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  1. Article ; Online: A single episode of stress during adolescence impairs short-term memory and increases risk behaviour in an animal model of attention-deficit/hyperactivity disorder.

    Raony, Ícaro / Geraldo, Arnaldo / Pandolfo, Pablo

    Behavioural processes

    2021  Volume 187, Page(s) 104395

    Abstract: Adolescence is a period of increased sensitivity to stress and vulnerability to the manifestation of psychiatric disorders, such as attention-deficit/hyperactivity disorder (ADHD). Nevertheless, the relationship between stress during adolescence and ADHD ...

    Abstract Adolescence is a period of increased sensitivity to stress and vulnerability to the manifestation of psychiatric disorders, such as attention-deficit/hyperactivity disorder (ADHD). Nevertheless, the relationship between stress during adolescence and ADHD is still unclear. Knowing that stress can have long-term consequences, the aim of this study was to evaluate the impact of a single episode of restraint stress during adolescence on locomotion, risk behaviour and short-term memory in adult spontaneously hypertensive rats (SHR), a validated animal model of ADHD. A single episode of stress during adolescence increased risk behaviour and impaired short-term recognition memory, but did not alter locomotion in adult SHR. These findings show that stress during adolescence, even acute, may lead to long-term behavioural consequences in an animal model of ADHD.
    MeSH term(s) Adolescent ; Animals ; Attention Deficit Disorder with Hyperactivity ; Disease Models, Animal ; Humans ; Memory, Short-Term ; Rats ; Rats, Inbred SHR ; Risk-Taking
    Language English
    Publishing date 2021-04-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 196999-7
    ISSN 1872-8308 ; 0376-6357
    ISSN (online) 1872-8308
    ISSN 0376-6357
    DOI 10.1016/j.beproc.2021.104395
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4104: Show issues Location:
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  2. Article ; Online: Retinal outcomes of COVID-19: Possible role of CD147 and cytokine storm in infected patients with diabetes mellitus.

    Raony, Ícaro / Saggioro de Figueiredo, Camila

    Diabetes research and clinical practice

    2020  Volume 165, Page(s) 108280

    Keywords covid19
    Language English
    Publishing date 2020-06-25
    Publishing country Ireland
    Document type Letter
    ZDB-ID 632523-3
    ISSN 1872-8227 ; 0168-8227
    ISSN (online) 1872-8227
    ISSN 0168-8227
    DOI 10.1016/j.diabres.2020.108280
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    Zs.A 2047: Show issues Location:
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  3. Article: Irisin stimulates protective signaling pathways in rat hippocampal neurons.

    Lourenco, Mychael V / de Freitas, Guilherme B / Raony, Ícaro / Ferreira, Sergio T / De Felice, Fernanda G

    Frontiers in cellular neuroscience

    2022  Volume 16, Page(s) 953991

    Abstract: Physical exercise stimulates neuroprotective pathways, has pro-cognitive actions, and alleviates memory impairment in Alzheimer's disease (AD). Irisin is an exercise-linked hormone produced by cleavage of fibronectin type III domain containing protein 5 ( ...

    Abstract Physical exercise stimulates neuroprotective pathways, has pro-cognitive actions, and alleviates memory impairment in Alzheimer's disease (AD). Irisin is an exercise-linked hormone produced by cleavage of fibronectin type III domain containing protein 5 (FNDC5) in skeletal muscle, brain and other tissues. Irisin was recently shown to mediate the brain benefits of exercise in AD mouse models. Here, we sought to obtain insight into the neuroprotective actions of irisin. We demonstrate that adenoviral-mediated expression of irisin promotes extracellular brain derived neurotrophic factor (BDNF) accumulation in hippocampal cultures. We further show that irisin stimulates transient activation of extracellular signal-regulated kinase 1/2 (ERK 1/2), and prevents amyloid-β oligomer-induced oxidative stress in primary hippocampal neurons. Finally, analysis of RNA sequencing (RNAseq) datasets shows a trend of reduction of hippocampal FNDC5 mRNA with aging and tau pathology in humans. Results indicate that irisin activates protective pathways in hippocampal neurons and further support the notion that stimulation of irisin signaling in the brain may be beneficial in AD.
    Language English
    Publishing date 2022-09-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2022.953991
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  4. Article ; Online: Adenosine receptors participate in anabolic-androgenic steroid-induced changes on risk assessment/anxiety-like behaviors in male and female rats.

    Penna, D B S / Raony, Ícaro / Jardim-Messeder, Débora / Dos Santos-Rodrigues, Alexandre / Pandolfo, Pablo

    Physiology & behavior

    2022  Volume 261, Page(s) 114071

    Abstract: Anabolic-androgenic steroids (AAS) and caffeine can induce several behavioral alterations in humans and rodents. Administration of nandrolone decanoate is known to affect defensive responses to aversive stimuli, generally decreasing inhibitory control ... ...

    Abstract Anabolic-androgenic steroids (AAS) and caffeine can induce several behavioral alterations in humans and rodents. Administration of nandrolone decanoate is known to affect defensive responses to aversive stimuli, generally decreasing inhibitory control and increasing aggressivity but whether caffeine intake influences behavioral changes induced by AAS is unknown. The present study aimed to investigate behavioral effects of caffeine (a non-selective antagonist of adenosine receptors) alone or combined with nandrolone decanoate (one of the most commonly AAS abused) in female and male Lister Hooded rats. Our results indicated that chronic administration of nandrolone decanoate (10 mg/kg, i.m., once a week for 8 weeks) decreased risk assessment/anxiety-like behaviors (in the elevated plus maze test), regardless of sex. These effects were prevented by combined caffeine intake (0.1 g/L, p.o., ad libitum). Overall, the present study heralds a key role for caffeine intake in the modulation of nandrolone decanoate-induced behavioral changes in rats, suggesting adenosine receptors as candidate targets to manage impact of AAS on brain function and behavior.
    MeSH term(s) Animals ; Female ; Male ; Rats ; Anabolic Agents/pharmacology ; Anabolic Androgenic Steroids/pharmacology ; Anxiety/chemically induced ; Caffeine/pharmacology ; Nandrolone Decanoate/pharmacology ; Receptors, Purinergic P1/metabolism
    Chemical Substances Anabolic Agents ; Anabolic Androgenic Steroids ; Caffeine (3G6A5W338E) ; Nandrolone Decanoate (H45187T098) ; Receptors, Purinergic P1
    Language English
    Publishing date 2022-12-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3907-x
    ISSN 1873-507X ; 0031-9384
    ISSN (online) 1873-507X
    ISSN 0031-9384
    DOI 10.1016/j.physbeh.2022.114071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 747: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Trace amine-associated receptor 1 modulates motor hyperactivity, cognition, and anxiety-like behavior in an animal model of ADHD.

    Raony, Ícaro / Domith, Ivan / Lourenco, Mychael V / Paes-de-Carvalho, Roberto / Pandolfo, Pablo

    Progress in neuro-psychopharmacology & biological psychiatry

    2022  Volume 117, Page(s) 110555

    Abstract: Trace amine-associated receptor 1 (TAAR1) is a G protein-coupled receptor that has recently been implicated in several psychiatric conditions related to monoaminergic dysfunction, such as schizophrenia, substance use disorders, and mood disorders. ... ...

    Abstract Trace amine-associated receptor 1 (TAAR1) is a G protein-coupled receptor that has recently been implicated in several psychiatric conditions related to monoaminergic dysfunction, such as schizophrenia, substance use disorders, and mood disorders. Although attention-deficit/hyperactivity disorder (ADHD) is also related to changes in monoaminergic neurotransmission, studies that assess whether TAAR1 participates in the neurobiology of ADHD are lacking. We hypothesized that TAAR1 plays an important role in ADHD and might represent a potential therapeutic target. Here, we investigate if TAAR1 modulates behavioral phenotypes in Spontaneously Hypertensive Rats (SHR), the most validated animal model of ADHD, and Wistar Kyoto rats (WKY, used as a control strain). Our results showed that TAAR1 is downregulated in ADHD-related brain regions in SHR compared with WKY. While intracerebroventricular (i.c.v.) administration of the selective TAAR1 antagonist EPPTB impaired cognitive performance in SHR, i.c.v. administration of highly selective TAAR1 full agonist RO5256390 decreased motor hyperactivity, novelty-induced locomotion, and induced an anxiolytic-like behavior. Overall, our findings show that changes in TAAR1 levels/activity underlie behavior in SHR, suggesting that TAAR1 plays a role in the neurobiology of ADHD. Although additional confirmatory studies are required, TAAR1 might be a potential pharmacological target for individuals with this disorder.
    MeSH term(s) Animals ; Anxiety/drug therapy ; Attention Deficit Disorder with Hyperactivity/psychology ; Behavior, Animal ; Cognition ; Disease Models, Animal ; Hyperkinesis ; Psychomotor Agitation ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Receptors, G-Protein-Coupled/genetics
    Chemical Substances Receptors, G-Protein-Coupled ; Trace amine-associated receptor 1 (XMC8VP6RI2)
    Language English
    Publishing date 2022-03-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 781181-0
    ISSN 1878-4216 ; 0278-5846
    ISSN (online) 1878-4216
    ISSN 0278-5846
    DOI 10.1016/j.pnpbp.2022.110555
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1342: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: SARS-CoV-2 Targeting the Retina: Host-virus Interaction and Possible Mechanisms of Viral Tropism.

    de Figueiredo, Camila Saggioro / Raony, Ícaro / Giestal-de-Araujo, Elizabeth

    Ocular immunology and inflammation

    2020  Volume 28, Issue 8, Page(s) 1301–1304

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Betacoronavirus/physiology ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/virology ; Eye Infections, Viral/epidemiology ; Eye Infections, Viral/virology ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/virology ; Retina/virology ; SARS-CoV-2 ; Viral Tropism
    Keywords covid19
    Language English
    Publishing date 2020-09-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1193873-0
    ISSN 1744-5078 ; 0927-3948
    ISSN (online) 1744-5078
    ISSN 0927-3948
    DOI 10.1080/09273948.2020.1799037
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    Zs.A 4004: Show issues Location:
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  7. Article: Retinal outcomes of COVID-19: Possible role of CD147 and cytokine storm in infected patients with diabetes mellitus

    Raony, Ícaro / Saggioro de Figueiredo, Camila

    Diabetes Res Clin Pract

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #614181
    Database COVID19

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  8. Article ; Online: Retinal outcomes of COVID-19

    Raony, Ícaro / Saggioro de Figueiredo, Camila

    Diabetes Research and Clinical Practice

    Possible role of CD147 and cytokine storm in infected patients with diabetes mellitus

    2020  Volume 165, Page(s) 108280

    Keywords Internal Medicine ; Endocrinology, Diabetes and Metabolism ; Endocrinology ; General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 632523-3
    ISSN 1872-8227 ; 0168-8227
    ISSN (online) 1872-8227
    ISSN 0168-8227
    DOI 10.1016/j.diabres.2020.108280
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    Zs.A 2047: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: SARS-CoV-2 Targeting the Retina: Host-virus Interaction and Possible Mechanisms of Viral Tropism

    de Figueiredo, Camila Saggioro / Raony, Ícaro / Giestal-de-Araujo, Elizabeth

    Ocul Immunol Inflamm

    Abstract: Background: Coronavirus disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome Coronavirus 2 10 (SARS-CoV-2). Recent studies demonstrated not only retinal impairments but also detected SARS-CoV-2 in the retina of patients with COVID-19. ... ...

    Abstract Background: Coronavirus disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome Coronavirus 2 10 (SARS-CoV-2). Recent studies demonstrated not only retinal impairments but also detected SARS-CoV-2 in the retina of patients with COVID-19. Purpose: This letter discusses the retinal tropism of SARS-CoV-2, describing possible routes for this coronavirus to reach the retina and cellular mechanisms involved in the retinal cell infection. Conclusions: Determining how SARS-CoV-2 can affect the retinal tissue is essential for the development of new therapeutic strategies and preventive measures, as well as for understanding the possible relationship between COVID-19 damage to the retina and to the brain.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #780198
    Database COVID19

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  10. Article ; Online: SARS-CoV-2 Targeting the Retina

    de Figueiredo, Camila Saggioro / Raony, Ícaro / Giestal-de-Araujo, Elizabeth

    Ocular Immunology and Inflammation

    Host–virus Interaction and Possible Mechanisms of Viral Tropism

    2020  , Page(s) 1–4

    Keywords Immunology and Allergy ; Ophthalmology ; covid19
    Language English
    Publisher Informa UK Limited
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 1193873-0
    ISSN 1744-5078 ; 0927-3948
    ISSN (online) 1744-5078
    ISSN 0927-3948
    DOI 10.1080/09273948.2020.1799037
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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