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Article: Type 1 diabetes in a Nigerian family - occurrence in three out of four siblings: A case report.

Olamoyegun, Michael Adeyemi / Ala, Oluwabukola Ayodele

2019 Volume 10, Issue 10, Page(s) 511–516

Abstract: Background: Most occurrences of type 1 diabetes cases in any population are sporadic rather than familial. Hence, type 1 diabetes among siblings is a rare occurrence. Even more rare is for three or more siblings to develop type 1 diabetes. In this ... ...

Abstract	Background: Most occurrences of type 1 diabetes cases in any population are sporadic rather than familial. Hence, type 1 diabetes among siblings is a rare occurrence. Even more rare is for three or more siblings to develop type 1 diabetes. In this report, we describe a case of a Nigerian family in which type 1 diabetes occurred in three siblings among four children with neither parent having diabetes. All three siblings are positive for glutamic acid decarboxylase and anti-islet cell antibodies. Case summary: There were four siblings (three males and one female) born to a couple without a diagnosis of diabetes. The eldest child (male) was diagnosed with diabetes at the age of 15, the second child (female) was diagnosed at the age of 11 and the fourth child (male) was diagnosed at the age of 9. All the siblings presented with similar osmotic symptoms and were diagnosed of diabetic ketoacidosis. All of them had markedly reduced serum C-peptide levels with high levels of glutamic acid decarboxylase and insulinoma-associated protein-2 antibodies. We could not perform genetic analysis of HLA-DR, DQ and CTLA4 in the siblings as well as the parents; hence haplotypes could not be characterized. Both parents of the probands have no prior history of diabetes, and their blood glucose and glycated hemoglobin levels were within normal ranges. The third child (male) has no history suggestive of diabetes, and his blood glucose and glycated hemoglobin have remained within normal ranges. Conclusion: Although the occurrence of type 1 diabetes in proband siblings is uncommon, screening for diabetes among siblings especially with islet autoantibodies should be encouraged.
Language	English
Publishing date	2019-09-01
Publishing country	United States
Document type	Case Reports
ZDB-ID	2583471-X
ISSN	1948-9358
ISSN	1948-9358
DOI	10.4239/wjd.v10.i10.511
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Article ; Online: Coexistence of type 1 and type 2 diabetes mellitus: a case report of "double" diabetes in a 17-year-old Nigerian girl.

Olamoyegun, Michael Adeyemi / Ala, Oluwabukola Ayodele / Ugwu, Ejiofor

The Pan African medical journal

2020 Volume 37, Page(s) 35

Abstract: Double diabetes otherwise known as hybrid diabetes, a new variant, is a combination of both type 1 and type 2 diabetes in children and adolescents. It is a diabetes variant increasing in prevalence in developed countries because of epidemic obesity among ...

Abstract	Double diabetes otherwise known as hybrid diabetes, a new variant, is a combination of both type 1 and type 2 diabetes in children and adolescents. It is a diabetes variant increasing in prevalence in developed countries because of epidemic obesity among children and adolescents but extremely rare in developing countries. Double diabetes is characterized by features of both type 1 (diabetes auto-antibodies) and type 2 (obesity and insulin resistance). This occurrence can either develop on a background of type 1 diabetes due to an abnormal increase in weight from physiological growth spurt in adolescents or from high insulin dosage developing on a background of type 2 diabetes. The variant has been linked to possible increased cardiovascular risks and worsened morbidity including poor glycaemic control. Here, we report a case of a 17-year-old girl who developed features of type 2 diabetes on a background of type 1 diagnosed 6 years after T1D diagnosis.
MeSH term(s)	Adolescent ; Autoantibodies/analysis ; Diabetes Mellitus, Type 1/diagnosis ; Diabetes Mellitus, Type 1/epidemiology ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/epidemiology ; Female ; Humans ; Insulin Resistance ; Nigeria ; Pediatric Obesity/epidemiology
Chemical Substances	Autoantibodies
Language	English
Publishing date	2020-09-08
Publishing country	Uganda
Document type	Case Reports
ZDB-ID	2514347-5
ISSN	1937-8688 ; 1937-8688
ISSN (online)	1937-8688
ISSN	1937-8688
DOI	10.11604/pamj.2020.37.35.25191
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Article ; Online: Mobile phone ownership and willingness to receive mHealth services among patients with diabetes mellitus in South-West, Nigeria.

Olamoyegun, Michael Adeyemi / Raimi, Taiwo Hassan / Ala, Oluwabukola Ayodele / Fadare, Joseph Olusesan

The Pan African medical journal

2020 Volume 37, Page(s) 29

Abstract: Introduction: mobile phone technology is increasingly used to overcome traditional barriers to limiting access to diabetes care. This study evaluated mobile phone ownership and willingness to receive and pay for mobile phone-based diabetic services ... ...

Abstract	Introduction: mobile phone technology is increasingly used to overcome traditional barriers to limiting access to diabetes care. This study evaluated mobile phone ownership and willingness to receive and pay for mobile phone-based diabetic services among people with diabetes in South-West, Nigeria. Methods: two hundred and fifty nine patients with diabetes were consecutively recruited from three tertiary health institutions in South-West, Nigeria. Questionnaire was used to evaluate mobile phone ownership, willingness to receive and pay for mobile phone-based diabetic health care services via voice call and text messaging. Results: 97.3% owned a mobile phone, with 38.9% and 61.1% owning smartphone and basic phone respectively. Males were significantly more willing to receive mobile-phone-based health services than females (81.1% vs 68.1%, p=0.025), likewise married compared to unmarried [77.4% vs 57.1%, p=0.036]. Voice calls (41.3%) and text messages (32.4%), were the most preferred modes of receiving diabetes-related health education with social media (3.1%) and email (1.5%) least. Almost three-quarter of participants (72.6%) who owned mobile phone, were willing to receive mobile phone-based diabetes health services. The educational status of patients (adjusted OR [AOR]: 1.7{95% CI: 1.6 to 2.1}), glucometers possession (AOR: 2.0 [95% CI: 1.9 to 2.1) and type of mobile phone owned (AOR: 2.9 [95% CI: 2.8 to 5.0]) were significantly associated with the willingness to receive mobile phone-based diabetic services. Conclusion: the majority of study participants owned mobile phones and would be willing to receive and pay for diabetes-related healthcare delivery services provided the cost is minimal and affordable.
MeSH term(s)	Adult ; Aged ; Cell Phone/statistics & numerical data ; Cross-Sectional Studies ; Delivery of Health Care/economics ; Delivery of Health Care/methods ; Diabetes Mellitus/therapy ; Educational Status ; Female ; Humans ; Male ; Middle Aged ; Nigeria ; Ownership/statistics & numerical data ; Patient Acceptance of Health Care/statistics & numerical data ; Surveys and Questionnaires ; Telemedicine/economics ; Telemedicine/methods ; Text Messaging
Keywords	covid19
Language	English
Publishing date	2020-09-08
Publishing country	Uganda
Document type	Journal Article
ZDB-ID	2514347-5
ISSN	1937-8688 ; 1937-8688
ISSN (online)	1937-8688
ISSN	1937-8688
DOI	10.11604/pamj.2020.37.29.25174
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Article: Mobile Phone Use in the Management of Diabetes in Nigeria: A New Potential Weapon.

Olamoyegun, M A / Emuoyibofarhe, O J / Ala, O A / Ugwu, E

West African journal of medicine

2020 Volume 37, Issue 3, Page(s) 201–208

Abstract: Diabetes Mellitus (DM) is one of the leading chronic diseases in low- and middle-income countries globally including Nigeria The morbidities and mortalities associated with diabetes especially in Nigeria, have remained unacceptably high compared to many ... ...

Abstract	Diabetes Mellitus (DM) is one of the leading chronic diseases in low- and middle-income countries globally including Nigeria The morbidities and mortalities associated with diabetes especially in Nigeria, have remained unacceptably high compared to many other nations. It has become one of the leading causes of stroke, blindness, heart attack and end-stage kidney disease. Most deaths occur in those below 60 years of age, the productive segments of the population. Health situation in Nigeria is characterised by double burden of illness, grossly inadequate health spending, and inadequate healthcare personnel especially in the rural areas. Shortage of diabetes care specialist is one of the major barriers to diabetes care in Nigeria. Mobile phone has emerged as one of the potent strategies that can impact positively on diabetes care if properly harnessed. The ubiquitous access and the multitasking nature of mobile phones are great opportunities to improve diabetes prevention, patient care, encourage self-management, support healthy behavioural changes and an ideal way of providing patient-centred care at the frequency and intensity that patient desires. In addition, there is a potential for mobile phones to provide an effective way of giving support to patients in rural and remote areas where health care provider contact may be less accessible. Use of short message services (SMS) phone calls, video calls and the use of social media networking applications are some of the ways a mobile phone can be used in diabetes management.
MeSH term(s)	Cell Phone ; Cell Phone Use/statistics & numerical data ; Diabetes Mellitus/therapy ; Humans ; Middle Aged ; Nigeria ; Reminder Systems ; Self Care ; Text Messaging
Language	French
Publishing date	2020-05-08
Publishing country	Nigeria
Document type	Journal Article
ZDB-ID	1132088-6
ISSN	0189-160X
ISSN	0189-160X
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Article ; Online: Audit of insulin prescription patterns and associated burden among diabetics in a tertiary health institution in Nigeria.

Olamoyegun, Michael A / Akinlade, Akinyemi T / Ala, Oluwabukola A

African health sciences

2018 Volume 18, Issue 4, Page(s) 852–864

Abstract: Background: Insulin is one of the most important anti-diabetic agents in the management of diabetes even among type 2 diabetic.: Objective: There was need to assess insulin adherence, mode of insulin delivery and burden of insulin usage among ... ...

Abstract	Background: Insulin is one of the most important anti-diabetic agents in the management of diabetes even among type 2 diabetic. Objective: There was need to assess insulin adherence, mode of insulin delivery and burden of insulin usage among diabetics. Methods: A cross-sectional, prospective questionnaire, orally administered at a Diabetes Clinic of a University Teaching Hospital, SouthWest, Nigeria. Participants were consecutive patients with diabetes who were 18 years or older presently on insulin either alone or in combination with other anti-diabetic agents for at least 3 months. Baseline demographic and insulin treatment information were obtained. Results: Two hundred and thirteen (213) participants were studied. Of these, 21 (9.9%) had T1DM and 192 (90.1%) had T2DM, (means age, 58.6 ± 13.1 years, mean duration of diabetes, 7.0 ± 6.9 years). Insulin adherence was noted in 72.8% with better adherence among those who self-injected insulin compared to those who were injected by health care professionals (HCPs) or relations. Among the respondents, 80.8% were on human insulin and pre-mixed insulin was the most commonly used form of insulin (52.6%). Most participants (52.6%) were taking 10-20 units per day, only 22 (10.3%) were on >40units/day. Reuse of insulin needle was found in 74.6% of the participants. Major reasons for insulin omission were non-availability of insulin and patients being tired of insulin injection. Conclusion: The insulin adherence among diabetics in this study was high. Non-availability of insulin, insulin injection pain and being tired of continual insulin usage were some of the reasons for non-adherent to insulin usage.
MeSH term(s)	Adult ; Aged ; Cross-Sectional Studies ; Diabetes Mellitus/drug therapy ; Drug Administration Routes ; Drug Therapy, Combination ; Drug Utilization/statistics & numerical data ; Female ; Glycated Hemoglobin A ; Health Knowledge, Attitudes, Practice ; Humans ; Hypoglycemic Agents/administration & dosage ; Hypoglycemic Agents/adverse effects ; Hypoglycemic Agents/therapeutic use ; Injection Site Reaction ; Insulin ; Male ; Medication Adherence/psychology ; Medication Adherence/statistics & numerical data ; Middle Aged ; Nigeria ; Prospective Studies ; Socioeconomic Factors
Chemical Substances	Glycated Hemoglobin A ; Hypoglycemic Agents ; Insulin
Language	English
Publishing date	2018-12-31
Publishing country	Uganda
Document type	Journal Article
ZDB-ID	2240308-5
ISSN	1729-0503 ; 1680-6905
ISSN (online)	1729-0503
ISSN	1680-6905
DOI	10.4314/ahs.v18i4.3
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Zs.A 3851: Show issues

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Article: Patterns and outcomes of medical admissions in the accident and emergency department of a tertiary health center in a rural community of Ekiti, Nigeria.

Ogunmola, Olarinde Jeffrey / Olamoyegun, Michael A

Journal of emergencies, trauma, and shock

2014 Volume 7, Issue 4, Page(s) 261–267

Abstract: Background: Low and middle-income countries like Nigeria face many challenges in emergency medical care owing to poor treatment facilities and inadequately trained personnel. Most Nigerians live in rural areas. The disease and death burdens in accident ... ...

Abstract	Background: Low and middle-income countries like Nigeria face many challenges in emergency medical care owing to poor treatment facilities and inadequately trained personnel. Most Nigerians live in rural areas. The disease and death burdens in accident and emergency departments in this setting have not been closely studied. Aim: To determine the basic demographics, disease burden, and outcomes for accident and emergency admissions. Settings and design: This retrospective study was carried out on patients admitted to an accident and emergency department. Materials and methods: A retrospective review of medical admissions to the accident and emergency wards of the Federal Medical Centre, Ido-Ekiti, Ekiti State, southwest Nigeria, between January 2010 and December 2012. Statistical analysis used: The data were analyzed using SPSS Version 16 software. The results were presented in descriptive and tabular forms. Result: In all, 2922 patients were admitted during the study period (age range, 11-100 years; mean, 51.89 ± 20.11 years). There were 1679 (57.5%) males and 1243 (42.5%) females, with a ratio of 1.4:1. Young adults (aged 40 years and under) formed the highest age group (46.8%). The number of patients admitted for non-communicable diseases were high (1989 patients: 68.07%). Among non-communicable diseases, cardiovascular disorders were the most frequent (797; 27.28%). The most common cause of deaths was cardiovascular disease (33.5%). Conclusion: Young adults and males were the groups most commonly admitted. Non-communicable diseases were more frequent than communicable diseases. The proportion of patients discharged against medical advice and fatalities requires urgent attention.
Language	English
Publishing date	2014-10-22
Publishing country	India
Document type	Journal Article
ZDB-ID	2461111-6
ISSN	0974-519X ; 0974-2700
ISSN (online)	0974-519X
ISSN	0974-2700
DOI	10.4103/0974-2700.142744
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Article: Pattern of Self-care practices among type 2 diabetes patients in Southwest, Nigeria.

Enikuomehin, A C / Olamoyegun, M A / Ojo, O A / Ajani, G D / Akinlade, T A / Ala, O A

Nigerian journal of clinical practice

2021 Volume 24, Issue 7, Page(s) 978–985

Abstract: Background: Self-care practices in individuals with diabetes are important skills required to effectively prevent, manage, and limit complications associated with diabetes since patients spend considerably less time with health care providers than spend ...

Abstract	Background: Self-care practices in individuals with diabetes are important skills required to effectively prevent, manage, and limit complications associated with diabetes since patients spend considerably less time with health care providers than spend alone to manage their diabetes condition. Aims: The aim of the study was to assess self-cate practices and their determinants among patients with type 2 diabetes. Hence, this study aimed at assessing self-care practices and their determinants among patients with type 2 diabetes. Materials and methods: This cross-sectional, descriptive, multi-center study was conducted among 348 type 2 diabetes patients selected from six tertiary hospitals in Southwest Nigeria. Descriptive statistical analysis was employed for categorical and continuous variables and multivariable logistic regression assessed association between determinant factors and adherence to self-monitoring of blood glucose (SMBG). Results: Of the study participants, 83.1%, 66.9%, 28.4%, and 27.9% adhered to prescribed medications, physical exercise, had meal plans incorporated into their diabetes management and SMBG, respectively. There was a statistically significant association between male gender, duration of diabetes, and previous episode of hypoglycemia with adherence to SMBG practices while lower educational level and use of insulin were associated with less likelihood of adherence to prescribed medications. Conclusion: The degree to which individuals with diabetes adhered to recommended self-care practice components were less than satisfactory especially SMBG, physical activity, and having meal plans.
MeSH term(s)	Blood Glucose ; Blood Glucose Self-Monitoring ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/therapy ; Humans ; Male ; Nigeria ; Self Care
Chemical Substances	Blood Glucose
Language	English
Publishing date	2021-07-12
Publishing country	India
Document type	Journal Article ; Multicenter Study
ZDB-ID	1458330-6
ISSN	1119-3077
ISSN	1119-3077
DOI	10.4103/njcp.njcp_527_20
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Zs.A 4975: Show issues

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Article ; Online: Evaluation of dyslipidemia, lipid ratios, and atherogenic index as cardiovascular risk factors among semi-urban dwellers in Nigeria.

Olamoyegun, Michael Adeyemi / Oluyombo, Rotimi / Asaolu, Stephen Olabode

Annals of African medicine

2016 Volume 15, Issue 4, Page(s) 194–199

Abstract: Background and objectives: The increasing frequency of cardiovascular disease (CVD) rests on the presence of major cardiovascular risk factors including dyslipidemia. This dyslipidemia is also a target for the prevention and treatment of many ... ...

Abstract	Background and objectives: The increasing frequency of cardiovascular disease (CVD) rests on the presence of major cardiovascular risk factors including dyslipidemia. This dyslipidemia is also a target for the prevention and treatment of many cardiovascular diseases. Hence, identification of individuals at risk of CVD is needed for early identification and prevention. The study was carried out to evaluate dyslipidemia using the lipid ratios and indices instead of just the conventional lipid profile. Methodology: It was a cross-sectional study with 699 participants recruited from semi-urban communities in Nigeria. Anthropometric indices, blood pressure, and fasting lipid profiles were determined. Abnormalities in lipid indices and lipid ratios with atherogenic index were also determined. SPSS software version 17.0 were used for analysis, P< 0.05 was considered statistically significant. Results: There were 699 participants with a mean age of 64.45 ± 15.53 years. Elevated total cholesterol, high low-density lipoprotein-cholesterol, elevated triglyceride, and low high-density lipoprotein were seen in 5.3%, 19.3%, 4.4%, and 76.3% of the participants, respectively. The Castelli's risk index-I (CRI-I) predicted the highest prevalence of predisposition to cardiovascular risk (47.8%) with females being at significantly higher risk (55.2% vs. 29.3%, P< 0.001). Atherogenic coefficient, CRI-II, CHOLIndex, atherogenic index of plasma (AIP) predicted a cardiovascular risk prevalence of 22.5%, 15.9%, 11.2%, and 11.0%, respectively, with no significant difference in between the sexes. Conclusions: Serum lipid ratios and AIP may be used in addition to lipid parameters in clinical practice to assess cardiovascular risks even when lipid profiles are apparently normal. AIP was more gender specific amidst the lipid ratios.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Atherosclerosis ; Cardiovascular Diseases/epidemiology ; Cholesterol/blood ; Cholesterol, HDL/blood ; Cholesterol, LDL/blood ; Cross-Sectional Studies ; Dyslipidemias/blood ; Dyslipidemias/epidemiology ; Female ; Humans ; Male ; Middle Aged ; Nigeria/epidemiology ; Prevalence ; Risk Factors ; Sex Factors ; Suburban Population ; Triglycerides/blood ; Urban Population
Chemical Substances	Cholesterol, HDL ; Cholesterol, LDL ; Triglycerides ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2016-10
Publishing country	India
Document type	Journal Article
ZDB-ID	2165792-0
ISSN	0975-5764 ; 1596-3519
ISSN (online)	0975-5764
ISSN	1596-3519
DOI	10.4103/1596-3519.194280
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Article: MESUDD: towards a multi-lingua expert system for rural m-healthcare.

Oladosu, John Babalola / Olamoyegun, Michael Adeyemi

International journal of electronic healthcare

2012 Volume 7, Issue 2, Page(s) 141–156

Abstract: A good number of applications and hardware devices for healthcare services have been produced through research efforts. A key limitation of the existing systems that are implemented for mobile devices, however, is that they have not adequately addressed ... ...

Abstract	A good number of applications and hardware devices for healthcare services have been produced through research efforts. A key limitation of the existing systems that are implemented for mobile devices, however, is that they have not adequately addressed language barrier, deplorable access to medical practitioners, cost constraints among other challenges peculiar to rural communities in developing and underdeveloped countries. This paper presents one of the solutions developed in our research efforts at addressing some of the aforementioned limitations of the existing systems. The work produced a novel mobile software tool that addresses the provisioning of real-time language translation for illiterate indigenous patients to interact with a medical expert system via a small mobile computing device for diagnoses and drug prescription where there is no doctor. Usability assessment of the tool was conducted by engaging physicians, paramedics and patients. The result of that assessment is presented.
MeSH term(s)	Cell Phone ; Decision Support Systems, Clinical/instrumentation ; Humans ; Language ; Multilingualism ; Nigeria ; Rural Health Services/organization & administration ; Telemedicine/instrumentation ; Translating
Language	English
Publishing date	2012
Publishing country	Switzerland
Document type	Journal Article
ISSN	1741-8453
ISSN	1741-8453
DOI	10.1504/IJEH.2012.049875
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Article ; Online: QTc interval prolongation in HIV-negative versus HIV-positive subjects with or without antiretroviral drugs.

Ogunmola, Olarinde Jeffrey / Oladosu, Yusuf O / Olamoyegun, Michael A

Annals of African medicine

2015 Volume 14, Issue 4, Page(s) 169–176

Abstract: Background: QTc interval prolongation signifies an increased risk of life-threatening arrhythmia and sudden cardiac death. Cardiac manifestations of human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome have become increasingly ... ...

Abstract	Background: QTc interval prolongation signifies an increased risk of life-threatening arrhythmia and sudden cardiac death. Cardiac manifestations of human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome have become increasingly important causes of morbidity and mortality. We investigated HIV-positive patients to determine the effects of HIV infection, antiretroviral drugs, and identifiable confounders on QTc prolongation. Materials and methods: A case-control study was conducted in a rural tertiary health center in Nigeria. Data collected included demographic variables, body mass index, blood pressure, HIV status, antiretroviral treatment (ART), duration of HIV infection and treatment, CD4 T-lymphocyte count, heart rate (HR), and QT interval. QT was corrected for HR using Bazett's formula. Results: The sample frame comprised 89 (42.4%) HIV-negative subjects (39.3% male, 60.7% female; mean age, 36.28 ± 7.03 years); 45 (21.4%) HIV-positive, ART-naïve patients (31.1% male, 68.9% female; mean age, 36.48 ± 9.12 years); and 76 (36.2%) HIV-positive patients on ART (27.6% male, 72.4% female; mean age, 39.00 ± 7.68 years). The QTc interval and resting HR were higher in HIV-positive, drug-naïve patients than in the other two groups (P < 0.001). Female sex was associated with prolonged QTc intervals in all groups. Conclusion: HIV-positive patients may be at higher risk of sudden cardiac death due to fatal arrhythmia secondary to QTc interval-related cardiac events. Healthcare providers should be aware that a prolonged QTc interval is a potential indicator of increased cardiovascular risk and should exercise caution in prescribing potentially QT-prolonging medications to HIV-positive patients.
MeSH term(s)	Adult ; Antiretroviral Therapy, Highly Active ; Blood Pressure ; Body Mass Index ; Cardiovascular Diseases ; Case-Control Studies ; Electrocardiography/drug effects ; Electrocardiography/methods ; Female ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Infections/physiopathology ; Heart Rate/drug effects ; Humans ; Long QT Syndrome/complications ; Long QT Syndrome/diagnosis ; Long QT Syndrome/physiopathology ; Male ; Middle Aged ; Nigeria ; Risk Factors
Language	English
Publishing date	2015-10
Publishing country	India
Document type	Journal Article
ZDB-ID	2165792-0
ISSN	0975-5764 ; 1596-3519
ISSN (online)	0975-5764
ISSN	1596-3519
DOI	10.4103/1596-3519.152072
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