportunity for national and sub-national estimates for TB incidence and mortality. Methods: We developed a model is a compartmental, deterministic framework, taking account of TB natural history, as well as India's healthcare system including health care seeking from public and private sector. To address changes in TB burden owing to COVID disruptions, we followed same model that used by WHO in the global TB Report 2022 with additional impact of delta wave in 2021. Major sources of data included National TB Prevalence survey, trends in caseloads in public and private sector including their contribution and mortality information. Results: We estimated total TB incidence of 2.77 million in the year 2022 as against 2.97 in the year 2015 and corresponding TB mortality of 0.32 and 0.36 million respectively. In terms of rate per 1,00,000 TB incidence in 2022 was 196 as compared to 225 in the year 2015 and mortality was 23 and 27 respectively. TB incidence estimates are similar to what was estimated by WHO, while mortality estimates appear different in our estimates due to different calibration targets depending on in-country published data. Conclusion: Even if TB burden is infeasible to measure directly, a range of data can nonetheless offer indirect evidence for its estimation: mathematical modelling can be a helpful tool for bringing together these diverse sources of evidence, and deriving estimates that are consistent with them all. While the RGI reported mortality is an important source of information, its quality and ...
Keywords	tuberculosis ; incidence ; mortality ; estimation ; india ; Public aspects of medicine ; RA1-1270
Subject code	310
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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