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Article ; Online: Correspondência epistolar do neurofisiologista Miguel Rolando Covian

Eneida Nogueira Damasceno / Marina Massimi

Revista Brasileira de História da Ciência, Vol 7, Iss

2021 Volume 1

Abstract: ... epistolar do neurofisiologista Miguel Rolando Covian, e tem como objetivo destacar a necessidade de atenção ... apropriadas mesmo enquanto se encontram em acesso restrito. Miguel Rolando Covian foi um neurofisiologista ...

Abstract	Este artigo descreve um trabalho de organização, com vistas à preservação da correspondência epistolar do neurofisiologista Miguel Rolando Covian, e tem como objetivo destacar a necessidade de atenção a este gênero de fontes enquanto documentos históricos. As correspondências epistolares trazem em seus conteúdos informações de caráter íntimo e pessoal que adentram o campo das questões éticas e as colocam sob proteção legal por determinado período de tempo. Assim, os cuidados com a preservação destes documentos são fundamentais, por se tratar de fontes primárias originais que necessitam ser preservadas em condições apropriadas mesmo enquanto se encontram em acesso restrito. Miguel Rolando Covian foi um neurofisiologista argentino que chegou ao Brasil em 1955 para assumir o então recém-criado Departamento de Fisiologia da Faculdade de Medicina de Ribeirão Preto. À frente deste Departamento, elevou-o a um nível de reconhecimento nacional e internacional, um centro de excelência em pesquisa no Brasil e no mundo. Culto e profundo conhecedor de filosofia, comunicava-se com amigos e cientistas de diversas regiões do mundo. A correspondência epistolar de Covian guarda em seu conteúdo inúmeras possibilidades de pesquisas no campo histórico; porém, sendo ele um cientista, um foco maior incide sobre a História das Ciências, com destaque para a História da Medicina, da Biologia, da Psicologia e da Neurofisiologia.
Keywords	Miguel Rolando Covian ; correspondência ; preservação de documentos ; Epistemology. Theory of knowledge ; BD143-237 ; Science ; Q ; History (General) ; D1-2009
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	Sociedade Brasileira de História da Ciência
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: VALIDAÇÃO DO MAPA DE VULNERABILIDADE INTRÍNSECA DA BACIA DO RIO SÃO MIGUEL (MG) POR CORRELAÇÕES DE MAPAS HIDROQUÍMICOS DE NITRATO

THIAGO NOGUEIRA LUCON / DÉBORA LARA PEREIRA / PAULO HENRIQUE GALVÃO / PEDRO HENRIQUE DA SILVA ASSUNÇÃO

Revista Águas Subterrâneas, Vol 0, Iss

2019

Abstract: ... de vulnerabilidade intrínseca da bacia do rio São Miguel (≈ 520 km²) por meio de estudos utilizando o mapeamento ...

Abstract	Grande parte da água consumida pela humanidade é oriunda de reservas subterrâneas e, devido à ocupação do solo sem planejamento, o risco de contaminação de aquíferos pode gerar problemas no desenvolvimento econômico e social de uma região. Estudos que visam a caracterização de áreas vulneráveis à contaminação de aquíferos podem auxiliar nesse planejamento do controle da qualidade da água. Consequentemente, uma validação do mapa é favorável para sua confiabilidade. Nesse contexto, a pesquisa buscou validar o mapa de vulnerabilidade intrínseca da bacia do rio São Miguel (≈ 520 km²) por meio de estudos utilizando o mapeamento hidroquímico com os teores anômalos de nitrato acima dos valores permitidos pela Resolução do CONAMA nº 396. A bacia está localizada no centro oeste de Minas Gerais, inserida no extremo meridional da bacia do rio São Francisco, com presença de rochas carbonáticas neoproterozoicas do Grupo Bambuí, pertencentes à Formação Sete Lagoas. O método de vulnerabilidade EPIK é realizado por meio do mapeamento sistemático dos seguintes parâmetros: epicarste (E); cobertura de proteção (P); condições de infiltração (I) e desenvolvimento cárstico (K). Para a validação do mapa de vulnerabilidade intrínseca, foi utilizado o mapa de concentrações anômalas de NO3-; os dados foram adquiridos por meio de um monitoramento sazonal de dois anos hidrológicos, a partir dos 39 pontos de monitoramento distribuídos ao longo da bacia. Os resultados hidroquímicos de NO3- anômalos da água subterrânea corresponderam às áreas mais vulneráveis, logo, o mapeamento de vulnerabilidade foi validado.
Keywords	River ; lake ; and water-supply engineering (General) ; TC401-506 ; Physical geography ; GB3-5030
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	Associação Brasileira de Águas Subterrâneas
Document type	Article ; Online
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Article ; Online: CONTAMINAÇÃO SAZONAL DAS ÁGUAS SUBTERRÂNEAS DA BACIA DO RIO SÃO MIGUEL (MG) POR CÁDMIO E PROPOSIÇÃO DE VALORES DE BACKGROUND

THIAGO NOGUEIRA LUCON / PAULO HENRIQUE GALVÃO / PEDRO HENRIQUE DA SILVA ASSUNÇÃO / DÉBORA LARA PEREIRA

Revista Águas Subterrâneas, Vol 0, Iss

2019

Abstract: ... da bacia do rio São Miguel, utilizando-se do mapeamento hidroquímico, visando o melhor conhecimento ...

Abstract	A pesquisa buscou analisar as concentrações químicas do elemento cádmio (Cd) das águas subterrâneas da bacia do rio São Miguel, utilizando-se do mapeamento hidroquímico, visando o melhor conhecimento sobre a qualidade dessas águas perante padrões estabelecidos pelas legislações vigentes, além de verificar a influência da sazonalidade e propor valores de background para este elemento. A bacia está localizada no centro oeste de Minas Gerais, extremo meridional da bacia do rio São Francisco, inserida na Província Cárstica de Arcos Pains, representada principalmente por rochas carbonáticas e pelíticas da Formação Sete Lagoas (Grupo Bambuí), com exposições secundárias do embasamento granito-gnáissico pertencentes ao Complexo Campo Belo. A partir das análises químicas, realizou-se um tratamento de dados pelo Microsoft Excel®, onde foram gerados gráficos para uma melhor interpretação dos resultados. Com o intuito de melhorar a visualização dos resultados, as concentrações de Cd foram inseridas no ArcGis® 10.1 a fim de confeccionar mapas hidroquímicos de isovalores, utilizando as seguintes ferramentas (extensões) do sistema: Spatial Analyst, Spatial Tools e Inverse Distance Weighted (IDW). Além disso, os resultados foram comparados a valores orientados para verificar se as águas da região se encontram em conformidade com os padrões para consumo humano. Para 153 amostras de água subterrânea, as concentrações de Cd variaram de 0,001 a 15,63 μg/L, com cerca de 20% apresentando valores superiores a 1 µg/L, ou seja, acima do encontrado para as 110 estações analisadas pelo mundo todo; pouco mais de 1% apresentam valores superiores a 5 µg/L, superando as concentrações relatadas para as regiões cársticas da China ocidental (1 a 4 μg/L). O maior valor de Cd encontrado (15,63 µg/L) apresentou valor próximo ao relatado no aquífero cárstico de Yucatán, México, de 17,6 μg/L. Com isso, verificou-se a influência da sazonalidade na distribuição das concentrações de Cd.
Keywords	River ; lake ; and water-supply engineering (General) ; TC401-506 ; Physical geography ; GB3-5030
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	Associação Brasileira de Águas Subterrâneas
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Vismodegib treatment for recurrent basal cell carcinoma - a successful case report.

Lé, Ana Maria / Nogueira, Miguel / Araújo, Alexandra / Horta, Miguel

European journal of dermatology : EJD

2023 Volume 33, Issue 3, Page(s) 332–333

MeSH term(s)	Humans ; Carcinoma, Basal Cell/drug therapy ; Anilides/therapeutic use ; Pyridines/therapeutic use ; Skin Neoplasms/drug therapy
Chemical Substances	HhAntag691 ; Anilides ; Pyridines
Language	English
Publishing date	2023-09-12
Publishing country	France
Document type	Case Reports ; Journal Article
ZDB-ID	1128666-0
ISSN	1952-4013 ; 1167-1122
ISSN (online)	1952-4013
ISSN	1167-1122
DOI	10.1684/ejd.2023.4508
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Article ; Online: Very early OCT response to intravenous pulse steroid in Vogt-Koyanagi-Harada disease.

Leitão, Miguel / Pinto, Rita / Nogueira, Vanda

BMJ case reports

2023 Volume 16, Issue 5

MeSH term(s)	Humans ; Uveomeningoencephalitic Syndrome/diagnosis ; Uveomeningoencephalitic Syndrome/drug therapy ; Visual Acuity ; Steroids/therapeutic use
Chemical Substances	Steroids
Language	English
Publishing date	2023-05-16
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2023-255186
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Article ; Online: Multi-beam, WDM-based photonic beamformer with spectrum reuse.

Oliveira, Rui / Nogueira, Rogério N / Drummond, Miguel V

Optics letters

2023 Volume 49, Issue 1, Page(s) 53–56

Abstract: This manuscript presents a wavelength-division multiplexing (WDM)-based photonic beamformer for an RF phased array antenna transmitter, capable of simultaneously generating multiple beams using the same optical spectrum. In the proposed architecture, for ...

Abstract	This manuscript presents a wavelength-division multiplexing (WDM)-based photonic beamformer for an RF phased array antenna transmitter, capable of simultaneously generating multiple beams using the same optical spectrum. In the proposed architecture, for each RF beam, a WDM signal comprising the modulated RF sidebands undergoes complex-valued filtering, while another WDM signal with the same channels, but carrying only optical carriers, goes through an optical frequency-shifting stage. The proposed architecture allows the same WDM channels to be reused for multiple RF beams. The detection of the frequency-shifted optical carrier and the filtered RF sideband of each WDM channel at the photodetector produces a frequency-converted, correctly weighted signal to be fed to each antenna element. The features described herein are analytically derived, numerically simulated, and experimentally demonstrated. Results showcase two independent beams being transmitted in different directions.
Language	English
Publishing date	2023-12-22
Publishing country	United States
Document type	Journal Article
ISSN	1539-4794
ISSN (online)	1539-4794
DOI	10.1364/OL.506509
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Article ; Online: Rare cutaneous amyloid lesions as multiple myeloma presenting symptom.

Lé, Ana Maria / Nogueira, Miguel / Coelho, André / Ferreira, Sandra

International journal of dermatology

2023 Volume 63, Issue 2, Page(s) e41–e43

MeSH term(s)	Humans ; Multiple Myeloma/complications ; Multiple Myeloma/diagnosis ; Multiple Myeloma/pathology ; Skin/pathology ; Amyloid
Chemical Substances	Amyloid
Language	English
Publishing date	2023-12-13
Publishing country	England
Document type	Letter
ZDB-ID	412254-9
ISSN	1365-4632 ; 0011-9059 ; 1461-1244
ISSN (online)	1365-4632
ISSN	0011-9059 ; 1461-1244
DOI	10.1111/ijd.16971
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Article: Inter-comparison of ERA-5, ERA-interim and GPCP rainfall over the last 40 years: Process-based analysis of systematic and random differences

Nogueira, Miguel

Journal of hydrology. 2020 Apr., v. 583

2020

Abstract: This study presents a comprehensive inter-comparison between two widely used rainfall datasets – the Global Precipitation Climatology Project (GPCP) and the ERA-Interim reanalysis – and the recently released ERA-5, which will replace ERA-Interim as the ... ...

Abstract	This study presents a comprehensive inter-comparison between two widely used rainfall datasets – the Global Precipitation Climatology Project (GPCP) and the ERA-Interim reanalysis – and the recently released ERA-5, which will replace ERA-Interim as the main European Centre for Medium-Range Weather and Forecasting (ECMWF) reanalysis by 2020. Systematic and random error components were computed for the reanalysis datasets over the 1979–2018 period using GPCP as reference. The analysis was taken at monthly timescale at 2.5° spatial resolution, limited by GPCP. Despite its resolution limitations and complex algorithms, GPCP has been extensively used for model evaluation due to its global and long-term (over 40 years) coverage. Over most of the tropics, and over localized mid-latitude regions, ERA-5 showed lower bias and unbiased root-mean squared error (ubRMSE), as well as higher correlations, compared to ERA-Interim. Throughout the rest of the globe, these error metrics displayed similar values between both reanalysis, except over localized regions of the eastern tropical Pacific, the Andes and the Himalayas, where ERA-Interim outperformed ERA-5. A process-based analysis revealed that ERA-Interim tended to overestimate deep convection and moisture flux convergence over the tropical oceans and land, leading to excessive rainfall. Similarly, ERA-Interim showed significant rainfall underestimation over the mid-latitude oceans due to underestimation of deep convection and moisture flux convergence. Both cases were significantly improved in ERA-5, likely due to its improved parameterizations and higher resolution. Indeed, the differences in monthly rainfall between the two reanalysis were mainly due to improved dynamical (circulation) rather than thermodynamical (Clausius-Clapeyron) processes or surface evaporation changes. Nonetheless, the results also revealed improved representation of the moisture sink/source patterns over the tropical oceans in ERA-5. Finally, there were significant differences in the long-term rainfall trend patterns amongst the three datasets (with differences reaching ~30%/decade), that can extend even to the sign of the trend, with the most notorious differences occurring over tropical Africa. Furthermore, ERA-5 didn’t show improved representation of these trends. In fact, the trend of global-mean rainfall in ERA-Interim was closer to GPCP than ERA-5.
Keywords	algorithms ; climatology ; convection ; data collection ; evaporation ; hydrology ; latitude ; models ; oceans ; rain ; tropics ; Africa ; Andes region ; Himalayan region
Language	English
Dates of publication	2020-04
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1473173-3
ISSN	1879-2707 ; 0022-1694
ISSN (online)	1879-2707
ISSN	0022-1694
DOI	10.1016/j.jhydrol.2020.124632
Database	NAL-Catalogue (AGRICOLA)

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Article: Upadacitinib for the treatment of psoriatic arthritis.

Fonseca, Diogo / Nogueira, Miguel / Torres, Tiago

Drugs in context

2023 Volume 12

Abstract: Psoriatic arthritis is a chronic systemic inflammatory disease that presents with a variable clinical course and is typically associated with joint inflammation, together with cutaneous psoriasis. In recent decades, knowledge of the pathogenesis of ... ...

Abstract	Psoriatic arthritis is a chronic systemic inflammatory disease that presents with a variable clinical course and is typically associated with joint inflammation, together with cutaneous psoriasis. In recent decades, knowledge of the pathogenesis of psoriatic arthritis has advanced considerably and has allowed for development of new highly effective therapies, transforming the treatment landscape. Upadacitinib is a Janus kinase inhibitor (JAK) that is orally reversible with high selectivity for JAK1 and its signal transduction molecules. The results obtained in the phase III clinical trials (SELECT-PsA 1 and SELEC-PsA 2) demonstrated that upadacitinib was highly effective over placebo and non-inferior to adalimumab in several important domains of the disease. Improvements were observed in dactylitis, enthesitis and spondylitis as well as in physical function, pain, fatigue and overall quality of life. The safety profile of these results resembled that of adalimumab, apart from a slightly higher rate of herpes zoster infection, an increase of creatine kinase and an incidence of lymphopenia. However, none of these events was considered a serious adverse advent. Additionally, another analysis demonstrated that combining upadacitinib with methotrexate was associated with a similar efficacy to upadacitinib in monotherapy, both for patients that are naive to biologics treatment and for those previously treated with biologics. Therefore, upadacitinib is a new option for the treatment of psoriatic arthritis, presenting a series of beneficial characteristics. At this stage, it is important to collect long-term data to confirm the efficacy and safety profiles shown in clinical trials.
Language	English
Publishing date	2023-02-28
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2719560-0
ISSN	1740-4398 ; 1745-1981
ISSN (online)	1740-4398
ISSN	1745-1981
DOI	10.7573/dic.2022-11-6
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Article ; Online: Fetal heart rate variability and infant self-regulation: the impact of mother's prenatal depressive symptoms.

Pinto, Tiago Miguel / Nogueira-Silva, Cristina / Figueiredo, Bárbara

Journal of reproductive and infant psychology

2023 , Page(s) 1–14

Abstract: Background: Foetal heart rate (FHR) variability is considered a marker of foetal neurobehavioral development associated with infant self-regulation and thus may be an early precursor of the adverse impact of mother's prenatal depressive symptoms on ... ...

Abstract	Background: Foetal heart rate (FHR) variability is considered a marker of foetal neurobehavioral development associated with infant self-regulation and thus may be an early precursor of the adverse impact of mother's prenatal depressive symptoms on infant self-regulation. Objective: This study analysed the mediator role of FHR variability in the association between mother's prenatal depressive symptoms and infant self-regulation at three months. Methods: The sample comprised 86 first-born infants and their mothers. Mothers reported on depressive symptoms at the first trimester of pregnancy and on depressive symptoms and infant self-regulation at three months postpartum. FHR variability was recorded during routine cardiotocography at the third trimester of pregnancy. A mediation model was tested, adjusting for mother's postnatal depressive symptoms. Results: Higher levels of mother's prenatal depressive symptoms were associated with both lower FHR variability and lower infant self-regulation at three months. FHR variability was associated with infant self-regulation and mediated the association between mother's prenatal depressive symptoms and infant self-regulation at three months. Conclusion: Findings suggested FHR variability as an early precursor of infant self-regulation that underlies the association between mother's prenatal depressive symptoms and infant self-regulation. Infants of mothers with higher levels of prenatal depressive symptoms could be at risk of self-regulation problems, partially due to their lower FHR variability.
Language	English
Publishing date	2023-09-19
Publishing country	England
Document type	Journal Article
ZDB-ID	639124-2
ISSN	1469-672X ; 0264-6838
ISSN (online)	1469-672X
ISSN	0264-6838
DOI	10.1080/02646838.2023.2257730
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