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  1. AU=Borthwick L. A.
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  1. Artikel ; Online: Standardization of the Verification Nurse Role in the Delivery of Chemotherapy and Biotherapy.

    Caltieri, Lisa / Schumann, Mary / Hambright, Katie / Smith, Julie / Borthwick, Asya / Temperino, Linda

    Clinical journal of oncology nursing

    2024  Band 28, Heft 1, Seite(n) 101–106

    Abstract: After a chemotherapy overdose in 1994 resulted in the death of one patient and the permanent injury of another, the role of the verification nurse was created at a National Cancer Institute-designated comprehensive cancer c. ...

    Abstract After a chemotherapy overdose in 1994 resulted in the death of one patient and the permanent injury of another, the role of the verification nurse was created at a National Cancer Institute-designated comprehensive cancer c.
    Mesh-Begriff(e) Humans ; Nurse's Role ; Biological Therapy ; Reference Standards
    Sprache Englisch
    Erscheinungsdatum 2024-01-22
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2014665-6
    ISSN 1538-067X ; 1092-1095
    ISSN (online) 1538-067X
    ISSN 1092-1095
    DOI 10.1188/24.CJON.101-106
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: The IL-1 cytokine family and its role in inflammation and fibrosis in the lung.

    Borthwick, L A

    Seminars in immunopathology

    2016  Band 38, Heft 4, Seite(n) 517–534

    Abstract: The IL-1 cytokine family comprises 11 members (7 ligands with agonist activity, 3 receptor antagonists and 1 anti-inflammatory cytokine) and is recognised as a key mediator of inflammation and fibrosis in multiple tissues including the lung. IL-1 ... ...

    Abstract The IL-1 cytokine family comprises 11 members (7 ligands with agonist activity, 3 receptor antagonists and 1 anti-inflammatory cytokine) and is recognised as a key mediator of inflammation and fibrosis in multiple tissues including the lung. IL-1 targeted therapies have been successfully employed to treat a range of inflammatory conditions such as rheumatoid arthritis and gouty arthritis. This review will introduce the members of the IL-1 cytokine family, briefly discuss the cellular origins and cellular targets and provide an overview of the role of these molecules in inflammation and fibrosis in the lung.
    Mesh-Begriff(e) Animals ; Cytokines/genetics ; Cytokines/metabolism ; Fibrosis ; Humans ; Inflammation/etiology ; Inflammation/metabolism ; Inflammation/pathology ; Inflammation Mediators/metabolism ; Interleukin-1/genetics ; Interleukin-1/metabolism ; Lung Diseases/etiology ; Lung Diseases/metabolism ; Lung Diseases/pathology ; Receptors, Interleukin-1/metabolism ; Risk Factors ; Signal Transduction
    Chemische Substanzen Cytokines ; Inflammation Mediators ; Interleukin-1 ; Receptors, Interleukin-1
    Sprache Englisch
    Erscheinungsdatum 2016-07
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2316828-6
    ISSN 1863-2300 ; 1863-2297
    ISSN (online) 1863-2300
    ISSN 1863-2297
    DOI 10.1007/s00281-016-0559-z
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Computational NMR investigation of mixed-metal (Al,Sc)-MIL-53 and its phase transitions.

    Davis, Zachary H / Borthwick, Emma A L / Morris, Russell E / Ashbrook, Sharon E

    Physical chemistry chemical physics : PCCP

    2023  Band 25, Heft 39, Seite(n) 26486–26496

    Abstract: Compositionally complex metal-organic frameworks (MOFs) have properties that depend on local structure that is often difficult to characterise. In this paper a density functional theory (DFT) computational study of mixed-metal (Al,Sc)-MIL-53, a flexible ... ...

    Abstract Compositionally complex metal-organic frameworks (MOFs) have properties that depend on local structure that is often difficult to characterise. In this paper a density functional theory (DFT) computational study of mixed-metal (Al,Sc)-MIL-53, a flexible MOF with several different forms, was used to calculate the relative energetics of these forms and to predict NMR parameters that can be used to evaluate whether solid-state NMR spectroscopy can be used to differentiate, identify and characterise the forms adopted by mixed-metal MOFs of different composition. The NMR parameters can also be correlated with structural features in the different forms, giving fundamental insight into the nature and origin of the interactions that affect nuclear spins. Given the complexity of advanced NMR experiments required, and the potential need for expensive and difficult isotopic enrichment, the computational work is invaluable in predicting which experiments and approaches are likely to give the most information on the disorder, local structure and pore forms of these mixed-metal MOFs.
    Sprache Englisch
    Erscheinungsdatum 2023-10-11
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d3cp04147f
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Buch ; Online: Neural Locality Sensitive Hashing for Entity Blocking

    Wang, Runhui / Kong, Luyang / Tao, Yefan / Borthwick, Andrew / Golac, Davor / Johnson, Henrik / Hijazi, Shadie / Deng, Dong / Zhang, Yongfeng

    2024  

    Abstract: Locality-sensitive hashing (LSH) is a fundamental algorithmic technique widely employed in large-scale data processing applications, such as nearest-neighbor search, entity resolution, and clustering. However, its applicability in some real-world ... ...

    Abstract Locality-sensitive hashing (LSH) is a fundamental algorithmic technique widely employed in large-scale data processing applications, such as nearest-neighbor search, entity resolution, and clustering. However, its applicability in some real-world scenarios is limited due to the need for careful design of hashing functions that align with specific metrics. Existing LSH-based Entity Blocking solutions primarily rely on generic similarity metrics such as Jaccard similarity, whereas practical use cases often demand complex and customized similarity rules surpassing the capabilities of generic similarity metrics. Consequently, designing LSH functions for these customized similarity rules presents considerable challenges. In this research, we propose a neuralization approach to enhance locality-sensitive hashing by training deep neural networks to serve as hashing functions for complex metrics. We assess the effectiveness of this approach within the context of the entity resolution problem, which frequently involves the use of task-specific metrics in real-world applications. Specifically, we introduce NLSHBlock (Neural-LSH Block), a novel blocking methodology that leverages pre-trained language models, fine-tuned with a novel LSH-based loss function. Through extensive evaluations conducted on a diverse range of real-world datasets, we demonstrate the superiority of NLSHBlock over existing methods, exhibiting significant performance improvements. Furthermore, we showcase the efficacy of NLSHBlock in enhancing the performance of the entity matching phase, particularly within the semi-supervised setting.
    Schlagwörter Computer Science - Information Retrieval ; Computer Science - Databases
    Thema/Rubrik (Code) 005 ; 006
    Erscheinungsdatum 2024-01-31
    Erscheinungsland us
    Dokumenttyp Buch ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Nation-wide surveillance of ticks (Acari: Argasidae) on bats (Chiroptera) in Singapore.

    Kwak, Mackenzie L / Hitch, Alan T / Low, Dolyce H W / Borthwick, Sophie A / Markowsky, Greg / McInnes, Daniel / Smith, Gavin J D / Nakao, Ryo / Mendenhall, Ian H

    Acta tropica

    2024  Band 256, Seite(n) 107248

    Abstract: Bats and ticks are important sources of zoonotic pathogens. Therefore, understanding the diversity, distribution, and ecology of both groups is crucial for public health preparedness. Soft ticks (Argasidae) are a major group of ectoparasites commonly ... ...

    Abstract Bats and ticks are important sources of zoonotic pathogens. Therefore, understanding the diversity, distribution, and ecology of both groups is crucial for public health preparedness. Soft ticks (Argasidae) are a major group of ectoparasites commonly associated with bats. The multi-host life cycle of many argasids make them important vectors of pathogens. Over nine years (2011-2020), surveillance was undertaken to identify the ticks associated with common bats in Singapore. During this period, the bat tick Ornithodoros batuensis was detected within populations of two cave roosting bat species: Eonycteris spelaea and Penthetor lucasi. We examined the relationship between bat species, roosting behaviour, and probability of O. batuensis infestation. We also estimated the relationship between bat life history variables (body condition index, sex, and age) on the probability of infestation and tick count. This represents the first detection of O. batuensis and the genus Ornithodoros within Singapore. We also provide evidence of the continued persistence of Argas pusillus in Singapore with the second local record.
    Sprache Englisch
    Erscheinungsdatum 2024-05-09
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 210415-5
    ISSN 1873-6254 ; 0001-706X
    ISSN (online) 1873-6254
    ISSN 0001-706X
    DOI 10.1016/j.actatropica.2024.107248
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Epigenetic reprogramming in liver fibrosis and cancer.

    Wilson, Caroline L / Mann, Derek A / Borthwick, Lee A

    Advanced drug delivery reviews

    2017  Band 121, Seite(n) 124–132

    Abstract: Novel insights into the epigenetic control of chronic liver diseases are now emerging. Recent advances in our understanding of the critical roles of DNA methylation, histone modifications and ncRNA may now be exploited to improve management of fibrosis/ ... ...

    Abstract Novel insights into the epigenetic control of chronic liver diseases are now emerging. Recent advances in our understanding of the critical roles of DNA methylation, histone modifications and ncRNA may now be exploited to improve management of fibrosis/cirrhosis and cancer. Furthermore, improved technologies for the detection of epigenetic markers from patients' blood and tissues will vastly improve diagnosis, treatment options and prognostic tracking. The aim of this review is to present recent findings from the field of liver epigenetics and to explore their potential for translation into therapeutics to prevent disease promoting epigenome reprogramming and reverse epigenetic changes.
    Mesh-Begriff(e) Animals ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Cellular Reprogramming/genetics ; Epigenesis, Genetic/genetics ; Humans ; Liver Cirrhosis/genetics ; Liver Cirrhosis/metabolism ; Liver Cirrhosis/pathology ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology
    Sprache Englisch
    Erscheinungsdatum 2017-10-25
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 639113-8
    ISSN 1872-8294 ; 0169-409X
    ISSN (online) 1872-8294
    ISSN 0169-409X
    DOI 10.1016/j.addr.2017.10.011
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Advanced Physiotherapy Practice: A qualitative study on the potential challenges and barriers to implementation in Ghana.

    Tawiah, Andrews Kwabena / Borthwick, Alan / Woodhouse, Linda

    Physiotherapy theory and practice

    2018  Band 36, Heft 2, Seite(n) 307–315

    Abstract: ... ...

    Abstract Objective
    Mesh-Begriff(e) Attitude of Health Personnel ; Developing Countries ; Female ; Ghana ; Health Services Accessibility/organization & administration ; Humans ; Male ; Physical Therapy Modalities ; Physical Therapy Specialty/organization & administration ; Qualitative Research
    Sprache Englisch
    Erscheinungsdatum 2018-06-13
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1045333-7
    ISSN 1532-5040 ; 0959-3985
    ISSN (online) 1532-5040
    ISSN 0959-3985
    DOI 10.1080/09593985.2018.1484535
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Nanostructured Channel for Improving Emission Efficiency of Hybrid Light-Emitting Field-Effect Transistors.

    Galán-González, Alejandro / Pander, Piotr / MacKenzie, Roderick C I / Bowen, Leon / Zeze, Dagou A / Borthwick, Robert J / Thompson, Richard L / Dias, Fernando B / Chaudhry, Mujeeb Ullah

    ACS photonics

    2023  Band 10, Heft 12, Seite(n) 4315–4321

    Abstract: We report on the mechanism of enhancing the luminance and external quantum efficiency (EQE) by developing nanostructured channels in hybrid (organic/inorganic) light-emitting transistors (HLETs) that combine a solution-processed oxide and a polymer ... ...

    Abstract We report on the mechanism of enhancing the luminance and external quantum efficiency (EQE) by developing nanostructured channels in hybrid (organic/inorganic) light-emitting transistors (HLETs) that combine a solution-processed oxide and a polymer heterostructure. The heterostructure comprised two parts: (i) the zinc tin oxide/zinc oxide (ZTO/ZnO), with and without ZnO nanowires (NWs) grown on the top of the ZTO/ZnO stack, as the charge transport layer and (ii) a polymer Super Yellow (SY, also known as PDY-132) layer as the light-emitting layer. Device characterization shows that using NWs significantly improves luminance and EQE (≈1.1% @ 5000 cd m
    Sprache Englisch
    Erscheinungsdatum 2023-12-10
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2330-4022
    ISSN 2330-4022
    DOI 10.1021/acsphotonics.3c01080
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: miRNA Expression in Fibroblastic Foci within Idiopathic Pulmonary Fibrosis Lungs Reveals Novel Disease-Relevant Pathways.

    Sabater, Laura / Gossart, Jean B / Hernandez, Inmaculada / Rico, Daniel / Blanchard, Andy / Borthwick, Lee A / Fisher, Andrew J / Majo, Joaquim / Jiwa, Kasim / Collins, Amy / Abbate, Giuseppe / Oakley, Fiona / Mann, Derek A / Mann, Jelena

    The American journal of pathology

    2023  Band 193, Heft 4, Seite(n) 417–429

    Abstract: miRNAs are 22 nucleotides long and belong to a class of noncoding RNAs that plays an important role in regulating gene expression at a post-transcriptional level. Studies show aberrant levels of miRNAs to be associated with profibrotic processes in ... ...

    Abstract miRNAs are 22 nucleotides long and belong to a class of noncoding RNAs that plays an important role in regulating gene expression at a post-transcriptional level. Studies show aberrant levels of miRNAs to be associated with profibrotic processes in idiopathic pulmonary fibrosis (IPF). However, most of these studies used whole IPF tissue or in vitro monocultures in which fibrosis was artificially induced. The current study used laser microdissection to collect fibroblastic foci (FF), the key pathologic lesion in IPF, isolated miRNAs, and compared their expression levels with those found in whole IPF lung tissue and/or in vitro cultured fibroblast from IPF or normal lungs. Sequencing libraries were generated, and data generated were bioinformatically analyzed. A total of 18 miRNAs were significantly overexpressed in FF tissue when compared with whole IPF tissue. Of those, 15 were unique to FF. Comparison of FF with cultured IPF fibroblasts also revealed differences in miRNA composition that impacted several signaling pathways. The miRNA composition of FF is both overlapping and distinct from that of whole IPF tissue or cultured IPF fibroblasts and highlights the importance of characterizing FF biology as a phenotypically and functionally discrete tissue microenvironment.
    Mesh-Begriff(e) Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Lung/pathology ; Idiopathic Pulmonary Fibrosis/metabolism ; Fibroblasts/metabolism
    Chemische Substanzen MicroRNAs
    Sprache Englisch
    Erscheinungsdatum 2023-01-20
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2943-9
    ISSN 1525-2191 ; 0002-9440
    ISSN (online) 1525-2191
    ISSN 0002-9440
    DOI 10.1016/j.ajpath.2022.12.015
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Cencurut virus: A novel

    Low, Dolyce H W / Ch'ng, Lena / Su, Yvonne C F / Linster, Martin / Zhang, Rong / Zhuang, Yan / Kwak, Mackenzie L / Borthwick, Sophie A / Hitch, Alan T / Smith, Gavin J D / Mendenhall, Ian H

    One health (Amsterdam, Netherlands)

    2023  Band 16, Seite(n) 100529

    Abstract: ... ...

    Abstract Orthonairovirus
    Sprache Englisch
    Erscheinungsdatum 2023-03-29
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 2834831-X
    ISSN 2352-7714
    ISSN 2352-7714
    DOI 10.1016/j.onehlt.2023.100529
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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