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Book ; Article ; Online: Farm Level Comparison of H.R. 2646 and S. 1731

Richardson, James W. / Outlaw, Joe L. / Anderson, David P. / Schumann, Keith D. / Feldman, Paul A. / Sartwelle, James D., III / Gill, Chope / Kaman, Paul / Houston, Christy M. / Womack, Abner W.

2002

Abstract: The provisions in the House (H.R. 2646) and Senate (S. 1731) farm bills are analyzed with respect ... panels are reconvened frequently to update their farm’s data. The representative farm data base has been ...

Abstract	The provisions in the House (H.R. 2646) and Senate (S. 1731) farm bills are analyzed with respect to their impacts on 94 representative crop, livestock, and dairy farms. The analysis incorporates both historical price and production risk for the farms so the “safety net” aspects of the bills can be compared. Representative crop livestock and dairy farms for major production regions across the county are analyzed. Information to describe and simulate these farms comes from a panel of farmers in each local area. The farm panels are reconvened frequently to update their farm’s data. The representative farm data base has been used for policy analysis for more than 15 years. The simulation model used for the analysis was developed by AFPC scientists.
Keywords	Agribusiness ; Agricultural and Food Policy
Language	English
Publishing country	us
Document type	Book ; Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Broad-spectrum antiviral activity of the acyclic guanosine phosphonate (R,S)-HPMPG.

Terry, B J / Mazina, K E / Tuomari, A V / Haffey, M L / Hagen, M / Feldman, A / Slusarchyk, W A / Young, M G / Zahler, R / Field, A K

Antiviral research

1988 Volume 10, Issue 4-5, Page(s) 235–251

Abstract: R,S)-9-(3-hydroxy-2-phosphonomethoxypropyl)guanine [(R,S)-HPMPG] exhibits broad spectrum antiviral ... its thymidine kinase deficient variant are equally sensitive to (R,S)-HPMPG. (R,S)-HPMPG is 100-fold more potent ... However, (R,S)-HPMPG is toxic when administered repeatedly at 44 mg/kg/day in uninfected adult mice ...

Abstract	(R,S)-9-(3-hydroxy-2-phosphonomethoxypropyl)guanine [(R,S)-HPMPG] exhibits broad spectrum antiviral activity with an ED50 of less than 1 microM against herpes simplex virus (HSV) types 1 and 2, varicella zoster virus, human cytomegalovirus (HCMV) and vaccinia in plaque reduction assays. Wild type HSV-2 and its thymidine kinase deficient variant are equally sensitive to (R,S)-HPMPG. (R,S)-HPMPG is 100-fold more potent than acyclovir (ED50 = 0.45 microM vs. 44 microM, respectively) against HCMV in cell culture, and 10-fold more active than acyclovir in extending survival time in mice intraperitoneally infected with 70 LD50 HSV-1. However, (R,S)-HPMPG is toxic when administered repeatedly at 44 mg/kg/day in uninfected adult mice. The diphosphoryl derivative of HPMPG was enzymatically synthesized and is a competitive inhibitor of HSV-1 DNA polymerase relative to dGTP (K1 = 0.03 microM). HPMPG-PP is 70-fold less active at inhibiting HeLa DNA polymerase alpha than HSV-1 DNA polymerase. At concentrations between 0.3 and 1.5 microM (R,S)-HPMPG inhibited HSV-1 DNA replication greater than or equal to 50% in infected cells as measured by nucleic acid hybridization. Consistent with inhibition of viral DNA synthesis, 6 to 30 microM (R,S)-HPMPG reduces late viral polypeptide synthesis in HSV-1 infected cells. These data indicate that (R,S)-HPMPG is a thymidine kinase independent broad spectrum antiviral drug which is capable of inhibiting viral DNA polymerase.
MeSH term(s)	Acyclovir/analogs & derivatives ; Acyclovir/pharmacology ; Animals ; Antiviral Agents/chemical synthesis ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Antiviral Agents/toxicity ; Cell Line ; Cytomegalovirus/drug effects ; DNA Replication/drug effects ; DNA Viruses/drug effects ; DNA, Viral/biosynthesis ; DNA, Viral/drug effects ; Female ; Ganciclovir ; Guanine/analogs & derivatives ; Guanine/chemical synthesis ; Guanine/pharmacology ; Guanine/therapeutic use ; Guanine/toxicity ; HeLa Cells ; Herpes Simplex/drug therapy ; Herpesvirus 3, Human/drug effects ; Mice ; Molecular Structure ; Nucleic Acid Synthesis Inhibitors ; Organophosphorus Compounds ; Simplexvirus/drug effects ; Vaccinia virus/drug effects ; Vero Cells ; Viral Proteins/biosynthesis ; Virus Replication/drug effects
Chemical Substances	Antiviral Agents ; DNA, Viral ; Nucleic Acid Synthesis Inhibitors ; Organophosphorus Compounds ; Viral Proteins ; 9-(3-hydroxy-2-phosphonomethoxypropyl)guanine (113852-36-1) ; Guanine (5Z93L87A1R) ; Ganciclovir (P9G3CKZ4P5) ; Acyclovir (X4HES1O11F)
Language	English
Publishing date	1988-12-01
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article
ZDB-ID	306628-9
ISSN	1872-9096 ; 0166-3542
ISSN (online)	1872-9096
ISSN	0166-3542
DOI	10.1016/0166-3542(88)90034-4
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Zs.A 1627: Show issues

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Article: The French Randomized Optimal Stenting Trial: a prospective evaluation of provisional stenting guided by coronary velocity reserve and quantitative coronary angiography. F.R.O.S.T. Study Group.

Lafont, A / Dubois-Randé, J L / Steg, P G / Dupouy, P / Carrié, D / Coste, P / Furber, A / Beygui, F / Feldman, L J / Rahal, S / Tron, C / Hamon, M / Grollier, G / Commeau, P / Richard, P / Colin, P / Bauters, C / Karrillon, G / Ledru, F /

Citron, B / Marié, F N / Kern, M

Journal of the American College of Cardiology

2000 Volume 36, Issue 2, Page(s) 404–409

Abstract: Objectives: We sought to make a prospective comparison of systematic stenting with provisional stenting guided by Doppler measurements of coronary velocity reserve and quantitative coronary angiography.: Background: Despite the increasing use of ... ...

Abstract	Objectives: We sought to make a prospective comparison of systematic stenting with provisional stenting guided by Doppler measurements of coronary velocity reserve and quantitative coronary angiography. Background: Despite the increasing use of stents during percutaneous transluminal coronary angioplasty, it is unclear whether systematic stenting is superior to a strategy of provisional stenting in which stents are placed only in patients with unsatisfactory results or as a bail-out procedure. Methods: Two hundred fifty-one patients undergoing elective coronary angioplasty were randomly assigned either to provisional stenting (group 1, in which stenting was performed if postangioplasty coronary velocity reserve was <2.2 and/or residual stenosis > or =35% or as bail-out) or to systematic stenting (group 2). The primary end point was the six-month angiographic minimal lumen diameter (MLD). Major adverse cardiac events were secondary end points (death, acute myocardial infarction and target lesion revascularization). Results: Stenting was performed in 48.4% of patients in group 1 and 100% of patients in group 2 (p<0.01). Six months after angioplasty, the MLD did not differ between groups (1.90+/-0.79 mm vs. 1.99+/-0.70 mm, p = 0.39), as was the rate of binary restenosis (27.1% vs. 21.4%, p = 0.37). Among patients with restenosis, 13/32 (40.6%) in group 1 but 100% (25/25) in group 2 had in-stent restenosis (p<0.01). Target lesion revascularization (15.1% vs. 14.4% in groups 1 and 2 respectively, p = 0.89) and major adverse cardiac events (15.1% vs. 16.0%, p = 0.85) were not significantly different. Conclusions: Systematic stenting does not provide superior angiographic results at six months as compared with provisional stenting.
MeSH term(s)	Aged ; Angioplasty, Balloon, Coronary ; Coronary Angiography ; Coronary Disease/therapy ; Coronary Vessels/pathology ; Echocardiography, Doppler ; Humans ; Middle Aged ; Prospective Studies ; Stents
Language	English
Publishing date	2000-08
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	605507-2
ISSN	1558-3597 ; 0735-1097
ISSN (online)	1558-3597
ISSN	0735-1097
DOI	10.1016/s0735-1097(00)00747-6
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Zs.A 1846: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 196: Show issues

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Article ; Online: Venipuncture Site Influences Blood-drop Volume in C57BL/6 Mice.

Lavin, Elizabeth S / Feldman, Erica R / Soprano, Scott M / Moore, Elizabeth S

Journal of the American Association for Laboratory Animal Science : JAALAS

2024

Abstract: Many experiments require the collection of serial blood samples from mice. However, the size of mice limits the volume of blood that can be safely collected as a survival procedure. In IACUC protocols, investigators may report the amount of blood they ... ...

Abstract	Many experiments require the collection of serial blood samples from mice. However, the size of mice limits the volume of blood that can be safely collected as a survival procedure. In IACUC protocols, investigators may report the amount of blood they collect from mice as a number of drops. Many institutions, including ours, use an anecdotal conversion factor (1 drop of mouse blood = 25 µL) to ensure that blood-collection volumes are compliant with institutional guidelines. To our knowledge, previous work has not experimentally determined the volume of a drop of mouse blood. In this 10-wk crossover experiment, 2 phlebotomists bled 30 C57BL/6J mice from 3 sites (facial, saphenous, and tail) using one or 2 different needle gauge sizes per site. Male and female mice were weighed weekly and divided among 5 groups (
Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Journal Article
ISSN	2769-6677
ISSN (online)	2769-6677
DOI	10.30802/AALAS-JAALAS-23-000083
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: The Seven ages of man. Edited by Robert R. Sears [and] S. Shirley Feldman

Feldman, S. Shirley / Sears, Robert R

1973

MeSH term(s)	Child Development ; Personality Development
Language	English
Size	vii, 145 p., illus.
Publisher	Kaufmann
Publishing place	Los Altos, Calif
Document type	Book
Note	Revised articles which appeared originally in New society during 1964.
ISBN	9780913232071 ; 0913232076
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: Ensuring Ethical Postprogression Therapy for Patients in Randomized Trial Control Arms.

Cliff, Edward R Scheffer / Kesselheim, Aaron S / Feldman, William B

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2023 Volume 41, Issue 24, Page(s) 3984–3987

MeSH term(s)	Humans ; Disease-Free Survival ; Clinical Protocols
Language	English
Publishing date	2023-06-21
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.22.02675
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Zs.A 1847: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 650: Show issues

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Article ; Online: Surgery for Spinal Stenosis in Achondroplasia: Causes of Reoperation and Reduction of Risks.

Hariharan, Arun R / Nugraha, Hans K / Huser, Aaron J / Feldman, David S

Journal of pediatric orthopedics

2024

Abstract: Background: Individuals with achondroplasia are prone to symptomatic spinal stenosis requiring surgery. Revision rates are thought to be high; however, the precise causes and rates of reoperation are unknown. The primary aim of this study is to ... ...

Abstract	Background: Individuals with achondroplasia are prone to symptomatic spinal stenosis requiring surgery. Revision rates are thought to be high; however, the precise causes and rates of reoperation are unknown. The primary aim of this study is to investigate the causes of reoperation after initial surgical intervention in individuals with achondroplasia and spinal stenosis. In addition, we report on surgical techniques aimed at reducing the risks of these reoperations. Methods: A retrospective review was conducted over an 8-year period of all patients with achondroplasia at a single institution that serves as a large referral center for patients with skeletal dysplasias. Patients with achondroplasia who underwent spinal surgery for stenosis were identified and the need for revision surgery was studied. Data collected included demographic, surgical, and revision details. Fisher exact test was used to determine if an association existed between construct type and the need for revisions. Results: Thirty-three of the 130 (22%) patients with achondroplasia required spinal stenosis surgery. Twenty-four individuals who met the criteria were selected for analysis. The initial spine surgery was at an average age of 18.7 years (SD: 10.1 y). Nine patients (38%) required revision surgeries, and 3 required multiple revisions. Five of 9 (56%) of the revisions had primary surgery at an outside institution. Revision surgeries were due to caudal pseudarthrosis (the distal instrumented segment) (8), proximal junctional kyphosis (PJK) (7), and new neurological symptoms (7). There was a significant association found between construct type and the need for revision (P=0.0111). The pairwise comparison found that short fusions were significantly associated with the need for revision compared with the interbody group (P=0.0180). PJK was associated with short fusions when compared with the long fusion group (P=0.0294) and the interbody group (P=0.0300). Caudal pseudarthrosis was associated with short fusions when compared with the interbody group (P=0.0015). Multivariate logistic regression found long fusion with an interbody was predictive of and protective against the need for revision surgery (P=0.0246). To date, none of the initial cases that had long fusions with caudal interbody required a revision for distal pseudarthrosis. Conclusions: In patients with achondroplasia, the rate of surgery for spinal stenosis is 22% and the risk of revision is 38% and is primarily due to pseudarthrosis, PJK, and recurrent neurological symptoms. Surgeons should consider discussing spinal surgery as part of the patient's life plan and should consider wide decompression of the stenotic levels and long fusion with the use of an interbody cage at the caudal level in all patients to reduce risks of revision. Level of evidence: Level IV-Retrospective case series.
Language	English
Publishing date	2024-04-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	604642-3
ISSN	1539-2570 ; 0271-6798
ISSN (online)	1539-2570
ISSN	0271-6798
DOI	10.1097/BPO.0000000000002687
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Zs.A 1681: Show issues

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Article ; Online: The mechanics of risk adjustment and incentives for coding intensity in Medicare.

Carlin, Caroline S / Feldman, Roger / Jung, Jeah

Health services research

2024

Abstract: Objective: To study diagnosis coding intensity across Medicare programs, and to examine the impacts of changes in the risk model adopted by the Centers for Medicare and Medicaid Services (CMS) for 2024.: Data sources and study setting: Claims and ... ...

Abstract	Objective: To study diagnosis coding intensity across Medicare programs, and to examine the impacts of changes in the risk model adopted by the Centers for Medicare and Medicaid Services (CMS) for 2024. Data sources and study setting: Claims and encounter data from the CMS data warehouse for Traditional Medicare (TM) beneficiaries and Medicare Advantage (MA) enrollees. Study design: We created cohorts of MA enrollees, TM beneficiaries attributed to Accountable Care Organizations (ACOs), and TM non-ACO beneficiaries. Using the 2019 Hierarchical Condition Category (HCC) software from CMS, we computed HCC prevalence and scores from base records, then computed incremental prevalence and scores from health risk assessments (HRA) and chart review (CR) records. Data collection/extraction methods: We used CMS's 2019 random 20% sample of individuals and their 2018 diagnosis history, retaining those with 12 months of Parts A/B/D coverage in 2018. Principal findings: Measured health risks for MA and TM ACO individuals were comparable in base records for propensity-score matched cohorts, while TM non-ACO beneficiaries had lower risk. Incremental health risk due to diagnoses in HRA records increased across coverage cohorts in line with incentives to maximize risk scores: +0.9% for TM non-ACO, +1.2% for TM ACO, and + 3.6% for MA. Including HRA and CR records, the MA risk scores increased by 9.8% in the matched cohort. We identify the HCC groups with the greatest sensitivity to these sources of coding intensity among MA enrollees, comparing those groups to the new model's areas of targeted change. Conclusions: Consistent with previous literature, we find increased health risk in MA associated with HRA and CR records. We also demonstrate the meaningful impacts of HRAs on health risk measurement for TM coverage cohorts. CMS's model changes have the potential to reduce coding intensity, but they do not target the full scope of hierarchies sensitive to coding intensity.
Language	English
Publishing date	2024-01-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	410435-3
ISSN	1475-6773 ; 0017-9124
ISSN (online)	1475-6773
ISSN	0017-9124
DOI	10.1111/1475-6773.14272
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Zs.A 582: Show issues

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Article ; Online: A case report of an unusual cause of increased impedance after generator exchange.

Feldman, Daniel R / Kiessling, Mark H / Sangha, Rajbir S

European heart journal. Case reports

2023 Volume 7, Issue 4, Page(s) ytad161

Abstract: Background: Remote monitoring has emerged as a complement to in-person care for patient with cardiac implantable electronic devices (CIEDs). It provides the care team with information about device integrity, programming issues, or other medical data (i ... ...

Abstract	Background: Remote monitoring has emerged as a complement to in-person care for patient with cardiac implantable electronic devices (CIEDs). It provides the care team with information about device integrity, programming issues, or other medical data (i.e. arrhythmias) and since 2015 has been recognized as a part of standard management by the Heart and Rhythm Society for all patients with CIEDs. However, while it can provide invaluable information to providers, the volume of generated data can increase the risk of oversight. We present a novel case of apparent device malfunction that on closer scrutiny was obvious, but provides a lesson in the mechanisms by which data can be artifactual. Case summary: A 62-year-old male presented after his cardiac resynchronization therapy-defibrillator (CRT-D) alerted him that his device was at an elective replacement interval (ERI). He underwent an uncomplicated generator exchange; however, 2 weeks later, a remote alert showed that his device was at ERI and all impedances were above the upper limit. Device interrogation the following day demonstrated that the new device was functioning appropriately and his home monitor had in fact paired with his old generator. He obtained a new home monitor, and subsequent remote transmissions have demonstrated that his device is functioning appropriately. Discussion: This case demonstrates the importance of careful review of details from home-monitoring data. While concerning for device malfunction, there could be alternative causes when alerts are generated by remote monitoring. To our knowledge, this is the first report of this mechanism of alert via a home-monitoring device and should be considered when reviewing unusual remote download data.
Language	English
Publishing date	2023-04-10
Publishing country	England
Document type	Case Reports
ISSN	2514-2119
ISSN (online)	2514-2119
DOI	10.1093/ehjcr/ytad161
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Article: Innate Error Immunities of the Th17 Immune Pathway Associated With Chronic Mucocutaneous Candidiasis: A Systematic Review.

Mirza, Verda S / Zaino, Mallory L / Feldman, Steven R

Journal of drugs in dermatology : JDD

2023 Volume 22, Issue 12, Page(s) 1197–1203

Abstract: Background: Candida albicans is an opportunistic pathogenic yeast commensal in human mucosa. In individuals with compromised immune systems, it can present as chronic mucocutaneous candidiasis (CMC) or systemic infection. CMC often exists in the ... ...

Abstract	Background: Candida albicans is an opportunistic pathogenic yeast commensal in human mucosa. In individuals with compromised immune systems, it can present as chronic mucocutaneous candidiasis (CMC) or systemic infection. CMC often exists in the presence of other infectious phenotypes due to dysfunction of the Th17 immune response. Objective: To examine innate error immunities (IEI) of the Th17 immune response associated with CMC. Methods: MEDLINE PubMed, Embase, and Web of Science were searched for keywords and Medical Subject Headings (MeSH) related to the subject of interest. Nonapplicable and non-primary research methodologies were excluded. Results: We identified 266 articles; 89 were removed for being a duplicate, 108 for irrelevance, and 51 for being a review. We examined 18 studies, 5 on murine models, and 13 human studies. Conclusion: Case reports in patients with CMC have identified a range of mutations in IL-17F, IL-17RA, IL-17RC, and ACT1. Mouse models confirm the role of IL-17A and IL-17F in disease susceptibility. J Drugs Dermatol. 2023;22(12):1197-1203. doi:10.36849/JDD.7579.
MeSH term(s)	Humans ; Animals ; Mice ; Interleukin-17/metabolism ; Candidiasis, Chronic Mucocutaneous/genetics ; Candidiasis, Chronic Mucocutaneous/pathology ; Immunity, Innate ; Candida albicans ; Mutation
Chemical Substances	Interleukin-17
Language	English
Publishing date	2023-12-02
Publishing country	United States
Document type	Systematic Review ; Journal Article
ZDB-ID	2145090-0
ISSN	1545-9616
ISSN	1545-9616
DOI	10.36849/JDD.7579
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