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Article ; Online: Chemical derivatization strategies for enhancing the HPLC analytical performance of natural active triterpenoids.

Huang, Xiao-Feng / Xue, Ying / Yong, Li / Wang, Tian-Tian / Luo, Pei / Qing, Lin-Sen

2023 Volume 14, Issue 3, Page(s) 295–307

Abstract: Triterpenoids widely exist in nature, displaying a variety of pharmacological activities. Determining triterpenoids in different matrices, especially in biological samples holds great significance. High-performance liquid chromatography (HPLC) has become ...

Abstract	Triterpenoids widely exist in nature, displaying a variety of pharmacological activities. Determining triterpenoids in different matrices, especially in biological samples holds great significance. High-performance liquid chromatography (HPLC) has become the predominant method for triterpenoids analysis due to its exceptional analytical performance. However, due to the structural similarities among botanical samples, achieving effective separation of each triterpenoid proves challenging, necessitating significant improvements in analytical methods. Additionally, triterpenoids are characterized by a lack of ultraviolet (UV) absorption groups and chromophores, along with low ionization efficiency in mass spectrometry. Consequently, routine HPLC analysis suffers from poor sensitivity. Chemical derivatization emerges as an indispensable technique in HPLC analysis to enhance its performance. Considering the structural characteristics of triterpenoids, various derivatization reagents such as acid chlorides, rhodamines, isocyanates, sulfonic esters, and amines have been employed for the derivatization analysis of triterpenoids. This review comprehensively summarized the research progress made in derivatization strategies for HPLC detection of triterpenoids. Moreover, the limitations and challenges encountered in previous studies are discussed, and future research directions are proposed to develop more effective derivatization methods.
Language	English
Publishing date	2023-07-08
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2630174-X
ISSN	2214-0883 ; 2095-1779
ISSN (online)	2214-0883
ISSN	2095-1779
DOI	10.1016/j.jpha.2023.07.004
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Sen lin ho jen lei sheng huo

Wang, Chao-feng

1956

Title translation	Forests and human life
Keywords	Forest ecology.
Language	Chinese
Size	25 p.
Edition	Ti 1 pan.
Publisher	Chung-kuo lin yeh chʻu pan she
Publishing place	Pei-ching
Document type	Book
Database	NAL-Catalogue (AGRICOLA)

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Article: Psychometric Validation of the Persian Version of the COVID-19-Related Psychological Distress Scale and Association with COVID-19 Fear, COVID-19 Anxiety, Optimism, and Lack of Resilience.

Nazari, Nabi / Zekiy, Angelina Olegovna / Feng, Lin-Sen / Griffiths, Mark D

International journal of mental health and addiction

2021 Volume 20, Issue 5, Page(s) 2665–2680

Abstract: The outbreak of the coronavirus disease-2019 (COVID-19) has resulted in a global health crisis. The COVID-19 pandemic has caused psychological distress, both in infected and uninfected individuals. The present study evaluated the validity and factor ... ...

Abstract	The outbreak of the coronavirus disease-2019 (COVID-19) has resulted in a global health crisis. The COVID-19 pandemic has caused psychological distress, both in infected and uninfected individuals. The present study evaluated the validity and factor structure of the COVID-19-Related Psychological Distress Scale (CORPDS) among the general public of the Persian-speaking population. The original version of the CORPDS was translated and back-translated into Persian, followed by a pilot study. A total sample (
Language	English
Publishing date	2021-05-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2235886-9
ISSN	1557-1882 ; 1557-1874
ISSN (online)	1557-1882
ISSN	1557-1874
DOI	10.1007/s11469-021-00540-z
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Article: Development and validation of the thyroid cancer self-perceived discrimination scale to identify patients at high risk for psychological problems.

Liu, Zhi-Jin / Feng, Lin-Sen / Li, Feng / Yang, Li-Rong / Wang, Wan-Qi / He, Yuan / Meng, Zong-Ting / Wang, Yu-Feng

Frontiers in oncology

2023 Volume 13, Page(s) 1182821

Abstract: Objective: To develop a Thyroid Cancer Self-Perceived Discrimination Scale (TCSPDS) to identify patients at high risk for psychological problems and to test its reliability, validity and acceptability.: Methods: Using classical test theory, a total ... ...

Abstract	Objective: To develop a Thyroid Cancer Self-Perceived Discrimination Scale (TCSPDS) to identify patients at high risk for psychological problems and to test its reliability, validity and acceptability. Methods: Using classical test theory, a total of 176 thyroid cancer patients from November 2021 to October 2022 were recruited to develop the TCSPDS. Item analysis was used to improve the preliminary TCSPDS. Exploratory factor analysis (EFA), confirmatory factor analysis (CFA) and structural equation model (SEM) were used to test the construct validity of the final TCSPDS. Pearson correlation coefficient was used to analyze the validity coefficient between TCSPDS and EORTC QLQ-C30 to test the criterion-related validity (CRV) of the final TCSPDS. The internal consistency coefficient (Cronbach's alpha coefficient), split half reliability (Spearman-Brown coefficient) and test-retest reliability were used to verify the reliability of the final TCSPDS. The questionnaire completion time and effective response rate were used to validate the acceptability of the final TCSPDS. Results: The TCSPDS consisted of 20 items and was divided into 3 subscales: 8 items for stigma, 6 items for self-deprecation, and 6 items for social avoidance. The TCSPDS had good validity (χ Conclusion: The TCSPDS could be used for early identification and assessment of the level of self-perceived discrimination in patients with thyroid cancer, which may provide a scientific basis for health education, social support and psychosocial oncology services in the future, especially in Southwest China.
Language	English
Publishing date	2023-07-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1182821
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Article ; Online: Cognition of the warning symptoms and risk factors for cancer among Chinese college students: a cross-sectional study based on a summer social practice activity.

Feng, Lin-Sen / Li, Qing-Li / Yang, Qing / Zhu, Yu-Lu / Yin, Fu-Lin / Wang, Qi-Yao / Zhong, Wen-Jue / Wu, Xiao-Qian / Yan, Ruo-Yu / Dong, Zheng-Jiao

Annals of medicine

2024 Volume 55, Issue 2, Page(s) 2299574

Abstract: Background: To investigate the cognition of cancer warning symptoms and cancer risk factors among Chinese college students, analyze the influencing factors, and explain the correlations between cancer cognition and cancer symptom discrimination, cancer ... ...

Abstract	Background: To investigate the cognition of cancer warning symptoms and cancer risk factors among Chinese college students, analyze the influencing factors, and explain the correlations between cancer cognition and cancer symptom discrimination, cancer fear and psychological distress. Methods: Chinese college students were recruited in this cross-sectional study funded by a summer social practice activity in Yunnan Province, China. Cognition rates of cancer warning symptoms and cancer risk factors were evaluated using Cancer Warning symptoms Cognition Questionnaire (CWSCQ) and Cancer Risk Factors Cognition Questionnaire (CRFCQ), respectively. Factors associated with cognition of cancer warning symptoms, and factors associated with cognition of cancer risk factors were evaluated using multiple linear regression analysis. Interactions between cancer cognition, cancer symptom discrimination, psychological distress, and cancer fear were evaluated by structural equation modeling. Results: There were 846 effective samples, with an effective rate of 80.9%. The cognition rates of cancer warning symptoms were from 47.9% to 84.4%, which were affected by cancer symptom discrimination, education, attitudes towards cancer screening, living expenses, drinking history, and ways to obtain cancer knowledge ( Conclusions: The overall cancer cognition situation among Chinese college students is not optimistic, which highlights the necessity of improving the cancer health literacy among Chinese college students. With the increasing morbidity and mortality rates of cancer, it is necessary to raise awareness of early detection, and early treatment of cancer among the general public. Health education interventions are helpful to improve cancer health literacy.
MeSH term(s)	Humans ; Cross-Sectional Studies ; China/epidemiology ; Students/psychology ; Neoplasms/epidemiology ; Surveys and Questionnaires ; Risk Factors ; Cognition ; Health Knowledge, Attitudes, Practice
Language	English
Publishing date	2024-01-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1004226-x
ISSN	1365-2060 ; 1651-2219 ; 0785-3890 ; 1743-1387
ISSN (online)	1365-2060 ; 1651-2219
ISSN	0785-3890 ; 1743-1387
DOI	10.1080/07853890.2023.2299574
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Article ; Online: Preclinical Investigations on Anti-fibrotic Potential of Long-Term Oral Therapy of Sodium Astragalosidate in Animal Models of Cardiac and Renal Fibrosis.

Chen, Xiao-Yi / Wang, Tian-Tian / Shen, Qing / Ma, Hao / Li, Zhan-Hua / Yu, Xi-Na / Huang, Xiao-Feng / Qing, Lin-Sen / Luo, Pei

ACS pharmacology & translational science

2024 Volume 7, Issue 2, Page(s) 421–431

Abstract: In traditional Chinese medicine, Radix Astragali has played a vital role in treating progressive fibrotic diseases. One of its main active components, astragaloside IV, is a promising anti-fibrotic treatment despite its extremely low bioavailability. Our ...

Abstract	In traditional Chinese medicine, Radix Astragali has played a vital role in treating progressive fibrotic diseases. One of its main active components, astragaloside IV, is a promising anti-fibrotic treatment despite its extremely low bioavailability. Our study aimed to optimize sodium astragalosidate (SA) by salt formation to improve solubility and oral absorption for anti-fibrotic therapy
Language	English
Publishing date	2024-01-12
Publishing country	United States
Document type	Journal Article
ISSN	2575-9108
ISSN (online)	2575-9108
DOI	10.1021/acsptsci.3c00264
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Nanomaterial-based optical- and electrochemical-biosensors for urine glucose detection: A comprehensive review

Wang, Tian-Tian / Huang, Xiao-Feng / Huang, Hui / Luo, Pei / Qing, Lin-Sen

Advanced sensor and energy materials. 2022 Sept., v. 1, no. 3

2022

Abstract: Urine glucose detection is an important diagnostic tool for screening and early diagnosis of diabetes mellitus. Detection of urine glucose has many advantages over blood glucose, such as non-invasive, easy-to-detect, simple sampling and being well ... ...

Abstract	Urine glucose detection is an important diagnostic tool for screening and early diagnosis of diabetes mellitus. Detection of urine glucose has many advantages over blood glucose, such as non-invasive, easy-to-detect, simple sampling and being well accepted by patients. Therefore, it is commonly used to monitor diabetes progression, assist in therapeutic intervention as well as in point-of-care testing (POCT). In recent years, with the development of material science, electrochemistry and miniaturization technology, novel applications of natural enzymes, nanozymes as well as nanomaterials, such as metal (Au, Pt, Ni, Co, etc.), alloy, grapheme, in the analysis of urine glucose level have been increasing sharply. In particular, different types of nanozymes-based biosensors, inspired by natural enzymes, have been developed with improved characteristics of being low-cost, stable, and mass-produced. On the other hand, making use of portable devices, such as smartphones and microfluidic paper-based analytical devices, has facilitated on site accurate urine glucose monitoring in real time. All these rapid advancements in nanotechnologies and devices have contributed greatly to the development of cost effective, highly sensitive, user friendly urine glucose biosensors. This review summarizes the most recent improvements in two major types of urine glucose biosensors: the optical- and electrochemical-biosensors. We also discuss the limitations, challenges and perspectives of these biosensors. Finally, we propose future research directions, development trends and potential clinical applications of nanomaterial-based biosensors developed for urine glucose detection.
Keywords	alloys ; biosensors ; blood glucose ; cost effectiveness ; diabetes mellitus ; early diagnosis ; electrochemistry ; energy ; glucose ; mobile telephones ; therapeutics ; urinalysis ; urine
Language	English
Dates of publication	2022-09
Publishing place	Elsevier B.V.
Document type	Article
ISSN	2773-045X
DOI	10.1016/j.asems.2022.100016
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Proteomic and ultrastructural analysis of Clara cell and type II alveolar epithelial cell-type lung cancer cells.

Hou, Wen-Li / Chang, Ming / Liu, Xiao-Feng / Hu, Lin-Sen / Hua, Shu-Cheng

Translational cancer research

2022 Volume 9, Issue 2, Page(s) 565–576

Abstract: Background: Currently, the identification of Clara cell and type II alveolar epithelial cell-type cancer cells requires electron microscopy, which is a time-consuming and expensive process involving a complicated tissue sampling procedure. The aim of ... ...

Abstract	Background: Currently, the identification of Clara cell and type II alveolar epithelial cell-type cancer cells requires electron microscopy, which is a time-consuming and expensive process involving a complicated tissue sampling procedure. The aim of this study was to identify unique biomarkers for Clara cell and type II alveolar epithelial cell-type lung cancer cells, respectively, with proteomic profiling. Methods: Six human lung adenocarcinoma cell lines (A549, NCI-H358, NCI-H1650, HCC827, NCI-H1395, and NCI-H1975) were investigated for their ultrastructural characteristics. The differentially expressed proteins (DEPs) were screened between NCI-H358 cells (Clara cell type) and A549 cells (type II alveolar epithelial cell type) using two-dimensional difference gel electrophoresis (2D-DIGE) and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS/MS), and then they were validated by western blot. The protein expression levels of endoplasmic reticulum oxidoreductin 1-α (ERO1L), Clara cell 10-kD protein (CC10), and surfactant protein C (SP-C) were also determined in the six cell lines assayed. Results: NCI-H358 cells featured Clara cell differentiation; A549, NCI-H1975, and HCC827 cells had characteristics of type II alveolar epithelial cells; and NCI-H1395 and NCI-H1650 cells had no differentiation characteristics of any lung adenocarcinoma cell type. Five DEPs including ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1), cytokeratin 19 (CK19), cytokeratin 8 (CK8), ERO1L, and peroxiredoxin 2 (PRDX2) between NCI-H358 and A549 cells were identified for further validation; however, none of them showed suitability as an effective biomarker. Similarly, CC10 and SP-C were not appropriate biomarkers. Conclusions: Cytological subtypes of NCI-H1975 and HCC827 cells were identified, but no promising biomarker was discovered in the present study.
Language	English
Publishing date	2022-01-20
Publishing country	China
Document type	Journal Article
ZDB-ID	2901601-0
ISSN	2219-6803 ; 2218-676X
ISSN (online)	2219-6803
ISSN	2218-676X
DOI	10.21037/tcr.2019.12.04
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Article ; Online: Cognition of the warning symptoms and risk factors for cancer among Chinese college students

Lin-sen Feng / Qing-li Li / Qing Yang / Yu-lu Zhu / Fu-lin Yin / Qi-yao Wang / Wen-jue Zhong / Xiao-qian Wu / Ruo-yu Yan / Zheng-jiao Dong

Annals of Medicine, Vol 55, Iss

a cross-sectional study based on a summer social practice activity

2023 Volume 2

Abstract: AbstractBackground To investigate the cognition of cancer warning symptoms and cancer risk factors among Chinese college students, analyze the influencing factors, and explain the correlations between cancer cognition and cancer symptom discrimination, ... ...

Abstract	AbstractBackground To investigate the cognition of cancer warning symptoms and cancer risk factors among Chinese college students, analyze the influencing factors, and explain the correlations between cancer cognition and cancer symptom discrimination, cancer fear and psychological distress.Methods Chinese college students were recruited in this cross-sectional study funded by a summer social practice activity in Yunnan Province, China. Cognition rates of cancer warning symptoms and cancer risk factors were evaluated using Cancer Warning symptoms Cognition Questionnaire (CWSCQ) and Cancer Risk Factors Cognition Questionnaire (CRFCQ), respectively. Factors associated with cognition of cancer warning symptoms, and factors associated with cognition of cancer risk factors were evaluated using multiple linear regression analysis. Interactions between cancer cognition, cancer symptom discrimination, psychological distress, and cancer fear were evaluated by structural equation modeling.Results There were 846 effective samples, with an effective rate of 80.9%. The cognition rates of cancer warning symptoms were from 47.9% to 84.4%, which were affected by cancer symptom discrimination, education, attitudes towards cancer screening, living expenses, drinking history, and ways to obtain cancer knowledge (p < 0.05). The cognition rates of cancer risk factors were from 46.3% to 91.3% in participants, which were affected by education, cancer symptom discrimination, psychological distress, attitudes towards cancer screening, life satisfaction, cancer history in relatives and friends, ways to obtain cancer knowledge, smoking history, and nursing history for cancer patients (p < 0.05). Cancer cognition and cancer symptom discrimination showed intermediary effects on psychological distress and cancer fear (p < 0.001).Conclusions The overall cancer cognition situation among Chinese college students is not optimistic, which highlights the necessity of improving the cancer health literacy among Chinese college students. ...
Keywords	Cancer warning symptoms ; cancer risk factors ; cognition ; Chinese college students ; Medicine ; R
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Selective hydrogenation of 1,3-butadiene catalyzed by a single Pd atom anchored on graphene: the importance of dynamics.

Feng, Yingxin / Zhou, Linsen / Wan, Qiang / Lin, Sen / Guo, Hua

Chemical science

2018 Volume 9, Issue 27, Page(s) 5890–5896

Abstract: The active-site structure, reaction mechanism, and product selectivity of the industrially important selective hydrogenation of 1,3-butadiene are investigated using first principles for an emerging single-atom Pd catalyst anchored on graphene. Density ... ...

Abstract	The active-site structure, reaction mechanism, and product selectivity of the industrially important selective hydrogenation of 1,3-butadiene are investigated using first principles for an emerging single-atom Pd catalyst anchored on graphene. Density functional theory calculations suggest that the mono-π-adsorbed reactant undergoes sequential hydrogenation by Pd-activated H
Language	English
Publishing date	2018-06-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2559110-1
ISSN	2041-6539 ; 2041-6520
ISSN (online)	2041-6539
ISSN	2041-6520
DOI	10.1039/c8sc00776d
Database	MEDical Literature Analysis and Retrieval System OnLINE

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