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Article ; Online: Caryocar coriaceum fruits as a potential alternative to combat fungal and bacterial infections: In vitro evaluation of methanolic extracts.

Almeida-Bezerra, José Weverton / Pereira da Cruz, Rafael / Silva Pereira, Raimundo Luiz / Bezerra da Silva, Viviane / de Oliveira Bezerra de Sousa, Daniele / Da Silva Neto, João Xavier / Lopes de Souza, Larissa Alves / Salgueiro Araújo, Nadine Monteiro / Gomes Silva, Rafael Guimarães / Lucetti, Daniel Luna / Melo Coutinho, Henrique Douglas / Bezerra Morais-Braga, Maria Flaviana / Morais de Oliveira, Antônio Fernando

Microbial pathogenesis

2023 Volume 181, Page(s) 106203

Abstract: Caryocar coriaceum, commonly known as 'pequi', is a medicinal species used traditionally for the herbal treatment of infectious and parasitic diseases in the Brazilian Northeast region. In this study, we investigated whether the fruits of C. coriaceum ... ...

Abstract	Caryocar coriaceum, commonly known as 'pequi', is a medicinal species used traditionally for the herbal treatment of infectious and parasitic diseases in the Brazilian Northeast region. In this study, we investigated whether the fruits of C. coriaceum have bioactive chemical constituents against etiological agents of infectious diseases. The methanolic extract of the internal mesocarp of the fruits of C. coriaceum (MECC) was chemically analyzed and evaluated for its antimicrobial and drug-enhancing activity against multidrug-resistant pathogenic bacteria (Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus), and Candida spp. strains. The extract had flavones, flavonols, xanthones, catechins, and flavanones as major classes. A total of 11.26 mg GAE/g of phenolics, and 5.98 mg QE/g of flavonoids were found. No intrinsic antibacterial activity was observed; however, the extract was able to intensify the action of gentamicin and erythromycin against multi-resistant strains. The anti-Candida effect observed in this study was mainly due to the formation of reactive oxygen species. The extract was capable of causing damage to the plasmatic membrane of Candida tropicalis through pores formation. Our findings partially support the ethnopharmacological uses of the fruit pulp of C. coriaceum against infectious and parasitic diseases.
MeSH term(s)	Plant Extracts/chemistry ; Fruit/chemistry ; Methanol ; Anti-Bacterial Agents/pharmacology ; Candida ; Bacterial Infections ; Microbial Sensitivity Tests
Chemical Substances	Plant Extracts ; Methanol (Y4S76JWI15) ; Anti-Bacterial Agents
Language	English
Publishing date	2023-06-15
Publishing country	England
Document type	Journal Article
ZDB-ID	632772-2
ISSN	1096-1208 ; 0882-4010
ISSN (online)	1096-1208
ISSN	0882-4010
DOI	10.1016/j.micpath.2023.106203
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Article ; Online: Psychological effects caused by the COVID-19 pandemic in health professionals: A systematic review with meta-analysis.

da Silva Neto, Raimundo Monteiro / Benjamim, Cicero Jonas Rodrigues / de Medeiros Carvalho, Poliana Moreira / Neto, Modesto Leite Rolim

Progress in neuro-psychopharmacology & biological psychiatry

2020 Volume 104, Page(s) 110062

Abstract: Background: Psychological suffering by health professionals may be associated with the uncertainty of a safe workplace. Front-line professionals exposed and involved in the diagnosis and treatment of COVID-19 patients are more susceptible.: Method: ... ...

Abstract	Background: Psychological suffering by health professionals may be associated with the uncertainty of a safe workplace. Front-line professionals exposed and involved in the diagnosis and treatment of COVID-19 patients are more susceptible. Method: This review was conducted based on papers that were published at MEDLINE, BMJ, PsycINFO, and LILACS, the according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA). Results: Health professionals had a higher level of anxiety (13.0 vs. 8.5%, p < 0.01, OR = 1.6152; 95%CI 1.3283 to 1.9641; p < 0.0001) and depression 12.2 vs. 9.5%; p = 0.04; OR = 1.3246; 95%CI 1.0930 to 1.6053; p = 0.0042), besides somatizations and insomnia compared to professionals from other areas. Conclusion: Health professionals, regardless of their age, showed significant levels of mental disorders. We observed a prevalence of anxiety and depression. Insomnia was a risk factor for both.
MeSH term(s)	COVID-19 ; Coronavirus Infections ; Health Personnel/psychology ; Humans ; Mental Disorders/epidemiology ; Mental Disorders/etiology ; Mental Disorders/psychology ; Occupational Diseases/epidemiology ; Occupational Diseases/etiology ; Occupational Diseases/psychology ; Pandemics ; Pneumonia, Viral ; Prevalence ; Stress, Psychological
Keywords	covid19
Language	English
Publishing date	2020-08-06
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	781181-0
ISSN	1878-4216 ; 0278-5846
ISSN (online)	1878-4216
ISSN	0278-5846
DOI	10.1016/j.pnpbp.2020.110062
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Article ; Online: From cow manure to bioactive carbon dots: a light-up probe for bioimaging investigations, glucose detection and potential immunotherapy agent for melanoma skin cancer.

Horst, Frederico Hillesheim / Rodrigues, Carime Vitória da Silva / Carvalho, Pedro Henrique Pimenta Rocha / Leite, Amanda Monteiro / Azevedo, Ricardo Bentes / Neto, Brenno A D / Corrêa, José Raimundo / Garcia, Mônica Pereira / Alotaibi, Saud / Henini, Mohamed / Chaves, Sacha Braun / Rodrigues, Marcelo Oliveira

RSC advances

2021 Volume 11, Issue 11, Page(s) 6346–6352

Abstract: Bioactive carbon dots (C-dots) ... ...

Abstract	Bioactive carbon dots (C-dots) with
Language	English
Publishing date	2021-02-03
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d0ra10859f
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Article ; Online: Caryocar coriaceum fruits as a potential alternative to combat fungal and bacterial infections: In vitro evaluation of methanolic extracts

Microbial Pathogenesis. 2023 Aug., v. 181 p.106203-

2023

Abstract: Caryocar coriaceum, commonly known as ‘pequi’, is a medicinal species used traditionally for the herbal treatment of infectious and parasitic diseases in the Brazilian Northeast region. In this study, we investigated whether the fruits of C. coriaceum ... ...

Abstract	Caryocar coriaceum, commonly known as ‘pequi’, is a medicinal species used traditionally for the herbal treatment of infectious and parasitic diseases in the Brazilian Northeast region. In this study, we investigated whether the fruits of C. coriaceum have bioactive chemical constituents against etiological agents of infectious diseases. The methanolic extract of the internal mesocarp of the fruits of C. coriaceum (MECC) was chemically analyzed and evaluated for its antimicrobial and drug-enhancing activity against multidrug-resistant pathogenic bacteria (Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus), and Candida spp. strains. The extract had flavones, flavonols, xanthones, catechins, and flavanones as major classes. A total of 11.26 mg GAE/g of phenolics, and 5.98 mg QE/g of flavonoids were found. No intrinsic antibacterial activity was observed; however, the extract was able to intensify the action of gentamicin and erythromycin against multi-resistant strains. The anti-Candida effect observed in this study was mainly due to the formation of reactive oxygen species. The extract was capable of causing damage to the plasmatic membrane of Candida tropicalis through pores formation. Our findings partially support the ethnopharmacological uses of the fruit pulp of C. coriaceum against infectious and parasitic diseases.
Keywords	Candida tropicalis ; Caryocar coriaceum ; Escherichia coli ; Pseudomonas aeruginosa ; Staphylococcus aureus ; antibacterial properties ; erythromycin ; etiology ; flavanols ; flavanones ; flavonols ; fruit pulp ; fungi ; gentamicin ; mesocarp ; multiple drug resistance ; pathogenesis ; reactive oxygen species ; traditional medicine ; xanthones ; Candidiasis ; Chapada do Araripe ; Infectious and parasitic diseases
Language	English
Dates of publication	2023-08
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	632772-2
ISSN	1096-1208 ; 0882-4010
ISSN (online)	1096-1208
ISSN	0882-4010
DOI	10.1016/j.micpath.2023.106203
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The presence of antibiotics and multidrug-resistant Staphylococcus aureus reservoir in a low-order stream spring in central Brazil.

Dos Santos, Igor Romeiro / da Silva, Isabela Náthaly Machado / de Oliveira Neto, Jerônimo Raimundo / de Oliveira, Naiara Raica Lopes / de Sousa, Adriano Roberto Vieira / de Melo, Anielly Monteiro / de Paula, Joelma Abadia Marciano / do Amaral, Cátia Lira / Silveira-Lacerda, Elisângela de Paula / da Cunha, Luiz Carlos / Bailão, Elisa Flávia Luiz Cardoso

Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology

2023 Volume 54, Issue 2, Page(s) 997–1007

Abstract: The disposal of industrial effluents strongly influences low-order streams, which makes them fragile ecosystems that can be impacted by contamination. In central Brazil, the Extrema River spring targets the dumping of pharmaceutical products from the ... ...

Abstract	The disposal of industrial effluents strongly influences low-order streams, which makes them fragile ecosystems that can be impacted by contamination. In central Brazil, the Extrema River spring targets the dumping of pharmaceutical products from the surrounding industries. So, this work aimed to investigate the presence of antibiotics in Extrema River spring samples and the isolation of Staphylococcus aureus, a potential multidrug-resistant bacteria, verifying the antimicrobial resistance profile of these isolates. Three campaigns were carried out in different locals (P1-P3) between October and December 2021, in the dry and rainy seasons. The high-performance liquid chromatography-tandem mass spectrometry (LCMS) approach indicated the presence of sulfamethoxazole (≥ 1 ng/L), metronidazole (< 0.5 ng/L), and chloramphenicol (< 5 ng/L) in the water samples in November (rainy season). S. aureus was isolated in P1 (n = 128), P2 (n = 168), and P3 (n = 36), with greater resistance to trimethoprim-sulfamethoxazole (90%), clindamycin (70%), and gentamicin (60%). The presence of antibiotics in the Extrema River spring may cause S. aureus antibiotic resistance development. The presence of antibiotics and the high percentage of isolated multidrug-resistant S. aureus in the Extrema River spring cause concern and indicate the clandestine dumping of effluents from nearby pharmaceutical industries. Since preserving the springs of low-order streams is important for the environment and public health, we encourage monitoring the wastewater from Extrema River's nearby pharmaceutical industries and preserving the spring of this river.
MeSH term(s)	Humans ; Anti-Bacterial Agents/pharmacology ; Methicillin-Resistant Staphylococcus aureus ; Staphylococcus aureus ; Brazil ; Ecosystem ; Staphylococcal Infections ; Drug Resistance, Multiple, Bacterial ; Microbial Sensitivity Tests
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2023-04-22
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2017175-4
ISSN	1678-4405 ; 1517-8382
ISSN (online)	1678-4405
ISSN	1517-8382
DOI	10.1007/s42770-023-00973-9
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Article ; Online: A rare case of primary breast angiosarcoma in a male: a case report.

da Silva, Benedito Borges / Eulálio Filho, Walberto Monteiro Neiva / Costa, Pedro Vitor Lopes / Silva, Rozirene Araújo / Junior, Ariton Mendes Conde / Chagas, Diego Cipriano / de Almeida Melo, Mariella / Neto, Fidelis Manes / Tavares, Cleciton Braga / de Sousa Júnior, Edilson Carvalho / Coelho, Eid Gonçalves / Campelo, Viriato / Gebrim, Luis Henrique / da Silva Junior, Raimundo Gerônimo

BMC cancer

2018 Volume 18, Issue 1, Page(s) 978

Abstract: Background: Sarcomas account for less than 1% of primary breast cancers, and breast angiosarcomas are responsible for only 0.05% of all breast malignancies. The male breast has the same potential for malignant transformation as the female breast. ... ...

Abstract	Background: Sarcomas account for less than 1% of primary breast cancers, and breast angiosarcomas are responsible for only 0.05% of all breast malignancies. The male breast has the same potential for malignant transformation as the female breast. However, due to anatomical differences in the breast and the low incidence of angiosarcoma, it is difficult to determine how male breasts can be affected by this type of tumor. Case presentation: A 36-year-old male patient was admitted to the hospital with a palpable lump in his right breast. Lymphadenopathy was negative. Ultrasonography showed a hypoechoic mass with partially defined contours, measuring 4.0 × 3.0 cm, with muscle infiltration. Histological examination revealed a malignant tumor. Radical mastectomy was then performed with clear surgical margins. The patient began chemotherapy with paclitaxel. Following the second cycle of chemotherapy, he presented with headache and seizures due to a frontal lobe metastasis. Twenty days after the onset of neurological symptoms, the patient died. Conclusions: Primary angiosarcomas of the male breast are extremely rare. This is the sixth case published in the literature. It is in agreement with other studies in the literature concerning clinical presentation and poor prognosis. Treatment consists in surgical removal of the tumor with clear margins and without axillary lymphadenectomy.
MeSH term(s)	Adult ; Brain Neoplasms/secondary ; Breast Neoplasms, Male/pathology ; Breast Neoplasms, Male/therapy ; Chemotherapy, Adjuvant ; Hemangiosarcoma/pathology ; Hemangiosarcoma/therapy ; Humans ; Male ; Paclitaxel/therapeutic use
Chemical Substances	Paclitaxel (P88XT4IS4D)
Language	English
Publishing date	2018-10-16
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1471-2407
ISSN (online)	1471-2407
DOI	10.1186/s12885-018-4895-3
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Article: Additive Manufacturing for Surgical Planning of Mandibular Fracture.

Brito, Nadja Maria da Silva Oliveira / Soares, Renata de Souza Coelho / Monteiro, Erik Lafitt Tavares / Martins, Sergio Charifker Ribeiro / Cavalcante, Josuel Raimundo / Grempel, Rafael Grotta / Neto, José Augusto de Oliveira

Acta stomatologica Croatica

2016 Volume 50, Issue 4, Page(s) 348–353

Abstract: Currently, imaging techniques such as Computed Tomography with three-dimensional reconstruction (3D) and Magnetic Resonances are being routinely used in pre-surgical planning in all fields of medicine. Nowadays, virtual three-dimensional images, commonly ...

Abstract	Currently, imaging techniques such as Computed Tomography with three-dimensional reconstruction (3D) and Magnetic Resonances are being routinely used in pre-surgical planning in all fields of medicine. Nowadays, virtual three-dimensional images, commonly displayed on two-dimensional surfaces, such as the computer screen, can be used to produce rapidly prototyped models, with excellent dimensional accuracy and fine reproduction of anatomical structures, providing professionals with the ability to use the biomodel in planning and simulating medical and dental procedures (oral and maxillofacial surgery, making individualized facial implants and prostheses, measurements and previous adaptations of prefabricated fixation plates), thus contributing to considerable reductions in surgical time and consequently the duration of anesthesia, minimizing infection risks and reducing hospital costs. In this report, we describe a case of surgical planning and treatment of bilateral atrophic mandibular fracture, in which, for surgical planning, authors used Rapid Prototyping as an adjunct tool, considering the advantages already outlined.
Language	English
Publishing date	2016-12
Publishing country	Croatia
Document type	Journal Article
ZDB-ID	603047-6
ISSN	0001-7019
ISSN	0001-7019
DOI	10.15644/asc50/4/8
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Article ; Online: CRESCIMENTO E DESENVOLVIMENTO DE AVEIA PRETA EM RESPOSTA À INOCULAÇÃO COM Azospirillum brasilense E ADUBAÇÃO NITROGENADA

Douglas Vilas Boas Correa Filho / Érika Cristina Souza da Silva Correia / Francisco José Domingues Neto / David Vitor dos Santos / Tiago Alexandre da Silva / Raimundo Nonato Farias Monteiro / Lais Fernanda Fontana

Colloquium Agrariae, Vol 13, Iss

2017 Volume 2

Abstract: A bactéria Azospirillum brasilense vem ganhando destaque quando inoculadas em sementes, resultando em incrementos no sistema radicular, produção de massa seca e produtividade das culturas. Objetivou-se com esse trabalho avaliar o efeito da inoculação de ... ...

Abstract	A bactéria Azospirillum brasilense vem ganhando destaque quando inoculadas em sementes, resultando em incrementos no sistema radicular, produção de massa seca e produtividade das culturas. Objetivou-se com esse trabalho avaliar o efeito da inoculação de A. brasilense e a aplicação de diferentes doses de nitrogênio sob a produção da aveia preta. O experimento foi realizado nas dependências do campo experimental pertencente à Faculdade de Tecnologia Paulista, Lupércio-SP, cujas coordenadas geográficas de referência são: latitude: 22º24'59'' S, longitude 49°48'56'' W e altitude 669 m. O delineamento experimental foi em blocos casualizados com cinco tratamentos (T1= testemunha, aveia preta não inoculada com A. brasilense e sem aplicação de N; T2= A. brasilense na dose de 0,25 mL/ 14 g de semente, no momento da semeadura; T3= N 50% na dose de 19 g/ 2 m², 30 dias após a germinação; T4= N 100% na dose de 38 g/ 2 m² e T5= N 150% na dose de 57 g/ 2 m², 30 dias após a germinação) e quatro repetições. A semeadura foi realizada manualmente e em linhas, sendo semeadas 292 sementes por metro linear. Aos 90 dias após a semeadura avaliou-se a altura das plantas e em seguida, as plantas foram colhidas e avaliada a massa fresca da parte aérea e das sementes e, após secas em estufa, avaliou-se a massa seca da parte aérea e sementes. Houve efeito significativo da aplicação de A. brasilense e nitrogênio em plantas de aveia preta para todos os parâmetros avaliados, exceto altura, massa seca da parte aérea e massa fresca da semente.
Keywords	Avena strigosa ; bactéria diazotrófica ; fixação biológica de nitrogênio ; adubação nitrogenada ; Agriculture ; S ; Agriculture (General) ; S1-972
Language	Portuguese
Publishing date	2017-12-01T00:00:00Z
Publisher	University of Western Sao Paulo, UNOESTE
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: CRESCIMENTO E DESENVOLVIMENTO DE AVEIA PRETA EM RESPOSTA À INOCULAÇÃO COM Azospirillum brasilense E ADUBAÇÃO NITROGENADA

Colloquium Agrariae, Vol 13, Iss

2017 Volume 2

Abstract	A bactéria Azospirillum brasilense vem ganhando destaque quando inoculadas em sementes, resultando em incrementos no sistema radicular, produção de massa seca e produtividade das culturas. Objetivou-se com esse trabalho avaliar o efeito da inoculação de A. brasilense e a aplicação de diferentes doses de nitrogênio sob a produção da aveia preta. O experimento foi realizado nas dependências do campo experimental pertencente à Faculdade de Tecnologia Paulista, Lupércio-SP, cujas coordenadas geográficas de referência são: latitude: 22º24'59'' S, longitude 49°48'56'' W e altitude 669 m. O delineamento experimental foi em blocos casualizados com cinco tratamentos (T1= testemunha, aveia preta não inoculada com A. brasilense e sem aplicação de N; T2= A. brasilense na dose de 0,25 mL/ 14 g de semente, no momento da semeadura; T3= N 50% na dose de 19 g/ 2 m², 30 dias após a germinação; T4= N 100% na dose de 38 g/ 2 m² e T5= N 150% na dose de 57 g/ 2 m², 30 dias após a germinação) e quatro repetições. A semeadura foi realizada manualmente e em linhas, sendo semeadas 292 sementes por metro linear. Aos 90 dias após a semeadura avaliou-se a altura das plantas e em seguida, as plantas foram colhidas e avaliada a massa fresca da parte aérea e das sementes e, após secas em estufa, avaliou-se a massa seca da parte aérea e sementes. Houve efeito significativo da aplicação de A. brasilense e nitrogênio em plantas de aveia preta para todos os parâmetros avaliados, exceto altura, massa seca da parte aérea e massa fresca da semente.
Keywords	Avena strigosa ; bactéria diazotrófica ; fixação biológica de nitrogênio ; adubação nitrogenada ; Agriculture ; S ; Agriculture (General) ; S1-972
Language	Portuguese
Publishing date	2017-12-01T00:00:00Z
Publisher	University of Western Sao Paulo, UNOESTE
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Covid-19 e o impacto nas populações vulneráveis

Francisco Ricardo Nascimento Freitas / Alysson Santos Alves / Antônio Tiago da Silva Souza / Carlos Eduardo Bezerra Pontes / Débora Joyce Nascimento Freitas / Edmar José Fortes Júnior / Francisco Lukas Rodrigues Martins / Hyan Crysthyan Apolinário Silveira / Marisa Carla Silveira Alves / Natan Araújo de Carvalho / Paulo César Monteiro Florêncio / Raimundo Graças Almeida Lima Neto / Daniela França de Barros / José Ivo dos Santos Pedrosa

Research, Society and Development, Vol 9, Iss

uma revisão integrativa

2020 Volume 10

Abstract: O novo coronavírus surgiu na China no fim de 2019 e já em março de 2020 era considerado uma pandemia infectando milhões de pessoas com seu alto poder de transmissibilidade. Por conta disso, a saúde de muitas pessoas que são mais frágeis por condições pré- ...

Abstract	O novo coronavírus surgiu na China no fim de 2019 e já em março de 2020 era considerado uma pandemia infectando milhões de pessoas com seu alto poder de transmissibilidade. Por conta disso, a saúde de muitas pessoas que são mais frágeis por condições pré-existentes pode também estarem mais suscetíveis a maiores consequências. O objetivo deste estudo é reunir outras pesquisas que descrevem quais pessoas estão mais sujeitas a COVID-19 e suas complicações nas vidas das mesmas. O presente estudo é embasado nas normas de uma revisão bibliográfica e foi realizado através de pesquisas nas bases de dados eletrônicas: Web of Science e ScienceDirect, utilizando as palavras chaves na língua inglesa e portuguesa. Dos 1994 resultados encontrados apenas 17 se adequaram aos critérios de inclusão e exclusão. Os resultados encontrados conceberam a resposta para o objetivo, descrevendo a situação de vulnerabilidade individual através da classificação de grupo de riscos contendo pessoas de faixa etária elevada, complicações cardiovasculares gerais, diabetes, hipertensão, disfunções renais, problemas hepáticos, pacientes com algum tipo de câncer, pós-operatórios, obesidade e pessoas mais frágeis momentaneamente que merecem um pouco mais de atenção como grávidas, recém-nascidos e crianças. Destarte, conclui-se que as pessoas que se enquadram em alguma ou mais de uma dessas categorias merecem um cuidado e apoio redobrado tanto para tratar de suas fragilidades inerentes quanto para superar a pandemia causada pelo SARS-Cov-2.
Keywords	Saúde ; Vulneráveis ; Coronavírus ; Special aspects of education ; LC8-6691 ; Science (General) ; Q1-390 ; Social Sciences ; H
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ciências
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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