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  1. Article: Psychiatric manifestations of AIDS spectrum disorders.

    Vomvouras, S

    Southern medical journal

    1989  Volume 82, Issue 3, Page(s) 352–357

    Abstract: This paper reviews the proposed etiology and epidemiology of the acquired immunodeficiency syndrome (AIDS). It summarizes the psychiatric symptoms associated with members of high-risk groups, patients who have AIDS-related complex (ARC) or AIDS, and ... ...

    Abstract This paper reviews the proposed etiology and epidemiology of the acquired immunodeficiency syndrome (AIDS). It summarizes the psychiatric symptoms associated with members of high-risk groups, patients who have AIDS-related complex (ARC) or AIDS, and patients who are seropositive yet asymptomatic. It differentiates between psychiatric manifestations predating and following prodromal symptoms of immunodeficiency and elucidates diagnostic criteria that may assist in this differentiation process. The importance of diagnostic distinction between premorbid, reactive, functional, and neuropsychiatric manifestations is emphasized. A brief description of suggested treatment and management regimens for the various forms of AIDS-related psychopathology then follows.
    MeSH term(s) Acquired Immunodeficiency Syndrome/complications ; Acquired Immunodeficiency Syndrome/diagnosis ; Acquired Immunodeficiency Syndrome/epidemiology ; Acquired Immunodeficiency Syndrome/psychology ; Adaptation, Psychological ; Diagnosis, Differential ; Homosexuality ; Humans ; Male ; Mental Disorders/diagnosis ; Mental Disorders/epidemiology ; Mental Disorders/etiology ; Mental Disorders/therapy ; Methods ; Opportunistic Infections/etiology ; Risk Factors ; Social Conditions ; Substance-Related Disorders/complications ; Suicide ; United States
    Language English
    Publishing date 1989-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 185329-6
    ISSN 1541-8243 ; 0038-4348
    ISSN (online) 1541-8243
    ISSN 0038-4348
    DOI 10.1097/00007611-198903000-00018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Multiple pigmented nail bands during hydroxyurea therapy: an uncommon finding.

    Vomvouras, S / Pakula, A S / Shaw, J M

    Journal of the American Academy of Dermatology

    1991  Volume 24, Issue 6 Pt 1, Page(s) 1016–1017

    MeSH term(s) Aged ; Female ; Fingers ; Humans ; Hydroxyurea/adverse effects ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Nail Diseases/chemically induced ; Pigmentation Disorders/chemically induced
    Chemical Substances Hydroxyurea (X6Q56QN5QC)
    Language English
    Publishing date 1991-06
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/s0190-9622(08)80119-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Pruritic urticarial papules and plaques of pregnancy: clinical and immunopathologic observations in 57 patients.

    Aronson, I K / Bond, S / Fiedler, V C / Vomvouras, S / Gruber, D / Ruiz, C

    Journal of the American Academy of Dermatology

    1998  Volume 39, Issue 6, Page(s) 933–939

    Abstract: Background: Pruritic urticarial papules and plaques of pregnancy (PUPPP) has been described either as a homogeneous or a polymorphic clinical process. Its cause is unknown.: Objective: We attempted to characterize the clinical and immunopathologic ... ...

    Abstract Background: Pruritic urticarial papules and plaques of pregnancy (PUPPP) has been described either as a homogeneous or a polymorphic clinical process. Its cause is unknown.
    Objective: We attempted to characterize the clinical and immunopathologic findings in PUPPP on the basis of long-term clinical and immunopathologic observations.
    Methods: The clinical and immunopathologic features of 57 patients with PUPPP were evaluated.
    Results: The clinical features in 57 patients with PUPPP were categorized into three types: mainly urticarial papules and plaques (type I), nonurticarial erythema, papules, or vesicles (type II), and combinations of the two forms (type III). Direct immunofluorescence studies in 48 of the 57 patients showed nonspecific immunoreactants in dermal blood vessels and/or moderate granular deposits at the dermoepidermal junction in 15 patients.
    Conclusion: Type I PUPPP differed from types II and III in clinical appearance and distribution (absence of face, palm, and sole lesions), but trimester onset, parity, and direct immunofluorescence findings were not significantly different among the three groups.
    MeSH term(s) Adolescent ; Adult ; Female ; Humans ; Pregnancy ; Pregnancy Complications/classification ; Pregnancy Complications/immunology ; Pregnancy Complications/pathology ; Pregnancy Trimesters ; Pruritus/classification ; Pruritus/immunology ; Pruritus/pathology ; Urticaria/classification ; Urticaria/immunology ; Urticaria/pathology
    Language English
    Publishing date 1998-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/s0190-9622(98)70265-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Pharmacokinetic interaction between ritonavir and didanosine when administered concurrently to HIV-infected patients.

    Cato, A / Qian, J / Hsu, A / Vomvouras, S / Piergies, A A / Leonard, J / Granneman, R

    Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association

    1998  Volume 18, Issue 5, Page(s) 466–472

    Abstract: The effect of coadministration of ritonavir and didanosine (ddI) on the pharmacokinetics of these drugs was investigated in a single-center, three-period, crossover study. Eighteen asymptomatic, HIV-positive men were assigned randomly to 6 different ... ...

    Abstract The effect of coadministration of ritonavir and didanosine (ddI) on the pharmacokinetics of these drugs was investigated in a single-center, three-period, crossover study. Eighteen asymptomatic, HIV-positive men were assigned randomly to 6 different sequences of 3 regimens: ddI (200 mg every 12 hours) alone for 4 days, ritonavir (600 mg every 12 hours) alone for 4 days, and 4 days of ddI with ritonavir under dose-staggering conditions. Although not statistically significant, ritonavir concentrations were slightly higher on average (<10%) with concurrent administration of ddI compared with those of ritonavir alone. In contrast, ddI concentrations were lower with concurrent administration compared with those of ddI alone; maximum concentration and area under the concentration-time curve were reduced by about 15% (p < .05). The ddI elimination rate constant was unaffected by ritonavir, suggesting no change in ddI's systemic metabolism. Adverse events were similar between regimens. The relatively minor changes in ritonavir and ddI pharmacokinetics are probably not clinically relevant; therefore, dosage adjustment of either compound appears unnecessary when administered concurrently. However, the combination regimen of ddI and ritonavir continue to be evaluated clinically.
    MeSH term(s) Adult ; Anti-HIV Agents/pharmacokinetics ; Anti-HIV Agents/therapeutic use ; Area Under Curve ; Cross-Over Studies ; Didanosine/pharmacokinetics ; Didanosine/therapeutic use ; Drug Interactions ; Drug Therapy, Combination ; HIV Infections/drug therapy ; HIV Infections/metabolism ; HIV Protease Inhibitors/pharmacokinetics ; HIV Protease Inhibitors/therapeutic use ; Humans ; Male ; Middle Aged ; Reverse Transcriptase Inhibitors/pharmacokinetics ; Reverse Transcriptase Inhibitors/therapeutic use ; Ritonavir/pharmacokinetics ; Ritonavir/therapeutic use
    Chemical Substances Anti-HIV Agents ; HIV Protease Inhibitors ; Reverse Transcriptase Inhibitors ; Didanosine (K3GDH6OH08) ; Ritonavir (O3J8G9O825)
    Language English
    Publishing date 1998-08-15
    Publishing country United States
    Document type Clinical Trial ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 645053-2
    ISSN 1944-7884 ; 1077-9450 ; 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135
    ISSN (online) 1944-7884 ; 1077-9450
    ISSN 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135
    DOI 10.1097/00042560-199808150-00008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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