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  1. Book ; Online: High-power sub-picosecond filamentation at 1.03 {\mu}m with high repetition rates between 10 kHz and 100 kHz

    Löscher, Robin / Moreno, Victor / Adamou, Dionysis / Kesim, Denizhan K. / Schroeder, Malte C. / Clerici, Matteo / Wolf, Jean-Pierre / Saraceno, Clara J.

    2023  

    Abstract: Filamentation has been extensively explored and is well understood at repetition rates < 1 kHz due to the typical availability of multi-mJ laser systems at moderate average power. The advent of high-power Yb-lasers opened new possibilities for ... ...

    Abstract Filamentation has been extensively explored and is well understood at repetition rates < 1 kHz due to the typical availability of multi-mJ laser systems at moderate average power. The advent of high-power Yb-lasers opened new possibilities for filamentation research. However, so far, high average power Yb systems have mostly been explored to increase the driving pulse energy to several hundreds of mJ, and not at significantly higher repetition rates. In this paper, we study for the first time long filaments at unprecedented high repetition rates of 10 kHz, 40 kHz, and 100 kHz using a 500-W Yb-doped thin-disk amplifier driver operating with sub-700 fs pulses. We compare the filament length, density hole, and fluorescence at constant peak power but different repetition rates and find a strong dependence on filament length and density depletion with repetition rate. Our analysis reveals the emergence of a significant stationary density depletion at repetition rates of 40 kHz and 100 kHz. The corresponding reduction in breakdown threshold by increasing the laser repetition rate observed in our study signifies a promising avenue for enhancing the efficiency and reliability of electric discharge triggering in various scenarios. Using capacitive plasma probe measurements, we address the limitations of fluorescence imaging-based measurements and demonstrate a systematic underestimation of filament length. This work contributes to a deeper understanding of the interplay between laser repetition rates, filamentation, and heat-driven density depletion effects from high-repetition-rate high-power laser systems and will contribute to guide future research making use of filaments at high repetition rates.
    Keywords Physics - Optics ; Physics - Plasma Physics
    Subject code 621
    Publishing date 2023-09-07
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: A 30 m-resolution land use-land cover product for the Colombian Andes and Amazon using cloud-computing

    González-González, Andrés / Clerici, Nicola / Quesada, Benjamin

    International journal of applied earth observation and geoinformation. 2022 Mar., v. 107

    2022  

    Abstract: ... OLI 8 data, we here present a new LULC product for the Colombian Amazon and Andes at 30 m × 30 m ...

    Abstract Land use-land cover (LULC) data are critical inputs for policy and scientific research in hydrology, climatology, territory planning and conservation. Colombia, a megadiverse country and deforestation hotspot on Earth, critically needs recent and high-resolution information on land use and land cover. Using Landsat OLI 8 data, we here present a new LULC product for the Colombian Amazon and Andes at 30 m × 30 m resolution for year 2018, using classification and validation procedures based on the Google Earth Engine cloud-based platform. The novel products show high overall accuracy (>90%), are achieved with high automatization and improve current coarser LULC datasets for Colombia. All the processing procedures used are open access and distributable to the scientific community.
    Keywords Internet ; Landsat ; climatology ; data collection ; deforestation ; hydrology ; issues and policy ; land use and land cover maps ; spatial data ; Amazonia ; Andes region ; Colombia
    Language English
    Dates of publication 2022-03
    Publishing place Elsevier B.V.
    Document type Article
    ISSN 1569-8432
    DOI 10.1016/j.jag.2022.102688
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Pharmacological Efficacy and Gastrointestinal Safety of Different Aspirin Formulations for Cardiovascular Prevention: A Narrative Review.

    Clerici, Bianca / Cattaneo, Marco

    Journal of cardiovascular development and disease

    2023  Volume 10, Issue 4

    Abstract: Aspirin inhibits platelet function by irreversibly inhibiting the synthesis of thromboxane A2 (TxA2). Aspirin, at low doses, is widely used for cardiovascular prevention. Gastrointestinal discomfort, mucosal erosions/ulcerations and bleeding are frequent ...

    Abstract Aspirin inhibits platelet function by irreversibly inhibiting the synthesis of thromboxane A2 (TxA2). Aspirin, at low doses, is widely used for cardiovascular prevention. Gastrointestinal discomfort, mucosal erosions/ulcerations and bleeding are frequent complications of chronic treatment. To reduce these adverse effects, different formulations of aspirin have been developed, including enteric-coated (EC) aspirin, the most widely used aspirin formulation. However, EC aspirin is less effective than plain aspirin in inhibiting TxA2 production, especially in subjects with high body weight. The inadequate pharmacological efficacy of EC aspirin is mirrored by lower protection from cardiovascular events in subjects weighing >70 kg. Endoscopic studies showed that EC aspirin causes fewer erosions of the gastric mucosa compared to plain aspirin (which is absorbed in the stomach) but causes mucosal erosions in the small intestine, where it is absorbed. Several studies demonstrated that EC aspirin does not reduce the incidence of clinically relevant gastrointestinal ulceration and bleeding. Similar results were found for buffered aspirin. Although interesting, the results of experiments on the phospholipid-aspirin complex PL2200 are still preliminary. Considering its favorable pharmacological profile, plain aspirin should be the preferred formulation to be used for cardiovascular prevention.
    Language English
    Publishing date 2023-03-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2777082-5
    ISSN 2308-3425 ; 2308-3425
    ISSN (online) 2308-3425
    ISSN 2308-3425
    DOI 10.3390/jcdd10040137
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The impact of efficacy of long-acting injectable antipsychotics on caregivers' burden of patients with schizophrenia.

    Capuzzi, Enrico / Quitadamo, Cecilia / Caldiroli, Alice / Clerici, Massimo / Buoli, Massimiliano

    International clinical psychopharmacology

    2024  

    Language English
    Publishing date 2024-02-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 632837-4
    ISSN 1473-5857 ; 0268-1315
    ISSN (online) 1473-5857
    ISSN 0268-1315
    DOI 10.1097/YIC.0000000000000539
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Immune Checkpoint molecules in solid organ transplantation: a promising way to prevent rejection.

    Righi, Ilaria / Trabattoni, Daria / Rosso, Lorenzo / Vaira, Valentina / Clerici, Mario

    Immunology letters

    2024  , Page(s) 106860

    Abstract: Immune checkpoint (IC) molecules modulate immune responses upon antigen presentation; the interaction between different IC molecules will result in the stimulation or, rather, the thwarting of such responses. Tumor cells express increased amounts of ... ...

    Abstract Immune checkpoint (IC) molecules modulate immune responses upon antigen presentation; the interaction between different IC molecules will result in the stimulation or, rather, the thwarting of such responses. Tumor cells express increased amounts of inhibitory IC molecules in an attempt to evade immune responses; therapeutic agents have been developed that bind inhibitory IC molecules, restoring tumor-directed immune responses and changing the prognosis of a number of cancers. Stimulation of inhibitory IC molecules could be beneficial in preventing rejection in the setting of solid organ transplantation (SOT), and in vivo as well as in vivo results obtained in animal models show this to indeed to be the case. With the exception of belatacept, a monoclonal antibody (mAb) in which an IgG Fc fragment is linked to the extracellular domain of CTLA-4, this has not yet translated into the generation of novel therapeutic approaches to prevent SOT rejection. We provide a review of state-of-the art knowledge on the role played by IC molecules in transplantation, confident that innovative research will lead to new avenues to manage rejection in solid organ transplant.
    Language English
    Publishing date 2024-04-25
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 445150-8
    ISSN 1879-0542 ; 0165-2478
    ISSN (online) 1879-0542
    ISSN 0165-2478
    DOI 10.1016/j.imlet.2024.106860
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Laboratory Diagnosis of Antiphospholipid Syndrome in Anticoagulated Patients.

    Tripodi, Armando / Scalambrino, Erica / Clerici, Marigrazia / Peyvandi, Flora

    Biomedicines

    2023  Volume 11, Issue 6

    Abstract: The laboratory diagnosis of antiphospholipid syndrome (APS) requires the measurement of solid-phase antibodies to cardiolipin or β2-Glycoprotein-I and the search for lupus anticoagulant (LA). The diagnosis of patients whilst on anticoagulation is ... ...

    Abstract The laboratory diagnosis of antiphospholipid syndrome (APS) requires the measurement of solid-phase antibodies to cardiolipin or β2-Glycoprotein-I and the search for lupus anticoagulant (LA). The diagnosis of patients whilst on anticoagulation is impaired by the difficult interpretation of results, at least for LA, owing to the fact that prolongations of clotting times induced by LA superimpose those induced by anticoagulants. This is a matter of concern as treating physicians very often need to know the APS status of their patients to make a decision on secondary antithrombotic prophylaxis. This article aims to review the effect brought about by anticoagulants on APS diagnosis and discuss the options that can be used to overcome such an effect.
    Language English
    Publishing date 2023-06-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11061760
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Acute Ocular Complications after Recently Diagnosed Goodpasture's Syndrome - An Unusual Case of Hypertensive Retinopathy.

    Eppenberger, Leila Sara / Schmid, Martin K / Clerici, Michele

    Klinische Monatsblatter fur Augenheilkunde

    2023  Volume 240, Issue 4, Page(s) 505–508

    Title translation Akute okuläre Komplikationen nach kürzlich diagnostiziertem Goodpasture-Syndrom – ein ungewöhnlicher Fall von hypertensiver Retinopathie.
    MeSH term(s) Humans ; Anti-Glomerular Basement Membrane Disease/complications ; Anti-Glomerular Basement Membrane Disease/diagnosis ; Eye ; Hypertensive Retinopathy/etiology ; Hypertensive Retinopathy/complications
    Language English
    Publishing date 2023-04-25
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 80175-6
    ISSN 1439-3999 ; 0344-6360 ; 0344-6387 ; 0023-2165
    ISSN (online) 1439-3999
    ISSN 0344-6360 ; 0344-6387 ; 0023-2165
    DOI 10.1055/a-2034-6314
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Living With Chronic HIV Disease in the Antiretroviral Era: The Impact of Neurocognitive Impairment on Everyday Life Functions.

    Ripamonti, Enrico / Clerici, Mario

    Topics in antiviral medicine

    2021  Volume 29, Issue 3, Page(s) 386–396

    Abstract: Although there is extensive literature around the biologic correlations of neurocognitive function in HIV/AIDS, less is known about the impact in everyday living. We conducted a systematic review of the association of neurocognitive impairment with ... ...

    Abstract Although there is extensive literature around the biologic correlations of neurocognitive function in HIV/AIDS, less is known about the impact in everyday living. We conducted a systematic review of the association of neurocognitive impairment with everyday life functions in people with HIV on antiretroviral therapy. We specifically focused on attention, executive function, processing speed, and the central executive component of the working memory. We considered 3 domains of everyday functions: (1) autonomy, (2) decision making and adherence to treatment, and (3) quality of life and psychologic wellbeing. The relationship between neurocognitive impairment and mental health was examined, given its correlation with everyday life functions. Results indicate that people with HIV do experience problems with autonomy of daily living (especially if aged older than 50 years) and with decision making, and neurocognitive impairment plays a role in this regard. Psychologic wellbeing is associated with executive function and processing speed. These patients may also have a reduced quality of life, but the relationship between quality of life and cognition is uncertain or could be mediated by other factors. Neurocognitive impairment correlates with depression and anxiety; however, the relationship of cognitive performance with apathy is still controversial.
    MeSH term(s) Aged ; Anti-Retroviral Agents/therapeutic use ; Cognition ; Executive Function ; HIV Infections/complications ; HIV Infections/drug therapy ; Humans ; Quality of Life
    Chemical Substances Anti-Retroviral Agents
    Language English
    Publishing date 2021-08-09
    Publishing country United States
    Document type Journal Article ; Systematic Review
    ZDB-ID 2656632-1
    ISSN 2161-5853 ; 2161-5853
    ISSN (online) 2161-5853
    ISSN 2161-5853
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Refractory immune thrombocytopenia in adults: Towards a new definition.

    Arnold, Donald M / Clerici, Bianca / Ilicheva, Ekaterina / Ghanima, Waleed

    British journal of haematology

    2023  Volume 203, Issue 1, Page(s) 23–27

    Abstract: Immune thrombocytopenia (ITP) is an autoimmune haematological disorder characterized by immune-mediated thrombocytopenia and a variable risk of bleeding. Despite the availability of multiple treatment options, some patients are considered refractory ... ...

    Abstract Immune thrombocytopenia (ITP) is an autoimmune haematological disorder characterized by immune-mediated thrombocytopenia and a variable risk of bleeding. Despite the availability of multiple treatment options, some patients are considered refractory since they do not achieve a platelet count response to multiple treatments and are at risk of bleeding. The term 'refractory' has been used to identify this patient group; however, with the advent of multiple lines of treatment, its meaning has become ambiguous. To address this issue, we reviewed previous definitions of refractory ITP, solicited the views of ITP experts and collected data from registries to inform a definition. Twenty ITP experts who attended the 7th Expert Meeting of the Intercontinental Cooperative ITP Study Group in September 2022 answered a web-based survey: 95% felt that there was a need for a new definition of refractory ITP for clinical and research purposes. The use of the term refractory, accompanied by a clear indication of the type and timing of failed treatments, was supported by 85% of respondents. Preliminary data on the frequency of refractory patients from the McMaster and Norwegian ITP Registries demonstrated that the proportion of adult ITP patients who had failed first-line therapy, rituximab, thrombopoietin receptor agonists, any immune suppressant medication and splenectomy ranged from 0.4% to 3.8%. We propose a definition of refractory ITP that could be evaluated in future studies.
    MeSH term(s) Humans ; Adult ; Purpura, Thrombocytopenic, Idiopathic/diagnosis ; Purpura, Thrombocytopenic, Idiopathic/therapy ; Thrombocytopenia ; Platelet Count ; Emotions ; Immunosuppressive Agents
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2023-08-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.19075
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Extracellular Vesicles as Biomarkers for Parkinson's Disease: How Far from Clinical Translation?

    Gualerzi, Alice / Picciolini, Silvia / Bedoni, Marzia / Guerini, Franca Rosa / Clerici, Mario / Agliardi, Cristina

    International journal of molecular sciences

    2024  Volume 25, Issue 2

    Abstract: Parkinson's disease (PD) is a neurodegenerative disorder affecting about 10 million people worldwide with a prevalence of about 2% in the over-80 population. The disease brings in also a huge annual economic burden, recently estimated by the Michael J ... ...

    Abstract Parkinson's disease (PD) is a neurodegenerative disorder affecting about 10 million people worldwide with a prevalence of about 2% in the over-80 population. The disease brings in also a huge annual economic burden, recently estimated by the Michael J Fox Foundation for Parkinson's Research to be USD 52 billion in the United States alone. Currently, no effective cure exists, but available PD medical treatments are based on symptomatic prescriptions that include drugs, surgical approaches and rehabilitation treatment. Due to the complex biology of a PD brain, the design of clinical trials and the personalization of treatment strategies require the identification of accessible and measurable biomarkers to monitor the events induced by treatment and disease progression and to predict patients' responsiveness. In the present review, we strive to briefly summarize current knowledge about PD biomarkers, focusing on the role of extracellular vesicles as active or involuntary carriers of disease-associated proteins, with particular attention to those research works that envision possible clinical applications.
    MeSH term(s) Humans ; Parkinson Disease/diagnosis ; Extracellular Vesicles ; Biomarkers ; Brain ; Disease Progression
    Chemical Substances Biomarkers
    Language English
    Publishing date 2024-01-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25021136
    Database MEDical Literature Analysis and Retrieval System OnLINE

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