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Book ; Online ; E-Book: Preparative chromatography

Schulte, Michael / Schmidt-Traub, H. / Seidel-Morgenstern, Andreas

2020

Author's details	edited by H. Schmidt-Traub, Michael Schulte, Andreas Seidel-Morgenstern
Keywords	Preparative layer chromatography
Subject code	543.8
Language	English
Size	1 online resource (651 pages)
Publisher	Wiley-VCH
Publishing place	Weinheim, Germany
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	3-527-81633-X ; 3-527-81634-8 ; 3-527-81631-3 ; 3-527-34486-1 ; 978-3-527-81633-0 ; 978-3-527-81634-7 ; 978-3-527-81631-6 ; 978-3-527-34486-4
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Toxoplasma gondii Does Not Inhibit the Assisted Colonization of Eastern Barred Bandicoots (Perameles gunnii) to Phillip Island, Victoria, Australia.

Adriaanse, Katherine / Lynch, Michael / Sutherland, Duncan / Traub, Rebecca / Lowe, Jasmine / Hufschmid, Jasmin

Journal of wildlife diseases

2023 Volume 60, Issue 1, Page(s) 116–125

Abstract: Eastern barred bandicoots (Perameles gunnii) are thought to be highly susceptible to disease caused by infection with the protozoan parasite Toxoplasma gondii. This study followed a population of 67 P. gunnii introduced onto the Summerland Peninsula, ... ...

Abstract	Eastern barred bandicoots (Perameles gunnii) are thought to be highly susceptible to disease caused by infection with the protozoan parasite Toxoplasma gondii. This study followed a population of 67 P. gunnii introduced onto the Summerland Peninsula, Phillip Island, Australia, where the prevalence of T. gondii infection in the feral cat population was known to be very high. Prior to release, bandicoots were tested for serologic exposure to T. gondii using the modified agglutination test. A subset of bandicoots was tested on four occasions after release onto the peninsula. No seroconversion was detected at any time point. A subset of bandicoots was radiotracked after release and at two additional trapping sessions to help monitor survival. Toxoplasma gondii DNA was not detected by PCR in eight carcasses recovered for necropsy. Fourteen founder bandicoots (21% of founders) were known to be alive at 500 d post-release. A total of 29 unmarked bandicoots were trapped over the study period, confirming that the bandicoots were successfully reproducing on the island. Body weight, packed cell volume, and total plasma protein were used as measures of individual animal health; population health was inferred from these data. Body weight was significantly associated with trip number, with a general trend of increasing weight after release onto the island. This study showed that eastern barred bandicoots were able to establish a new population despite a probably high environmental load of T. gondii.
MeSH term(s)	Animals ; Cats ; Victoria ; Toxoplasma ; Animals, Wild ; Marsupialia/parasitology ; Body Weight ; Toxoplasmosis, Animal/epidemiology ; Antibodies, Protozoan ; Cat Diseases
Chemical Substances	Antibodies, Protozoan
Language	English
Publishing date	2023-10-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	410709-3
ISSN	1943-3700 ; 0090-3558
ISSN (online)	1943-3700
ISSN	0090-3558
DOI	10.7589/JWD-D-23-00069
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Thesis: Die Verwertbarkeit von Selbstgesprächen im Strafverfahren

Traub, Michael

(Strafrechtliche Fragen der Gegenwart ; 6)

2015

Author's details	Michael Traub
Series title	Strafrechtliche Fragen der Gegenwart ; 6
Keywords	Selbstgespräch ; Strafverfahren ; Beweisverwertung ; Deutschland ; Beweismittel
Language	German
Size	227 S., 24 cm
Publisher	Logos-Verl
Publishing place	Berlin
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Univ., Diss.--Würzburg, 2015
ISBN	3832540733 ; 9783832540739
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: Involvement of IL-4, IL-13 and Their Receptors in Pancreatic Cancer.

Shi, Jingwei / Song, Xujun / Traub, Benno / Luxenhofer, Michael / Kornmann, Marko

International journal of molecular sciences

2021 Volume 22, Issue 6

Abstract: Interleukin (IL)-4 and IL-13 are known as pleiotropic Th2 cytokines with a wide range of biological properties and functions especially in immune responses. In addition, increasing activities have also been determined in oncogenesis and tumor progression ...

Abstract	Interleukin (IL)-4 and IL-13 are known as pleiotropic Th2 cytokines with a wide range of biological properties and functions especially in immune responses. In addition, increasing activities have also been determined in oncogenesis and tumor progression of several malignancies. It is now generally accepted that IL-4 and IL-13 can exert effects on epithelial tumor cells through corresponding receptors. Type II IL-4 receptor (IL-4Rα/IL-13Rα1), predominantly expressed in non-hematopoietic cells, is identified to be the main target for both IL-4 and IL-13 in tumors. Moreover, IL-13 can also signal by binding to the IL-13Rα2 receptor. Structural similarity due to the use of the same receptor complex generated in response to IL-4/IL-13 results in overlapping but also distinct signaling pathways and functions. The aim of this review was to summarize knowledge about IL-4 and IL-13 and their receptors in pancreatic cancer in order understand the implication of IL-4 and IL-13 and their receptors for pancreatic tumorigenesis and progression and for developing possible new diagnostic and therapeutic targets.
MeSH term(s)	Carcinogenesis/genetics ; Humans ; Interleukin-13/genetics ; Interleukin-13 Receptor alpha1 Subunit/genetics ; Interleukin-13 Receptor alpha2 Subunit/genetics ; Interleukin-4/genetics ; Interleukin-4 Receptor alpha Subunit/genetics ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/pathology ; Receptors, Interleukin/genetics ; Signal Transduction/genetics
Chemical Substances	IL4 protein, human ; Interleukin-13 ; Interleukin-13 Receptor alpha1 Subunit ; Interleukin-13 Receptor alpha2 Subunit ; Interleukin-4 Receptor alpha Subunit ; Receptors, Interleukin ; Interleukin-4 (207137-56-2)
Language	English
Publishing date	2021-03-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22062998
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Remediation of Mild, Acute Radiation Dermatitis Using a Stem Cell-Based Topical: A Real-World Case Report.

Traub, Michael / Vendetti, Pamela / McGee, Steven / Maguire, Greg

Integrative medicine (Encinitas, Calif.)

2021 Volume 20, Issue 6, Page(s) 30–34

Abstract: Introduction: Wounds of the skin induced by irradiation involve a disruption of skin homeostasis and an increase in inflammation. Physiological renormalization treatment strategies using the molecules released from stem cells that restore proteostasis ... ...

Abstract	Introduction: Wounds of the skin induced by irradiation involve a disruption of skin homeostasis and an increase in inflammation. Physiological renormalization treatment strategies using the molecules released from stem cells that restore proteostasis and regulate the immune system and reduce inflammation may be effective in treating skin conditions. Previous studies of severe radiation dermatitis found a significant reduction in symptoms using a combination product of the secretome from adipose mesenchymal stem cells and dermal fibroblasts, but mild radiation dermatitis has yet to be studied using this product. Case presentation: This is a case report of radiation dermatitis in a patient with an uncommon cutaneous basosquamous cell carcinoma with perineural invasion that warranted radiation therapy. In this study we used S2RM technology, a proprietary combination of stem cell-released molecules from multiple types of skin stem cells, to renormalize homeostasis of the skin, including a renormalization of proteostasis to treat a mild form of radiation dermatitis induced by Intensity Modulated Radiation Therapy. Dramatic reductions in pain, redness, and inflammation, more rapid and complete wound healing, and an overall enhancement of the appearance of the skin were achieved in this patient. Discussion: The current study demonstrates that as part of the palliative care strategies for cancer patients, the simple topical application of S2RM technology is a powerful means to renormalize homeostasis of the skin and remediate mild radiation dermatitis. The reduction of inflammation in the skin is important to reducing systemic inflammation and related comorbidities.
Language	English
Publishing date	2021-09-09
Publishing country	United States
Document type	Case Reports
ZDB-ID	2100529-1
ISSN	1945-7081 ; 1546-993X
ISSN (online)	1945-7081
ISSN	1546-993X
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Potassium Channels as Therapeutic Targets in Pulmonary Arterial Hypertension.

Redel-Traub, Gabriel / Sampson, Kevin J / Kass, Robert S / Bohnen, Michael S

Biomolecules

2022 Volume 12, Issue 10

Abstract: Pulmonary arterial hypertension (PAH) is a devastating disease with high morbidity and mortality. Deleterious remodeling in the pulmonary arterial system leads to irreversible arterial constriction and elevated pulmonary arterial pressures, right heart ... ...

Abstract	Pulmonary arterial hypertension (PAH) is a devastating disease with high morbidity and mortality. Deleterious remodeling in the pulmonary arterial system leads to irreversible arterial constriction and elevated pulmonary arterial pressures, right heart failure, and eventually death. The difficulty in treating PAH stems in part from the complex nature of disease pathogenesis, with several signaling compounds known to be involved (e.g., endothelin-1, prostacyclins) which are indeed targets of PAH therapy. Over the last decade, potassium channelopathies were established as novel causes of PAH. More specifically, loss-of-function mutations in the KCNK3 gene that encodes the two-pore-domain potassium channel KCNK3 (or TASK-1) and loss-of-function mutations in the ABCC8 gene that encodes a key subunit, SUR1, of the ATP-sensitive potassium channel (KATP) were established as the first two potassium channelopathies in human cohorts with pulmonary arterial hypertension. Moreover, voltage-gated potassium channels (Kv) represent a third family of potassium channels with genetic changes observed in association with PAH. While other ion channel genes have since been reported in association with PAH, this review focuses on KCNK3, KATP, and Kv potassium channels as promising therapeutic targets in PAH, with recent experimental pharmacologic discoveries significantly advancing the field.
MeSH term(s)	Humans ; Potassium Channels, Tandem Pore Domain/genetics ; Pulmonary Arterial Hypertension ; Channelopathies/drug therapy ; Channelopathies/genetics ; Hypertension, Pulmonary/drug therapy ; Hypertension, Pulmonary/genetics ; Hypertension, Pulmonary/pathology ; Endothelin-1 ; Nerve Tissue Proteins/metabolism ; Familial Primary Pulmonary Hypertension/genetics ; Potassium Channels, Voltage-Gated ; Prostaglandins I ; Potassium ; KATP Channels/genetics
Chemical Substances	Potassium Channels, Tandem Pore Domain ; Endothelin-1 ; Nerve Tissue Proteins ; Potassium Channels, Voltage-Gated ; Prostaglandins I ; Potassium (RWP5GA015D) ; KATP Channels
Language	English
Publishing date	2022-09-22
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom12101341
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Impact of Radiotherapy on Malfunctions and Battery Life of Cardiac Implantable Electronic Devices in Cancer Patients.

Lisowski, Dominik / Lutyj, Paul / Abazari, Arya / Weick, Stefan / Traub, Jan / Polat, Bülent / Flentje, Michael / Kraft, Johannes

Cancers

2023 Volume 15, Issue 19

Abstract: Purpose: This study analyses a large number of cancer patients with CIEDs for device malfunction and premature battery depletion by device interrogation after each radiotherapy fraction and compares different guidelines in regard to patient safety.: ... ...

Abstract	Purpose: This study analyses a large number of cancer patients with CIEDs for device malfunction and premature battery depletion by device interrogation after each radiotherapy fraction and compares different guidelines in regard to patient safety. Methods: From 2007 to 2022, a cohort of 255 patients was analyzed for CIED malfunctions via immediate device interrogation after every RT fraction. Results: Out of 324 series of radiotherapy treatments, with a total number of 5742 CIED interrogations, nine device malfunctions (2.8%) occurred. Switching into back-up/safety mode and software errors occurred four times each. Once, automatic read-out could not be performed. The median prescribed cumulative dose at planning target volume (PTV) associated with CIED malfunction was 45.0 Gy (IQR 36.0-64.0 Gy), with a median dose per fraction of 2.31 Gy (IQR 2.0-3.0 Gy). The median maximum dose at the CIED at time of malfunction was 0.3 Gy (IQR 0.0-1.3 Gy). No correlation between CIED malfunction and maximum photon energy ( Conclusion: Radiation-induced malfunctions of CIEDs and premature battery depletion are rare. If recommendations of national safety guidelines are followed, only a portion of the malfunctions would be detected directly after occurrence. Nevertheless, patient safety would not be compromised.
Language	English
Publishing date	2023-10-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15194830
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Article ; Online: Machine Learning-Based Prediction of Malnutrition in Surgical In-Patients: A Validation Pilot Study.

Kramer, Diether / Jauk, Stefanie / Veeranki, Sai / Schrempf, Michael / Traub, Julia / Kugel, Eva / Prisching, Anna / Domnanich, Sandra / Leopold, Maria / Krisper, Peter / Sendlhofer, Gerald

Studies in health technology and informatics

2024 Volume 313, Page(s) 156–157

Abstract: Background: Malnutrition in hospitalised patients can lead to serious complications, worse patient outcomes and longer hospital stays. State-of-the-art screening methods rely on scores, which need additional manual assessments causing higher workload.!## ...

Abstract	Background: Malnutrition in hospitalised patients can lead to serious complications, worse patient outcomes and longer hospital stays. State-of-the-art screening methods rely on scores, which need additional manual assessments causing higher workload. Objectives: The aim of this prospective study was to validate a machine learning (ML)-based approach for an automated prediction of malnutrition in hospitalised patients. Methods: For 159 surgical in-patients, an assessment of malnutrition by dieticians was compared to the ML-based prediction conducted in the evening of admission. Results: The model achieved an accuracy of 83.0% and an AUROC of 0.833 in the prospective validation cohort. Conclusion: The results of this pilot study indicate that an automated malnutrition screening could replace manual screening tools in hospitals.
MeSH term(s)	Humans ; Machine Learning ; Pilot Projects ; Malnutrition/diagnosis ; Male ; Female ; Prospective Studies ; Aged ; Middle Aged ; Nutrition Assessment
Language	English
Publishing date	2024-04-30
Publishing country	Netherlands
Document type	Journal Article ; Validation Study
ISSN	1879-8365
ISSN (online)	1879-8365
DOI	10.3233/SHTI240029
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Fix the broken food system in three steps.

Schmidt-Traub, Guido / Obersteiner, Michael / Mosnier, Aline

Nature

2019 Volume 569, Issue 7755, Page(s) 181–183

MeSH term(s)	Agriculture/methods ; Agriculture/organization & administration ; Agriculture/statistics & numerical data ; Animals ; Biodiversity ; Climate Change ; Commerce ; Efficiency, Organizational ; Food Supply/methods ; Food Supply/statistics & numerical data ; Forestry/trends ; Humans ; Nutritional Status ; Sustainable Development
Language	English
Publishing date	2019-05-17
Publishing country	England
Document type	Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/d41586-019-01420-2
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Zs.MG 9: Show issues
Zs.MO 244: Show issues

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Article ; Online: How can diverse national food and land-use priorities be reconciled with global sustainability targets? Lessons from the FABLE initiative

Singh, Vartika / Mosnier, Aline / Schmidt-Traub, Guido / Obersteiner, Michael / Jones, Sarah / DeClerck, Fabrice

Sustainability Science

2023

Abstract: There is an urgent need for countries to transition their national food and land-use systems toward food and nutritional security, climate stability, and environmental integrity. How can countries satisfy their demands while jointly delivering the ... ...

Abstract	There is an urgent need for countries to transition their national food and land-use systems toward food and nutritional security, climate stability, and environmental integrity. How can countries satisfy their demands while jointly delivering the required transformative change to achieve global sustainability targets? Here, we present a collaborative approach developed with the FABLE—Food, Agriculture, Biodiversity, Land, and Energy—Consortium to reconcile both global and national elements for developing national food and land-use system pathways. This approach includes three key features: (1) global targets, (2) country-driven multi-objective pathways, and (3) multiple iterations of pathway refinement informed by both national and international impacts. This approach strengthens policy coherence and highlights where greater national and international ambition is needed to achieve global goals (e.g., the SDGs). We discuss how this could be used to support future climate and biodiversity negotiations and what further developments would be needed.
Keywords	land use ; food ; nutritional security ; climate ; environmental protection ; sustainability ; policies ; strategies ; impacts ; sustainable development goals ; biodiversity ; food systems
Language	English
Publishing date	2023-08-08T09:33:02Z
Publisher	Springer
Publishing country	fr
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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