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  1. Article ; Online: More on Pre-Covid-19, SARS-CoV-2-Negative MIS-C. Reply.

    Benezech, Sarah / Khoryati, Liliane / Belot, Alexandre

    The New England journal of medicine

    2024  Volume 390, Issue 8, Page(s) 771–772

    MeSH term(s) Child ; Humans ; COVID-19/complications ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2400160
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  2. Article ; Online: A new drug for rare diseases: pozelimab for CHAPLE disease.

    Belot, Alexandre / Benezech, Sarah / Tusseau, Maud

    Lancet (London, England)

    2024  Volume 403, Issue 10427, Page(s) 592–593

    MeSH term(s) Humans ; Rare Diseases/drug therapy ; Orphan Drug Production ; Antibodies, Monoclonal ; Drug Approval
    Chemical Substances Antibodies, Monoclonal
    Language English
    Publishing date 2024-01-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(23)02652-1
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  3. Article ; Online: Lupus systémique de l’enfant.

    Laurent, Audrey / Belot, Alexandre

    La Revue du praticien

    2023  Volume 73, Issue 7, Page(s) 775–781

    Abstract: CHILDHOOD-ONSET SYSTEMIC LUPUS. Childhood-onset systemic lupus (SL) is a rare multifactorial autoimmune disease belonging to connectivitis. Clinical presentation is very heterogeneous with multi-systemic involvement: skin, joint, renal, hematological, ... ...

    Title translation Childhood-onset systemic lupus.
    Abstract CHILDHOOD-ONSET SYSTEMIC LUPUS. Childhood-onset systemic lupus (SL) is a rare multifactorial autoimmune disease belonging to connectivitis. Clinical presentation is very heterogeneous with multi-systemic involvement: skin, joint, renal, hematological, neuropsychiatric, pulmonary, cardiac among others. Renal involvement is particularly frequent and severe in children and must be checked ou on a regular basis by screening for proteinuria. Lab exams show the production of antibodies directed against the native double-stranded DNA, excessive production of type I interferon, consumption of complement is observed during periods of flare-up. There are rare forms of monogenic SL which must be evocated in case of early-onset, familial cases or when occurring in boys.
    MeSH term(s) Child ; Male ; Humans ; Autoimmune Diseases ; Kidney ; Proteinuria/diagnosis ; Proteinuria/etiology
    Language French
    Publishing date 2023-10-05
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
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  4. Article ; Online: New classification for juvenile idiopathic arthritis: Is the Tower of Babel falling?

    Belot, Alexandre

    Joint bone spine

    2017  Volume 85, Issue 2, Page(s) 139–141

    MeSH term(s) Adolescent ; Antibodies, Antinuclear/immunology ; Arthritis, Juvenile/classification ; Arthritis, Juvenile/immunology ; Child ; Cytokines/metabolism ; Female ; Forecasting ; Humans ; Male ; Sensitivity and Specificity ; Severity of Illness Index
    Chemical Substances Antibodies, Antinuclear ; Cytokines
    Language English
    Publishing date 2017-08-05
    Publishing country France
    Document type Editorial ; Review
    ZDB-ID 2020487-5
    ISSN 1778-7254 ; 1297-319X
    ISSN (online) 1778-7254
    ISSN 1297-319X
    DOI 10.1016/j.jbspin.2017.08.001
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  5. Article ; Online: "P2RY8-son" break of tolerance promotes SLE.

    Tusseau, Maud / Belot, Alexandre

    The Journal of experimental medicine

    2021  Volume 219, Issue 1

    Abstract: In this issue of JEM, He et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20211004) associate novel P2RY8 genetic variants to lupus, expanding the field of monogenic autoimmunity. The authors demonstrate that P2RY8 prevents the expansion of DNA- ... ...

    Abstract In this issue of JEM, He et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20211004) associate novel P2RY8 genetic variants to lupus, expanding the field of monogenic autoimmunity. The authors demonstrate that P2RY8 prevents the expansion of DNA-reactive B cells by restraining B cell mobility and activation within the germinal center.
    MeSH term(s) B-Lymphocytes ; DNA ; Germinal Center ; Humans ; Lupus Erythematosus, Systemic/genetics ; Nuclear Family ; Receptors, Purinergic P2Y
    Chemical Substances P2RY8 protein, human ; Receptors, Purinergic P2Y ; DNA (9007-49-2)
    Language English
    Publishing date 2021-12-13
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20211972
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  6. Article ; Online: Compound Heterozygous Mutations in PRKCD Associated with Early-Onset Lupus and Severe and Invasive Infections in Siblings.

    Roderick, Marion R / Jefferson, Lucy / Renton, William / Belot, Alexandre

    Journal of clinical immunology

    2023  Volume 43, Issue 4, Page(s) 703–705

    MeSH term(s) Humans ; Siblings ; Mutation/genetics ; Phenotype ; Heterozygote ; Protein Kinase C-delta
    Chemical Substances PRKCD protein, human (EC 2.7.11.13) ; Protein Kinase C-delta (EC 2.7.11.13)
    Language English
    Publishing date 2023-01-18
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 779361-3
    ISSN 1573-2592 ; 0271-9142
    ISSN (online) 1573-2592
    ISSN 0271-9142
    DOI 10.1007/s10875-022-01416-0
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  7. Article ; Online: Multisystem Inflammatory Syndrome in Children in the United States.

    Belot, Alexandre / Levy-Bruhl, Daniel

    The New England journal of medicine

    2020  Volume 383, Issue 18, Page(s) 1793–1794

    MeSH term(s) COVID-19 ; Child ; Coronavirus Infections/epidemiology ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; Syndrome ; Systemic Inflammatory Response Syndrome ; United States/epidemiology
    Keywords covid19
    Language English
    Publishing date 2020-10-21
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2026136
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  8. Article ; Online: Superior Mesenteric Artery Pseudoaneurysm Induced by Accidental Ingestion of a Foreign Body: Case Report.

    Al Harthy, Ahmed / Belot, Alexandre / Feugier, Patrick

    EJVES vascular forum

    2022  Volume 54, Page(s) 36–39

    Abstract: Background: Superior mesenteric artery (SMA) pseudoaneurysm is a very rare condition, typically associated with trauma, inflammation, and infection, and as a post-operative complication. If left untreated it can lead to serious consequences such as ... ...

    Abstract Background: Superior mesenteric artery (SMA) pseudoaneurysm is a very rare condition, typically associated with trauma, inflammation, and infection, and as a post-operative complication. If left untreated it can lead to serious consequences such as rupture and fatal haemorrhage.
    Report: A 17 year old male presented to the emergency department with a history of intermittent progressive epigastric pain with no preceding significant symptoms of a possible cause. He was initially treated conservatively until the intensity of pain was so severe an abdominal computed tomography (CT) scan was justified. A pseudoaneurysm of the SMA was found. Full inflammatory and immunological workup was unremarkable. Repeat CT scan showed the SMA pseudoaneurysm was larger, mandating surgical intervention; the vascular surgeon suggested an exploratory laparotomy. Intra-operatively, unexpectedly, a wooden foreign body measuring 5.0 × 0.3 × 0.5 cm was seen once the aneurysm sac was opened. The pseudoaneurysm was repaired and the abdomen closed after ascertaining that all other organs were intact. The patient had a simple recovery with no complications and was discharged home. The follow up CT scans were unremarkable.
    Conclusion: Pseudoaneurysm of the SMA in the paediatric age group is an extremely rare and life threatening phenomenon. The clinical presentation may be subtle, leading to delayed diagnosis. Early surgical intervention may be lifesaving and prevent further complications.
    Language English
    Publishing date 2022-01-10
    Publishing country England
    Document type Case Reports
    ISSN 2666-688X
    ISSN (online) 2666-688X
    DOI 10.1016/j.ejvsvf.2022.01.002
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  9. Article ; Online: Therapy for Multisystem Inflammatory Syndrome in Children.

    Ouldali, Naïm / Belot, Alexandre / Angoulvant, François

    The New England journal of medicine

    2021  Volume 385, Issue 13, Page(s) e42

    MeSH term(s) COVID-19/complications ; Child ; Humans ; SARS-CoV-2 ; Syndrome ; Systemic Inflammatory Response Syndrome
    Language English
    Publishing date 2021-08-11
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2111096
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  10. Article ; Online: Rôle des macrophages dans le développement de l’arthrite juvénile - LACC1 fait-il le lien ?

    Mathieu, Anne-Laure / Omarjee, Ommar / Walzer, Thierry / Belot, Alexandre

    Medecine sciences : M/S

    2022  Volume 38, Issue 2, Page(s) 133–135

    Title translation Macrophage involvement in juvenile arthritis onset: LACC1 bridges the gap?
    MeSH term(s) Arthritis, Juvenile/complications ; Humans ; Intracellular Signaling Peptides and Proteins ; Macrophages
    Chemical Substances Intracellular Signaling Peptides and Proteins ; LACC1 protein, human
    Language French
    Publishing date 2022-02-18
    Publishing country France
    Document type News ; Research Support, Non-U.S. Gov't
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/2021253
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