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  1. Book ; Online: Psychomotor symptomatology in psychiatric illnesses

    Walther, Sebastian / Morrens, Manuel

    2015  

    Abstract: Psychomotor symptoms are those symptoms that are characterized by deficits in the initiation, execution and monitoring of movements, such as psychomotor slowing, catatonia, neurological soft signs (NSS), reduction in motor activity or extrapyramidal ... ...

    Abstract Psychomotor symptoms are those symptoms that are characterized by deficits in the initiation, execution and monitoring of movements, such as psychomotor slowing, catatonia, neurological soft signs (NSS), reduction in motor activity or extrapyramidal symptoms (EPS). These symptoms have not always received the attention they deserve although they can be observed in a wide range of psychiatric illnesses, including mood disorders, psychotic disorders, anxiety disorders, pervasive developmental disorders and personality disorders. Nevertheless, these symptoms seem to have prognostic value on clinical and functional outcome in several pathologies. In the late 19th century, the founding fathers of modern psychiatry (including Kahlbaum, Wernicke, Kraepelin and Bleuler) had a strong focus on psychomotor abnormalities in their description and definitions of psychiatric illnesses and systematically recognized these as core features of several psychiatric pathologies.-

    Nevertheless, emphasis on these symptoms has reduced substantially since the emergence of psychopharmacology, given the association between antipsychotics or antidepressants and medication-induced motor deficits. This has resulted in the general idea that most if not all psychomotor deficits were merely side effects of their treatment rather than intrinsic features of the illness. Yet, the last two decades a renewed interest in these deficits can be observed and has yielded an exponential growth of research into these psychomotor symptoms in several psychiatric illnesses. This recent evolution is also reflected in the increased appreciation of these symptoms in the DSM-5. As a result of this increased focus, new insights into the clinical and demographical presentation, the etiology, the course, the prognostic value as well as treatment aspects of psychomotor symptomatology in different illnesses has emerged. Still, many new questions arise from these findings.-

    This research topic is comprised of all types of contributions (original research, reviews, and opinion piece) with a focus on psychomotor symptomatology in a psychiatric illness, especially research focusing on one or more of the following topics: the clinical presentation of the psychomotor syndrome; the course through the illness; the diagnostical specificity of the syndrome; the underlying neurobiological or neuropsychological processes; new assessment techniques; pharmacological or non-pharmacological treatment strategies
    Keywords Psychiatry ; Medicine (General)
    Size 1 electronic resource (137 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020091158
    ISBN 9782889197255 ; 2889197255
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Choice of Outcome Measure Predicts Anti-Inflammatory Treatment Efficacy in Major Depressive Disorder [Letter].

    Wessa, Céline / Morrens, Manuel / De Picker, Livia J

    Neuropsychiatric disease and treatment

    2023  Volume 19, Page(s) 515–517

    Language English
    Publishing date 2023-03-04
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2186503-6
    ISSN 1178-2021 ; 1176-6328
    ISSN (online) 1178-2021
    ISSN 1176-6328
    DOI 10.2147/NDT.S407852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Tracking TRYCAT: A Critical Appraisal of Kynurenine Pathway Quantifications in Blood.

    Coppens, Violette / Verkerk, Robert / Morrens, Manuel

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 825948

    Language English
    Publishing date 2022-02-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.825948
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Biology of BDSM: A Systematic Review.

    Wuyts, Elise / Morrens, Manuel

    The journal of sexual medicine

    2021  Volume 19, Issue 1, Page(s) 144–157

    Abstract: ... for future research to replicate and supplement current results. Wuyts E, Morrens M. The Biology of BDSM ...

    Abstract Introduction: BDSM is an abbreviation used to reference the concepts of bondage and discipline, dominance and submission, sadism and masochism, enacted by power exchanges between consensual partners. In recent years, attention has shifted from the idea of BDSM as a pathological and tabooed niche practice towards viewing BDSM as a healthy form of intimacy.
    Aim: This systematic review brings together all existing literature on the biology of BDSM and places it in a broader biological context.
    Methods: A systematic search was conducted on PubMed, Web of Science and PsycARTICLES, of which 10 articles are included and discussed in this systematic review.
    Results: There is evidence for cortisol changes in submissives as a result of a BDSM interaction, suggesting involvement of the physiological stress system. Endocannabinoid changes implicate the pleasure and reward system. In dominants, this biologically measured pleasure seemed to be dependent on power play rather than pain play. Testosterone and oxytocin are also implicated in BDSM, though their role is less evident. Research into brain region activity patterns related to BDSM interest suggests a role for the parietal operculum and ventral striatum in the context of the pleasure and reward system, the primary and secondary somatosensory cortex in the context of pain perception, empathy-related circuits such as the anterior insula, anterior midcingulate cortex and sensorimotor cortex and the left frontal cortex in the context of social and sexual interactions. Pain thresholds are shown to be higher in submissive individuals and a BDSM interaction may cause pain thresholds to rise in submissives as well.
    Conclusion: BDSM interactions are complex and influenced by several psychological, social and biological processes. Though research is limited, there is emerging evidence for an interaction between several biological systems involved in these types of interests and activities. This means there is an important role for future research to replicate and supplement current results. Wuyts E, Morrens M. The Biology of BDSM: A Systematic Review. J Sex Med 2022;19:144-157.
    MeSH term(s) Biology ; Humans ; Masochism/psychology ; Pleasure/physiology ; Sadism/psychology ; Sexual Behavior/psychology
    Language English
    Publishing date 2021-12-06
    Publishing country Netherlands
    Document type Journal Article ; Systematic Review
    ZDB-ID 2251959-2
    ISSN 1743-6109 ; 1743-6095
    ISSN (online) 1743-6109
    ISSN 1743-6095
    DOI 10.1016/j.jsxm.2021.11.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Case report: Psychosis with catatonia in an adult man: a presentation of neurosarcoidosis.

    Van Hoye, Griet / Willekens, Barbara / Vanden Bossche, Stephanie / Morrens, Manuel / Van Den Eede, Filip

    Frontiers in psychiatry

    2024  Volume 15, Page(s) 1276744

    Abstract: Introduction: Sarcoidosis is a multisystem non-caseous granulomatous disease of unknown origin with predominant lung involvement and a variable clinical course. Although rare, neuropsychiatric manifestations such as confusion, problems in orientation, ... ...

    Abstract Introduction: Sarcoidosis is a multisystem non-caseous granulomatous disease of unknown origin with predominant lung involvement and a variable clinical course. Although rare, neuropsychiatric manifestations such as confusion, problems in orientation, memory dysfunction, delusions, hallucinations and catatonia can be presenting features of sarcoidosis with nervous system involvement, also known as neurosarcoidosis.
    Case description: We present a 39-year-old man with acute-onset vertigo, balance problems and confusion quickly developing delusions, hallucinations, catatonic symptoms and suicidal behaviour. Symptoms appeared to be a manifestation of neurosarcoidosis.
    Diagnostic assessment: The differential diagnosis of psychosis is broad and should include pertinent auto-immune disorders, paraneoplastic, oncologic, metabolic, and neurodegenerative disorders. Basic systemic screening should include blood and urinary tests, a chest X-ray, brain CT scan and ECG. If neurosarcoidosis is suspected, an MRI of the brain with contrast and lumbar puncture are most appropriate. Multidisciplinary collaboration is essential to arrive at a correct diagnosis and effective management of the patient.
    Discussion: Despite the large number of sarcoidosis and psychosis studies, the etiology and pathogenesis of both illnesses remain incompletely understood. A common inflammatory etiopathological pathway has been postulated.
    Conclusions: Clinicians should consider organic causes when confronted with a middle-aged patient experiencing a first psychotic episode with an atypical onset, catatonic features, or dysfunction in orientation and/or memory, a complete lack of a positive familial psychiatric history and/or an atypical response to (psycho)pharmacological treatment.
    Language English
    Publishing date 2024-03-04
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2024.1276744
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Motor learning and performance in schizophrenia and aging: two different patterns of decline.

    Hulstijn, Wouter / Cornelis, Claudia / Morsel, Anne / Timmers, Maarten / Morrens, Manuel / Sabbe, Bernard G C

    Experimental brain research

    2024  Volume 242, Issue 4, Page(s) 879–899

    Abstract: Psychomotor slowing has consistently been observed in schizophrenia, however research on motor learning in schizophrenia is limited. Additionally, motor learning in schizophrenia has never been compared with the waning of motor learning abilities in the ... ...

    Abstract Psychomotor slowing has consistently been observed in schizophrenia, however research on motor learning in schizophrenia is limited. Additionally, motor learning in schizophrenia has never been compared with the waning of motor learning abilities in the elderly. Therefore, in an extensive study, 30 individuals with schizophrenia, 30 healthy age-matched controls and 30 elderly participants were compared on sensorimotor learning tasks including sequence learning and adaptation (both explicit and implicit), as well as tracking and aiming. This paper presents new findings on an explicit motor sequence learning task, an explicit verbal learning task and a simple aiming task and summarizes all previously published findings of this large investigation. Individuals with schizophrenia and elderly had slower Movement Time (MT)s compared with controls in all tasks, however both groups improved over time. Elderly participants learned slower on tracking and explicit sequence learning while individuals with schizophrenia adapted slower and to a lesser extent to movement perturbations in adaptation tasks and performed less well on cognitive tests including the verbal learning task. Results suggest that motor slowing is present in schizophrenia and the elderly, however both groups show significant but different motor skill learning. Cognitive deficits seem to interfere with motor learning and performance in schizophrenia while task complexity and decreased movement precision interferes with motor learning in the elderly, reflecting different underlying patterns of decline in these conditions. In addition, evidence for motor slowing together with impaired implicit adaptation supports the influence of cerebellum and the cerebello-thalamo-cortical-cerebellar (CTCC) circuits in schizophrenia, important for further understanding the pathophysiology of the disorder.
    MeSH term(s) Humans ; Aged ; Psychomotor Performance/physiology ; Schizophrenia ; Learning/physiology ; Aging ; Verbal Learning
    Language English
    Publishing date 2024-03-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1201-4
    ISSN 1432-1106 ; 0014-4819
    ISSN (online) 1432-1106
    ISSN 0014-4819
    DOI 10.1007/s00221-024-06797-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: What Can Be Learned from Dimensional Perspectives on Psychiatry?

    Walther, Sebastian / Morrens, Manuel

    Neuropsychobiology

    2020  Volume 79, Issue 4-5, Page(s) 249–250

    MeSH term(s) Humans ; Mental Disorders/classification ; Mental Disorders/immunology ; Mental Disorders/pathology ; Mental Disorders/physiopathology ; Psychiatry/methods
    Language English
    Publishing date 2020-06-08
    Publishing country Switzerland
    Document type Introductory Journal Article
    ZDB-ID 442239-9
    ISSN 1423-0224 ; 0302-282X
    ISSN (online) 1423-0224
    ISSN 0302-282X
    DOI 10.1159/000508762
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Attitudes of patients with schizophrenia spectrum or bipolar disorders towards medication self-management during hospitalisation.

    Loots, Elke / Dilles, Tinne / Van Rompaey, Bart / Morrens, Manuel

    Journal of clinical nursing

    2023  Volume 33, Issue 4, Page(s) 1459–1469

    Abstract: Background: Medication self-management (MSM) is defined as a person's ability to cope with medication treatment for a chronic condition, along with the associated physical and psychosocial effects that the medication causes in their daily lives. For ... ...

    Abstract Background: Medication self-management (MSM) is defined as a person's ability to cope with medication treatment for a chronic condition, along with the associated physical and psychosocial effects that the medication causes in their daily lives. For many patients, it is important to be able to self-manage their medication successfully, as they will often be expected to do after discharge.
    Aim: The aim of this study was to describe the willingness and attitudes of patients with schizophrenia spectrum or bipolar disorders regarding MSM during hospital admission. A secondary aim was to identify various factors associated with patient willingness to participate in MSM and to describe their assumptions concerning needs and necessary conditions, as well as their attitudes towards their medication.
    Methods: A multicentre, quantitative cross-sectional observational design was used to study the willingness and attitudes of psychiatric patients regarding MSM during hospitalisation. The study adhered to guidelines for Strengthening the Reporting of Observational Studies in Epidemiology (STROBE).
    Results: In this study, 84 patients, of which 43 were patients with schizophrenia spectrum disorders and 41 were patients with bipolar disorders, participated. A majority of the patients (81%) were willing to participate in MSM during their hospitalisation. Analysis revealed patients are more willing to MSM if they are younger (r = -.417, p < .001) and a decreasing number of medicines (r = -.373, p = .003). Patients' willingness was positively associated with the extent of support by significant others during and after hospitalisation (Pearson's r = .298, p = .011). Patients were convinced that they would take their medication more correctly if MSM were to be allowed during hospitalisation (65%).
    Conclusion: Most of the patients were willing to self-manage their medication during hospitalisation, however, under specific conditions such as being motivated to take their medication correctly and to understand the benefits of their medication.
    Relevance to clinical practice: From a policy point of view, our study provided useful insights into how patients look at MSM to enable the development of future strategies. Since patients are willing to self-manage their medication during hospitalisation, this may facilitate its implementation.
    Patient contribution: Patients were recruited for this study. Participation was voluntary, and signed informed consent was obtained from all participants prior to the questionnaire.
    MeSH term(s) Humans ; Bipolar Disorder/drug therapy ; Schizophrenia/drug therapy ; Self-Management ; Cross-Sectional Studies ; Hospitalization
    Language English
    Publishing date 2023-12-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1159483-4
    ISSN 1365-2702 ; 0962-1067 ; 1752-9816
    ISSN (online) 1365-2702
    ISSN 0962-1067 ; 1752-9816
    DOI 10.1111/jocn.16936
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Perspective: Solving the Heterogeneity Conundrum of TSPO PET Imaging in Psychosis.

    De Picker, Livia / Morrens, Manuel

    Frontiers in psychiatry

    2020  Volume 11, Page(s) 362

    Abstract: Positron emission tomography using ligands targeting translocator protein 18 kDa (TSPO PET) is an innovative method to visualize and quantify glial inflammatory responses in the central nervous ... ...

    Abstract Positron emission tomography using ligands targeting translocator protein 18 kDa (TSPO PET) is an innovative method to visualize and quantify glial inflammatory responses in the central nervous system
    Language English
    Publishing date 2020-05-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2020.00362
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The attitude of healthcare providers towards medication self-management in hospitalized patients diagnosed with schizophrenia or bipolar disorders.

    Loots, Elke / Dilles, Tinne / Hadouchi, Sarah / Van Rompaey, Bart / Morrens, Manuel

    Journal of psychiatric and mental health nursing

    2023  Volume 30, Issue 4, Page(s) 761–772

    Abstract: Background: Medication self-management (MSM) is considered an important aspect of pharmacotherapy and plays an essential role in the treatment of various illnesses. To date, research into the willingness and attitude of psychiatric healthcare providers ... ...

    Abstract Background: Medication self-management (MSM) is considered an important aspect of pharmacotherapy and plays an essential role in the treatment of various illnesses. To date, research into the willingness and attitude of psychiatric healthcare providers toward MSM in patients diagnosed with schizophrenia or bipolar disorders during hospitalization is lacking.
    Aim: The aim of this study was to identify healthcare providers' willingness to MSM and assess their attitude, conditions, benefits, and ability toward it during hospitalization.
    Methods: A multicenter, quantitative cross-sectional observational design was used to study psychiatric healthcare providers' attitude to MSM during hospitalization in patients diagnosed with schizophrenia or bipolar disorders.
    Results: In this study, 173 healthcare providers, of which 147 were nurses and 26 psychiatrists, participated. During hospitalization, 86% of the healthcare providers were willing to MSM. Regularly evaluating patients' ability regarding MSM during hospitalization was seen as an important condition (94%). Psychiatrists were significantly less convinced that MSM during hospitalization has a positive impact on adherence when compared to nurses (respectively 54% vs. 77%, p = .009).
    Discussion: Most healthcare providers indicated that they were willing to MSM in patients diagnosed with schizophrenia or bipolar disorders during hospitalization under specific conditions.
    MeSH term(s) Humans ; Schizophrenia/drug therapy ; Schizophrenia/diagnosis ; Bipolar Disorder/drug therapy ; Cross-Sectional Studies ; Self-Management ; Health Personnel
    Language English
    Publishing date 2023-02-04
    Publishing country England
    Document type Multicenter Study ; Journal Article
    ZDB-ID 1328479-4
    ISSN 1365-2850 ; 1351-0126
    ISSN (online) 1365-2850
    ISSN 1351-0126
    DOI 10.1111/jpm.12903
    Database MEDical Literature Analysis and Retrieval System OnLINE

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