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Article ; Online: Letter by Wen et al Regarding Article, "Validation of Wall Enhancement as a New Imaging Biomarker of Unruptured Cerebral Aneurysm".

Wen, Dingke / Ma, Lu / Yang, Mu

2019 Volume 50, Issue 10, Page(s) e305

MeSH term(s)	Aneurysm, Ruptured ; Biomarkers ; Cerebral Angiography ; Humans ; Intracranial Aneurysm
Chemical Substances	Biomarkers
Language	English
Publishing date	2019-08-29
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	80381-9
ISSN	1524-4628 ; 0039-2499 ; 0749-7954
ISSN (online)	1524-4628
ISSN	0039-2499 ; 0749-7954
DOI	10.1161/STROKEAHA.119.026830
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Article: Network Pharmacology Prediction and Molecular Docking-Based Strategy to Discover the Potential Pharmacological Mechanism of Wen-Yu-Jin against Pulmonary Fibrosis in a Mouse Model.

Wang, Lu / Zhu, Wenxiang / Sun, Rui / Liu, Jing / Ma, Qihong / Zhang, Binbin / Shi, Yuanyuan

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 7753508

Abstract: ... side effects. Wen-yu-jin (WYJ), one of the commonly used herbs in China, can treat respiratory diseases ...

Abstract	Background: Pulmonary fibrosis (PF) is a devastating lung disease, resulting in gas exchange dysfunction until death. The two drugs approved by the FDA, pirfenidone and nintedanib, have obvious side effects. Wen-yu-jin (WYJ), one of the commonly used herbs in China, can treat respiratory diseases. The potential effects and the underlying mechanism of WYJ against PF are unclear. Purpose: Employing network pharmacology, molecular docking, and in vivo and in vitro experiments to explore the potential effects and underlying mechanisms of WYJ in the treatment of PF. Methods: Ultra-high pressure liquid chromatography combined with linear ion trap-orbital tandem mass spectrometry (UHPLC-LTQ-orbital trap) was used to identify compounds of WYJ. We got PF-related targets and WYJ compounds-related targets from public databases and further completed critical targets exploration, network construction, and pathway analysis by network pharmacology. Molecular docking predicted binding activity of WYJ compounds and critical targets. Based on the above results, in vivo and in vitro experiments validated the potential effects and mechanisms of WYJ against PF. Results: 23 major compositions of WYJ were identified based on UHPLC-LTQ-Orbitrap. According to the results of network pharmacology, STAT3, SRC, IL6, MAPK1, AKT1, EGFR, MAPK8, MAPK14, and IL1B are critical therapeutic targets. Molecular docking results showed that most of the compounds have good binding activities with critical targets. The results of in vivo and in vitro experiments showed that WYJ alleviated the process of fibrosis by targeting MAPK and STAT3 pathways. Conclusion: Network pharmacology, molecular docking, and in vivo and in vitro experiments showed the potential effects and mechanisms of WYJ against PF, which provides a theoretical basis for the treatment of WYJ with PF.
Language	English
Publishing date	2022-02-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/7753508
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Zs.A 5995: Show issues

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Article ; Online: Network Pharmacology Prediction and Molecular Docking-Based Strategy to Discover the Potential Pharmacological Mechanism of Wen-Yu-Jin against Pulmonary Fibrosis in a Mouse Model

Lu Wang / Wenxiang Zhu / Rui Sun / Jing Liu / Qihong Ma / Binbin Zhang / Yuanyuan Shi

Evidence-Based Complementary and Alternative Medicine, Vol

2022 Volume 2022

Abstract: ... side effects. Wen-yu-jin (WYJ), one of the commonly used herbs in China, can treat respiratory diseases ...

Abstract	Background. Pulmonary fibrosis (PF) is a devastating lung disease, resulting in gas exchange dysfunction until death. The two drugs approved by the FDA, pirfenidone and nintedanib, have obvious side effects. Wen-yu-jin (WYJ), one of the commonly used herbs in China, can treat respiratory diseases. The potential effects and the underlying mechanism of WYJ against PF are unclear. Purpose. Employing network pharmacology, molecular docking, and in vivo and in vitro experiments to explore the potential effects and underlying mechanisms of WYJ in the treatment of PF. Methods. Ultra-high pressure liquid chromatography combined with linear ion trap-orbital tandem mass spectrometry (UHPLC-LTQ-orbital trap) was used to identify compounds of WYJ. We got PF-related targets and WYJ compounds-related targets from public databases and further completed critical targets exploration, network construction, and pathway analysis by network pharmacology. Molecular docking predicted binding activity of WYJ compounds and critical targets. Based on the above results, in vivo and in vitro experiments validated the potential effects and mechanisms of WYJ against PF. Results. 23 major compositions of WYJ were identified based on UHPLC-LTQ-Orbitrap. According to the results of network pharmacology, STAT3, SRC, IL6, MAPK1, AKT1, EGFR, MAPK8, MAPK14, and IL1B are critical therapeutic targets. Molecular docking results showed that most of the compounds have good binding activities with critical targets. The results of in vivo and in vitro experiments showed that WYJ alleviated the process of fibrosis by targeting MAPK and STAT3 pathways. Conclusion. Network pharmacology, molecular docking, and in vivo and in vitro experiments showed the potential effects and mechanisms of WYJ against PF, which provides a theoretical basis for the treatment of WYJ with PF.
Keywords	Other systems of medicine ; RZ201-999
Subject code	540
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: UHPLC-MS-based metabolomics and chemoinformatics study reveals the neuroprotective effect and chemical characteristic in Parkinson's disease mice after oral administration of Wen-Shen-Yang-Gan decoction.

Zhu, Guoxue / Wang, Wang / Chen, Chang / Tang, Lili / Liang, Yan / Zhang, Zhennian / Lu, Yan / Zhao, Yang

Aging

2021 Volume 13, Issue 15, Page(s) 19510–19528

Abstract: ... Traditional Chinese medicine (TCM) has been utilized to treat the dysfunction of the autonomic nervous system. Wen-Shen-Yang ...

Abstract	Parkinson's disease (PD), the typical neurodegenerative disease, is characterized by the progressive loss of dopaminergic neurons in the substantia nigra (SN). However, no therapeutic agent used currently could slow down neuronal cell loss so as to decelerate or halt the progression of PD. Traditional Chinese medicine (TCM) has been utilized to treat the dysfunction of the autonomic nervous system. Wen-Shen-Yang-Gan decoction (WSYGD) has a good effect on the clinical treatment of PD with constipation. However, it is not clear which ingredients and what mechanism are responsible for the therapeutic effect. In this study, the pharmacodynamic study of WSYGD in PD mice was applied. Concurrently, a novel method for the identification of metabolic profiles of WSYGD has been developed. Finally, we found that WSYGD could protect the PD mice induced by rotenone. The underlying mechanism of the protective effect may be related to the reduction of the DA neurons apoptosis via reducing inflammatory reaction. By virtue of UPLC-MS and chemoinformatics method, 35 prototype compounds and 27 metabolites were filtered out and tentatively characterized. In conclusion, this study provides an insight into the metabolism of WSYGD
MeSH term(s)	Administration, Oral ; Animals ; Antiparkinson Agents/isolation & purification ; Antiparkinson Agents/pharmacology ; Cheminformatics/methods ; Chromatography, High Pressure Liquid ; Disease Models, Animal ; Dopaminergic Neurons/drug effects ; Dopaminergic Neurons/pathology ; Male ; Metabolomics ; Mice ; Mice, Inbred C57BL ; Multivariate Analysis ; Neuroprotective Agents/isolation & purification ; Neuroprotective Agents/pharmacology ; Parkinson Disease/drug therapy ; Parkinson Disease/pathology ; Plant Extracts/isolation & purification ; Plant Extracts/pharmacology ; Rotenone ; Substantia Nigra/drug effects ; Substantia Nigra/pathology ; Tandem Mass Spectrometry
Chemical Substances	Antiparkinson Agents ; Neuroprotective Agents ; Plant Extracts ; Rotenone (03L9OT429T)
Language	English
Publishing date	2021-08-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.203361
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Systems Pharmacology Dissection of Traditional Chinese Medicine Wen-Dan Decoction for Treatment of Cardiovascular Diseases.

Lan, Tao-Hua / Zhang, Lu-Lu / Wang, Yong-Hua / Wu, Huan-Lin / Xu, Dan-Ping

Evidence-based complementary and alternative medicine : eCAM

2018 Volume 2018, Page(s) 5170854

Abstract: ... the underlying molecular mechanisms of a clinically effective herb formula (Wen-Dan Decoction) in treating CVDs ... 127 potential active compounds and their corresponding 283 direct targets were identified in Wen-Dan ... the pharmacological mechanisms of Wen-Dan Decoction. A "CVDs pathway" consisted of several regulatory modules ...

Abstract	Cardiovascular diseases (CVDs) have been recognized as first killer of human health. The underlying mechanisms of CVDs are extremely complicated and not fully revealed, leading to a challenge for CVDs treatment in modern medicine. Traditional Chinese medicine (TCM) characterized by multiple compounds and targets has shown its marked effects on CVDs therapy. However, system-level understanding of the molecular mechanisms is still ambiguous. In this study, a system pharmacology approach was developed to reveal the underlying molecular mechanisms of a clinically effective herb formula (Wen-Dan Decoction) in treating CVDs. 127 potential active compounds and their corresponding 283 direct targets were identified in Wen-Dan Decoction. The networks among active compounds, targets, and diseases were built to reveal the pharmacological mechanisms of Wen-Dan Decoction. A "CVDs pathway" consisted of several regulatory modules participating in therapeutic effects of Wen-Dan Decoction in CVDs. All the data demonstrates that Wen-Dan Decoction has multiscale beneficial activity in CVDs treatment, which provides a new way for uncovering the molecular mechanisms and new evidence for clinical application of Wen-Dan Decoction in cardiovascular disease.
Language	English
Publishing date	2018-05-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2018/5170854
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 5995: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Quantification of Nineteen Bioactive Components in the Ancient Classical Chinese Medicine Formula of Wen-Dan Decoction and Its Commercial Preparations by UHPLC-QQQ-MS/MS.

Zhang, Bing / Qi, Dongli / Deng, Xiuping / Ma, Zhe / Wu, Yumei / Xue, Zhifeng / Kebebe, Dereje / Lu, Peng / Pi, Jiaxin / Guo, Pan / Li, Nan / Liu, Zhidong

Molecules (Basel, Switzerland)

2019 Volume 24, Issue 11

Abstract: A UHPLC-QQQ-MS/MS method was developed to quantify the significant constituents in Wen-Dan ...

Abstract	A UHPLC-QQQ-MS/MS method was developed to quantify the significant constituents in Wen-Dan Decoction (WDD), a traditional Chinese medicine. Analysis of 19 compounds was conducted on an ACQUITY UPLC
MeSH term(s)	Chromatography, High Pressure Liquid/methods ; Cluster Analysis ; Drugs, Chinese Herbal/chemistry ; Limit of Detection ; Medicine, Chinese Traditional ; Phytochemicals/analysis ; Phytochemicals/chemistry ; Reference Standards ; Tandem Mass Spectrometry
Chemical Substances	Drugs, Chinese Herbal ; Phytochemicals ; wendan
Language	English
Publishing date	2019-05-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules24112031
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.MO 81: Show issues

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Article ; Online: Wen Dan Decoction for hemorrhagic stroke and ischemic stroke.

Xu, Jia-Hua / Huang, Yan-Mei / Ling, Wei / Li, Yang / Wang, Min / Chen, Xiang-Yan / Sui, Yi / Zhao, Hai-Lu

Complementary therapies in medicine

2015 Volume 23, Issue 2, Page(s) 298–308

Abstract: ... we report the existing clinical evidence of the Pinellia Ternata containing formula Wen Dan Decoction (WDD ...

Abstract	Objective: The use of traditional Chinese medicine (TCM) in stroke is increasing worldwide. Here we report the existing clinical evidence of the Pinellia Ternata containing formula Wen Dan Decoction (WDD) for the treatment of ischemic stroke and hemorrhagic stroke. Methods: PubMed, CNKI, Wan Fang database, Cochrane Library and online Clinical Trial Registry were searched up to 26 February 2013 for randomized, controlled clinical trials (RCTs) using WDD as intervention versus Western conventional medicine as control to treat stroke. Clinical outcomes were improvement of the Neurological Functional Deficit Scores (NFDS) and overall therapeutic efficacy rates including rate of cure. Meta-regression analysis using Hedges'g was performed for RCTs with significant heterogeneity. Results: A total of 22 RCTs of ischemic stroke and 4 RCTs of hemorrhagic stroke, involving 2214 patients (1167 used WDD), met our inclusion criteria. Meta-analysis of the 13 RCTs reporting NFDS improvement favored WDD over the control (mean difference=-3.40, 95% confidence intervals [CI]=[-4.64, -2.15]). Rate of overall therapeutic efficacy (odds ratio [OR]=3.39, 95%CI=[1.81, 6.37]) for hemorrhagic stroke were significantly higher in WDD treated patients than the control subjects. In the 1898 patients with ischemic stroke, WDD medication also achieved higher rates of cure (OR=2.22, 95%CI=[1.66, 2.97]) and overall therapeutic efficacy (OR=3.31, 95%CI=[2.54, 4.31]) than the conventional treatment. Conclusions: WDD displays benefits on improvement of neurological function and overall therapeutic efficacy in post-stroke patients. TCM such as WDD may serve as a therapeutic tool of dual actions to explore the common mechanisms underlying cerebral hemorrhage and ischemia.
MeSH term(s)	Brain Ischemia/drug therapy ; Brain Ischemia/physiopathology ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Intracranial Hemorrhages/drug therapy ; Intracranial Hemorrhages/physiopathology ; Odds Ratio ; Randomized Controlled Trials as Topic ; Stroke/drug therapy ; Stroke/physiopathology ; Treatment Outcome
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2015-04
Publishing country	Scotland
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1155895-7
ISSN	1873-6963 ; 0965-2299
ISSN (online)	1873-6963
ISSN	0965-2299
DOI	10.1016/j.ctim.2015.01.001
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 3726: Show issues

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Article: Efficacy of the wen dan decoction, a Chinese herbal formula, for metabolic syndrome.

Huang, Yan-Mei / Xu, Jia-Hua / Ling, Wei / Li, Yang / Zhang, Xiao-Xi / Dai, Zhi-Kai / Sui, Yi / Zhao, Hai-Lu

Alternative therapies in health and medicine

2015 Volume 21, Issue 4, Page(s) 54–67

Abstract: ... patients using the Wen Dan decoction (WDD), a CM formula, versus Western conventional therapeutics ...

Abstract	Context: Metabolic syndrome (MS) refers to the clustering of metabolic derangements that include hyperglycemia, dyslipidemia, hypertension, and chronic kidney impairment. Those conditions are well known as being synergistically responsible for morbidity from cardiovascular disease as well as for driving the global epidemic of type 2 diabetes. It is still unknown whether an exact unifying pathogenesis of MS exists. Objective: The meta-analysis intended to analyze the use of Chinese medicine (CM) as a therapeutic tool to explore indirectly the unifying pathogenesis of MS. Methods: PubMed, the Chinese National Knowledge Infrastructure (CNKI), and the Wanfang databases were systematically searched from inception to November 2013 for randomized, controlled trials (RCTs) that compared treatment efficacy for MS patients using the Wen Dan decoction (WDD), a CM formula, versus Western conventional therapeutics. Outcome measures: Measurements included tests of the overall therapeutic efficacy of WDD for hyperglycemia, hypertension, dyslipidemia, and renal functions, and the study also analyzed adverse events. Data were expressed as weighted mean differences (WMDs), with 95% confidence intervals (95% CIs) and the odds ratio (OR). Results: A total of 31 RCTs were included for meta-analysis, involving 2512 patients and including 1282 participants in the intervention groups. The pooled data favored WDD over the control treatments as follows: (1) hyperglycemia, with a WMD of -0.95 mmol/L (95% CI: -1.19 to -0.71); (2) hypertension, with a WMD of -7.40 mm Hg (95% CI: -9.86 to -4.93); (3) dyslipidemia: (a) total cholesterol (TC), with a WMD of -0.62 mmol/L (95% CI: -0.90 to -0.33); (b) triglycerides (TGs), with a WMD of -0.32 mmol/L (95% CI: -0.52 to -0.13); (c) low-density lipoproteins (LDPs), with a WMD of -0.22 mmol/L (95% CI: -0.41 to -0.02); and (d) high-density lipoproteins (HDPs), with a WMD of 0.10 mmol/L (95% CI: 0.03 to 0.17); and (4) of renal functions: (a) urea, with a WMD of -3.41 mmol/L (95% CI: -5.50 to -1.32) and (b) creatinine, with a WMD of -68.81 μmol/L (95% CI: -132.63 to -4.98). No statistical significance was documented in creatinine clearance between the 2 treatments with a WMD of 15.47 mL/min (95% CI: -7.71 to 38.64). The overall efficacy rate was 91.4% for WDD and 66.9% for the control treatments (OR: 5.33; 95% CI: 4.06 to 6.99). Adverse events were rare and minor. Conclusions: The consistent improvements found in metabolic profiles by use of the single herbal formula may indirectly imply a common pathogenesis in MS.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Drugs, Chinese Herbal/adverse effects ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Metabolic Syndrome/drug therapy ; Metabolic Syndrome/physiopathology ; Middle Aged ; Treatment Outcome
Chemical Substances	Drugs, Chinese Herbal ; wendan
Language	English
Publishing date	2015-07
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
ZDB-ID	1225073-9
ISSN	1078-6791
ISSN	1078-6791
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 4504: Show issues

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Book: Zhong guo wen hua shi

Lü, Simian

(Bei da da ke tang ; 北大大课堂)

2010

Author's details	Lü si mian zhu
Series title	Bei da da ke tang 北大大课堂
Keywords	China
Language	Chinese
Size	1, 205 p, ill, 23 cm
Edition	Di 1 ban
Publisher	Bei jing da xue chu ban she
Publishing place	Bei jing
Document type	Book
ISBN	7301158424 ; 9787301158425
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Systems Pharmacology Dissection of Traditional Chinese Medicine Wen-Dan Decoction for Treatment of Cardiovascular Diseases

Tao-Hua Lan / Lu-Lu Zhang / Yong-Hua Wang / Huan-Lin Wu / Dan-Ping Xu

Evidence-Based Complementary and Alternative Medicine, Vol

2018 Volume 2018

Abstract: ... the underlying molecular mechanisms of a clinically effective herb formula (Wen-Dan Decoction) in treating CVDs ... 127 potential active compounds and their corresponding 283 direct targets were identified in Wen-Dan ... the pharmacological mechanisms of Wen-Dan Decoction. A “CVDs pathway” consisted of several regulatory modules ...

Abstract	Cardiovascular diseases (CVDs) have been recognized as first killer of human health. The underlying mechanisms of CVDs are extremely complicated and not fully revealed, leading to a challenge for CVDs treatment in modern medicine. Traditional Chinese medicine (TCM) characterized by multiple compounds and targets has shown its marked effects on CVDs therapy. However, system-level understanding of the molecular mechanisms is still ambiguous. In this study, a system pharmacology approach was developed to reveal the underlying molecular mechanisms of a clinically effective herb formula (Wen-Dan Decoction) in treating CVDs. 127 potential active compounds and their corresponding 283 direct targets were identified in Wen-Dan Decoction. The networks among active compounds, targets, and diseases were built to reveal the pharmacological mechanisms of Wen-Dan Decoction. A “CVDs pathway” consisted of several regulatory modules participating in therapeutic effects of Wen-Dan Decoction in CVDs. All the data demonstrates that Wen-Dan Decoction has multiscale beneficial activity in CVDs treatment, which provides a new way for uncovering the molecular mechanisms and new evidence for clinical application of Wen-Dan Decoction in cardiovascular disease.
Keywords	Other systems of medicine ; RZ201-999
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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