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Article ; Online: Correction to: The cost analysis of flexible ureteroscopic lithotripsy in 302 cases.

Gurbuz, Cenk / Atış, Gokhan / Arikan, Ozgur / Efiloglu, Ozgur / Yıldırım, Asıf / Danacıoglu, Onur / Caskurlu, Turhan

2022 Volume 50, Issue 4, Page(s) 509

Language	English
Publishing date	2022-04-28
Publishing country	Germany
Document type	Published Erratum
ZDB-ID	2703553-0
ISSN	2194-7236 ; 2194-7228
ISSN (online)	2194-7236
ISSN	2194-7228
DOI	10.1007/s00240-022-01329-y
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Article: The Clinical Impact of Physical Activity on the Diagnosis of Prostate Cancer and Postprostatectomy Functional Outcomes in the Elderly.

Kazan, Ozgur / Akalin, Mustafa Kaan / Culpan, Meftun / Atis, Gokhan / Yildirim, Asif

Sisli Etfal Hastanesi tip bulteni

2023 Volume 57, Issue 2, Page(s) 210–215

Abstract: Objectives: The effect of physical activity on prostate cancer is controversial. We aimed to investigate the effect of physical activity on prostate cancer detection and functional outcomes after radical prostatectomy.: Methods: Between 2019 and 2020, ...

Abstract	Objectives: The effect of physical activity on prostate cancer is controversial. We aimed to investigate the effect of physical activity on prostate cancer detection and functional outcomes after radical prostatectomy. Methods: Between 2019 and 2020, 166 patients who underwent prostate biopsy were included. The physical activity scores of patients were evaluated by the Physical Activity Scale for the Elderly (PASE) questionnaire before the procedure. PASE scores were compared between the patients with and without prostate cancer and local and metastatic aggressiveness of cancer. Patients who underwent radical prostatectomy were followed up for 12 months to analyze the effect of physical activity on erectile dysfunction (ED) and urinary incontinence (UI). Results: There was no significant difference between patients with and without prostate cancer in terms of PASE scores (187.7 vs. 195.5, p=0.665). PASE scores were also similar when separated according to D'Amico risk classification and metastatic events. Twenty-seven patients who underwent radical prostatectomy were evaluated in terms of functional outcomes at the first year of surgery. PASE scores of the patients with severe ED were lower than mild-moderate ED, but no statistically significant difference was observed (197.0 vs. 268.5, p=0.267). Patients with persistent UI had a significantly lower PASE score overall than continent patients (128.3 vs. 271.1, p=0.001), and PASE score was the only independent predictor of UI following radical prostatectomy. Conclusion: The effect of physical activity on prostate cancer development or aggressiveness could not be determined. Physical activity was associated with a reduced risk of UI following radical prostatectomy.
Language	English
Publishing date	2023-06-20
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	3026862-X
ISSN	1308-5123 ; 1302-7123
ISSN (online)	1308-5123
ISSN	1302-7123
DOI	10.14744/SEMB.2023.32549
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Oncologic outcomes of postoperative adjuvant versus salvage radiotherapy in prostate cancer.

Şendoğan, Furkan / Turan, Turgay / Keser, Ferhat / Hancilar, Tayfun / Atis, Gokhan / Yildirim, Asif

Central European journal of urology

2023 Volume 76, Issue 2, Page(s) 109–115

Abstract: Introduction: The aim of this study was to compare the long-term oncological results of patients with the diagnosis of prostate cancer who underwent open radical retropubic prostatectomy (RRP) and subsequent adjuvant (ART) or salvage radiotherapy (SRT).! ...

Abstract	Introduction: The aim of this study was to compare the long-term oncological results of patients with the diagnosis of prostate cancer who underwent open radical retropubic prostatectomy (RRP) and subsequent adjuvant (ART) or salvage radiotherapy (SRT). Material and methods: A total of 145 patients underwent open RRP for prostate cancer and subsequent ART or SRT postoperatively between 2010 and 2019. ART (n = 56) is defined as the group of patients with prostate-specific antigen (PSA) <0.2 ng/mL or with positive lymph nodes without PSA increase who received radiotherapy within the first 6 months of urinary continence. SRT (n = 89) is defined as the group of patients with PSA >0.2 ng/mL who received RT before PSA amounted to 0.5 ng/mL. Results: Statistically no significant difference was found between groups in terms of age, prostate volume, final pathology Gleason scores, lymphadenectomy, duration of androgen deprivation therapy (ADT), time to relapse after radiotherapy, development of biochemical recurrence and disease progression. Extraprostatic extension, seminal vesicle invasion and surgical margin positivity were significantly higher in the ART group. No difference was found between the groups in terms of biochemical recurrence-free survival, while cancer-specific survival and overall survival rates were significantly higher in the SRT group. Conclusions: It was found that cancer-specific and overall survival was better in the SRT group. It will be more appropriate to follow-up until the recurrence and then to perform SRT after the relapse in the postoperative period.
Language	English
Publishing date	2023-03-31
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2672528-9
ISSN	2080-4873 ; 2080-4806
ISSN (online)	2080-4873
ISSN	2080-4806
DOI	10.5173/ceju.2023.190
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Article ; Online: Early versus delayed ureterolithotripsy following obstructive acute pyelonephritis treatment.

Kazan, Huseyin Ozgur / Cicek, Muhammet / Caskurlu, Hulya / Atis, Ramazan Gokhan / Yildirim, Asif

Urologia

2023 Volume 91, Issue 1, Page(s) 147–153

Abstract: Background and objectives: There is no recommendation on the timing of ureterolithotripsy after the treatment of obstructive acute pyelonephritis (APN). The effect of early and delayed ureterolithotripsy on postoperative urinary tract infection (UTI) ... ...

Abstract	Background and objectives: There is no recommendation on the timing of ureterolithotripsy after the treatment of obstructive acute pyelonephritis (APN). The effect of early and delayed ureterolithotripsy on postoperative urinary tract infection (UTI) and other complications was investigated. Methods: Patients who underwent ureterolithotripsy after obstructive APN treatment between February 2017 and August 2021 were divided into two groups, those operated during hospitalization and those operated within 3 months after discharge. Two groups were compared in terms of stone-free status, postoperative complications, postoperative UTI, and urosepsis rates. Results: Of the 91 patients included in the study, 68 were in the early ureterolithotripsy group, while 23 patients were in the delayed ureterolithotripsy group. The postoperative UTI rate was significantly higher in patients who underwent early ureterolithotripsy (29.4% vs 8.7%, Conclusion: There is no consensus on the timing of stone removal after treatment of obstructive APN. Early ureterolithoripsy and moderate/severe perinephric fat stranding on non-contrast CT are risk factors for postoperative UTI.
MeSH term(s)	Humans ; Ureteral Calculi/therapy ; Pyelonephritis ; Urinary Tract Infections ; Kidney ; Risk Factors
Language	English
Publishing date	2023-11-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	204043-8
ISSN	1724-6075 ; 0376-0057 ; 0391-5603
ISSN (online)	1724-6075
ISSN	0376-0057 ; 0391-5603
DOI	10.1177/03915603231210604
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Article ; Online: The effect of bioelectric impedance analysis on the success of extracorporeal shock wave lithotripsy.

Keser, Ferhat / Culpan, Meftun / Cakici, Mehmet Caglar / Atis, Ramazan Gokhan / Yildirim, Asif

Urolithiasis

2023 Volume 51, Issue 1, Page(s) 93

Abstract: Bioelectric impedance analysis (BIA) is a non-invasive method that can show the distribution of fatty and lean mass of the body. In this study, we aimed to determine the effect of BIA on extracorporeal shock wave lithotripsy (SWL) success. Our secondary ... ...

Abstract	Bioelectric impedance analysis (BIA) is a non-invasive method that can show the distribution of fatty and lean mass of the body. In this study, we aimed to determine the effect of BIA on extracorporeal shock wave lithotripsy (SWL) success. Our secondary aim was to determine the factors predicting transition from a single SWL session to multiple sessions. Patients who underwent SWL due to kidney stones were prospectively included. Demographics, pre-procedural BIA parameters (fat percentage, obesity degree, muscle mass, total water and metabolic rate), stone parameters, and number of SWL sessions were recorded. Univariate and multivariate regression analyzes were made to determine independent risk factors for success. Then, the successful group was divided into two subgroups according to their SWL session number as one session or multiple sessions and multivariate regression analysis was made to determine independent risk factors. Stone-free status was achieved in 114 (61.2%) of 186 patients. Stone Hounsfield Unit (HU) (OR: 0.998, p = 0.004), stone volume (OR: 0.999, p = 0.023) and fat percentage (OR: 0.933, p = 0.001) were independent risk factors for stone-free status in multivariate analysis. HU value of the stone (OR: 1.003, p = 0.005) and age (OR: 1.032, p = 0.031) were determined as independent risk factors for transition to multiple sessions in the subgroup analysis of the successful group. Fat percentage, stone volume, and stone density were determined as factors affecting success in SWL. Routine use of BIA may be considered to predict success before SWL. The probability of SWL success in a single session decreases as the age and stone's HU value increase.
MeSH term(s)	Humans ; Electric Impedance ; Tomography, X-Ray Computed/methods ; Kidney Calculi/therapy ; Lithotripsy/adverse effects ; Lithotripsy/methods ; Multivariate Analysis ; Treatment Outcome ; Ureteral Calculi/therapy ; Retrospective Studies
Language	English
Publishing date	2023-07-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2703553-0
ISSN	2194-7236 ; 2194-7228
ISSN (online)	2194-7236
ISSN	2194-7228
DOI	10.1007/s00240-023-01465-z
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Article: Primary Epithelioid Angiomyolipoma of Adrenal Gland: Case Report and Literature Review.

Cicek, Muhammet / Kazan, Huseyin Ozgur / Atis, Ramazan Gokhan / Yildirim, Asif

Prague medical report

2022 Volume 123, Issue 3, Page(s) 199–205

Abstract: Angiomyolipomas (AMLs) are mesenchymal tumours derived from perivascular epithelioid cells. Although AMLs are generally known as benign and extremely rare epithelioid variants of AML, they may be potentially aggressive. Here we present an adrenal ... ...

Abstract	Angiomyolipomas (AMLs) are mesenchymal tumours derived from perivascular epithelioid cells. Although AMLs are generally known as benign and extremely rare epithelioid variants of AML, they may be potentially aggressive. Here we present an adrenal epithelioid AML and the literature review. A 64-year-old female patient was diagnosed with a left adrenal mass detected incidentally on ultrasonography. Preoperative abdominal CT (computed tomography) showed a 95×68 mm heterogeneous contrast enhancement mass lesion in the left adrenal gland. The lesion was hormone inactive in the endocrinological evaluation, and left laparoscopic adrenalectomy was performed. The patient was discharged on the 2nd postoperative day. Pathology was reported as epithelioid subtype AML. The patient has no local recurrence or metastasis in the 18-month follow-up period and imaging. Adrenal epithelioid AML is an extremely rare and potentially aggressive variant. According to the literature, open or laparoscopic adrenalectomy seems to be suitable option for disease management.
MeSH term(s)	Adrenal Glands/pathology ; Adrenalectomy ; Angiomyolipoma/diagnosis ; Angiomyolipoma/pathology ; Angiomyolipoma/surgery ; Female ; Hormones ; Humans ; Leukemia, Myeloid, Acute/surgery ; Middle Aged
Chemical Substances	Hormones
Language	English
Publishing date	2022-09-01
Publishing country	Czech Republic
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	2148569-0
ISSN	1214-6994
ISSN	1214-6994
DOI	10.14712/23362936.2022.19
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Article: The clinical impact of androgen deprivation therapy on SARS-CoV-2 infection rates and disease severity.

Kazan, Özgür / Çulpan, Meftun / Efiloğlu, Özgür / Atiş, Gökhan / Yildirim, Asıf

Turkish journal of urology

2022 Volume 47, Issue 6, Page(s) 495–500

Abstract: Objective: The protective effect of androgen deprivation therapy (ADT) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel hypothesis. ADT may protect patients with prostate cancer through the inhibition of androgen receptor- ... ...

Abstract	Objective: The protective effect of androgen deprivation therapy (ADT) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel hypothesis. ADT may protect patients with prostate cancer through the inhibition of androgen receptor-dependent transmembrane serine protease type 2. We analyzed the role of ADT on SARS-CoV-2 infection risk and disease severity. Material and methods: Between August 2020 and June 2021, patients with prostate cancer were included in our study. Patients were divided into two groups as men receiving ADT or not. Patients' characteristics such as prostate cancer grade and stage, comorbidities, SARS-CoV-2 infection status, and infection severity were assessed. SARS-CoV-2-infected close relatives and patients' compliance with the precautions against SARSCoV- 2 were also analyzed. Results: A total of 365 patients, 138 (37.8%) with ADT and 227 (62.2%) without ADT, were included in our analysis. Patients with ADT were older (71.8 vs 66.9 years, P ¼ .001) and had a higher rate of chronic obstructive pulmonary disease (11.6% vs 5.7%, P ¼ .044). Patients receiving ADT were more often locally advanced and metastatic (80.4% vs 32.6%, P ¼ .001). SARS-CoV-2 infection rates were statistically similar between patients who received and did not receive ADT (9.4% vs 13.2%, P ¼ .275, respectively). There was no significant difference between two groups in terms of hospitalization rates (2.9% vs 0.9%, P ¼ .205). In multivariate analysis, the presence of SARS-CoV-2-infected close relatives and precautions score were only independent predictors for both risk of SARS-CoV-2 infection and infection severity. Conclusion: We could not find any effect of ADT on risk and severity of SARS-CoV-2 infection. SARSCoV- 2 infection and hospitalization rates were similar between patients with and without ADT.
Language	English
Publishing date	2022-02-03
Publishing country	Turkey
Document type	Journal Article
ISSN	2149-3235
ISSN	2149-3235
DOI	10.5152/tud.2021.21278
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Article ; Online: What is the best anesthesia method for circumcision? Comparison of local and general anesthesia

Emre Kandemir / Kenan Toprak / Ahmet Tahra / Özgür Efiloğlu / Gökhan Atış / Asıf Yıldırım

Yeni Üroloji Dergisi, Vol 18, Iss 1, Pp 16-

Prospective clinical study

2023 Volume 23

Abstract: Objective: It was aimed to compare the methods of local anesthesia and general anesthesia with circumcision study questionnaire applied before and after circumcision. Material and Methods: Parents of children aged 0-12 years who applied for circumcision ... ...

Abstract	Objective: It was aimed to compare the methods of local anesthesia and general anesthesia with circumcision study questionnaire applied before and after circumcision. Material and Methods: Parents of children aged 0-12 years who applied for circumcision between June and December 2021 who agreed to participate in the study were asked to fill out the circumcision study questionnaire. All patients were operated with same surgeon and surgical method. Patients were divided into local and general anesthesia groups, and data were compared. Results: Our study included 282 patients; general anesthesia was applied to 132 patients (48.9%), and local anesthesia was applied to 144 patients (51.1%). Age and weight averages of patients who were administered local anesthesia and age preferences suitable for circumcision were significantly lower than those in general anesthesia group (p:0.001). There was no significant difference between socioeconomic levels, educational status and reasons for circumcision in both groups (p≥0.05). Patients’ need for postoperative care and recovery time was significantly lower in the local anesthesia group (p:0.001). Conclusion: Circumcision is a surgical operation that can be performed safely with local or general anesthesia. Parents who want circumcision in the early months of life mostly prefer local anesthesia. Postoperative recovery time is shorter in this group. Preference for anesthesia has changed in favor of general anesthesia in advanced ages, including the sexual development period. The knowledge and awareness level of our society about circumcision has increased compared to previous years. Keywords: circumcision, local anesthesia, general anesthesia, urinary tract infection
Keywords	Medicine ; R ; Specialties of internal medicine ; RC581-951 ; Diseases of the genitourinary system. Urology ; RC870-923
Subject code	616 ; 610
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Ali İhsan Taşçı
Document type	Article ; Online
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Article ; Online: The Relationship Between Lymphocyte Subtypes with Clinicopathological Features and Prognosis of Prostate Cancer in Patients Undergoing Radical Prostatectomy.

Sendogan, Furkan / Turan, Turgay / Erman, Hayriye / Danacioglu, Yavuz Onur / Isman, Ferruh Kemal / Atis, Ramazan Gokhan / Silay, M Selcuk / Caskurlu, Turhan / Yildirim, Asif

Urology research & practice

2023 Volume 49, Issue 4, Page(s) 253–258

Abstract: Objective: The immune system has an essential role in the development of cancer by showing both anti-tumor and pro-tumor activities. Understanding the immune func- tion of patients with malignancy is of clinical importance for the evaluation, treatment, ...

Abstract	Objective: The immune system has an essential role in the development of cancer by showing both anti-tumor and pro-tumor activities. Understanding the immune func- tion of patients with malignancy is of clinical importance for the evaluation, treatment, and prognosis of the disease. We aimed to evaluate lymphocyte subtypes in peripheral blood samples of prostate cancer patients and their relationship with clinicopathologi- cal features and prognosis. Methods: One hundred thirty-seven patients who underwent open radical prosta- tectomy were included in our study. The percentages of CD3+T lymphocyte, CD19+ B lymphocyte, CD16/56 natural killer cells, CD4+ helper T lymphocyte, CD8+ cytotoxic T lymphocyte, and CD45 total lymphocyte were evaluated for each patient using the blood sample taken into a hemogram tube before surgery. Results: The pathological stage was T2 for 64 of the cases and T3 for 73. The mean follow-up period of the patients was 12.81 ± 6.20 months. The CD3+/CD4+ counts of the patients with pathological stage T2 were found to be statistically significantly higher than stage T3. There was a statistically significant negative correlation between the prostate-specific antigen levels and CD3+/CD4+ percentages of the patients. There was no statistical significance between the percentages of lymphocyte subtypes and the presence of surgical margin, biochemical recurrence, adjuvant therapy, and cancer upgrade. Conclusion: We consider that the increase in the pathological stage and prostate-spe- cific antigen value and the decrease in the number of CD4+ T lymphocyte subtypes may be prognostic markers in prostate cancer patients.
Language	English
Publishing date	2023-10-25
Publishing country	Turkey
Document type	Journal Article
ISSN	2980-1478
ISSN (online)	2980-1478
DOI	10.5152/tud.2023.22220
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Article ; Online: Factors influencing the decision-making in laparoscopic partial nephrectomy for small renal masses.

Kazan, Ozgur / Cakici, Mehmet Caglar / Kokurcan, Alihan / Ozenc, Gorkem / Karakoyunlu, Nihat / Atis, Gokhan / Imamoglu, Muhammet Abdurrahim / Yildirim, Asif

Urologia

2023 Volume 90, Issue 4, Page(s) 693–701

Abstract: Background and objectives: We analyzed the factors affecting the decision on surgical approach such as hilum dissection, vessel clamping, and the warm ischemia time (WIT) in laparoscopic partial nephrectomy (LPN) for small renal masses (SRMs).: ... ...

Abstract	Background and objectives: We analyzed the factors affecting the decision on surgical approach such as hilum dissection, vessel clamping, and the warm ischemia time (WIT) in laparoscopic partial nephrectomy (LPN) for small renal masses (SRMs). Methods: Patients who underwent LPN for SRMs between 2011 and 2021 in two centers were retrospectively screened. Standardized R.E.N.A.L. nephrometry score (RNS) and each of the components were scored on a Likert scale and the effect on the surgical approach was examined by using them separately. Results: A total of 133 patients, 85 of whom were on-clamp and 48 were off-clamp, were included in the study. Greater tumor size, low BMI, higher RNS, upper pole tumor, low exophytic rate, and nearness to the collecting system were statistically significant for both on/off-clamp and hilar dissection decisions. In multivariate analysis, greater tumor size, upper pole tumor, lower rate of exophytic part (E2), nearness to the collecting system (N3) were independent risk factors for vessel clamping. Greater tumor size and lower exophytic tumor rate (E2) were independent risk factors for hilum dissection. We could not identify any factor affecting WIT. Conclusion: Individual components of RNS may serve as a better tool for decision-making on vessel clamping and hilum dissection during LPN for SRMs.
MeSH term(s)	Humans ; Kidney Neoplasms/surgery ; Kidney Neoplasms/pathology ; Retrospective Studies ; Nephrectomy ; Carcinoma, Renal Cell/surgery ; Carcinoma, Renal Cell/pathology ; Laparoscopy ; Treatment Outcome
Language	English
Publishing date	2023-07-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	204043-8
ISSN	1724-6075 ; 0376-0057 ; 0391-5603
ISSN (online)	1724-6075
ISSN	0376-0057 ; 0391-5603
DOI	10.1177/03915603231189025
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