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  1. Article ; Online: Is

    Morton, Arianna B / Vareechon, Chairut / Pettengill, Matthew A

    Microbiology spectrum

    2023  , Page(s) e0129223

    Language English
    Publishing date 2023-09-06
    Publishing country United States
    Document type Letter
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.01292-23
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  2. Article: Cladophialophora bantiana

    Tsang, Daniel / Haddad, Sara / Sahin, Ziver / Vareechon, Chairut / Sternlieb, Mitchell / Royer, Tricia

    IDCases

    2022  Volume 30, Page(s) e01639

    Abstract: Recipients of solid organ transplants are at risk for a variety of infections due to their immunocompromised status. The types of infections are often correlated to the timing from their transplant. After about six to twelve months, transplant recipients ...

    Abstract Recipients of solid organ transplants are at risk for a variety of infections due to their immunocompromised status. The types of infections are often correlated to the timing from their transplant. After about six to twelve months, transplant recipients remain at risk for typical community acquired pathogens, late viral infections, and fungal infections including atypical molds such as
    Language English
    Publishing date 2022-11-05
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2745454-X
    ISSN 2214-2509
    ISSN 2214-2509
    DOI 10.1016/j.idcr.2022.e01639
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  3. Article: Eight-Year-Old Male With Primary Amebic Meningoencephalitis.

    Vareechon, Chairut / Tarro, Thomas / Polanco, Claudia / Anand, Vikram / Pannaraj, Pia S / Dien Bard, Jennifer

    Open forum infectious diseases

    2019  Volume 6, Issue 8, Page(s) ofz349

    Abstract: Naegleria ... ...

    Abstract Naegleria fowleri
    Language English
    Publishing date 2019-07-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofz349
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  4. Article: Infective Endocarditis in a Pediatric Patient.

    Vareechon, Chairut / Bender, Jeffrey M / Zhou, Shengmei / Dien Bard, Jennifer

    The journal of applied laboratory medicine

    2018  Volume 3, Issue 4, Page(s) 720–723

    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Bacteremia/diagnosis ; Bacteremia/microbiology ; Bacteremia/therapy ; Blood Culture ; Cardiac Surgical Procedures ; Child ; Computed Tomography Angiography ; Echocardiography ; Endocarditis, Bacterial/blood ; Endocarditis, Bacterial/diagnosis ; Endocarditis, Bacterial/microbiology ; Endocarditis, Bacterial/therapy ; Humans ; Male ; Pneumococcal Infections/blood ; Pneumococcal Infections/diagnosis ; Pneumococcal Infections/microbiology ; Pneumococcal Infections/therapy ; Streptococcus pneumoniae/isolation & purification ; Treatment Outcome ; Tricuspid Valve/diagnostic imaging ; Tricuspid Valve/surgery ; Tricuspid Valve Insufficiency/blood ; Tricuspid Valve Insufficiency/diagnosis ; Tricuspid Valve Insufficiency/microbiology ; Tricuspid Valve Insufficiency/therapy
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2018-11-30
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 2576-9456
    ISSN 2576-9456
    DOI 10.1373/jalm.2018.027722
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A 5-year study of the performance of the Verigene Gram-positive blood culture panel in a pediatric hospital.

    Vareechon, Chairut / Mestas, Javier / Polanco, Claudia M / Dien Bard, Jennifer

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

    2018  Volume 37, Issue 11, Page(s) 2091–2096

    Abstract: High accuracy of direct from positive blood culture molecular panels is imperative, particularly for the detection of resistance determinants as it allows for antimicrobial optimization prior to conventional susceptibility testing. In this study, we ... ...

    Abstract High accuracy of direct from positive blood culture molecular panels is imperative, particularly for the detection of resistance determinants as it allows for antimicrobial optimization prior to conventional susceptibility testing. In this study, we provide extensive data since implementation of the Verigene Gram-positive blood culture panel (BC-GP) in 2013. Within 5 years, 1636 blood culture bottles positive for a Gram-positive organism were tested on the BC-GP panel. The BC-GP panel identified 1520 Gram-positive organisms in 1636 (92.9%) blood cultures tested. For positive blood cultures, we observed 96.4% (806/834) concordance to the species level. Compared with conventional antimicrobial susceptibility testing, the positive percent agreement (PPA) of methicillin-resistant SA (MRSA) (50) and methicillin-resistant SE (MRSE) (365) was 100%. The mecA gene was detected in two methicillin-susceptible Staphylococcus aureus (MSSA) and one methicillin-susceptible S. epidermidis (MSSE) with a negative percent agreement (NPA) of 99.1% (221/223) and 99.2% (120/121), respectively. The PPA and NPA for vancomycin-resistant Enterococcus faecium (VRE) was 100%. The BC-GP panel demonstrated excellent performance and clinicians can confidently de-escalate antimicrobial therapy in the absence of mecA and vanA/B gene.
    MeSH term(s) Bacteremia ; Bacteriological Techniques ; Blood Culture ; Cross Infection ; Drug Resistance, Bacterial ; Genes, Bacterial ; Gram-Positive Bacteria/drug effects ; Gram-Positive Bacteria/genetics ; Gram-Positive Bacterial Infections/diagnosis ; Gram-Positive Bacterial Infections/microbiology ; Hospitals, Pediatric ; Humans ; Molecular Diagnostic Techniques ; Retrospective Studies
    Language English
    Publishing date 2018-08-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 603155-9
    ISSN 1435-4373 ; 0934-9723 ; 0722-2211
    ISSN (online) 1435-4373
    ISSN 0934-9723 ; 0722-2211
    DOI 10.1007/s10096-018-3343-2
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  6. Article ; Online: The prevalence of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) IgG antibodies in intensive care unit (ICU) healthcare personnel (HCP) and its implications-a single-center, prospective, pilot study.

    Mughal, Mohsin Sheraz / Kaur, Ikwinder Preet / Patton, Chandler D / Mikhail, Nagy H / Vareechon, Chairut / Granet, Kenneth M

    Infection control and hospital epidemiology

    2020  Volume 42, Issue 5, Page(s) 638–639

    MeSH term(s) Antibodies, Viral ; Antibody Formation ; COVID-19 ; Delivery of Health Care ; Humans ; Immunoglobulin G ; Intensive Care Units ; Pilot Projects ; Prevalence ; Prospective Studies ; SARS-CoV-2
    Chemical Substances Antibodies, Viral ; Immunoglobulin G
    Keywords covid19
    Language English
    Publishing date 2020-06-12
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 639378-0
    ISSN 1559-6834 ; 0195-9417 ; 0899-823X
    ISSN (online) 1559-6834
    ISSN 0195-9417 ; 0899-823X
    DOI 10.1017/ice.2020.298
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  7. Article ; Online: Notes from the Field: Fatal Naegleria fowleri Meningoencephalitis After Swimming in Hot Spring Water - California, 2018.

    Vugia, Duc J / Richardson, James / Tarro, Thomas / Vareechon, Chairut / Pannaraj, Pia S / Traub, Elizabeth / Cope, Jennifer R / Balter, Sharon

    MMWR. Morbidity and mortality weekly report

    2019  Volume 68, Issue 36, Page(s) 793–794

    Language English
    Publishing date 2019-09-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 412775-4
    ISSN 1545-861X ; 0149-2195
    ISSN (online) 1545-861X
    ISSN 0149-2195
    DOI 10.15585/mmwr.mm6836a3
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  8. Article: The prevalence of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) IgG antibodies in intensive care unit (ICU) healthcare personnel (HCP) and its implications-a single-center, prospective, pilot study

    Mughal, Mohsin Sheraz / Kaur, Ikwinder Preet / Patton, Chandler D / Mikhail, Nagy H / Vareechon, Chairut / Granet, Kenneth M

    Infect Control Hosp Epidemiol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #615788
    Database COVID19

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  9. Article ; Online: The prevalence of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) IgG antibodies in intensive care unit (ICU) healthcare personnel (HCP) and its implications—a single-center, prospective, pilot study

    Mughal, Mohsin Sheraz / Kaur, Ikwinder Preet / Patton, Chandler D. / Mikhail, Nagy H. / Vareechon, Chairut / Granet, Kenneth M.

    Infection Control & Hospital Epidemiology

    2020  , Page(s) 1–2

    Keywords Microbiology (medical) ; Epidemiology ; Infectious Diseases ; covid19
    Language English
    Publisher Cambridge University Press (CUP)
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 639378-0
    ISSN 1559-6834 ; 0195-9417 ; 0899-823X
    ISSN (online) 1559-6834
    ISSN 0195-9417 ; 0899-823X
    DOI 10.1017/ice.2020.298
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  10. Article ; Online: Pseudomonas aeruginosa Effector ExoS Inhibits ROS Production in Human Neutrophils.

    Vareechon, Chairut / Zmina, Stephanie Elizabeth / Karmakar, Mausita / Pearlman, Eric / Rietsch, Arne

    Cell host & microbe

    2017  Volume 21, Issue 5, Page(s) 611–618.e5

    Abstract: Neutrophils are the first line of defense against bacterial infections, and the generation of reactive oxygen species is a key part of their arsenal. Pathogens use detoxification systems to avoid the bactericidal effects of reactive oxygen species. Here ... ...

    Abstract Neutrophils are the first line of defense against bacterial infections, and the generation of reactive oxygen species is a key part of their arsenal. Pathogens use detoxification systems to avoid the bactericidal effects of reactive oxygen species. Here we demonstrate that the Gram-negative pathogen Pseudomonas aeruginosa is susceptible to reactive oxygen species but actively blocks the reactive oxygen species burst using two type III secreted effector proteins, ExoS and ExoT. ExoS ADP-ribosylates Ras and prevents it from interacting with and activating phosphoinositol-3-kinase (PI3K), which is required to stimulate the phagocytic NADPH-oxidase that generates reactive oxygen species. ExoT also affects PI3K signaling via its ADP-ribosyltransferase activity but does not act directly on Ras. A non-ribosylatable version of Ras restores reactive oxygen species production and results in increased bacterial killing. These findings demonstrate that subversion of the host innate immune response requires ExoS-mediated ADP-ribosylation of Ras in neutrophils.
    MeSH term(s) ADP Ribose Transferases/antagonists & inhibitors ; ADP Ribose Transferases/metabolism ; ADP-Ribosylation/drug effects ; Animals ; Bacterial Toxins/antagonists & inhibitors ; Bacterial Toxins/immunology ; Colony Count, Microbial ; Epithelium/pathology ; Eye/pathology ; Female ; GTPase-Activating Proteins/antagonists & inhibitors ; Humans ; Immunity, Innate ; Mice, Inbred C57BL ; NADPH Oxidases/metabolism ; Neutrophils/enzymology ; Neutrophils/immunology ; Neutrophils/metabolism ; Phagocytosis ; Phosphatidylinositol 3-Kinases/metabolism ; Pseudomonas Infections/immunology ; Pseudomonas Infections/microbiology ; Pseudomonas aeruginosa/immunology ; Pseudomonas aeruginosa/metabolism ; Pseudomonas aeruginosa/pathogenicity ; Reactive Oxygen Species/metabolism ; Signal Transduction/drug effects ; Survival Analysis ; Type III Secretion Systems/drug effects ; ras Proteins/drug effects ; ras Proteins/metabolism
    Chemical Substances Bacterial Toxins ; ExoT protein, Pseudomonas aeruginosa ; GTPase-Activating Proteins ; Reactive Oxygen Species ; Type III Secretion Systems ; NADPH Oxidases (EC 1.6.3.-) ; ADP Ribose Transferases (EC 2.4.2.-) ; exoenzyme S (EC 2.4.2.31) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; ras Proteins (EC 3.6.5.2)
    Language English
    Publishing date 2017-05-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2278004-X
    ISSN 1934-6069 ; 1931-3128
    ISSN (online) 1934-6069
    ISSN 1931-3128
    DOI 10.1016/j.chom.2017.04.001
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