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Article ; Online: Tao-Hong-Si-Wu decoction improves depressive symptoms in model rats via amelioration of BDNF-CREB-arginase I axis disorders.

Zhang, Xiaoping / Li, Zeng / Shen, Chuanpu / He, Jinzhi / Wang, Longfei / Di, Lei / Rui, Bin / Li, Ning / Liu, Zhicheng

2022 Volume 60, Issue 1, Page(s) 1739–1750

Abstract: Context: The traditional Chinese medicine formula Tao-Hong-Si-Wu decoction (TSD), used ...

Abstract	Context: The traditional Chinese medicine formula Tao-Hong-Si-Wu decoction (TSD), used for treating ischaemic stroke, has the potential to treat depressive disorder (DD). Objective: To explore the effective targets of TSD on DD animal models. Materials and methods: Sprague-Dawley (SD) rats were modelled by inducing chronic unpredictable mild stress (CUMS) during 35 days and treated with three dosages of TSD (2.5, 5 and 10 g/kg) or fluoxetine (10 mg/kg) by oral gavage for 14 days. Bodyweight measurements and behavioural tests were performed to observe the effect of TSD on the CUMS animals. A gas chromatography coupled with mass spectrometry (GC-MS)-based metabolomic analysis was conducted to reveal the metabolic characteristics related to the curative effect of TSD. Levels of the proteins associated with the feature metabolites were analysed. Results: Reduced immobile duration and crossed squares in the behavioural tests were raised by 48.6% and 32.9%, on average, respectively, by TSD treatment (ED Discussion and conclusions: TSD improves depression-like symptoms in CUMS rats. Further study will focus on the antidepressant-like effects of effective compounds contained in TSD.
MeSH term(s)	Animals ; Antidepressive Agents/pharmacology ; Arginase/metabolism ; Arginase/pharmacology ; Brain Ischemia ; Brain-Derived Neurotrophic Factor/metabolism ; Cyclic AMP Response Element-Binding Protein/metabolism ; Depression/drug therapy ; Depression/metabolism ; Drugs, Chinese Herbal ; Hippocampus ; Rats ; Rats, Sprague-Dawley ; Stress, Psychological/drug therapy ; Stress, Psychological/metabolism ; Stroke
Chemical Substances	Antidepressive Agents ; Brain-Derived Neurotrophic Factor ; Cyclic AMP Response Element-Binding Protein ; Drugs, Chinese Herbal ; si-wu decoction ; Arginase (EC 3.5.3.1)
Language	English
Publishing date	2022-09-11
Publishing country	England
Document type	Journal Article
ZDB-ID	1440131-9
ISSN	1744-5116 ; 1388-0209
ISSN (online)	1744-5116
ISSN	1388-0209
DOI	10.1080/13880209.2022.2116460
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Article ; Online: Tao-Hong-Si-Wu decoction improves depressive symptoms in model rats via amelioration of BDNF-CREB-arginase I axis disorders

Xiaoping Zhang / Zeng Li / Chuanpu Shen / Jinzhi He / Longfei Wang / Lei Di / Bin Rui / Ning Li / Zhicheng Liu

Pharmaceutical Biology, Vol 60, Iss 1, Pp 1739-

2022 Volume 1750

Abstract: Context The traditional Chinese medicine formula Tao-Hong-Si-Wu decoction (TSD), used for treating ...

Abstract	Context The traditional Chinese medicine formula Tao-Hong-Si-Wu decoction (TSD), used for treating ischaemic stroke, has the potential to treat depressive disorder (DD).Objective To explore the effective targets of TSD on DD animal models.Materials and methods Sprague-Dawley (SD) rats were modelled by inducing chronic unpredictable mild stress (CUMS) during 35 days and treated with three dosages of TSD (2.5, 5 and 10 g/kg) or fluoxetine (10 mg/kg) by oral gavage for 14 days. Bodyweight measurements and behavioural tests were performed to observe the effect of TSD on the CUMS animals. A gas chromatography coupled with mass spectrometry (GC–MS)-based metabolomic analysis was conducted to reveal the metabolic characteristics related to the curative effect of TSD. Levels of the proteins associated with the feature metabolites were analysed.Results Reduced immobile duration and crossed squares in the behavioural tests were raised by 48.6% and 32.9%, on average, respectively, by TSD treatment (ED50=3.2 g/kg). Antidepressant effects of TSD were associated with 13 decreased metabolites and the restorations of ornithine and urea in the serum. TSD (5 g/kg) raised serum serotonin by 54.1 mg/dL but suppressed arginase I (Arg I) by 47.8 mg/dL in the CUMS rats. Proteins on the brain-derived neurotrophic factor (BDNF)-cAMP response element-binding protein (CREB) axis that modulate the inhibition of Arg I were suppressed in the CUMS rats but reversed by the TSD intervention.Discussion and conclusions TSD improves depression-like symptoms in CUMS rats. Further study will focus on the antidepressant-like effects of effective compounds contained in TSD.
Keywords	Metabolomics ; GC–MS ; traditional Chinese medicine ; depressive disorder ; Therapeutics. Pharmacology ; RM1-950
Subject code	150
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Tao-Hong-Si-Wu decoction improves depressive symptoms in model rats via amelioration of BDNF-CREB-arginase I axis disorders

Zhang, Xiaoping / Li, Zeng / Shen, Chuanpu / He, Jinzhi / Wang, Longfei / Di, Lei / Rui, Bin / Li, Ning / Liu, Zhicheng

Pharmaceutical Biology. 2022 Dec. 31, v. 60, no. 1 p.1739-1750

2022

Abstract: The traditional Chinese medicine formula Tao-Hong-Si-Wu decoction (TSD), used for treating ...

Abstract	The traditional Chinese medicine formula Tao-Hong-Si-Wu decoction (TSD), used for treating ischaemic stroke, has the potential to treat depressive disorder (DD). To explore the effective targets of TSD on DD animal models. Sprague-Dawley (SD) rats were modelled by inducing chronic unpredictable mild stress (CUMS) during 35 days and treated with three dosages of TSD (2.5, 5 and 10 g/kg) or fluoxetine (10 mg/kg) by oral gavage for 14 days. Bodyweight measurements and behavioural tests were performed to observe the effect of TSD on the CUMS animals. A gas chromatography coupled with mass spectrometry (GC–MS)-based metabolomic analysis was conducted to reveal the metabolic characteristics related to the curative effect of TSD. Levels of the proteins associated with the feature metabolites were analysed. Reduced immobile duration and crossed squares in the behavioural tests were raised by 48.6% and 32.9%, on average, respectively, by TSD treatment (ED₅₀=3.2 g/kg). Antidepressant effects of TSD were associated with 13 decreased metabolites and the restorations of ornithine and urea in the serum. TSD (5 g/kg) raised serum serotonin by 54.1 mg/dL but suppressed arginase I (Arg I) by 47.8 mg/dL in the CUMS rats. Proteins on the brain-derived neurotrophic factor (BDNF)-cAMP response element-binding protein (CREB) axis that modulate the inhibition of Arg I were suppressed in the CUMS rats but reversed by the TSD intervention. TSD improves depression-like symptoms in CUMS rats. Further study will focus on the antidepressant-like effects of effective compounds contained in TSD.
Keywords	Oriental traditional medicine ; animals ; antidepressants ; arginase ; blood serum ; body weight ; fluoxetine ; gas chromatography ; mass spectrometry ; mental depression ; metabolites ; metabolomics ; ornithine ; serotonin ; stroke ; urea ; GC–MS ; traditional Chinese medicine ; depressive disorder
Language	English
Dates of publication	2022-1231
Size	p. 1739-1750.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	1440131-9
ISSN	1744-5116 ; 1388-0209
ISSN (online)	1744-5116
ISSN	1388-0209
DOI	10.1080/13880209.2022.2116460
Database	NAL-Catalogue (AGRICOLA)

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Book: Hong ma yi de jie ri li wu

Zhou, Jing / Shen, Fanfan

(Wo xi huan qu wei han zi you xi shu ; 我喜欢趣味汉字游戏书)

2006

Author's details	Zhou Jing zhu Shen Fanfan hui
Series title	Wo xi huan qu wei han zi you xi shu 我喜欢趣味汉字游戏书
Language	Chinese
Size	30 S., ill
Publisher	Jiangsu shao nian er tong chu ban she
Publishing place	Nanjing
Document type	Book
ISBN	9787534637032 ; 7534637031
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Voxel-Wise Fusion of 3T and 7T Diffusion MRI Data to Extract more Accurate Fiber Orientations.

Wu, Zhanxiong / Weng, Xinmeng / Shen, Jian / Hong, Ming

Brain topography

2024

Abstract: While 7T diffusion magnetic resonance imaging (dMRI) has high spatial resolution, its diffusion imaging quality is usually affected by signal loss due to B1 inhomogeneity, T2 decay, susceptibility, and chemical shift. In contrast, 3T dMRI has relative ... ...

Abstract	While 7T diffusion magnetic resonance imaging (dMRI) has high spatial resolution, its diffusion imaging quality is usually affected by signal loss due to B1 inhomogeneity, T2 decay, susceptibility, and chemical shift. In contrast, 3T dMRI has relative higher diffusion angular resolution, but lower spatial resolution. Combination of 3T and 7T dMRI, thus, may provide more detailed and accurate information about the voxel-wise fiber orientations to better understand the structural brain connectivity. However, this topic has not yet been thoroughly explored until now. In this study, we explored the feasibility of fusing 3T and 7T dMRI data to extract voxel-wise quantitative parameters at higher spatial resolution. After 3T and 7T dMRI data was preprocessed, respectively, 3T dMRI volumes were coregistered into 7T dMRI space. Then, 7T dMRI data was harmonized to the coregistered 3T dMRI B0 (b = 0) images. Last, harmonized 7T dMRI data was fused with 3T dMRI data according to four fusion rules proposed in this study. We employed high-quality 3T and 7T dMRI datasets (N = 24) from the Human Connectome Project to test our algorithms. The diffusion tensors (DTs) and orientation distribution functions (ODFs) estimated from the 3T-7T fused dMRI volumes were statistically analyzed. More voxels containing multiple fiber populations were found from the fused dMRI data than from 7T dMRI data set. Moreover, extra fiber directions were extracted in temporal brain regions from the fused dMRI data at Otsu's thresholds of quantitative anisotropy, but could not be extracted from 7T dMRI dataset. This study provides novel algorithms to fuse intra-subject 3T and 7T dMRI data for extracting more detailed information of voxel-wise quantitative parameters, and a new perspective to build more accurate structural brain networks.
Language	English
Publishing date	2024-04-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1078442-1
ISSN	1573-6792 ; 0896-0267
ISSN (online)	1573-6792
ISSN	0896-0267
DOI	10.1007/s10548-024-01046-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Oncolytic virotherapy evolved into the fourth generation as tumor immunotherapy.

Wang, Xianwang / Shen, Yihua / Wan, Xingxia / Hu, Xiaoqing / Cai, Wen-Qi / Wu, Zijun / Xin, Qiang / Liu, Xiaoqing / Gui, Jingang / Xin, Hong-Yi / Xin, Hong-Wu

Journal of translational medicine

2023 Volume 21, Issue 1, Page(s) 500

Abstract: Background: Oncolytic virotherapy (OVT) is a promising anti-tumor modality that utilizes oncolytic viruses (OVs) to preferentially attack cancers rather than normal tissues. With the understanding particularly in the characteristics of viruses and tumor ...

Abstract	Background: Oncolytic virotherapy (OVT) is a promising anti-tumor modality that utilizes oncolytic viruses (OVs) to preferentially attack cancers rather than normal tissues. With the understanding particularly in the characteristics of viruses and tumor cells, numerous innovative OVs have been engineered to conquer cancers, such as Talimogene Laherparepvec (T-VEC) and tasadenoturev (DNX-2401). However, the therapeutic safety and efficacy must be further optimized and balanced to ensure the superior safe and efficient OVT in clinics, and reasonable combination therapy strategies are also important challenges worthy to be explored. Main body: Here we provided a critical review of the development history and status of OVT, emphasizing the mechanisms of enhancing both safety and efficacy. We propose that oncolytic virotherapy has evolved into the fourth generation as tumor immunotherapy. Particularly, to arouse T cells by designing OVs expressing bi-specific T cell activator (BiTA) is a promising strategy of killing two birds with one stone. Amazing combination of therapeutic strategies of OVs and immune cells confers immense potential for managing cancers. Moreover, the attractive preclinical OVT addressed recently, and the OVT in clinical trials were systematically reviewed. Conclusion: OVs, which are advancing into clinical trials, are being envisioned as the frontier clinical anti-tumor agents coming soon.
MeSH term(s)	Humans ; Oncolytic Virotherapy ; Melanoma/therapy ; Oncolytic Viruses ; Neoplasms/therapy ; Immunotherapy ; Combined Modality Therapy
Language	English
Publishing date	2023-07-25
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2118570-0
ISSN	1479-5876 ; 1479-5876
ISSN (online)	1479-5876
ISSN	1479-5876
DOI	10.1186/s12967-023-04360-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: NLRC4 methylation and its response to intravenous immunoglobulin therapy in Kawasaki disease: a case control study.

Yu, Beirong / Zheng, Bangxu / Shen, Yu / Shen, Yijing / Qiu, Haiyan / Wu, Ling / Chen, Yuanling / Cai, Xiaohong / Wu, Junhua / Hong, Qingxiao

BMC pediatrics

2024 Volume 24, Issue 1, Page(s) 190

Abstract: Background: Kawasaki disease (KD) is a systemic vasculitis accompanied by many systemic physiological and biochemical changes. Elucidating its molecular mechanisms is crucial for diagnosing and developing effective treatments. NLR Family CARD Domain ... ...

Abstract	Background: Kawasaki disease (KD) is a systemic vasculitis accompanied by many systemic physiological and biochemical changes. Elucidating its molecular mechanisms is crucial for diagnosing and developing effective treatments. NLR Family CARD Domain Containing 4 (NLRC4) encodes the key components of inflammasomes that function as pattern recognition receptors. The purpose of this study was to investigate the potential of NLRC4 methylation as a biomarker for KD. Methods: In this study, pyrosequencing was utilized to analyze NLRC4 promoter methylation in blood samples from 44 children with initial complete KD and 51 matched healthy controls. Methylation at five CpG sites within the NLRC4 promoter region was evaluated. Results: Compared to controls, NLRC4 methylation significantly decreased in KD patients (CpG1: p = 2.93E-06; CpG2: p = 2.35E-05; CpG3: p = 6.46E-06; CpG4: p = 2.47E-06; CpG5: p = 1.26E-05; average methylation: p = 5.42E-06). These changes were significantly reversed after intravenous immunoglobulin (IVIG) treatment. ROC curve analysis demonstrated remarkable diagnostic capability of mean NLRC4 gene methylation for KD (areas under ROC curve = 0.844, sensitivity = 0.75, p = 9.61E-06, 95% confidence intervals were 0.762-0.926 for mean NLRC4 methylation). In addition, NLRC4 promoter methylation was shown to be significantly negatively correlated with the levels of central granulocyte percentage, age, mean haemoglobin quantity and mean erythrocyte volume. Besides, NLRC4 promoter methylation was positively correlated with lymphocyte percentage, lymphocyte absolute value. Conclusions: Our work revealed the role of peripheral NLRC4 hypomethylation in KD pathogenesis and IVIG treatment response, could potentially serve as a treatment monitoring biomarker, although its precise functions remain to be elucidated.
MeSH term(s)	Child ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Case-Control Studies ; Mucocutaneous Lymph Node Syndrome/diagnosis ; Mucocutaneous Lymph Node Syndrome/drug therapy ; Mucocutaneous Lymph Node Syndrome/genetics ; DNA Methylation ; Biomarkers ; Calcium-Binding Proteins/genetics ; CARD Signaling Adaptor Proteins/genetics
Chemical Substances	Immunoglobulins, Intravenous ; Biomarkers ; NLRC4 protein, human ; Calcium-Binding Proteins ; CARD Signaling Adaptor Proteins
Language	English
Publishing date	2024-03-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2041342-7
ISSN	1471-2431 ; 1471-2431
ISSN (online)	1471-2431
ISSN	1471-2431
DOI	10.1186/s12887-024-04672-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Discovery of a highly potent and orally available importin-

Huang, Jia-Luo / Yan, Xue-Long / Huang, Dong / Gan, Lu / Gao, Huahua / Fan, Run-Zhu / Li, Shen / Yuan, Fang-Yu / Zhu, Xinying / Tang, Gui-Hua / Chen, Hong-Wu / Wang, Junjian / Yin, Sheng

Acta pharmaceutica Sinica. B

2023 Volume 13, Issue 12, Page(s) 4934–4944

Abstract: Nuclear transporter importin- ...

Abstract	Nuclear transporter importin-
Language	English
Publishing date	2023-07-24
Publishing country	Netherlands
Document type	Journal Article
ISSN	2211-3835
ISSN	2211-3835
DOI	10.1016/j.apsb.2023.07.017
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Comparative Analysis of Growth, Survival, and Virulence Characteristics of

Pan, Xinye / Shen, Jinling / Hong, Yi / Wu, Yufan / Guo, Dehua / Zhao, Lina / Bu, Xiangfeng / Ben, Leijie / Wang, Xiang

Microorganisms

2024 Volume 12, Issue 2

Abstract: ... Listeria ... ...

Abstract	Listeria monocytogenes
Language	English
Publishing date	2024-02-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms12020345
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Respiration and growth of

Zhou, Jiaxian / Deng, Wenfang / Wu, Jiapeng / Xiang, Hua / Shen, Xiaomei / Lin, Jih-Gaw / Hong, Yiguo

Microbiology spectrum

2024 , Page(s) e0381123

Abstract: In the nitrogen biogeochemical cycle, the reduction of nitrous oxide (N: Importance: Nitrous oxide ( ... ...

Abstract	In the nitrogen biogeochemical cycle, the reduction of nitrous oxide (N Importance: Nitrous oxide (N
Language	English
Publishing date	2024-04-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.03811-23
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