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Article ; Online: Exploration of a hypoxia-immune-related microenvironment gene signature and prediction model for hepatitis C-induced early-stage fibrosis.

Chen, Chuwen / Cai, Haozheng / Shen, Junyi / Zhang, Xiaoyun / Peng, Wei / Li, Chuan / Lv, Haopeng / Wen, Tianfu

2024 Volume 22, Issue 1, Page(s) 116

Abstract: Background: Liver fibrosis contributes to significant morbidity and mortality in Western nations, primarily attributed to chronic hepatitis C virus (HCV) infection. Hypoxia and immune status have been reported to be significantly correlated with the ... ...

Abstract	Background: Liver fibrosis contributes to significant morbidity and mortality in Western nations, primarily attributed to chronic hepatitis C virus (HCV) infection. Hypoxia and immune status have been reported to be significantly correlated with the progression of liver fibrosis. The current research aimed to investigate the gene signature related to the hypoxia-immune-related microenvironment and identify potential targets for liver fibrosis. Method: Sequencing data obtained from GEO were employed to assess the hypoxia and immune status of the discovery set utilizing UMAP and ESTIMATE methods. The prognostic genes were screened utilizing the LASSO model. The infiltration level of 22 types of immune cells was quantified utilizing CIBERSORT, and a prognosis-predictive model was established based on the selected genes. The model was also verified using qRT-PCR with surgical resection samples and liver failure samples RNA-sequencing data. Results: Elevated hypoxia and immune status were linked to an unfavorable prognosis in HCV-induced early-stage liver fibrosis. Increased plasma and resting NK cell infiltration were identified as a risk factor for liver fibrosis progression. Additionally, CYP1A2, CBS, GSTZ1, FOXA1, WDR72 and UHMK1 were determined as hypoxia-immune-related protective genes. The combined model effectively predicted patient prognosis. Furthermore, the preliminary validation of clinical samples supported most of the conclusions drawn from this study. Conclusion: The prognosis-predictive model developed using six hypoxia-immune-related genes effectively predicts the prognosis and progression of liver fibrosis. The current study opens new avenues for the future prediction and treatment of liver fibrosis.
MeSH term(s)	Humans ; Hepatitis C, Chronic/complications ; Hepatitis C, Chronic/genetics ; Hepatitis C/complications ; Hepatitis C/genetics ; Hepacivirus/genetics ; Liver Cirrhosis/genetics ; Hypoxia/complications ; Hypoxia/genetics ; Prognosis ; Tumor Microenvironment ; Glutathione Transferase
Chemical Substances	GSTZ1 protein, human (EC 2.5.1.-) ; Glutathione Transferase (EC 2.5.1.18)
Language	English
Publishing date	2024-01-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2118570-0
ISSN	1479-5876 ; 1479-5876
ISSN (online)	1479-5876
ISSN	1479-5876
DOI	10.1186/s12967-024-04912-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: CX3CR1 regulates the development of renal interstitial fibrosis through macrophage polarization.

Xu, Linyong / Zhu, Yanping / Cai, Haozheng / Liu, Shu / Cao, Qingtai / Zhuang, Quan

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences

2023 Volume 48, Issue 7, Page(s) 957–966

Abstract: Objectives: The binding of CX3C chemokine receptor 1 (CX3CR1) and its unique ligand CX3C chemokine ligand 1 (CX3CL1) can promote the migration of inflammatory cells to the lesion and affect the progression of renal interstitial fibrosis, but the ... ...

Title translation	CX3CR1通过调控巨噬细胞极化影响肾间质纤维化.
Abstract	Objectives: The binding of CX3C chemokine receptor 1 (CX3CR1) and its unique ligand CX3C chemokine ligand 1 (CX3CL1) can promote the migration of inflammatory cells to the lesion and affect the progression of renal interstitial fibrosis, but the underlying mechanisms remain unclear. This study aims to investigate whether CX3CR1 affects renal interstitial fibrosis by macrophage polarization. Methods: A mouse model of renal interstitial fibrosis was established by unilateral ureteral obstruction (UUO). C57/B6 mice were divided into a CX3CR1 inhibitor group (injected with CX3CR1 inhibitor AZD8797) and a model group (injected with physiological saline). After continuous intraperitoneal injection for 5 days, the ligated lateral kidneys of mice were obtained on the 7th day. Hematoxylin and eosin (HE) staining and Masson staining were used to observe the infiltration of inflammatory cells and the collagen fiber deposition in renal interstitium, respectively. The mRNA and protein expressions of CX3CR1, alpha-smooth muscle actin ( Results: The infiltration of inflammatory cells and the collagen fiber deposition in renal interstitium were significantly reduced in the CX3CR1 inhibitor group. The mRNA and protein levels of Conclusions: Inhibiting CX3CR1 can effectively prevent the progression of renal interstitial fibrosis. The mechanism may be related to macrophage polarization towards M2 type and upregulation of Arg-1 expression.
MeSH term(s)	Animals ; Mice ; Collagen ; CX3C Chemokine Receptor 1/genetics ; Fibrosis ; Kidney Diseases ; Ligands
Chemical Substances	Collagen (9007-34-5) ; CX3C Chemokine Receptor 1 ; Ligands ; Cx3cr1 protein, mouse
Language	Chinese
Publishing date	2023-09-18
Publishing country	China
Document type	Journal Article
ZDB-ID	2168533-2
ISSN	1672-7347
ISSN	1672-7347
DOI	10.11817/j.issn.1672-7347.2023.220601
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Article ; Online: The Association between Regulatory T Cell Subpopulations and Severe Pneumonia Post Renal Transplantation.

Zhuang, Quan / Cai, Haozheng / Yang, Min / Peng, Bo / Luo, Yulin / Zhang, Ying / Ming, Yingzi

Journal of immunology research

2022 Volume 2022, Page(s) 8720438

Abstract: Severe pneumonia accounts for the majority of morbidity and mortality in renal allograft recipients due to immunosuppressant maintenance. Regulatory T cells (Tregs), which are involved in tackling infections under immunosuppressive conditions, are rarely ...

Abstract	Severe pneumonia accounts for the majority of morbidity and mortality in renal allograft recipients due to immunosuppressant maintenance. Regulatory T cells (Tregs), which are involved in tackling infections under immunosuppressive conditions, are rarely uncovered. We aimed to investigate the relationship between various Treg subpopulations and severe pneumonia after kidney transplantation (KTx). KTx recipients with pneumonia were divided into severe pneumonia and mild pneumonia groups. The frequencies and absolute numbers (Ab No.) of total Tregs (CD4
MeSH term(s)	Flow Cytometry ; Forkhead Transcription Factors ; HLA Antigens ; Humans ; Immunosuppressive Agents ; Kidney Transplantation/adverse effects ; Pneumonia/etiology ; T-Lymphocytes, Regulatory
Chemical Substances	Forkhead Transcription Factors ; HLA Antigens ; Immunosuppressive Agents
Language	English
Publishing date	2022-04-09
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2817541-4
ISSN	2314-7156 ; 2314-7156
ISSN (online)	2314-7156
ISSN	2314-7156
DOI	10.1155/2022/8720438
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Article ; Online: The networks of m

Li, Xinyu / Peng, Cheng / Zhu, Ziqing / Cai, Haozheng / Zhuang, Quan

Aging

2021 Volume 13, Issue 5, Page(s) 6273–6288

Abstract: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with a poor prognosis. The current coronavirus disease 2019 (COVID-19) shares some similarities with IPF. SARS-CoV-2 related genes have been reported to be broadly regulated by ... ...

Abstract	Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with a poor prognosis. The current coronavirus disease 2019 (COVID-19) shares some similarities with IPF. SARS-CoV-2 related genes have been reported to be broadly regulated by N
MeSH term(s)	Adenosine/analogs & derivatives ; Adenosine/genetics ; Adenosine/immunology ; Algorithms ; COVID-19/diagnosis ; COVID-19/genetics ; COVID-19/immunology ; Gene Regulatory Networks ; Humans ; Idiopathic Pulmonary Fibrosis/diagnosis ; Idiopathic Pulmonary Fibrosis/genetics ; Idiopathic Pulmonary Fibrosis/immunology ; Immunity ; Immunity, Cellular ; Prognosis ; RNA/genetics ; RNA/immunology ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/immunology ; SARS-CoV-2/immunology ; SARS-CoV-2/isolation & purification
Chemical Substances	RNA, Long Noncoding ; RNA (63231-63-0) ; N-methyladenosine (CLE6G00625) ; Adenosine (K72T3FS567)
Language	English
Publishing date	2021-03-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.202725
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Article: Single-Cell Transcriptomic Analysis of Peripheral Blood Reveals a Novel B-Cell Subset in Renal Allograft Recipients With Accommodation.

Zhuang, Quan / Li, Hao / Peng, Bo / Liu, Yang / Zhang, Ying / Cai, Haozheng / Liu, Shu / Ming, Yingzi

Frontiers in pharmacology

2021 Volume 12, Page(s) 706580

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-09-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.706580
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Article ; Online: The Combined Model of CX3CR1-Related Immune Infiltration Genes to Evaluate the Prognosis of Idiopathic Pulmonary Fibrosis.

Cai, Haozheng / Chen, Shijie / Li, Xinyu / Liu, Hanying / Zhang, Ying / Zhuang, Quan

Frontiers in immunology

2022 Volume 13, Page(s) 837188

Abstract: Background: High expression of chemokine (C-X3-C motif) receptor 1 (CX3CR1) was shown to contribute to the progression of many fibrotic diseases. However, there is still no study for the role of CX3CR1 in idiopathic pulmonary fibrosis (IPF). Therefore, ... ...

Abstract	Background: High expression of chemokine (C-X3-C motif) receptor 1 (CX3CR1) was shown to contribute to the progression of many fibrotic diseases. However, there is still no study for the role of CX3CR1 in idiopathic pulmonary fibrosis (IPF). Therefore, we aimed to identify CX3CR1-related immune infiltration genes (IIGs) in IPF and establish a combined risk model to evaluate the prognosis of IPF. Methods: A discovery cohort of IPF patients (GSE70867) was downloaded from the Gene Expression Omnibus dataset. We identified the composition of 22 kinds of immune cells infiltration by CIBERSORT. The Cox regression model with the LASSO method was used for identifying prognostic genes and developing CX3CR1-related IIGs. Kaplan-Meier was applied to plot the survival curve of prognosis model. Peripheral blood mononuclear cell (PBMC) and bronchoalveolar lavage fluid (BALF) were collected to be tested by quantitative reverse transcriptase-PCR (qRT-PCR) from 15 clinical samples, including 8 healthy controls (HC), 4 patients with usual interstitial pneumonia (UIP) and 3 patients with pulmonary fibrosis (FIB). Results: We found that high expression of CX3CR1 in BALF contributed to the poor prognosis in IPF patients. ALR4C, RAB37, GPR56, MARCKS, PXN and RASSF2 were identified as CX3CR1-related IIGs, which were highly expressed in PBMC of UIP/FIB patients than that of HC. Moreover, the expression of PXN was higher in FIB patients' PBMC than that of UIP ones. In the cohort of IPF patients, high infiltration of activated NK cells in BALF caused poor survival compared to low infiltration group. The infiltration of activated NK was regulated by CX3CR1-related IIGs. The combined risk model predicted that high expression of CX3CR1-related IIGs and high infiltrated activated NK cells caused poor prognosis in IPF patients. Conclusion: We identified a group of CX3CR1-related IIGs in IPF patients. This combined risk model provided new insights in the prognosis and therapy of IPF.
MeSH term(s)	Bronchoalveolar Lavage Fluid ; CX3C Chemokine Receptor 1/genetics ; Cohort Studies ; Humans ; Idiopathic Pulmonary Fibrosis/metabolism ; Leukocytes, Mononuclear/metabolism ; Prognosis
Chemical Substances	CX3C Chemokine Receptor 1 ; CX3CR1 protein, human
Language	English
Publishing date	2022-02-10
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.837188
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Article ; Online: Investigation of a Hypoxia-Immune-Related Microenvironment Gene Signature and Prediction Model for Idiopathic Pulmonary Fibrosis.

Li, Xinyu / Cai, Haozheng / Cai, Yufeng / Zhang, Quyan / Ding, Yinghe / Zhuang, Quan

Frontiers in immunology

2021 Volume 12, Page(s) 629854

Abstract: Background: There is growing evidence found that the role of hypoxia and immune status in idiopathic pulmonary fibrosis (IPF). However, there are few studies about the role of hypoxia and immune status in the lung milieu in the prognosis of IPF. This ... ...

Abstract	Background: There is growing evidence found that the role of hypoxia and immune status in idiopathic pulmonary fibrosis (IPF). However, there are few studies about the role of hypoxia and immune status in the lung milieu in the prognosis of IPF. This study aimed to develop a hypoxia-immune-related prediction model for the prognosis of IPF. Methods: Hypoxia and immune status were estimated with microarray data of a discovery cohort from the GEO database using UMAP and ESTIMATE algorithms respectively. The Cox regression model with the LASSO method was used for identifying prognostic genes and developing hypoxia-immune-related genes. Cibersort was used to evaluate the difference of 22 kinds of immune cell infiltration. Three independent validation cohorts from GEO database were used for external validation. Peripheral blood mononuclear cell (PBMC) and bronchoalveolar lavage fluid (BALF) were collected to be tested by Quantitative reverse transcriptase-PCR (qRT-PCR) and flow cytometry from 22 clinical samples, including 13 healthy controls, six patients with non-fibrotic pneumonia and three patients with pulmonary fibrosis. Results: Hypoxia and immune status were significantly associated with the prognosis of IPF patients. High hypoxia and high immune status were identified as risk factors for overall survival. CD8+ T cell, activated CD4+ memory T cell, NK cell, activated mast cell, M1 and M0 macrophages were identified as key immune cells in hypoxia-immune-related microenvironment. A prediction model for IPF prognosis was established based on the hypoxia-immune-related one protective and nine risk DEGs. In the independent validation cohorts, the prognostic prediction model performed the significant applicability in peripheral whole blood, peripheral blood mononuclear cell, and lung tissue of IPF patients. The preliminary clinical specimen validation suggested the reliability of most conclusions. Conclusions: The hypoxia-immune-based prediction model for the prognosis of IPF provides a new idea for prognosis and treatment.
Language	English
Publishing date	2021-06-14
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.629854
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Article ; Online: Design of Fast Acquisition System and Analysis of Geometric Feature for Highway Tunnel Lining Cracks Based on Machine Vision

Haozheng Wang / Qiang Wang / Junli Zhai / Dongyang Yuan / Weikang Zhang / Xiongyao Xie / Biao Zhou / Jielong Cai / Yuanshuai Lei

Applied Sciences, Vol 12, Iss 2516, p

2022 Volume 2516

Abstract: Under the dual effects of the rapid growth of tunnel mileage and operating years, the application and research of tunnel crack identification based on machine vision are increasing with the vigorous development of machine vision. However, due to the ... ...

Abstract	Under the dual effects of the rapid growth of tunnel mileage and operating years, the application and research of tunnel crack identification based on machine vision are increasing with the vigorous development of machine vision. However, due to the complex environment in tunnels, it is difficult to quickly obtain tunnel lining cracks via computer visions in the tunnel. Therefore, this paper presents the design of a fast acquisition system with the geometric feature analysis for tunnel lining cracks, which has been integrated into a tunnel fast inspection vehicle with a machine vision module. Through the research on the image acquisition system of the tunnel lining, the parameter selection of the crack shooting hardware system is determined, and the fast calculation method of shooting parameters is proposed. The geometric characteristic analysis of the tunnel lining crack image is employed to calculate crack width and determine the optimal gray value of crack extraction. Field tests have been conducted in the highway tunnels in Zhejiang and Yunnan provinces in China and the result indicates that the proposed approach yields much better performance in the detection efficiency, whose time of detection is only 1%, and the number of personnel required is only 40% of the traditional pure manual method. Compared with similar systems, it also has significant advantages in crack resolution and detection speed. This research provides a means of rapid acquisition of tunnel cracks and laying a foundation for the evaluation of the service performance of the tunnel.
Keywords	tunnel detection ; machine vision ; lining cracks ; image processing ; image acquisition ; system development ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	670
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Tolerogenic Dendritic Cells: The Pearl of Immunotherapy in Organ Transplantation.

Zhuang, Quan / Cai, Haozheng / Cao, Qingtai / Li, Zixin / Liu, Shu / Ming, Yingzi

Frontiers in immunology

2020 Volume 11, Page(s) 552988

Abstract: Over a half century, organ transplantation has become an effective method for the treatment of end-stage visceral diseases. Although the application of immunosuppressants (IS) minimizes the rate of allograft rejection, the common use of IS bring many ... ...

Abstract	Over a half century, organ transplantation has become an effective method for the treatment of end-stage visceral diseases. Although the application of immunosuppressants (IS) minimizes the rate of allograft rejection, the common use of IS bring many adverse effects to transplant patients. Moreover, true transplant tolerance is very rare in clinical practice. Dendritic cells (DCs) are thought to be the most potent antigen-presenting cells, which makes a bridge between innate and adaptive immunity. Among their subsets, a small portion of DCs with immunoregulatory function was known as tolerogenic DC (Tol-DC). Previous reports demonstrated the ability of adoptively transferred Tol-DC to approach transplant tolerance in animal models. In this study, we summarized the properties, ex vivo generation, metabolism, and clinical attempts of Tol-DC. Tol-DC is expected to become a substitute for IS to enable patients to achieve immune tolerance in the future.
MeSH term(s)	Animals ; Dendritic Cells/immunology ; Dendritic Cells/transplantation ; Graft Rejection/immunology ; Graft Rejection/prevention & control ; Graft Survival/immunology ; Humans ; Immunotherapy ; Organ Transplantation ; Transplantation Tolerance
Language	English
Publishing date	2020-10-06
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2020.552988
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Article ; Online: Psychological Impact and Coping Strategies of Frontline Medical Staff in Hunan Between January and March 2020 During the Outbreak of Coronavirus Disease 2019 (COVID‑19) in Hubei, China.

Cai, Haozheng / Tu, Baoren / Ma, Jing / Chen, Limin / Fu, Lei / Jiang, Yongfang / Zhuang, Quan

Medical science monitor : international medical journal of experimental and clinical research

2020 Volume 26, Page(s) e924171

Abstract: BACKGROUND Throughout China, during the recent epidemic in Hubei province, frontline medical staff have been responsible for tracing contacts of patients infected with coronavirus disease 2019 (COVID‑19). This study aimed to investigate the psychological ...

Abstract	BACKGROUND Throughout China, during the recent epidemic in Hubei province, frontline medical staff have been responsible for tracing contacts of patients infected with coronavirus disease 2019 (COVID‑19). This study aimed to investigate the psychological impact and coping strategies of frontline medical staff in Hunan province, adjacent to Hubei province, during the COVID‑19 outbreak between January and March 2020. MATERIAL AND METHODS A cross-sectional observational study included doctors, nurses, and other hospital staff throughout Hunan province between January and March 2020. The study questionnaire included five sections and 67 questions (scores, 0-3). The chi-squared χ² test was used to compare the responses between professional groups, age-groups, and gender. RESULTS Study questionnaires were completed by 534 frontline medical staff. The responses showed that they believed they had a social and professional obligation to continue working long hours. Medical staff were anxious regarding their safety and the safety of their families and reported psychological effects from reports of mortality from COVID‑19 infection. The availability of strict infection control guidelines, specialized equipment, recognition of their efforts by hospital management and the government, and reduction in reported cases of COVID‑19 provided psychological benefit. CONCLUSIONS The COVID‑19 outbreak in Hubei resulted in increased stress for medical staff in adjacent Hunan province. Continued acknowledgment of the medical staff by hospital management and the government, provision of infection control guidelines, specialized equipment and facilities for the management of COVID‑19 infection should be recognized as factors that may encourage medical staff to work during future epidemics.
MeSH term(s)	Adaptation, Psychological ; Adolescent ; Adult ; Anxiety/epidemiology ; Anxiety/etiology ; Betacoronavirus ; COVID-19 ; China/epidemiology ; Coronavirus Infections/epidemiology ; Coronavirus Infections/psychology ; Cross-Sectional Studies ; Educational Status ; Emotions ; Female ; Humans ; Male ; Middle Aged ; Motivation ; Pandemics ; Personnel, Hospital/psychology ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/psychology ; SARS-CoV-2 ; Stress, Psychological/epidemiology ; Stress, Psychological/etiology ; Surveys and Questionnaires ; Young Adult
Keywords	covid19
Language	English
Publishing date	2020-04-15
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	1439041-3
ISSN	1643-3750 ; 1234-1010
ISSN (online)	1643-3750
ISSN	1234-1010
DOI	10.12659/MSM.924171
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