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  1. Article ; Online: Limbal reconstruction in uveitic glaucoma patient with exposed Ahmed valve coincident with corneal melting and iris prolapse using multiple corneoscleral allografts.

    Kandarakis, Stylianos Artemios / Doumazos, Leonidas / Timpilis, Marios / Karageorgiou, Georgia / Petrou, Petros / Georgalas, Ilias

    Romanian journal of ophthalmology

    2024  Volume 68, Issue 1, Page(s) 60–64

    Abstract: Aim: ...

    Abstract Aim:
    MeSH term(s) Humans ; Middle Aged ; Glaucoma/complications ; Glaucoma/diagnosis ; Corneal Ulcer ; Cornea ; Iris ; Ethanol ; Allografts
    Chemical Substances Ethanol (3K9958V90M)
    Language English
    Publishing date 2024-04-01
    Publishing country Romania
    Document type Case Reports
    ZDB-ID 2842202-8
    ISSN 2501-2533 ; 2457-4325
    ISSN (online) 2501-2533
    ISSN 2457-4325
    DOI 10.22336/rjo.2024.12
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  2. Article ; Online: Complete resolution of subretinal fluid of the fellow eye following aflibercept injection in wet AMD.

    Rouvas, Alexandros / Theodossiadis, Panagiotis / Georgalas, Ilias / Gouliopoulos, Nikolaos

    Retinal cases & brief reports

    2023  

    Abstract: Purpose: To present a case of a patient with bilateral wet age-related macular degeneration (AMD) who was unilaterally treated with intravitreal aflibercept injections (IAIs) and the disease status in the fellow eye ameliorated after an IAI.: Methods!# ...

    Abstract Purpose: To present a case of a patient with bilateral wet age-related macular degeneration (AMD) who was unilaterally treated with intravitreal aflibercept injections (IAIs) and the disease status in the fellow eye ameliorated after an IAI.
    Methods: Retrospective case report.
    Results: A 72-year-old woman was diagnosed with wet and dry AMD in her right (OD) and left (OS) eye, respectively. In OD, treatment strategy comprised 3 monthly IAIs, followed by re-injections according-to-need, while optical coherence tomography (OCT) scans were performed before IAIs. One month after the second IAI, subretinal fluid developed in OS. One week later, an IAI was applied in OD; two days later the disease status in OS was assessed by fluorescein angiography and OCT. Surprisingly, in OS subretinal fluid completely resolved and fluorescein angiography did not detect leakage, highlighting the absence of an active choroidal neovascularization. The short interval between IAI and the resolution of exudative phenomena in the other eye is suggestive of a beneficial effect in the contralateral eye.
    Conclusion: Herein we showed that an IAI had an effect to the fellow untreated eye. Our observation is consistent with active aflibercept in the systemic circulation. To the best of our knowledge, no other report in literature has demonstrated this effect of aflibercept in wet AMD.
    Language English
    Publishing date 2023-11-07
    Publishing country United States
    Document type Journal Article
    ISSN 1937-1578
    ISSN (online) 1937-1578
    DOI 10.1097/ICB.0000000000001515
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  3. Article ; Online: Is there any association between the frequency of wet age-related macular degeneration recurrences and the seasons of the year?

    Rouvas, Alexandros / Bouratzis, Nikolaos / Georgalas, Ilias / Gouliopoulos, Nikolaos

    International ophthalmology

    2023  Volume 43, Issue 9, Page(s) 3287–3295

    Abstract: Purpose: To investigate whether a seasonal distribution of the frequency of exudative age-related macular degeneration (wet AMD) recurrences exists.: Methods: In total, 129 eyes with 171 recurrences in patients suffering from wet AMD were included in ...

    Abstract Purpose: To investigate whether a seasonal distribution of the frequency of exudative age-related macular degeneration (wet AMD) recurrences exists.
    Methods: In total, 129 eyes with 171 recurrences in patients suffering from wet AMD were included in the study. All the patients had been treated with intravitreal anti-VEGF injections according to Pro Re Nata treatment regimen. Recurrence was defined as the re-detection of sub-retinal fluid, intraretinal fluid, and/or sub-macular hemorrhage in optical coherence tomography scans, after at least two consecutive monthly examinations with a "dry" macula. The year was divided in three 4-month periods (zone A: June-September, zone B: October-January, and zone C: February-May) based on the weather conditions prevailing in each period. Mean temperature and hours of sunlight exposure were the main weather markers recorded.
    Results: Eighty-two recurrences (48%) occurred during the period June-September, 50 (29.2%) during the period October-January, and 39 (22.8%) during the period February-May (Chi-square = 17.5, p < 0.001). Among the groups, neither patients' age (78 ± 8 years A, 76 ± 7 years B, and 79 ± 8 years C, p = 0.15) nor gender status (40% men A, 36% men B, and 51% men C, p = 0.35) differed significantly. Mean temperature was 27.6 ± 1.8 °C, 15.1 ± 4.6 °C, and 16.5 ± 4.4 °C in zones A, B, and C, respectively. Hours (h) of sunlight exposure (average hours/month) were 344 ± 34 h, 188 ± 42 h, and 223 ± 57 h in zones A, B, and C.
    Conclusion: We demonstrated that the frequency of wet AMD recurrences is significantly elevated during the warmer months, possibly due to the higher levels of UV radiation and mean temperature. Further research is necessary to validate our findings.
    MeSH term(s) Male ; Humans ; Aged ; Aged, 80 and over ; Female ; Angiogenesis Inhibitors ; Vascular Endothelial Growth Factor A ; Seasons ; Follow-Up Studies ; Recurrence ; Macular Degeneration/drug therapy ; Wet Macular Degeneration/diagnosis ; Wet Macular Degeneration/drug therapy ; Wet Macular Degeneration/epidemiology ; Intravitreal Injections ; Tomography, Optical Coherence/methods ; Ranibizumab
    Chemical Substances Angiogenesis Inhibitors ; Vascular Endothelial Growth Factor A ; Ranibizumab (ZL1R02VT79)
    Language English
    Publishing date 2023-05-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 800087-6
    ISSN 1573-2630 ; 0165-5701
    ISSN (online) 1573-2630
    ISSN 0165-5701
    DOI 10.1007/s10792-023-02732-z
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    Zs.A 1479: Show issues Location:
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  4. Article ; Online: Unexpected Iris Mass Discovery Revealed after Pupil Dilation.

    Doumazos, Leonidas / Kandarakis, Stylianos A / Georgalas, Ilias

    Ophthalmology. Glaucoma

    2022  Volume 5, Issue 2, Page(s) 136

    MeSH term(s) Glaucoma, Angle-Closure ; Humans ; Iris ; Pupil
    Language English
    Publishing date 2022-03-23
    Publishing country United States
    Document type Journal Article
    ISSN 2589-4196
    ISSN (online) 2589-4196
    DOI 10.1016/j.ogla.2021.11.006
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  5. Article: Conjunctival Marginal Zone Lymphoma in a Patient With Neurofibromatosis Type 1: A Case Report.

    Florou, Chrysoula / Aissopou, Evaggelia / Papakonstantinou, Evangelia / Georgalas, Ilias / Droutsas, Konstantinos

    Cureus

    2023  Volume 15, Issue 11, Page(s) e49491

    Abstract: We present a case of painless bulbar conjunctival mass due to B-cell non-Hodgkin lymphoma (NHL), without systemic involvement, in a 76-year-old man. Following an excision biopsy, histopathologic examination and immunohistochemistry confirmed the ... ...

    Abstract We present a case of painless bulbar conjunctival mass due to B-cell non-Hodgkin lymphoma (NHL), without systemic involvement, in a 76-year-old man. Following an excision biopsy, histopathologic examination and immunohistochemistry confirmed the diagnosis, prompting a referral for hemato-oncological assessment. The patient underwent comprehensive laboratory and imaging scans, subsequently receiving combined chemo-immunotherapy that resulted in complete remission to date. This case is reported as it is crucial to recognize that a conjunctival insult might emerge in neurofibromatosis type 1 (NF1) patients.
    Language English
    Publishing date 2023-11-27
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.49491
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  6. Article ; Online: Correlations of Corneal Endothelial Morphology and Corneal Thickness With Anterior Segment Parameters in Healthy Individuals.

    Karmiris, Efthymios / Tsiogka, Anastasia / Tsiripidis, Konstantinos / Papakonstantinou, Evangelia / Georgalas, Ilias / Chalkiadaki, Evangelia

    Cornea

    2024  

    Abstract: Purpose: The purpose of this study was to investigate the associations between central corneal endothelial cell density (ECD), endothelial morphology, and corneal thickness (central corneal thickness) with the anterior chamber depth, corneal volume (CV), ...

    Abstract Purpose: The purpose of this study was to investigate the associations between central corneal endothelial cell density (ECD), endothelial morphology, and corneal thickness (central corneal thickness) with the anterior chamber depth, corneal volume (CV), white-to-white (WTW) distance, mean anterior chamber angle (CAmean), and gender in healthy individuals.
    Methods: This observational study included 136 healthy volunteers. The ECD, coefficient of variation of cell area, and hexagonal cell appearance ratio (%Hex) were measured by means of specular microscopy. The central corneal thickness, anterior chamber depth, CV, WTW distance, and the angle width of 12 points were taken by the Pentacam HR Scheimpflug anterior segment imaging. The arithmetical mean of the 12 points was considered as the CAmean. We used mixed effect linear regression model for the statistical analysis of the data.
    Results: ECD was positively correlated with CV (P = 0.028), while after adjusting for age, it was negatively correlated with age (P < 0.001). Coefficient of variation of cell area was positively correlated with CAmean (P = 0.036), while after adjusting for age, it was positively correlated with age (P < 0.001) and CAmean (P = 0.005). Hex was negatively correlated with WTW (P = 0.023) and CAmean (P = 0.025), and after adjusting for age, this correlation remained the same (P = 0.029 when correlated with WTW and P = 0.035 with CAmean).
    Conclusions: There were significant changes in the morphology of the corneal endothelial cells in eyes with wider anterior chamber angle. Greater pleomorphism and polymegethism of the corneal endothelium was observed in healthy patients with wider CAmean. Deepening of the anterior chamber as myopia progresses could render the corneal endothelium more fragile and susceptible to mechanical stress, which is an area worthy of further study.
    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604826-2
    ISSN 1536-4798 ; 0277-3740
    ISSN (online) 1536-4798
    ISSN 0277-3740
    DOI 10.1097/ICO.0000000000003515
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    Zs.A 1790: Show issues Location:
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  7. Article ; Online: β-Thalassemias.

    Georgalas, Ilias / Petrou, Petros / Kanakis, Menelaos

    The New England journal of medicine

    2021  Volume 384, Issue 22, Page(s) 2165–2166

    MeSH term(s) Female ; Humans ; Pregnancy ; Prenatal Diagnosis ; alpha-Thalassemia ; beta-Thalassemia/diagnosis ; beta-Thalassemia/therapy
    Language English
    Publishing date 2021-06-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2105064
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  8. Article: Long-term clinical outcomes obtained with bilateral implantation of a multifocal intraocular lens through two different-sized corneal incisions.

    Karmiris, Efthymios / Chalkiadaki, Evangelia / Papakonstantinou, Evangelia / Georgalas, Ilias

    Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society

    2022  Volume 36, Issue 2, Page(s) 207–212

    Abstract: Purpose: To evaluate the long-term visual function and patient satisfaction in patients implanted bilaterally with the same type of multifocal intraocular lens (MIOL), using either a 2.2 mm small corneal incision with bimanual irrigation/aspiration (I/A) ...

    Abstract Purpose: To evaluate the long-term visual function and patient satisfaction in patients implanted bilaterally with the same type of multifocal intraocular lens (MIOL), using either a 2.2 mm small corneal incision with bimanual irrigation/aspiration (I/A) or a conventional 2.75 mm incision with coaxial I/A.
    Methods: Prospective nonrandomized study including 100 eyes of 50 patients who underwent bilateral implantation of ReSTOR SN6AD1 through a 2.2 mm or 2.75 mm corneal incision. Outcomes included visual function measures (near, intermediate, and distance visual acuity [VA]), achievement of targeted refraction and postoperative astigmatism. Patient satisfaction was evaluated using a subjective questionnaire.
    Results: Three and 12 months postoperatively, distance uncorrected best VA (UBVA) was 0.98 ± 0.07, UBVA at 30 cm was J1 in 100% of cases and UBVA at 60 cm was J3 in 72% of cases. Targeted refraction was achieved in 84% of cases and postoperative astigmatism was -0.4 ± 0.3 diopters. There was no statistically significant difference in UBVA in all distances, targeted refraction and postoperative astigmatism between the small-incision bimanual and the conventional coaxial group. Sixty percent of the patients were satisfied, 30% were very satisfied and 10% declared that the result did not meet their expectations. Three out of 5 nonsatisfied patients had an angle kappa of 4° and the MIOL was not well-centered.
    Conclusion: An incision size of 2.2 mm compared to 2.75 mm, did not appear to result in less surgically induced astigmatism after the implantation of a MIOL. SN6AD1 is a reliable MIOL choice for spectacle independence. Good preoperative patient selection is of crucial importance for the outcome in MIOLs.
    Language English
    Publishing date 2022-08-29
    Publishing country India
    Document type Journal Article
    ZDB-ID 2515644-5
    ISSN 1319-4534
    ISSN 1319-4534
    DOI 10.4103/sjopt.sjopt_28_21
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  9. Article ; Online: Letter to the Editor: Comparison of Repeat Trabeculectomy Versus Ahmed Valve Implantation After Initial Failed Trabeculectomy Surgery.

    Kandarakis, Stylianos A / Filippopoulos, Theodoros / Doumazos, Leonidas / Petrou, Petros / Georgalas, Ilias

    Journal of glaucoma

    2023  Volume 33, Issue 4, Page(s) e19–e20

    MeSH term(s) Humans ; Trabeculectomy ; Intraocular Pressure ; Glaucoma/surgery ; Eye ; Glaucoma Drainage Implants ; Treatment Outcome ; Prosthesis Implantation ; Retrospective Studies
    Language English
    Publishing date 2023-10-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 913494-3
    ISSN 1536-481X ; 1057-0829
    ISSN (online) 1536-481X
    ISSN 1057-0829
    DOI 10.1097/IJG.0000000000002316
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    Zs.A 3795: Show issues Location:
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  10. Article: Endophthalmitis caused by

    Kandarakis, Stylianos A / Spernovasilis, Nikolaos / Georgalas, Ilias / Mendris, Michalis / Tsioutis, Constantinos / Agouridis, Aris P

    Germs

    2023  Volume 13, Issue 4, Page(s) 343–351

    Abstract: Introduction: Enterococcus casseliflavus: Methods: A thorough search of PubMed, PubMed Central, and Scopus databases was conducted, covering the period up to October 2022.: Results: A total of 53 records were identified, with 8 studies reporting a ...

    Abstract Introduction: Enterococcus casseliflavus
    Methods: A thorough search of PubMed, PubMed Central, and Scopus databases was conducted, covering the period up to October 2022.
    Results: A total of 53 records were identified, with 8 studies reporting a total of 21 cases meeting the inclusion criteria. Among these studies, 7 described isolated case reports, while 1 study described 14 cases. The overall quality of the reports was good, as all articles were determined to have low risk of bias. Vancomycin susceptibility was reported in only one case of isolated case reports, while the remaining cases were all vancomycin resistant. With regard to management, in most cases intravenous ampicillin and linezolid were administered, while only one study reported administration of vancomycin.
    Conclusions: Ophthalmologists should be aware of the potential for
    Language English
    Publishing date 2023-12-31
    Publishing country Romania
    Document type Journal Article ; Review
    ZDB-ID 2649305-6
    ISSN 2248-2997
    ISSN 2248-2997
    DOI 10.18683/germs.2023.1404
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