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Article ; Online: Lower vitamin D is associated with metabolic syndrome and insulin resistance in systemic lupus: data from an international inception cohort.

Chew, Christine / Reynolds, John A / Lertratanakul, Apinya / Wu, Peggy / Urowitz, Murray / Gladman, Dafna D / Fortin, Paul R / Bae, Sang-Cheol / Gordon, Caroline / Clarke, Ann E / Bernatsky, Sasha / Hanly, John G / Isenberg, David / Rahman, Anisur / Sanchez-Guerrero, Jorge / Romero-Diaz, Juanita / Merrill, Joan / Wallace, Daniel / Ginzler, Ellen /

Rheumatology (Oxford, England)

2021 Volume 60, Issue 10, Page(s) 4737–4747

Abstract: Objectives: Vitamin D (25(OH)D) deficiency and metabolic syndrome (MetS) may both contribute ... phenotype, therapy and vitamin D levels with MetS and insulin resistance.: Methods: The Systemic Lupus ... centres across 11 countries from 2000. Clinical, laboratory and therapeutic data were collected. Vitamin D ...

Abstract	Objectives: Vitamin D (25(OH)D) deficiency and metabolic syndrome (MetS) may both contribute to increased cardiovascular risk in SLE. We aimed to examine the association of demographic factors, SLE phenotype, therapy and vitamin D levels with MetS and insulin resistance. Methods: The Systemic Lupus International Collaborating Clinics (SLICC) enrolled patients recently diagnosed with SLE (<15 months) from 33 centres across 11 countries from 2000. Clinical, laboratory and therapeutic data were collected. Vitamin D level was defined according to tertiles based on distribution across this cohort, which were set at T1 (10-36 nmol/l), T2 (37-60 nmol/l) and T3 (61-174 nmol/l). MetS was defined according to the 2009 consensus statement from the International Diabetes Federation. Insulin resistance was determined using the HOMA-IR model. Linear and logistic regressions were used to assess the association of variables with vitamin D levels. Results: Of the 1847 patients, 1163 (63%) had vitamin D measured and 398 (34.2%) subjects were in the lowest 25(OH)D tertile. MetS was present in 286 of 860 (33%) patients whose status could be determined. Patients with lower 25(OH)D were more likely to have MetS and higher HOMA-IR. The MetS components, hypertension, hypertriglyceridemia and decreased high-density lipoprotein (HDL) were all significantly associated with lower 25(OH)D. Increased average glucocorticoid exposure was associated with higher insulin resistance. Conclusions: MetS and insulin resistance are associated with lower vitamin D in patients with SLE. Further studies could determine whether vitamin D repletion confers better control of these cardiovascular risk factors and improve long-term outcomes in SLE.
MeSH term(s)	Adult ; Cohort Studies ; Cross-Sectional Studies ; Female ; Global Health/statistics & numerical data ; Humans ; Insulin Resistance ; Lupus Erythematosus, Systemic/blood ; Lupus Erythematosus, Systemic/complications ; Male ; Metabolic Syndrome/epidemiology ; Metabolic Syndrome/etiology ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/epidemiology ; Young Adult
Chemical Substances	Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
Language	English
Publishing date	2021-04-05
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	1464822-2
ISSN	1462-0332 ; 1462-0324
ISSN (online)	1462-0332
ISSN	1462-0324
DOI	10.1093/rheumatology/keab090
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Article ; Online: Vitamin D insufficiency in a large female SLE cohort.

Toloza, S M A / Cole, D E C / Gladman, D D / Ibañez, D / Urowitz, M B

Lupus

2010 Volume 19, Issue 1, Page(s) 13–19

Abstract: The objective of this study was to determine the vitamin D status and its relationship with disease ... pregnant systemic lupus erythematosus women with dual-energy X-ray absorptiometry and vitamin D ... bone density. 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels were determined at the time of dual-energy ...

Abstract	The objective of this study was to determine the vitamin D status and its relationship with disease and therapy features and with bone mineral density in women with systemic lupus erythematosus. Non-pregnant systemic lupus erythematosus women with dual-energy X-ray absorptiometry and vitamin D measurements performed between May 1 2005 and August 31 2006 were studied. In each patient, the lowest T-score of the first dual-energy X-ray absorptiometry scan during the study period was used. In postmenopausal women, a T-score > or = 1.0 standard deviation was considered normal, between -1.0 and -2.5 standard deviations osteopenia and < or = 2.5 standard deviations osteoporosis; in premenopausal women a T-score > or = 2.5 standard deviations was normal and < or = 2.5 standard deviations defined as reduced bone density. 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels were determined at the time of dual-energy X-ray absorptiometry. A 25-hydroxyvitamin D level of <80 nmol/L was defined as sub-optimal and a level <40 nmol/L as deficient. Demographic and clinical variables were investigated for association with vitamin D levels by univariate and multivariate analyses. One-hundred and twenty-four systemic lupus erythematosus women had dual-energy X-ray absorptiometry scans and vitamin D assays performed during the study period. Sub-optimal 25-hydroxyvitamin D levels were found in 82 (66.7%) and deficient 25-hydroxyvitamin D levels in 22 (17.9%) patients. The disease-related features examined at the time of vitamin D assays or bone mineral density showed no correlation with vitamin D levels by univariate analyses. Neither 25-hydroxyvitamin D nor 1,25-dihydroxyvitamin D was associated with bone mineral density status among these patients. A multivariate logistic regression model identified season, cumulative glucocorticoid exposure, and serum creatinine as being associated with 25-hydroxyvitamin D levels, whereas ethnicity, glucocorticoid exposure, and serum creatinine were associated with 1,25-dihydroxyvitamin D levels. In conclusion, sub-optimal vitamin D status is common in women with systemic lupus erythematosus and is related to season, cumulative glucocorticoid dose, and serum creatinine.
MeSH term(s)	Adult ; Calcitriol/blood ; Cohort Studies ; Creatinine/blood ; Female ; Glucocorticoids/adverse effects ; Humans ; Logistic Models ; Lupus Erythematosus, Systemic/complications ; Middle Aged ; Multivariate Analysis ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D Deficiency/epidemiology
Chemical Substances	Glucocorticoids ; Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H) ; Creatinine (AYI8EX34EU) ; Calcitriol (FXC9231JVH)
Language	English
Publishing date	2010-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1154407-7
ISSN	1477-0962 ; 0961-2033
ISSN (online)	1477-0962
ISSN	0961-2033
DOI	10.1177/0961203309345775
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Article ; Online: The Combined Oral Stable Isotope Assessment of Muscle (COSIAM) reveals D-3 creatine derived muscle mass as a standout cross-sectional biomarker of muscle physiology vitality in older age.

Cegielski, Jessica / Brook, Matthew S / Phillips, Bethan E / Boereboom, Catherine / Gates, Amanda / Gladman, John F R / Smith, Kenneth / Wilkinson, Daniel J / Atherton, Philip J

GeroScience

2022 Volume 44, Issue 4, Page(s) 2129–2138

Abstract: ... 5 y)) into a 3-day trial. Subjects consumed D₃-creatine (D₃-Cr dilution ... to assess WBMM), D₂O (MPS by incorporation of alanine) and D₃-3-methylhistidine (D_{D₃-Cr/D₃-MH dilution for WBMM and MPB ...}

Abstract	Validated diagnostics of skeletal muscle vitality could benefit clinical and basic science in terms of mechanistic insights and in determining the efficacy of interventions, e.g. exercise/pharmaceuticals/nutrients. We recently developed a Combined Oral Assessment of Muscle (COSIAM) that can be used to simultaneously quantify whole-body muscle mass (WBMM), muscle protein synthesis (MPS) and muscle protein breakdown (MPB). Here, we aimed to establish, in a cross-sectional fashion, links between COSIAM parameters and established aspects of muscle function. We recruited 37 healthy older adults (male (M):female (F) (21/16); 72 ± 5 y)) into a 3-day trial. Subjects consumed D<sub>3</sub>-creatine (D<sub>3</sub>-Cr dilution to assess WBMM), D<sub>2</sub>O (MPS by incorporation of alanine) and D<sub>3</sub>-3-methylhistidine (D<sub>3</sub>-MH dilution to assess MPB). A biopsy at day 3 was used to determine MPS, and blood/urine samples were collected to determine D<sub>3</sub>-Cr/D<sub>3</sub>-MH dilution for WBMM and MPB. Physiological measures of muscle mass (e.g. DXA/ultrasound) and function (e.g. handgrip strength, maximum voluntary contraction (MVC), one-repetition maximum (1-RM)) were ascertained. A stepwise linear regression approach was used to address links between facets of COSIAM (MPS, MPB, WBMM) and muscle physiology. Despite expected differences in muscle mass, there were no significant differences in MPS or MPB between sexes. WBMM as measured using D<sub>3</sub>-Cr positively correlated with DXA-derived lean body mass (LBM) and appendicular LBM (ABLM). Stepwise linear regression was used to assess which combination of MPS, MPB, D<sub>3</sub>-Cr and absolute synthesis rate (ASR) best predicted physiological measures of muscle health in these older adults. D<sub>3</sub>-Cr WBMM alone was the best predictor of handgrip, 1RM and MVC, and outperformed more traditional measures of muscle mass by DXA. The COSIAM approach substantiates D<sub>3</sub>-Cr as a robust biomarker of multiple muscle physiology health biomarkers. Future work using COSIAM should focus upon how and which parameters it can inform upon in relation to disease progression and the efficacy of interventions.
MeSH term(s)	Aged ; Female ; Humans ; Male ; Biomarkers/metabolism ; Creatine/metabolism ; Cross-Sectional Studies ; Hand Strength ; Isotopes/metabolism ; Muscle Proteins/metabolism ; Muscle, Skeletal/metabolism
Chemical Substances	Biomarkers ; Creatine (MU72812GK0) ; Isotopes ; Muscle Proteins
Language	English
Publishing date	2022-03-18
Publishing country	Switzerland
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2886586-8
ISSN	2509-2723 ; 2509-2715
ISSN (online)	2509-2723
ISSN	2509-2715
DOI	10.1007/s11357-022-00541-3
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Article ; Online: 25-hydroxyvitamin D and cardiovascular disease in patients with systemic lupus erythematosus: data from a large international inception cohort.

Lertratanakul, Apinya / Wu, Peggy / Dyer, Alan / Urowitz, Murray / Gladman, Dafna / Fortin, Paul / Bae, Sang-Cheol / Gordon, Caroline / Clarke, Ann / Bernatsky, Sasha / Hanly, John G / Isenberg, David / Rahman, Anisur / Merrill, Joan / Wallace, Daniel J / Ginzler, Ellen / Khamashta, Munther / Bruce, Ian / Nived, Ola /

Sturfelt, Gunnar / Steinsson, Kristjan / Manzi, Susan / Dooley, Mary Anne / Kalunian, Kenneth / Petri, Michelle / Aranow, Cynthia / Font, Josep / van Vollenhoven, Ronald / Stoll, Thomas / Ramsey-Goldman, Rosalind

Arthritis care & research

2014 Volume 66, Issue 8, Page(s) 1167–1176

Abstract: Objective: An association between 25-hydroxyvitamin D (25[OH]D; vitamin D) deficiency and ... Vitamin D deficiency has been noted in systemic lupus erythematosus (SLE), and CVD is a major cause ... of morbidity and mortality in SLE. The objectives of this study were to estimate the associations of 25(OH)D ...

Abstract	Objective: An association between 25-hydroxyvitamin D (25[OH]D; vitamin D) deficiency and increased cardiovascular (CV) risk factors and CV disease (CVD) has been shown in general population studies. Vitamin D deficiency has been noted in systemic lupus erythematosus (SLE), and CVD is a major cause of morbidity and mortality in SLE. The objectives of this study were to estimate the associations of 25(OH)D levels with CV risk factors and to determine whether low baseline 25(OH)D levels predict future CV events in patients participating in an international inception cohort. Methods: Data were collected on 890 participants, including demographics, SLE activity and damage assessments, CV risk factors and events, medications, laboratory assessments of 25(OH)D levels, and inflammatory markers. Multiple logistic and Cox regressions were used to estimate the associations of baseline 25(OH)D levels with baseline CV risk factors and CVD events. The models were adjusted for age, sex, race, season, and country, with and without body mass index. Results: Patients in the higher quartiles of 25(OH)D were less likely to have hypertension and hyperlipidemia and were more likely to have lower C-reactive protein levels and lower Systemic Lupus Erythematosus Disease Activity Index 2000 scores at baseline when compared with the first quartile. Vitamin D levels were not independently associated with CVD event incidence; however, hazard ratios for CVD event incidence decreased with successively higher quartiles. Conclusion: Lower baseline 25(OH)D levels are associated with higher risk for CV risk factors and more active SLE at baseline. There may be a trend toward a lower likelihood of CVD events in those with higher baseline 25(OH)D levels.
MeSH term(s)	Adult ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/epidemiology ; Female ; Humans ; Incidence ; Lupus Erythematosus, Systemic/blood ; Lupus Erythematosus, Systemic/epidemiology ; Male ; Middle Aged ; Registries ; Risk Factors ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/epidemiology
Chemical Substances	Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
Language	English
Publishing date	2014-01-28
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	645059-3
ISSN	2151-4658 ; 0893-7524 ; 2151-464X
ISSN (online)	2151-4658
ISSN	0893-7524 ; 2151-464X
DOI	10.1002/acr.22291
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Article ; Online: Dynamics of vitamin D in patients with mild or inactive inflammatory bowel disease and their families.

Grunbaum, Avigyle / Holcroft, Christina / Heilpern, Debra / Gladman, Stephanie / Burstein, Barry / Menard, Maryse / Al-Abbad, Jasim / Cassoff, Jamie / MacNamara, Elizabeth / Gordon, Philip H / Szilagyi, Andrew

Nutrition journal

2013 Volume 12, Issue 1, Page(s) 145

Abstract: Background: 25(OH) vitamin D levels may be low in patients with moderately or severely active ... vitamin D levels in IBD. As a possible risk factor we hypothesize that vitamin D levels may also be low ... in families of IBD patients.: Objectives: To evaluate 25[OH] vitamin D levels in patients with IBD ...

Abstract	Background: 25(OH) vitamin D levels may be low in patients with moderately or severely active inflammatory bowel diseases (IBD: Crohn's disease and Idiopathic Ulcerative Colitis) but this is less clear in patients with mild or inactive IBD. Furthermore there is limited information of any family influence on 25(OH) vitamin D levels in IBD. As a possible risk factor we hypothesize that vitamin D levels may also be low in families of IBD patients. Objectives: To evaluate 25[OH] vitamin D levels in patients with IBD in remission or with mild activity. A second objective is to evaluate whether there are relationships within IBD family units of 25[OH] vitamin D and what are the influences associated with these levels. Methods: Participants underwent medical history, physical examination and a 114 item diet questionnaire. Serum 25[OH] vitamin D was measured, using a radioimmunoassay kit, (replete ≥ 75, insufficient 50-74, deficient < 25-50, or severely deficient < 25 nmol/L). Associations between 25[OH] vitamin D and twenty variables were evaluated using univariate regression. Multivariable analysis was also applied and intrafamilial dynamics were assessed. Results: 55 patients and 48 controls with their respective families participated (N206). 25[OH] vitamin D levels between patients and controls were similar (71.2 ± 32.8 vs. 68.3 ±26.2 nmol/L). Vitamin D supplements significantly increased intake but correlation with serum 25[OH] vitamin D was significant only during non sunny months among patients. Within family units, patients' families had mean replete levels (82.3 ± 34.2 nmol/L) and a modest correlation emerged during sunny months between patients and family (r2 =0.209 p = 0.032). These relationships were less robust and non significant in controls and their families. Conclusions: In patients with mild or inactive IBD 25[OH] vitamin D levels are less than ideal but are similar to controls. Taken together collectively, the results of this study suggest that patient family dynamics may be different in IBD units from that in control family units. However contrary to the hypothesis, intra familial vitamin D dynamics do not pose additional risks for development of IBD.
MeSH term(s)	Adolescent ; Adult ; Aged ; Body Mass Index ; C-Reactive Protein/metabolism ; Case-Control Studies ; Child ; Dietary Supplements ; Female ; Ferritins/blood ; Humans ; Inflammatory Bowel Diseases/blood ; Linear Models ; Male ; Middle Aged ; Multivariate Analysis ; Nutrition Assessment ; Risk Factors ; Seasons ; Vitamin D/administration & dosage ; Vitamin D/blood ; Young Adult
Chemical Substances	Vitamin D (1406-16-2) ; C-Reactive Protein (9007-41-4) ; Ferritins (9007-73-2)
Language	English
Publishing date	2013-11-09
Publishing country	England
Document type	Journal Article
ISSN	1475-2891
ISSN (online)	1475-2891
DOI	10.1186/1475-2891-12-145
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Article ; Online: Seasonal variation in vitamin D levels in psoriatic arthritis patients from different latitudes and its association with clinical outcomes.

Touma, Zahi / Eder, Lihi / Zisman, Devy / Feld, Joy / Chandran, Vinod / Rosen, Cheryl F / Shen, Hua / Cook, Richard J / Gladman, Dafna D

Arthritis care & research

2010 Volume 63, Issue 10, Page(s) 1440–1447

Abstract: Objective. Vitamin D insufficiency appears to be a pandemic problem and is more common ... in inhabitants of high latitude compared to low latitude areas. We aimed to determine the prevalence of vitamin D ... hydroxyvitamin D (25[OH]D) levels were determined. Multivariate linear and logistic mixed models were used ...

Abstract	Objective. Vitamin D insufficiency appears to be a pandemic problem and is more common in inhabitants of high latitude compared to low latitude areas. We aimed to determine the prevalence of vitamin D deficiency/insufficiency in patients with psoriatic arthritis (PsA), its seasonal and geographic variation, and the possible association with demographics and disease activity.Methods. This study was conducted in a northern geographic area and in a subtropical region from March 2009 to August 2009. Most subjects were assessed in both winter and summer. Demographics, clinical data, skin photo type, and serum 25-hydroxyvitamin D (25[OH]D) levels were determined. Multivariate linear and logistic mixed models were used to assess the relationship with serum 25(OH)D levels.Results. In total, 302 PsA patients were enrolled. Two hundred fifty-eight patients were evaluated during the winter,while 214 patients were evaluated during the summer. 25(OH)D levels in winter and summer were adequate (north: 41.3%winter and 41.4% summer, south: 42.1% winter and 35.1% summer), insufficient (north: 55.7% winter and 58.6% summer,south: 50.9% winter and 62.2% summer), and deficient (north: 3% winter and 0% summer, south: 7% winter and 2.7%summer) among patients. There was no association between 25(OH)D levels, geographic and seasonal interaction, race,employment status, and skin photo type or disease activity in both seasons. No association between disease activity in summer and vitamin D levels in winter could be found.Conclusion. A high prevalence of vitamin D insufficiency among PsA patients was found. There was no seasonal variation in 25(OH)D levels among PsA patients in the southern and northern sites. No association could be established between disease activity and vitamin D level.
MeSH term(s)	Adolescent ; Adult ; Arthritis, Psoriatic/blood ; Arthritis, Psoriatic/complications ; Female ; Humans ; Male ; Middle Aged ; Population Dynamics ; Prevalence ; Seasons ; Topography, Medical ; Treatment Outcome ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/epidemiology ; Young Adult
Chemical Substances	Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
Language	English
Publishing date	2010-03-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	645059-3
ISSN	2151-4658 ; 0893-7524 ; 2151-464X
ISSN (online)	2151-4658
ISSN	0893-7524 ; 2151-464X
DOI	10.1002/acr.20530
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Article: HLA-D region antigens in patients with rheumatoid arthritis.

McCusker, C T / Reid, B / Green, D / Gladman, D D / Buchanan, W W / Singal, D P

Arthritis and rheumatism

1991 Volume 34, Issue 2, Page(s) 192–197

Abstract: We studied the distribution of HLA-D region antigens in 2 groups of rheumatoid arthritis (RA ... from our laboratory and from other investigators on the incidence of HLA-D region antigens in RA, suggest that both DR ...

Abstract	We studied the distribution of HLA-D region antigens in 2 groups of rheumatoid arthritis (RA) patients: those with mild, nonprogressive disease, and those with severe disease. The results demonstrate that DR4 was significantly increased in both RA patient populations. The frequencies of DR1 and DR4-associated DQw7 alleles, however, were different in these 2 groups of patients. DR1 was significantly increased only in patients with mild RA, and DR4-associated DQw7 was significantly increased only in patients with severe disease. The results of the present study, together with previous data from our laboratory and from other investigators on the incidence of HLA-D region antigens in RA, suggest that both DR and DQ (A and B) genes may be important in conferring susceptibility to RA; DR in the mild forms of the disease, and DQ in severe RA.
MeSH term(s)	Alleles ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/genetics ; Arthritis, Rheumatoid/immunology ; Gene Amplification ; Gold/therapeutic use ; HLA-D Antigens/metabolism ; HLA-DR Antigens/genetics ; HLA-DR Antigens/metabolism ; HLA-DR4 Antigen/metabolism ; Humans ; Oligonucleotide Probes ; Polymerase Chain Reaction
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; HLA-D Antigens ; HLA-DR Antigens ; HLA-DR4 Antigen ; Oligonucleotide Probes ; Gold (7440-57-5)
Language	English
Publishing date	1991-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	127294-9
ISSN	1529-0131 ; 0004-3591 ; 2326-5191
ISSN (online)	1529-0131
ISSN	0004-3591 ; 2326-5191
DOI	10.1002/art.1780340210
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Article: Sex Effect in Psoriatic Arthritis.

Gladman, Dafna D

The Journal of rheumatology

2022 Volume 50, Issue 2, Page(s) 159–160

MeSH term(s)	Humans ; Arthritis, Psoriatic/drug therapy ; Antirheumatic Agents/therapeutic use ; Sex Factors
Chemical Substances	Antirheumatic Agents
Language	English
Publishing date	2022-10-15
Publishing country	Canada
Document type	Editorial ; Comment
ZDB-ID	194928-7
ISSN	1499-2752 ; 0315-162X
ISSN (online)	1499-2752
ISSN	0315-162X
DOI	10.3899/jrheum.220948
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Article: Dynamics of vitamin D in patients with mild or inactive inflammatory bowel disease and their families

Nutrition journal. 2013 Dec., v. 12, no. 1

2013

Abstract: BACKGROUND: 25(OH) vitamin D levels may be low in patients with moderately or severely active ... vitamin D levels in IBD. As a possible risk factor we hypothesize that vitamin D levels may also be low ... in families of IBD patients. OBJECTIVES: To evaluate 25[OH] vitamin D levels in patients with IBD in remission ...

Abstract	BACKGROUND: 25(OH) vitamin D levels may be low in patients with moderately or severely active inflammatory bowel diseases (IBD: Crohn’s disease and Idiopathic Ulcerative Colitis) but this is less clear in patients with mild or inactive IBD. Furthermore there is limited information of any family influence on 25(OH) vitamin D levels in IBD. As a possible risk factor we hypothesize that vitamin D levels may also be low in families of IBD patients. OBJECTIVES: To evaluate 25[OH] vitamin D levels in patients with IBD in remission or with mild activity. A second objective is to evaluate whether there are relationships within IBD family units of 25[OH] vitamin D and what are the influences associated with these levels. METHODS: Participants underwent medical history, physical examination and a 114 item diet questionnaire. Serum 25[OH] vitamin D was measured, using a radioimmunoassay kit, (replete ≥ 75, insufficient 50–74, deficient < 25–50, or severely deficient < 25� nmol/L). Associations between 25[OH] vitamin D and twenty variables were evaluated using univariate regression. Multivariable analysis was also applied and intrafamilial dynamics were assessed. RESULTS: 55 patients and 48 controls with their respective families participated (N206). 25[OH] vitamin D levels between patients and controls were similar (71.2 ± 32.8 vs. 68.3 ±26.2� nmol/L). Vitamin D supplements significantly increased intake but correlation with serum 25[OH] vitamin D was significant only during non sunny months among patients. Within family units, patients’ families had mean replete levels (82.3 ± 34.2� nmol/L) and a modest correlation emerged during sunny months between patients and family (r² =0.209 p = 0.032). These relationships were less robust and non significant in controls and their families. CONCLUSIONS: In patients with mild or inactive IBD 25[OH] vitamin D levels are less than ideal but are similar to controls. Taken together collectively, the results of this study suggest that patient family dynamics may be different in IBD units from that in control family units. However contrary to the hypothesis, intra familial vitamin D dynamics do not pose additional risks for development of IBD.
Keywords	blood serum ; clinical examination ; colitis ; diet ; idiopathic diseases ; medical history ; multivariate analysis ; patients ; questionnaires ; radioimmunoassays ; remission ; risk ; risk factors ; vitamin D
Language	English
Dates of publication	2013-12
Size	p. 722.
Publishing place	Springer-Verlag
Document type	Article
ZDB-ID	2091602-4
ISSN	1475-2891
ISSN	1475-2891
DOI	10.1186/1475-2891-12-145
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Article ; Online: Axial Psoriatic Arthritis.

Gladman, Dafna D

Current rheumatology reports

2021 Volume 23, Issue 6, Page(s) 35

Abstract: Purpose of review: To review current understanding of the prevalence, clinical features, outcome measures and recent therapeutic trials in axial psoriatic arthritis (axPsA).: Recent findings: The prevalence of axPsA is estimated at 40-50%. However, ... ...

Abstract	Purpose of review: To review current understanding of the prevalence, clinical features, outcome measures and recent therapeutic trials in axial psoriatic arthritis (axPsA). Recent findings: The prevalence of axPsA is estimated at 40-50%. However, the definition of axPsA remains unclear, therefore these estimates may be inaccurate. Ax PsA appears to be distinct from ankylosing spondylitis in demographic, clinical, genetic and therapeutic features. Because of the lack of widely accepted definition of axPsA it has been difficult to design therapeutic trials for this domain of PsA. Several studies have demonstrated the uniquness of axPsA. Few recent trials suggest that therapies that work for peripheral arthritis also work for axPsA.
MeSH term(s)	Arthritis, Psoriatic/diagnosis ; Arthritis, Psoriatic/drug therapy ; Arthritis, Psoriatic/epidemiology ; Humans ; Prevalence ; Severity of Illness Index ; Spondylitis, Ankylosing
Language	English
Publishing date	2021-04-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2057357-1
ISSN	1534-6307 ; 1523-3774
ISSN (online)	1534-6307
ISSN	1523-3774
DOI	10.1007/s11926-021-00999-8
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