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  1. Article ; Online: The key characteristics of SARS-CoV-2 infection of humans and of the city of Wuhan that made a pandemic inevitable and unavoidable

    Li Yuchen

    BIO Web of Conferences, Vol 61, p

    2023  Volume 01028

    Abstract: The significant worldwide effects of Coronavirus disease 2019 (COVID-19) have been apparent since its outbreak. This unprecedentedly widespread virus, SARS-CoV-2, has high infectivity, asymptomatic transmission, and a long-term incubation period. These ... ...

    Abstract The significant worldwide effects of Coronavirus disease 2019 (COVID-19) have been apparent since its outbreak. This unprecedentedly widespread virus, SARS-CoV-2, has high infectivity, asymptomatic transmission, and a long-term incubation period. These characteristics have led to the rapid spread of viruses between cities and humans. The cause of the outbreak of the epidemic in Wuhan is also due to the large population, transportation, and the healthcare system lack of public health prevention and intervention in Wuhan. This unavoidable pandemic not only because the virus has robust transmission, but also the city of Wuhan did not control the spread of the virus in the early stage of the epidemic. These factors lead to a huge public health problem worldwide.
    Keywords public health ; coronavirus disease 2019 ; covid-19 ; sars-cov-2 ; epidemiology ; primary healthcare ; intervention ; Microbiology ; QR1-502 ; Physiology ; QP1-981 ; Zoology ; QL1-991
    Subject code 360
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Computational screening of single-atom doped In

    Wang, Yuchen / Li, Shenggang

    Physical chemistry chemical physics : PCCP

    2023  Volume 26, Issue 1, Page(s) 381–389

    Abstract: The reverse water gas shift (RWGS) reaction is an important method for converting carbon dioxide ( ... ...

    Abstract The reverse water gas shift (RWGS) reaction is an important method for converting carbon dioxide (CO
    Language English
    Publishing date 2023-12-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d3cp04352e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Coinfection of Cage-Cultured Spotted Sea Bass (

    Zhou, Dandan / Zhang, Binzhe / Dong, Yuchen / Li, Xuepeng / Zhang, Jian

    Microorganisms

    2024  Volume 12, Issue 3

    Abstract: Spotted sea bass ( ...

    Abstract Spotted sea bass (
    Language English
    Publishing date 2024-02-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms12030503
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Exosomal encapsulation of miR-3198 promotes proliferation and migration of trophoblasts in preeclampsia.

    Li, Yuchen / Yu, Yanling / Li, Dejun / Li, Lei

    Journal of assisted reproduction and genetics

    2024  

    Abstract: Purpose: Preeclampsia (PE) is a vascular remodeling disorder cloesly linked to trophoblast dysfunction, involving defects in their proliferation, migration, and apoptosis. Maternal exosomal microRNAs (miRNAs) have been reported to play pivotal roles in ... ...

    Abstract Purpose: Preeclampsia (PE) is a vascular remodeling disorder cloesly linked to trophoblast dysfunction, involving defects in their proliferation, migration, and apoptosis. Maternal exosomal microRNAs (miRNAs) have been reported to play pivotal roles in the development of PE. However, the mechanism underlying the role of maternal exosomes in trophoblast dysfunction regarding the development of PE is poorly understood.
    Methods: Plasma exosomes from maternal peripheral blood were collected from pregnant women with PE and from those with normal pregnancy. Bioinformatics analysis was used to identify significantly differentially expressed miRNAs under these two conditions. The expression of the miR-3198 gene in plasma exosomes was detected using quantitative real-time polymerase chain reaction. Dual luciferase reporter assay was used to confirm binding of miR-3198 and 3'UTR region of WNT3. Cell proliferation was examined using the Cell Count Kit-8 and EdU assays, and flow cytometry was performed to detect apoptosis and cell cycle. Changes in cell migration were examined using transwell and scratch assays.
    Results: Patients with PE showed decreased expression of plasma-derived exosomal miR-3198. The proliferation and migration abilities of HTR-8/SVneo and primary human trophoblast cells were both improved when cocultured with miR-3198-rich exosomes. Exposure to miR-3198-enriched exosomes facilitated cell cycle progression but reduced apoptosis in HTR-8/SVneo cells. Notably, overexpression of miR-3198 partially prevented the inhibitory effects of WNT3 on proliferation and migration in HTR-8/SVneo cells.
    Conclusion: Exosomal miR-3198 in the maternal peripheral blood may regulate the biological functions of trophoblasts by targeting WNT3 and influence the development of diseases of placental origin.
    Language English
    Publishing date 2024-03-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1112577-9
    ISSN 1573-7330 ; 1058-0468
    ISSN (online) 1573-7330
    ISSN 1058-0468
    DOI 10.1007/s10815-024-03104-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Polygala tenuifolia

    Zhang, Yuchen / Tian, Jinzhou / Ni, Jingnian / Wei, Mingqing / Li, Ting / Shi, Jing

    Frontiers in pharmacology

    2024  Volume 14, Page(s) 1268000

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-01-12
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1268000
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: State of the Art of Lifecourse Cohort Establishment.

    Dai, Shaoqing / Qiu, Ge / Li, Yuchen / Yang, Shuhan / Yang, Shujuan / Jia, Peng

    China CDC weekly

    2024  Volume 6, Issue 14, Page(s) 300–304

    Language English
    Publishing date 2024-04-17
    Publishing country China
    Document type Journal Article
    ISSN 2096-7071
    ISSN (online) 2096-7071
    DOI 10.46234/ccdcw2024.058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A novel FA1-targeting fluorescent probe for specific discrimination and identification of human serum albumin from bovine serum albumin.

    Huyan, Yuchen / Nan, Xiaojing / Li, Hongjuan / Sun, Shiguo / Xu, Yongqian

    Chemical communications (Cambridge, England)

    2024  Volume 60, Issue 28, Page(s) 3810–3813

    Abstract: A novel probe C1 combining benzothiazole with a spiropyran section was developed for the specific detection of human serum albumin (HSA). The molecular docking suggested that the sulphonic acid group modification allowed C1 to form specific hydrogen ... ...

    Abstract A novel probe C1 combining benzothiazole with a spiropyran section was developed for the specific detection of human serum albumin (HSA). The molecular docking suggested that the sulphonic acid group modification allowed C1 to form specific hydrogen bonds with lysine (Lys137) at fatty acid site 1 (FA1) of HSA, thus enabling fluorescence differentiation between HSA and BSA.
    MeSH term(s) Humans ; Serum Albumin, Human/chemistry ; Serum Albumin, Bovine/chemistry ; Fluorescent Dyes/chemistry ; Molecular Docking Simulation ; Fatty Acids ; Spectrometry, Fluorescence ; Protein Binding
    Chemical Substances Serum Albumin, Human (ZIF514RVZR) ; Serum Albumin, Bovine (27432CM55Q) ; Fluorescent Dyes ; Fatty Acids
    Language English
    Publishing date 2024-04-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d4cc00407h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Sex Differences in the Relationship Between School Bullying Victimization and Complex Posttraumatic Stress Disorder: The Roles of Insecure Attachment.

    Li, Yuchen / Liu, Luming / Wang, Wenchao

    Journal of interpersonal violence

    2024  , Page(s) 8862605231221835

    Abstract: School bullying victimization is a highly concerning issue that can lead to a range of negative outcomes. Despite the research showing a significant association between bullying victimization and complex posttraumatic stress disorder (CPTSD), the ... ...

    Abstract School bullying victimization is a highly concerning issue that can lead to a range of negative outcomes. Despite the research showing a significant association between bullying victimization and complex posttraumatic stress disorder (CPTSD), the internal mechanisms with its two components (i.e., posttraumatic stress disorder symptoms [PTSD] and disorders of self-organization symptoms [DSO]) remain unclear. Previous studies have indicated that attachment style may influence the development of CPTSD symptoms and that there may be sex differences in attachment styles. Thus, the present study aims to examine the mediating role of insecure attachment between school bullying victimization and CPTSD symptoms in males and females. The study assessed bullying victimization, attachment orientation, and CPTSD (i.e., PTSD symptoms and DSO symptoms) symptoms in 675 college students (65.2% females;
    Language English
    Publishing date 2024-01-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2028900-5
    ISSN 1552-6518 ; 0886-2605
    ISSN (online) 1552-6518
    ISSN 0886-2605
    DOI 10.1177/08862605231221835
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  9. Article ; Online: Cascade Electrocatalytic and Thermocatalytic Reduction of CO

    Zhang, Jie / Kang, Xingsi / Yan, Yuchen / Ding, Xue / He, Lin / Li, Yanguang

    Angewandte Chemie (International ed. in English)

    2024  Volume 63, Issue 12, Page(s) e202315777

    Abstract: Electrochemical ... ...

    Abstract Electrochemical CO
    Language English
    Publishing date 2024-02-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202315777
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  10. Article ; Online: Multisystem Immune-Related Adverse Events from Dual-Agent Immunotherapy Use.

    Li, Yuchen / Pond, Gregory / McWhirter, Elaine

    Current oncology (Toronto, Ont.)

    2024  Volume 31, Issue 1, Page(s) 425–435

    Abstract: Background: little is known about the incidence and characteristics of multisystem immune-related adverse events (irAEs) associated with dual-agent ipilimumab and nivolumab use.: Methods: A retrospective cohort review was completed that included ... ...

    Abstract Background: little is known about the incidence and characteristics of multisystem immune-related adverse events (irAEs) associated with dual-agent ipilimumab and nivolumab use.
    Methods: A retrospective cohort review was completed that included cancer patients seen at the Juravinski Cancer Centre who received at least one dose of ipilimumab and nivolumab from 2018 to 2022. Patient characteristics, cancer types, and irAEs were recorded. Multivariate logistic and cox regressions were completed, comparing those who developed multisystem irAEs, single irAE, and no irAE.
    Results: A total of 123 patients were included in this study. Out of 123 patients, 72 (59%) had melanoma, 50/123 (41%) had renal cell carcinoma (RCC), and 1/123 (1%) had breast cancer. Multisystem irAEs were seen in 40% of the overall cohort. The most common irAE type was dermatitis (22%), followed by colitis (19%) and hepatitis (17%).
    Conclusions: Our study demonstrated that multisystem irAEs are prevalent amongst patients receiving ipilimumab and nivolumab. It is important for both physician education and the counseling and consent of patients to monitor the potential for multiple irAEs.
    MeSH term(s) Humans ; Immunotherapy/adverse effects ; Ipilimumab/adverse effects ; Ipilimumab/therapeutic use ; Nivolumab/adverse effects ; Nivolumab/therapeutic use ; Retrospective Studies ; Neoplasms/drug therapy ; Antineoplastic Agents, Immunological/therapeutic use
    Chemical Substances Ipilimumab ; Nivolumab (31YO63LBSN) ; Antineoplastic Agents, Immunological
    Language English
    Publishing date 2024-01-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1236972-x
    ISSN 1718-7729 ; 1198-0052
    ISSN (online) 1718-7729
    ISSN 1198-0052
    DOI 10.3390/curroncol31010028
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