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  1. Article: Anticancer effect of ursolic acid via mitochondria-dependent pathways.

    Feng, Xue-Min / Su, Xiu-Lan

    Oncology letters

    2019  Volume 17, Issue 6, Page(s) 4761–4767

    Abstract: Ursolic acid is a plant-derived pentacyclic triterpenoid found in various medicinal herbs and fruits. It has generated clinical interest due to its anti-inflammatory, antioxidative, antiapoptotic and anticarcinogenic effects. An increasing amount of ... ...

    Abstract Ursolic acid is a plant-derived pentacyclic triterpenoid found in various medicinal herbs and fruits. It has generated clinical interest due to its anti-inflammatory, antioxidative, antiapoptotic and anticarcinogenic effects. An increasing amount of evidence supports the anticancer effect of ursolic acid in various cancer cells. One of the hallmarks of malignant transformation is metabolic reprogramming that sustains macromolecule synthesis, bioenergetic demand and tumor cell survival. Mitochondria are important regulators of tumorigenes is as well as a major site of the metabolic reactions that facilitate this reprogramming and adaption to cellular and environmental changes. The current review explored the close association between the anticancer effect of ursolic acid and the activation of mitochondrial-dependent signaling pathways.
    Language English
    Publishing date 2019-03-19
    Publishing country Greece
    Document type Journal Article ; Review
    ZDB-ID 2573196-8
    ISSN 1792-1082 ; 1792-1074
    ISSN (online) 1792-1082
    ISSN 1792-1074
    DOI 10.3892/ol.2019.10171
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Comparison of Habitual Versus Recurrent Patellar Dislocation in Children and Adolescents: Differences in Radiological Features.

    Huang, Lin / Qian, Zhan-Hua / Yang, Zheng / Lv, Xue-Min / Feng, Chao

    Orthopaedic journal of sports medicine

    2023  Volume 11, Issue 7, Page(s) 23259671231180574

    Abstract: Background: Recurrent patellar dislocation (RPD) and habitual patellar dislocation (HPD) in flexion are frequently encountered in children and adolescents.: Purpose: To compare the radiological features of RPD and HPD in children and adolescents.: ... ...

    Abstract Background: Recurrent patellar dislocation (RPD) and habitual patellar dislocation (HPD) in flexion are frequently encountered in children and adolescents.
    Purpose: To compare the radiological features of RPD and HPD in children and adolescents.
    Study design: Cross-sectional study; Level of evidence, 3.
    Methods: Imaging data were collected from patients aged 9 to 15 years who received surgical treatment for HPD or RPD at a single institution between June 2015 and September 2020. The prevalence of trochlear dysplasia, tibial tubercle lateralization, and lower limb rotational deformity was assessed through hip/knee/ankle computed tomography (CT) using the following quantitative indicators: trochlear depth index, lateral trochlear inclination, sulcus angle, tibial tubercle-trochlear groove (TT-TG) distance, ratio of TT-TG distance to femoral width, TT-TG angle, femoral anteversion angle, and tibial external rotation angle. The morphology of trochlea and patella were graded on knee CT using the Dejour and Wiberg classification. The Insall-Salvati index and Caton-Deschamps index were used to evaluate the height of the patella on lateral view radiographs. To evaluate lower limbs malalignment, the mechanical lateral distal femoral angle and medial proximal tibial angle were measured on weightbearing full-length radiographs. The collected data were analyzed and compared between the HPD and RPD groups.
    Results: Enrolled were 15 patients (21 knees) diagnosed with HPD and 18 patients (22 knees) diagnosed with RPD. The age of first dislocation was significantly younger in the HPD group (7.6 ± 3.4 vs 11.2 ± 1.4 years;
    Conclusion: Patients in the HPD group presented with poorer trochlear and patellar development, lower patellar height, and less tibial external rotation compared with patients in the RPG group.
    Language English
    Publishing date 2023-07-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2706251-X
    ISSN 2325-9671
    ISSN 2325-9671
    DOI 10.1177/23259671231180574
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  3. Article: Endoscopic metal stenting for malignant hilar biliary obstruction: an update meta-analysis of unilateral versus bilateral stenting.

    Yang, Fang / Wang, Xue-Min / Xia, Feng-Fei / Han, Xin-Qiang

    Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques

    2021  Volume 16, Issue 3, Page(s) 472–481

    Abstract: Introduction: Malignant hilar biliary obstruction (MHBO) can arise in patients with malignant hilar hepatobiliary tumors or lymph nodules. Most MHBO patients are not suitable for surgical resection due to the advanced tumor stage. The only palliative ... ...

    Abstract Introduction: Malignant hilar biliary obstruction (MHBO) can arise in patients with malignant hilar hepatobiliary tumors or lymph nodules. Most MHBO patients are not suitable for surgical resection due to the advanced tumor stage. The only palliative treatment available is provided by endoscopic or percutaneous stenting.
    Aim: To compare the efficacy of endoscopic unilateral versus bilateral metal stent insertion for treating MHBO.
    Material and methods: A search of the PubMed, Embase, and Cochrane Library databases identified all relevant studies published until June 2020. The meta-analysis was undertaken using RevMan v5.3.
    Results: We identified 154 studies initially, eight of which were used in our meta-analysis. The eight studies included 818 MHBO patients treated using either endoscopic unilateral (n = 396) or bilateral (n = 422) metal stenting. No significant differences were observed between the two groups in clinical success rate (OR = 2.64; p = 0.18), complication rate (OR = 0.63; p = 0.46), or OS (HR = 1.03; p = 0.53). The bilateral group had a lower stent dysfunction rate without significance (OR = 1.43; p = 0.09). Significantly longer stent patency was observed in the bilateral group (HR = 1.28; p = 0.01). Technical success rate was significantly higher in the unilateral group (OR = 0.26; p = 0.04). Funnel plot analysis indicated an absence of publication bias related to the selected study endpoints.
    Conclusions: Our meta-analysis indicated that endoscopic unilateral stenting had a greater technical success rate for MHBO patients than bilateral stenting. However, the bilateral stenting could achieve longer stent patency.
    Language English
    Publishing date 2021-03-08
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2596147-0
    ISSN 2299-0054 ; 1895-4588
    ISSN (online) 2299-0054
    ISSN 1895-4588
    DOI 10.5114/wiitm.2021.104196
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  4. Article ; Online: A Systematic Review of the Potential Chemoprotective Effects of Resveratrol on Doxorubicin-Induced Cardiotoxicity: Focus on the Antioxidant, Antiapoptotic, and Anti-Inflammatory Activities.

    Hu, Li-Feng / Lan, Huan-Rong / Li, Xue-Min / Jin, Ke-Tao

    Oxidative medicine and cellular longevity

    2021  Volume 2021, Page(s) 2951697

    Abstract: Purpose: Although doxorubicin chemotherapeutic drug is commonly used to treat various solid and hematological tumors, its clinical use is restricted because of its adverse effects on the normal cells/tissues, especially cardiotoxicity. The use of ... ...

    Abstract Purpose: Although doxorubicin chemotherapeutic drug is commonly used to treat various solid and hematological tumors, its clinical use is restricted because of its adverse effects on the normal cells/tissues, especially cardiotoxicity. The use of resveratrol may mitigate the doxorubicin-induced cardiotoxic effects. For this aim, we systematically reviewed the potential chemoprotective effects of resveratrol against the doxorubicin-induced cardiotoxicity.
    Methods: In the current study, a systematic search was performed based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline for the identification of all relevant studies on "the role of resveratrol on doxorubicin-induced cardiotoxicity" in the electronic databases of Web of Science, PubMed, and Scopus up to March 2021 using search terms in their titles and abstracts. Two hundred and eighteen articles were screened in accordance with a predefined set of inclusion and exclusion criteria. Finally, 33 eligible articles were included in this systematic review.
    Results: The
    Conclusion: The results of this systematic review stated that coadministration of resveratrol alleviates the doxorubicin-induced cardiotoxicity. Resveratrol exerts these chemoprotective effects through several main mechanisms of antioxidant, antiapoptosis, and anti-inflammatory.
    MeSH term(s) Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Apoptosis/drug effects ; Cardiotoxicity/drug therapy ; Cardiotoxicity/etiology ; Doxorubicin/adverse effects ; Humans ; Resveratrol/pharmacology ; Resveratrol/therapeutic use
    Chemical Substances Anti-Inflammatory Agents ; Antioxidants ; Doxorubicin (80168379AG) ; Resveratrol (Q369O8926L)
    Language English
    Publishing date 2021-08-22
    Publishing country United States
    Document type Journal Article ; Systematic Review
    ZDB-ID 2455981-7
    ISSN 1942-0994 ; 1942-0994
    ISSN (online) 1942-0994
    ISSN 1942-0994
    DOI 10.1155/2021/2951697
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  5. Article ; Online: Endoscopic metal stenting for malignant hilar biliary obstruction

    Fang Yang / Xue-Min Wang / Feng-Fei Xia / Xin-Qiang Han

    Videosurgery and Other Miniinvasive Techniques, Vol 16, Iss 3, Pp 472-

    an update meta-analysis of unilateral versus bilateral stenting

    2021  Volume 481

    Keywords stent ; endoscopic ; malignant hilar biliary obstruction ; unilateral ; bilateral ; Medicine ; R
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Termedia Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: An Incidentally Identified Liver Mass.

    Zhang, Xu-Feng / Liu, Xue-Min / Lv, Yi

    Gastroenterology

    2019  Volume 157, Issue 3, Page(s) e10–e11

    MeSH term(s) Biopsy ; Humans ; Incidental Findings ; Liver/diagnostic imaging ; Liver/physiology ; Liver/surgery ; Male ; Splenosis/diagnosis ; Splenosis/surgery ; Tomography, X-Ray Computed ; Young Adult
    Language English
    Publishing date 2019-04-06
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2019.03.063
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  7. Article ; Online: Sex-determining region Y gene promotes liver fibrosis and accounts for sexual dimorphism in its pathophysiology.

    Wu, Xiao-Ning / Wang, Meng-Zhou / Zhang, Nan / Zhang, Wei / Dong, Jian / Ke, Meng-Yun / Xiang, Jun-Xi / Ma, Feng / Xue, Feng / Hou, Jing-Jing / Ma, Zhi-Jie / Wang, Fu-Min / Liu, Xue-Min / Wu, Rongqian / Pawlik, Timothy M / Ye, Kai / Yu, Jun / Zhang, Xu-Feng / Lyu, Yi

    Journal of hepatology

    2024  

    Abstract: Background & aims: Men are more prone to develop and die from liver fibrosis than women. In this study, we aim to investigate how sex-determining region Y gene (SRY) in hepatocytes promotes liver fibrosis.: Methods: Hepatocyte-specific Sry knock-in ( ... ...

    Abstract Background & aims: Men are more prone to develop and die from liver fibrosis than women. In this study, we aim to investigate how sex-determining region Y gene (SRY) in hepatocytes promotes liver fibrosis.
    Methods: Hepatocyte-specific Sry knock-in (KI), Sry knockout (KO), and Sry KI with platelet-derived growth factor receptor α (Pdgfrα) KO mice were generated. Liver fibrosis was induced in mice by bile duct ligation for 2 weeks or carbon tetrachloride treatment for 6 weeks. In addition, primary hepatocytes, hepatic stellate cells (HSCs), and immortalized cell lines were used for in vitro studies and mechanistic investigation.
    Results: Compared to females, the severity of toxin- or cholestasis-induced liver fibrosis is similarly increased in castrated and uncastrated male mice. Among all Y chromosome-encoded genes, SRY was the most significantly upregulated and consistently increased gene in fibrotic/cirrhotic livers in male patients and in mouse models. Sry KI mice developed exacerbated liver fibrosis, whereas Sry KO mice had alleviated liver fibrosis, compared to age- and sex-matched control mice after bile duct ligation or administration of carbon tetrachloride. Mechanistically, both our in vivo and in vitro studies illustrated that SRY in hepatocytes can transcriptionally regulate Pdgfrα expression, and promote HMGB1 (high mobility group box 1) release and subsequent HSC activation. Pdgfrα KO or treatment with the SRY inhibitor DAX1 in Sry KI mice abolished SRY-induced HMGB1 secretion and liver fibrosis.
    Conclusions: SRY is a strong pro-fibrotic factor and accounts for the sex disparity observed in liver fibrosis, suggesting its critical role as a potentially sex-specific therapeutic target for prevention and treatment of the disease.
    Impact and implication: We identified that a male-specific gene, sex-determining region Y gene (SRY), is a strong pro-fibrotic gene that accounts for the sex disparity observed in liver fibrosis. As such, SRY might be an appropriate target for surveillance and treatment of liver fibrosis in a sex-specific manner. Additionally, SRY might be a key player in the sexual dimorphism observed in hepatic pathophysiology more generally.
    Language English
    Publishing date 2024-02-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2024.01.036
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  8. Article ; Online: Personalized Immunotherapy in Colorectal Cancers

    Li-Feng Hu / Huan-Rong Lan / Dong Huang / Xue-Min Li / Ke-Tao Jin

    Frontiers in Oncology, Vol

    Where Do We Stand?

    2021  Volume 11

    Abstract: Colorectal cancer (CRC) is the second leading cause of cancer death in the world. Immunotherapy using monoclonal antibodies, immune-checkpoint inhibitors, adoptive cell therapy, and cancer vaccines has raised great hopes for treating poor prognosis ... ...

    Abstract Colorectal cancer (CRC) is the second leading cause of cancer death in the world. Immunotherapy using monoclonal antibodies, immune-checkpoint inhibitors, adoptive cell therapy, and cancer vaccines has raised great hopes for treating poor prognosis metastatic CRCs that are resistant to the conventional therapies. However, high inter-tumor and intra-tumor heterogeneity hinder the success of immunotherapy in CRC. Patients with a similar tumor phenotype respond differently to the same immunotherapy regimen. Mutation-based classification, molecular subtyping, and immunoscoring of CRCs facilitated the multi-aspect grouping of CRC patients and improved immunotherapy. Personalized immunotherapy using tumor-specific neoantigens provides the opportunity to consider each patient as an independent group deserving of individualized immunotherapy. In the recent decade, the development of sequencing and multi-omics techniques has helped us classify patients more precisely. The expansion of such advanced techniques along with the neoantigen-based immunotherapy could herald a new era in treating heterogeneous tumors such as CRC. In this review article, we provided the latest findings in immunotherapy of CRC. We elaborated on the heterogeneity of CRC patients as a bottleneck of CRC immunotherapy and reviewed the latest advances in personalized immunotherapy to overcome CRC heterogeneity.
    Keywords colorectal cancer ; immunotherapy ; personalized medicine ; neoantigen ; heterogeneity ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
    Subject code 610
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
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  9. Article: [Differential Expression of Long Non-coding RNA Cancer Susceptibility Candidate 2 and Imprinted Gene H19 in Extrahepatic Cholangiocarcinoma].

    Wang, Jia-Xing / Shen, Wen-Feng / Xiao, Rui / Feng, Xue-Min / Ma, Rui-Ting / Wang, Ze-Feng / Ren, Jian-Jun

    Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae

    2022  Volume 44, Issue 1, Page(s) 72–80

    Abstract: Objective To investigate the expression and the potential roles of long non-coding RNA(lncRNA)cancer susceptibility candidate 2(CASC2)and imprinted gene H19 in extrahepatic cholangiocarcinoma(ECC). Methods Four samples from patients with ECC were ... ...

    Abstract Objective To investigate the expression and the potential roles of long non-coding RNA(lncRNA)cancer susceptibility candidate 2(CASC2)and imprinted gene H19 in extrahepatic cholangiocarcinoma(ECC). Methods Four samples from patients with ECC were collected for high-throughput sequencing which was conducted to reveal the transcriptomic profiles of lncRNA CASC2 and H19.Bioinformatics tools were employed to predict the potential roles of the two genes.Another 22 ECC tissue samples and the cholangiocarcinoma cell lines(RBE,QBC939,HuH-28,and HuCCT1)with different degrees of differentiation were selected for validation.The para-carcinoma tissue and normal human intrahepatic biliary epithelial cell(HIBEC)were used as the control groups.The expression levels of lncRNA CASC2 and H19 in carcinoma tissue,para-carcinoma tissue,and cell lines were determined by real-time quantitative polymerase chain reaction(qRT-PCR).The correlation analysis was carried out for the clinical indicators of patients with the expression levels of the target genes. Results The two target genes showed significantly different expression between carcinoma tissue and para-carcinoma tissue(all
    MeSH term(s) Bile Duct Neoplasms/genetics ; Bile Ducts, Intrahepatic/metabolism ; Cholangiocarcinoma/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; RNA, Long Noncoding/genetics ; Tumor Suppressor Proteins/genetics
    Chemical Substances H19 long non-coding RNA ; RNA, Long Noncoding ; Tumor Suppressor Proteins ; long non-coding RNA CASC2, human
    Language Chinese
    Publishing date 2022-03-17
    Publishing country China
    Document type Journal Article
    ZDB-ID 604853-5
    ISSN 1000-503X
    ISSN 1000-503X
    DOI 10.3881/j.issn.1000-503X.14039
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  10. Article: Physiological Mechanism through Which Al Toxicity Inhibits Peanut Root Growth.

    Shi, Jianning / Zhao, Min / Zhang, Feng / Feng, Didi / Yang, Shaoxia / Xue, Yingbin / Liu, Ying

    Plants (Basel, Switzerland)

    2024  Volume 13, Issue 2

    Abstract: Al (Aluminum) poisoning is a significant limitation to crop yield in acid soil. However, the physiological process involved in the peanut root response to Al poisoning has not been clarified yet and requires further research. In order to investigate the ... ...

    Abstract Al (Aluminum) poisoning is a significant limitation to crop yield in acid soil. However, the physiological process involved in the peanut root response to Al poisoning has not been clarified yet and requires further research. In order to investigate the influence of Al toxicity stress on peanut roots, this study employed various methods, including root phenotype analysis, scanning of the root, measuring the physical response indices of the root, measurement of the hormone level in the root, and quantitative PCR (qPCR). This research aimed to explore the physiological mechanism underlying the reaction of peanut roots to Al toxicity. The findings revealed that Al poisoning inhibits the development of peanut roots, resulting in reduced biomass, length, surface area, and volume. Al also significantly affects antioxidant oxidase activity and proline and malondialdehyde contents in peanut roots. Furthermore, Al toxicity led to increased accumulations of Al and Fe in peanut roots, while the contents of zinc (Zn), cuprum (Cu), manganese (Mn), kalium (K), magnesium (Mg), and calcium (Ca) decreased. The hormone content and related gene expression in peanut roots also exhibited significant changes. High concentrations of Al trigger cellular defense mechanisms, resulting in differentially expressed antioxidase genes and enhanced activity of antioxidases to eliminate excessive ROS (reactive oxygen species). Additionally, the differential expression of hormone-related genes in a high-Al environment affects plant hormones, ultimately leading to various negative effects, for example, decreased biomass of roots and hindered root development. The purpose of this study was to explore the physiological response mechanism of peanut roots subjected to aluminum toxicity stress, and the findings of this research will provide a basis for cultivating Al-resistant peanut varieties.
    Language English
    Publishing date 2024-01-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants13020325
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