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Article ; Online: Prevalence and Molecular Characterization of Vancomycin Variable

Yoo, In Young / Kwon, Joo An / Lee, Miran / Jung, Seung-Hyun / Kim, Jung Ok / Ha, Sung Il / Park, Yeon-Joon

2024

Abstract: Vancomycin ... ...

Abstract	Vancomycin variable
Language	English
Publishing date	2024-03-13
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2677441-0
ISSN	2234-3814 ; 2234-3814
ISSN (online)	2234-3814
ISSN	2234-3814
DOI	10.3343/alm.2023.0430
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Sulfur Metabolism of the Gut Microbiome and Colorectal Cancer: The Threat to the Younger Generation.

Moon, Ji-Yeon / Kye, Bong-Hyeon / Ko, Seung-Hyun / Yoo, Ri Na

Nutrients

2023 Volume 15, Issue 8

Abstract: Colorectal cancer diagnosed in individuals under 50 years old is called early-onset colorectal cancer (EOCRC), and its incidence has been rising worldwide. Simultaneously occurring with increasing obesity, this worrisome trend is partly explained by the ... ...

Abstract	Colorectal cancer diagnosed in individuals under 50 years old is called early-onset colorectal cancer (EOCRC), and its incidence has been rising worldwide. Simultaneously occurring with increasing obesity, this worrisome trend is partly explained by the strong influence of dietary elements, particularly fatty, meaty, and sugary food. An animal-based diet, the so-called Western diet, causes a shift in dominant microbiota and their metabolic activity, which may disrupt the homeostasis of hydrogen sulfide concentration. Bacterial sulfur metabolism is recognized as a critical mechanism of EOCRC pathogenesis. This review evaluates the pathophysiology of how a diet-associated shift in gut microbiota, so-called the microbial sulfur diet, provokes injuries and inflammation to the colonic mucosa and contributes to the development of CRC.
MeSH term(s)	Colorectal Neoplasms/metabolism ; Diet, Western/adverse effects ; Gastrointestinal Microbiome/physiology ; Sulfur/metabolism ; Humans
Chemical Substances	Sulfur (70FD1KFU70)
Language	English
Publishing date	2023-04-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15081966
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Article ; Online: Effect of dipeptidyl peptidase-4 inhibitor on the progression of coronary artery disease evaluated by computed tomography in patients receiving insulin therapy for type 2 diabetes mellitus.

Choi, Young / Ko, Seung-Hyun / Chang, Kiyuk / Yoo, Ki Dong / Ihm, Sang-Hyun

Journal of diabetes

2023 Volume 15, Issue 11, Page(s) 944–954

Abstract: Background: We evaluated the effect of a dipeptidyl peptidase-4 inhibitor (DPP-4i) on the progression of obstructive coronary artery disease (OCAD) in patients with type 2 diabetes mellitus (T2DM) receiving insulin therapy.: Methods: Using a ... ...

Abstract	Background: We evaluated the effect of a dipeptidyl peptidase-4 inhibitor (DPP-4i) on the progression of obstructive coronary artery disease (OCAD) in patients with type 2 diabetes mellitus (T2DM) receiving insulin therapy. Methods: Using a multicenter clinical data warehouse, we analyzed the patients receiving insulin therapy for T2DM who underwent coronary computed tomography angiography (CCTA) for ≥2 times. The patients were divided into two groups according to the presence of DPP-4i prescription between the two CCTA examinations. The prevalence of OCAD (>50% stenosis on CCTA), new revascularization rates, and changes in the coronary calcium score (CCS) were analyzed. Results: A total of 623 patients were included, and a DPP-4i was prescribed to 380 (60.9%) patients. The median time difference between the two CCTAs was 39.0 (17.0-61.4) months. Newly developed OCAD at the follow-up CCTA was detected in 62 (16.3%) patients in the DPP-4i group and 76 (31.3%) patients in the no DPP-4i group (p < 0.001). The risk of new OCAD or new revascularization was lower in the DPP-4i group (19.7% vs. 38.7%; p < 0.001). After propensity score matching, the prevalence of new OCAD (15.9% vs. 29.5%; p = 0.001) and the composite rate of new OCAD or new revascularization (18.7% vs. 37.3%; p < 0.001) were lower in the DPP-4i group. The change in CCS per year did not differ significantly between the two groups (9.1 [0.1-56.8] vs. 13.5 [0.0-78.6]; p = 0.715). Conclusions: Add-on DPP-4i therapy would be beneficial in preventing coronary artery disease progression in patients with T2DM receiving insulin therapy.
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2/epidemiology ; Dipeptidyl-Peptidase IV Inhibitors/therapeutic use ; Insulin/therapeutic use ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/drug therapy ; Hypoglycemic Agents/therapeutic use ; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases/therapeutic use ; Tomography
Chemical Substances	Dipeptidyl-Peptidase IV Inhibitors ; Insulin ; Hypoglycemic Agents ; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases (EC 3.4.14.-)
Language	English
Publishing date	2023-08-01
Publishing country	Australia
Document type	Multicenter Study ; Journal Article
ZDB-ID	2503337-2
ISSN	1753-0407 ; 1753-0393
ISSN (online)	1753-0407
ISSN	1753-0393
DOI	10.1111/1753-0407.13449
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Article: Changes in Flight Altitude of Black-Tailed Gulls According to Temporal and Environmental Differences.

Park, Jong-Hyun / Jeong, In-Yong / Lee, Seung-Hae / Yoo, Jeong-Chil / Lee, Who-Seung

Animals : an open access journal from MDPI

2024 Volume 14, Issue 2

Abstract: In this study, GPS trackers were attached to black-tailed gulls ( ...

Abstract	In this study, GPS trackers were attached to black-tailed gulls (
Language	English
Publishing date	2024-01-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani14020202
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Article ; Online: A Network Meta-Analysis of Randomized Controlled Trials Assessing Intraoperative Anesthetic Therapies for Analgesic Efficacy and Morphine Consumption Following Total Knee Arthroplasty.

Yoo, Jae-Doo / Huh, Min-Hwan / Lee, Seung-Hyun / D'Lima, Darryl D / Shin, Young-Soo

The Journal of arthroplasty

2023 Volume 39, Issue 5, Page(s) 1361–1373

Abstract: Background: The purpose of this study was to compare intraoperative anesthetic therapies for total knee arthroplasty (TKA) regarding postoperative analgesic efficacy and morphine consumption by conducting a systematic literature search.: Methods: ... ...

Abstract	Background: The purpose of this study was to compare intraoperative anesthetic therapies for total knee arthroplasty (TKA) regarding postoperative analgesic efficacy and morphine consumption by conducting a systematic literature search. Methods: Randomized controlled trials of TKA using various anesthetic therapies were identified from various databases from conception through December 31, 2021. A network meta-analysis of relevant literature was performed to investigate which treatment showed better outcomes. In total, 40 trials were included in this study. Results: Surface under the cumulative ranking curve showed local infiltration anesthesia (LIA) with saphenous nerve block (SNB) to produce the best pain relief on postoperative days (PODs) 1 and 2 and the best reduction of morphine consumption on PODs 1 and 3. However, femoral nerve block showed the largest effect on pain relief on POD 3, and liposomal bupivacaine showed the largest effect on reduction of morphine consumption on POD 2. Conclusions: According to this network meta-analysis, surface under the cumulative ranking curve percentage showed that LIA with SNB provided the best analgesic effect after TKA. Furthermore, patients receiving LIA with SNB had the lowest consumption of morphine. Although femoral nerve block resulted in better pain relief on POD 3, LIA with SNB could be selected first when trying to reduce morphine consumption or increase early ambulation.
MeSH term(s)	Humans ; Arthroplasty, Replacement, Knee/adverse effects ; Morphine/therapeutic use ; Nerve Block/methods ; Network Meta-Analysis ; Pain, Postoperative/drug therapy ; Pain, Postoperative/etiology ; Femoral Nerve ; Randomized Controlled Trials as Topic ; Anesthetics ; Analgesics ; Analgesics, Opioid/therapeutic use ; Anesthetics, Local/therapeutic use
Chemical Substances	Morphine (76I7G6D29C) ; Anesthetics ; Analgesics ; Analgesics, Opioid ; Anesthetics, Local
Language	English
Publishing date	2023-11-10
Publishing country	United States
Document type	Meta-Analysis ; Journal Article
ZDB-ID	632770-9
ISSN	1532-8406 ; 0883-5403
ISSN (online)	1532-8406
ISSN	0883-5403
DOI	10.1016/j.arth.2023.11.007
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Zs.A 2134: Show issues

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Article ; Online: Vitreous Fatty Amides and Acyl Carnitines Are Altered in Intermediate Age-Related Macular Degeneration.

Yoon, Chang-Ki / Kim, Ye An / Park, Un Chul / Kwon, Seung-Hyun / Lee, Young / Yoo, Hyun Ju / Seo, Je Hyun / Yu, Hyeong Gon

Investigative ophthalmology & visual science

2023 Volume 64, Issue 3, Page(s) 28

Abstract: Purpose: Age-related macular degeneration (AMD) is the leading cause of visual impairment worldwide. In this study, we aimed to investigate the vitreous humor metabolite profiles of patients with intermediate AMD using untargeted metabolomics.: ... ...

Abstract	Purpose: Age-related macular degeneration (AMD) is the leading cause of visual impairment worldwide. In this study, we aimed to investigate the vitreous humor metabolite profiles of patients with intermediate AMD using untargeted metabolomics. Methods: We performed metabolomics using high-resolution liquid chromatography mass spectrometry on the vitreous humor of 31 patients with intermediate AMD and 30 controls who underwent vitrectomy for epiretinal membrane with or without cataract surgery. Univariate analyses after false discovery rate correction were performed to discriminate the metabolites and identify the significant metabolites of intermediate AMD. For biologic interpretation, enrichment and pathway analysis were conducted using MetaboAnalyst 5.0. Results: Of the 858 metabolites analyzed in the vitreous humor, 258 metabolites that distinguished patients with AMD from controls were identified (P values < 0.05). Ascorbic acid and uric acid levels increased in the AMD group (all P values < 0.05). The acyl carnitines, such as acetyl L-carnitine (1.37-fold), and fatty amides, such as anandamide (0.9-fold) and docosanamide (0.67-fold), were higher in patients with intermediate AMD. In contrast, nicotinamide (-0.55-fold), and succinic acid (-1.69-fold) were lower in patients with intermediate AMD. The metabolic pathway related oxidation of branched chain fatty acids and carnitine synthesis showed enrichment. Conclusions: Multiple metabolites related to fatty amides and acyl carnitine were found to be increased in the vitreous humor of patients with intermediate AMD, whereas succinic acid and nicotinamide were reduced, suggesting that altered metabolites related to fatty amides and acyl carnitines and energy metabolism may be implicated in the etiology of AMD.
MeSH term(s)	Humans ; Amides ; Carnitine ; Macular Degeneration ; Niacinamide ; Succinates ; Vitreous Body/metabolism
Chemical Substances	acylcarnitine ; Amides ; Carnitine (S7UI8SM58A) ; Niacinamide (25X51I8RD4) ; Succinates
Language	English
Publishing date	2023-03-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	391794-0
ISSN	1552-5783 ; 0146-0404
ISSN (online)	1552-5783
ISSN	0146-0404
DOI	10.1167/iovs.64.3.28
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Article ; Online: The Effect of Robot-Assisted Training on Arm Function, Walking, Balance, and Activities of Daily Living After Stroke: A Systematic Review and Meta-Analysis.

Yoo, Seung Don / Lee, Hyun Haeng

Brain & NeuroRehabilitation

2023 Volume 16, Issue 3, Page(s) e24

Abstract: This meta-analysis aimed to compare the effects of robot-assisted training (RAT) with those of conventional therapy (CT), considering the potential sources of heterogeneity in the previous studies. We searched three international electronic databases ( ... ...

Abstract	This meta-analysis aimed to compare the effects of robot-assisted training (RAT) with those of conventional therapy (CT), considering the potential sources of heterogeneity in the previous studies. We searched three international electronic databases (MEDLINE, Embase, and the Cochrane Library) to identify relevant studies. Risk of bias assessment was performed using the Cochrane's Risk of Bias 1.0 tool. The certainty of the evidence was evaluated using the Grading of Recommendations, Assessment, Development, and Evaluations method. The meta-analyses for each outcome of the respective domains were performed using 24 randomized controlled trials (RCTs) on robot-assisted arm training (RAAT) for arm function, 7 RCTs on RAAT for activities of daily living (ADL), 12 RCTs on robot-assisted gait training (RAGT) for balance, 6 RCTs on RAGT for walking, and 7 RCTs on RAGT for ADL. The random-effects model for the meta-analysis revealed that RAAT has significant superiority over CT in improving arm function, and ADL. We also showed that RAGT has significant superiority over CT in improving balance. Our study provides high-level evidence for the superiority of RAT over CT in terms of functional recovery after stroke. Therefore, physicians should consider RAT as a therapeutic option for facilitating functional recovery after stroke.
Language	English
Publishing date	2023-09-20
Publishing country	Korea (South)
Document type	Journal Article
ISSN	2383-9910
ISSN (online)	2383-9910
DOI	10.12786/bn.2023.16.e24
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Article ; Online: GenoMycAnalyzer: a web-based tool for species and drug resistance prediction for Mycobacterium genomes.

Kim, Doyoung / Shin, Jeong-Ih / Yoo, In Young / Jo, Sungjin / Chu, Jiyon / Cho, Woo Young / Shin, Seung-Hun / Chung, Yeun-Jun / Park, Yeon-Joon / Jung, Seung-Hyun

BMC genomics

2024 Volume 25, Issue 1, Page(s) 387

Abstract: Background: Drug-resistant tuberculosis (TB) is a major threat to global public health. Whole-genome sequencing (WGS) is a useful tool for species identification and drug resistance prediction, and many clinical laboratories are transitioning to WGS as ... ...

Abstract	Background: Drug-resistant tuberculosis (TB) is a major threat to global public health. Whole-genome sequencing (WGS) is a useful tool for species identification and drug resistance prediction, and many clinical laboratories are transitioning to WGS as a routine diagnostic tool. However, user-friendly and high-confidence automated bioinformatics tools are needed to rapidly identify M. tuberculosis complex (MTBC) and non-tuberculous mycobacteria (NTM), detect drug resistance, and further guide treatment options. Results: We developed GenoMycAnalyzer, a web-based software that integrates functions for identifying MTBC and NTM species, lineage and spoligotype prediction, variant calling, annotation, drug-resistance determination, and data visualization. The accuracy of GenoMycAnalyzer for genotypic drug susceptibility testing (gDST) was evaluated using 5,473 MTBC isolates that underwent phenotypic DST (pDST). The GenoMycAnalyzer database was built to predict the gDST for 15 antituberculosis drugs using the World Health Organization mutational catalogue. Compared to pDST, the sensitivity of drug susceptibilities by the GenoMycAnalyzer for first-line drugs ranged from 95.9% for rifampicin (95% CI 94.8-96.7%) to 79.6% for pyrazinamide (95% CI 76.9-82.2%), whereas those for second-line drugs ranged from 98.2% for levofloxacin (95% CI 90.1-100.0%) to 74.9% for capreomycin (95% CI 69.3-80.0%). Notably, the integration of large deletions of the four resistance-conferring genes increased gDST sensitivity. The specificity of drug susceptibilities by the GenoMycAnalyzer ranged from 98.7% for amikacin (95% CI 97.8-99.3%) to 79.5% for ethionamide (95% CI 76.4-82.3%). The incorporated Kraken2 software identified 1,284 mycobacterial species with an accuracy of 98.8%. GenoMycAnalyzer also perfectly predicted lineages for 1,935 MTBC and spoligotypes for 54 MTBC. Conclusions: GenoMycAnalyzer offers both web-based and graphical user interfaces, which can help biologists with limited access to high-performance computing systems or limited bioinformatics skills. By streamlining the interpretation of WGS data, the GenoMycAnalyzer has the potential to significantly impact TB management and contribute to global efforts to combat this infectious disease. GenoMycAnalyzer is available at http://www.mycochase.org .
MeSH term(s)	Humans ; Antitubercular Agents/pharmacology ; Antitubercular Agents/therapeutic use ; Mycobacterium tuberculosis/genetics ; Microbial Sensitivity Tests ; Tuberculosis, Multidrug-Resistant/drug therapy ; Nontuberculous Mycobacteria ; Drug Resistance ; Internet
Chemical Substances	Antitubercular Agents
Language	English
Publishing date	2024-04-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2041499-7
ISSN	1471-2164 ; 1471-2164
ISSN (online)	1471-2164
ISSN	1471-2164
DOI	10.1186/s12864-024-10320-3
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Article ; Online: Fatty acid amides as potential circulating biomarkers for sarcopenia.

Kim, Ye An / Lee, Seung Hun / Koh, Jung-Min / Kwon, Seung-Hyun / Lee, Young / Cho, Han Jin / Kim, Hanjun / Kim, Su Jung / Lee, Ji Hyun / Yoo, Hyun Ju / Seo, Je Hyun

Journal of cachexia, sarcopenia and muscle

2023 Volume 14, Issue 3, Page(s) 1558–1568

Abstract: Background: Sarcopenia is characterized by a progressive decrease in skeletal muscle mass and function with age. Given that sarcopenia is associated with various metabolic disorders, effective metabolic biomarkers for its early detection are required. ... ...

Abstract	Background: Sarcopenia is characterized by a progressive decrease in skeletal muscle mass and function with age. Given that sarcopenia is associated with various metabolic disorders, effective metabolic biomarkers for its early detection are required. We aimed to investigate the metabolic biomarkers related to sarcopenia in elderly men and perform experimental studies using metabolomics. Methods: Plasma metabolites from 142 elderly men, comprising a sarcopenia group and an age-matched control group, were measured using global metabolome profiling. Muscle and plasma samples from an aging mouse model of sarcopenia, as well as cell media and cell lysates during myoblast differentiation, were analysed based on targeted metabolome profiling. Based on these experimental results, fatty acid amides were quantified from human plasma as well as human muscle tissues. The association of fatty acid amide levels with sarcopenia parameters was evaluated. Results: Global metabolome profiling showed that fatty acid amide levels were significantly different in the plasma of elderly men with sarcopenia (all Ps < 0.01). Consistent with these results in human plasma, targeted metabolome profiling in an aging mouse model of sarcopenia showed decreased levels of fatty acid amides in plasma but not in muscle tissue. In addition, the levels of fatty acid amides increased in cell lysates during muscle cell differentiation. Targeted metabolome profiling in men showed decreased docosahexaenoic acid ethanolamide (DHA EA) levels in the plasma (P = 0.016) but not in the muscle of men with sarcopenia. DHA EA level was positively correlated with sarcopenia parameters such as skeletal muscle mass index (SMI) and handgrip strength (HGS) (P = 0.001, P = 0.001, respectively). The area under the receiver-operating characteristic curve (AUC) for DHA EA level ≤ 4.60 fmol/μL for sarcopenia was 0.618 (95% confidence interval [CI]: 0.532-0.698). DHA EA level ≤ 4.60 fmol/μL was associated with a significantly greater likelihood of sarcopenia (odds ratio [OR]: 2.11, 95% CI: 1.03-4.30), independent of HGS. The addition of DHA EA level to age and HGS significantly improved the AUC from 0.620 to 0.691 (P = 0.0497). Conclusions: Our study demonstrated that fatty acid amides are potential circulating biomarkers in elderly men with sarcopenia. DHA EA, in particular, strongly related to muscle mass and strength, can be a key metabolite to become a reliable metabolic biomarker for sarcopenia. Further research on fatty acid amides will provide insights into the metabolomic changes relevant to sarcopenia from an aging perspective.
MeSH term(s)	Male ; Animals ; Mice ; Humans ; Aged ; Sarcopenia ; Muscle, Skeletal ; Hand Strength/physiology ; Aging/physiology ; Biomarkers
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-05-01
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2586864-0
ISSN	2190-6009 ; 2190-5991
ISSN (online)	2190-6009
ISSN	2190-5991
DOI	10.1002/jcsm.13244
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Article ; Online: Enhancing Sustainability through Analysis and Prevention

Su-Hyung Kim / Kyung-Jin Ryu / Seung-Hyun Lee / Kyoung-Hoon Lee / Seong-Hun Kim / Yoo-Won Lee

Sustainability, Vol 15, Iss 21, p

A Study of Fatal Accidents on Trap Boats within the Commercial Fishing Industry

2023 Volume 15382

Abstract: The global commercial fishing industry, which employs approximately 159,800 seafarers worldwide (as reported by the Food and Agriculture Organization of the United Nations), faces a significant challenge in terms of safety. According to estimates by the ... ...

Abstract	The global commercial fishing industry, which employs approximately 159,800 seafarers worldwide (as reported by the Food and Agriculture Organization of the United Nations), faces a significant challenge in terms of safety. According to estimates by the International Labour Organization, approximately 24,000 seafarers lose their lives each year in fishing-related accidents. However, most existing guidelines for preventing maritime accidents primarily target vessels involved in international navigation, often inadequately addressing the unique risks faced by small-scale boats operating in coastal areas. This study focuses on trap fishery, a widely practiced fishing method globally, analyzing quantitative data from 1790 maritime accidents and conducting a survey involving 101 seafarers in South Korea. Utilizing Bayesian network analysis, aligned with Formal Safety Assessment protocols, the authors developed preventive guidelines aiming to reduce the rate of fatal accidents. The guidelines, derived from the data analysis, are anticipated to provide invaluable assistance to seafarers engaged in trap fishery not only in South Korea but also across various countries worldwide. By enhancing safety measures in this critical sector, this research will contribute to the overarching goal of sustainability within the global commercial fishing industry.
Keywords	commercial fishing vessel ; seafarers ; maritime accidents ; preventive guidelines ; sustainability ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	380
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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