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  1. Article ; Online: Psychosis and Infodemic Isolation Resulting in First Inpatient Hospitalization During the COVID-19 Pandemic A Case Series.

    Shanbour, Alaa / Khalid, Zaira / Fana, Michael

    The primary care companion for CNS disorders

    2020  Volume 22, Issue 3

    MeSH term(s) Adult ; Antipsychotic Agents/therapeutic use ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/psychology ; Delusions/drug therapy ; Delusions/virology ; Female ; Hospitalization ; Humans ; Male ; Pandemics ; Paranoid Disorders/drug therapy ; Paranoid Disorders/virology ; Patient Isolation/psychology ; Pneumonia, Viral/psychology ; Psychotic Disorders/drug therapy ; Psychotic Disorders/virology ; SARS-CoV-2 ; Young Adult
    Chemical Substances Antipsychotic Agents
    Keywords covid19
    Language English
    Publishing date 2020-06-04
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2675414-9
    ISSN 2155-7780 ; 2155-7772
    ISSN (online) 2155-7780
    ISSN 2155-7772
    DOI 10.4088/PCC.20l02649
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Acetyl-l-Carnitine and New-Onset Psychosis During the COVID-19 Pandemic.

    Dhir, Sakshi / Khalid, Zaira / Salcedo, Jisselly / Shanbour, Alaa

    The primary care companion for CNS disorders

    2020  Volume 22, Issue 6

    MeSH term(s) Acetylcarnitine/adverse effects ; Antipsychotic Agents/therapeutic use ; COVID-19 ; Delusions/chemically induced ; Delusions/drug therapy ; Dietary Supplements/adverse effects ; Humans ; Male ; Middle Aged ; Paranoid Disorders/chemically induced ; Paranoid Disorders/drug therapy ; Psychoses, Substance-Induced/drug therapy ; Psychoses, Substance-Induced/etiology ; Risperidone/therapeutic use ; Vitamin B Complex/adverse effects
    Chemical Substances Antipsychotic Agents ; Vitamin B Complex (12001-76-2) ; Acetylcarnitine (6DH1W9VH8Q) ; Risperidone (L6UH7ZF8HC)
    Language English
    Publishing date 2020-12-03
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2675414-9
    ISSN 2155-7780 ; 2155-7772
    ISSN (online) 2155-7780
    ISSN 2155-7772
    DOI 10.4088/PCC.20l02804
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Psychosis and Infodemic Isolation Resulting in First Inpatient Hospitalization During the COVID-19 Pandemic A Case Series

    Shanbour, Alaa / Khalid, Zaira / Fana, Michael

    Prim. care companion CNS disord. (Online)

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #595260
    Database COVID19

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  4. Article: Effect of Theta Transcranial Alternating Current Stimulation and Phase-Locked Transcranial Pulsed Current Stimulation on Learning and Cognitive Control.

    Mansouri, Farrokh / Shanbour, Alaa / Mazza, Frank / Fettes, Peter / Zariffa, José / Downar, Jonathan

    Frontiers in neuroscience

    2019  Volume 13, Page(s) 1181

    Abstract: Non-invasive brain stimulation (NIBS) is emerging as a robust treatment alternative for major depressive disorder, with a potential for achieving higher remission rates by providing targeted stimulation to underlying brain networks, such as the salience ... ...

    Abstract Non-invasive brain stimulation (NIBS) is emerging as a robust treatment alternative for major depressive disorder, with a potential for achieving higher remission rates by providing targeted stimulation to underlying brain networks, such as the salience network (SN). Growing evidence suggests that these therapeutic effects are dependent on the frequency and phase synchrony between SN oscillations and stimulation as well as the task-specific state of the SN during stimulation. However, the development of phase-synchronized non-invasive stimulation has proved challenging until recently. Here, we use a phase-locked pulsed brain stimulation approach to study the effects of two NIBS methods: transcranial alternating current stimulation (tACS) versus phase-locked transcranial pulsed current stimulation (tPCS), on the SN during an SN activating task. 20 healthy volunteers participated in the study. Each volunteer partook in four sessions, receiving one stimulation type at random (theta-tACS, peak tPCS, trough tPCS or sham) while undergoing a learning game, followed by an unstimulated test based on learned material. Each session lasted approximately 1.5 h, with an interval of at least 2 days to allow for washout and to avoid cross-over effects. Our results showed no statistically significant effect of stimulation on the event related potential (ERP) recordings, resting electroencephalogram (EEG), and the performance of the volunteers. While stimulation effects were not apparent in this study, the nominal performance of the phase-locking algorithm offers a technical foundation for further research in determining effective stimulation paradigms and conditions. Specifically, future work should investigate stronger stimulation and true task-specific stimulation of SN nodes responsible for the task as well as their recording. If refined, NIBS could offer an effective, homebased treatment option.
    Language English
    Publishing date 2019-11-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2019.01181
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Implementation of intermittent theta burst stimulation compared to conventional repetitive transcranial magnetic stimulation in patients with treatment resistant depression: A cost analysis.

    Mendlowitz, Andrew B / Shanbour, Alaa / Downar, Jonathan / Vila-Rodriguez, Fidel / Daskalakis, Zafiris J / Isaranuwatchai, Wanrudee / Blumberger, Daniel M

    PloS one

    2019  Volume 14, Issue 9, Page(s) e0222546

    Abstract: Background: Repetitive transcranial magnetic stimulation (rTMS) is an evidence-based treatment for depression that is increasingly implemented in healthcare systems across the world. A new form of rTMS called intermittent theta burst stimulation (iTBS) ... ...

    Abstract Background: Repetitive transcranial magnetic stimulation (rTMS) is an evidence-based treatment for depression that is increasingly implemented in healthcare systems across the world. A new form of rTMS called intermittent theta burst stimulation (iTBS) can be delivered in 3 min and has demonstrated comparable effectiveness to the conventional 37.5 min 10Hz rTMS protocol in patients with depression.
    Objectives: To compare the direct treatment costs per course and per remission for iTBS compared to 10Hz rTMS treatment in depression.
    Methods: We conducted a cost analysis from a healthcare system perspective using patient-level data from a large randomized non-inferiority trial (THREE-D). Depressed adults 18 to 65 received either 10Hz rTMS or iTBS treatment. Treatment costs were calculated using direct healthcare costs associated with equipment, coils, physician assessments and technician time over the course of treatment. Cost per remission was estimated using the proportion of patients achieving remission following treatment. Deterministic sensitivity analyses and non-parametric bootstrapping was used to estimate uncertainty.
    Results: From a healthcare system perspective, the average cost per patient was USD$1,108 (SD 166) for a course of iTBS and $1,844 (SD 304) for 10Hz rTMS, with an incremental net savings of $735 (95% CI 688 to 783). The average cost per remission was $3,695 (SD 552) for iTBS and $6,146 (SD 1,015) for 10Hz rTMS, with an average incremental net savings of $2,451 (95% CI 2,293 to 2,610).
    Conclusions: The shorter session durations and treatment capacity increase associated with 3 min iTBS translate into significant cost-savings per patient and per remission when compared to 10Hz rTMS.
    MeSH term(s) Adult ; Costs and Cost Analysis ; Depression/therapy ; Depressive Disorder, Major/therapy ; Depressive Disorder, Treatment-Resistant/economics ; Depressive Disorder, Treatment-Resistant/therapy ; Female ; Humans ; Male ; Middle Aged ; Prefrontal Cortex/physiology ; Theta Rhythm/physiology ; Transcranial Magnetic Stimulation/economics ; Transcranial Magnetic Stimulation/methods ; Treatment Outcome
    Language English
    Publishing date 2019-09-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0222546
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Inter-library loan at ZB MED

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  6. Article ; Online: Implementation of intermittent theta burst stimulation compared to conventional repetitive transcranial magnetic stimulation in patients with treatment resistant depression

    Andrew B Mendlowitz / Alaa Shanbour / Jonathan Downar / Fidel Vila-Rodriguez / Zafiris J Daskalakis / Wanrudee Isaranuwatchai / Daniel M Blumberger

    PLoS ONE, Vol 14, Iss 9, p e

    A cost analysis.

    2019  Volume 0222546

    Abstract: Background Repetitive transcranial magnetic stimulation (rTMS) is an evidence-based treatment for depression that is increasingly implemented in healthcare systems across the world. A new form of rTMS called intermittent theta burst stimulation (iTBS) ... ...

    Abstract Background Repetitive transcranial magnetic stimulation (rTMS) is an evidence-based treatment for depression that is increasingly implemented in healthcare systems across the world. A new form of rTMS called intermittent theta burst stimulation (iTBS) can be delivered in 3 min and has demonstrated comparable effectiveness to the conventional 37.5 min 10Hz rTMS protocol in patients with depression. Objectives To compare the direct treatment costs per course and per remission for iTBS compared to 10Hz rTMS treatment in depression. Methods We conducted a cost analysis from a healthcare system perspective using patient-level data from a large randomized non-inferiority trial (THREE-D). Depressed adults 18 to 65 received either 10Hz rTMS or iTBS treatment. Treatment costs were calculated using direct healthcare costs associated with equipment, coils, physician assessments and technician time over the course of treatment. Cost per remission was estimated using the proportion of patients achieving remission following treatment. Deterministic sensitivity analyses and non-parametric bootstrapping was used to estimate uncertainty. Results From a healthcare system perspective, the average cost per patient was USD$1,108 (SD 166) for a course of iTBS and $1,844 (SD 304) for 10Hz rTMS, with an incremental net savings of $735 (95% CI 688 to 783). The average cost per remission was $3,695 (SD 552) for iTBS and $6,146 (SD 1,015) for 10Hz rTMS, with an average incremental net savings of $2,451 (95% CI 2,293 to 2,610). Conclusions The shorter session durations and treatment capacity increase associated with 3 min iTBS translate into significant cost-savings per patient and per remission when compared to 10Hz rTMS.
    Keywords Medicine ; R ; Science ; Q
    Subject code 616
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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