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Article: The MATRICS Consensus Cognitive Battery: An Update.

Nuechterlein, Keith H / Green, Michael F / Kern, Robert S

Current topics in behavioral neurosciences

2022 Volume 63, Page(s) 1–18

Abstract: Through a series of NIMH-supported consensus-building meetings of experts and empirical comparisons of candidate tests, the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative developed a battery of standardized ... ...

Abstract	Through a series of NIMH-supported consensus-building meetings of experts and empirical comparisons of candidate tests, the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative developed a battery of standardized cognitive measures to allow reliable evaluation of results from clinical trials of promising interventions for core cognitive deficits in this disorder. Ten tests in seven cognitive domains were selected for the MATRICS Consensus Cognitive Battery (MCCB). The MCCB has now been translated into 39 languages/dialects and has been employed in more than 145 clinical trials. It has become the standard cognitive change measure for studies of both pharmacological and training-based interventions seeking to improve cognitive deficits in schizophrenia. We summarize its applications and its relationship to the subsequent development of the NIMH RDoC Matrix.
MeSH term(s)	Humans ; Neuropsychological Tests ; Consensus ; Schizophrenia/drug therapy ; Cognition ; Cognition Disorders/psychology
Language	English
Publishing date	2022-10-28
Publishing country	Germany
Document type	Journal Article
ISSN	1866-3370
ISSN	1866-3370
DOI	10.1007/7854_2022_395
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Article ; Online: Housing outcomes among homeless-experienced veterans engaged in vocational services.

Wong, Michelle S / Clair, Kimberly / Stigers, Peter J / Montgomery, Ann Elizabeth / Kern, Robert S / Gabrielian, Sonya

The American journal of orthopsychiatry

2022 Volume 92, Issue 6, Page(s) 741–747

Abstract: ... homelessness registry data for homeless-experienced Veterans engaged in U.S. Department of Veterans Affairs (VA ...

Abstract	Though unemployment and homelessness are closely intertwined, vocational services are rarely prioritized for homeless-experienced individuals engaging in housing services. Our goal was to examine associations between vocational service use and housing outcomes among homeless-experienced Veterans engaged in permanent supportive housing. We obtained data from Veterans Health Administration (VHA) medical record and homelessness registry data for homeless-experienced Veterans engaged in U.S. Department of Veterans Affairs (VA) Greater Los Angeles' permanent supportive housing program from October 2016 to September 2017 (n = 1,200). We used multivariate logistic regression to examine whether vocational service use was associated with housing attainment and/or premature permanent supportive housing exits. We found that Veterans in permanent supportive housing who used vocational services were more likely to attain housing (OR = 2.52, p < .001) than their peers who did not use these services. There were no between-group differences in the odds of premature exits from the permanent supportive housing program (OR = 1.92, p = .425). Our study suggests that, among homeless-experienced Veterans engaged in permanent supportive housing programs, those who use vocational services potentially may be more likely to attain housing. However, future research can better elucidate the pathways underlying vocational service use and housing outcomes for individuals in permanent supportive housing programs. Greater integration of vocational services and permanent supportive housing programs, and encouragement of vocational service use may enhance housing outcomes among permanent supportive housing participants. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
MeSH term(s)	United States ; Humans ; Housing ; Veterans ; United States Department of Veterans Affairs ; Ill-Housed Persons ; Logistic Models ; Public Housing
Language	English
Publishing date	2022-12-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	280031-7
ISSN	1939-0025 ; 0002-9432
ISSN (online)	1939-0025
ISSN	0002-9432
DOI	10.1037/ort0000650
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Article ; Online: Optimizing team science in an academic medical center: A qualitative examination of investigator perspectives.

Surratt, Hilary L / Otachi, Janet K / Slade, Emily / Kern, Philip A / King, Victoria / Kelly, Thomas H / DiPaola, Robert S

Journal of clinical and translational science

2023 Volume 7, Issue 1, Page(s) e57

Abstract: Introduction: Optimizing the effectiveness of a team-based approach to unite multiple disciplines in advancing specific translational areas of research is foundational to improving clinical practice. The current study was undertaken to examine ... ...

Abstract	Introduction: Optimizing the effectiveness of a team-based approach to unite multiple disciplines in advancing specific translational areas of research is foundational to improving clinical practice. The current study was undertaken to examine investigators' experiences of participation in transdisciplinary team science initiatives, with a focus on challenges and recommendations for improving effectiveness. Methods: Qualitative interviews were conducted with investigators from twelve multidisciplinary teams awarded pilot research funding by the University of Kentucky College of Medicine to better understand the barriers and facilitators to effective team science within an academic medical center. An experienced qualitative researcher facilitated one-on-one interviews, which lasted about one hour. Structured consensus coding and thematic analysis were conducted. Results: The sample was balanced by gender, career stage (five were assistant professor at the time of the award, seven were senior faculty), and training (six were PhDs; six were MD physicians). Key themes at the team-level centered on the tension between clinical commitments and research pursuits and the limitations for effective team functioning. Access to tangible support from home departments and key university centers was identified as a critical organizational facilitator of successful project completion. Organizational barriers centered on operationalizing protected time for physicians, gaps in effective mentoring, and limitations in operational support. Conclusions: Prioritizing tailored mentoring and career development support for early career faculty, and particularly physician faculty, emerged as a key recommendation for improving team science in academic medical centers. The findings contribute to establishing best practices and policies for team science in academic medical centers.
Language	English
Publishing date	2023-01-23
Publishing country	England
Document type	Journal Article
ISSN	2059-8661
ISSN (online)	2059-8661
DOI	10.1017/cts.2023.3
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Article ; Online: A Bayesian Network Approach to Social and Nonsocial Cognition in Schizophrenia: Are Some Domains More Fundamental than Others?

Abplanalp, Samuel J / Lee, Junghee / Horan, William P / Kern, Robert S / Penn, David L / Green, Michael F

Schizophrenia bulletin

2023 Volume 49, Issue 4, Page(s) 997–1006

Abstract: Objectives: Social and nonsocial cognition are defined as distinct yet related constructs. However, the relative independence of individual variables-and whether specific tasks directly depend on performance in other tasks-is still unclear. The current ... ...

Abstract	Objectives: Social and nonsocial cognition are defined as distinct yet related constructs. However, the relative independence of individual variables-and whether specific tasks directly depend on performance in other tasks-is still unclear. The current study aimed to answer this question by using a Bayesian network approach to explore directional dependencies among social and nonsocial cognitive domains. Study design: The study sample comprised 173 participants with schizophrenia (71.7% male; 28.3% female). Participants completed 5 social cognitive tasks and the MATRICS Consensus Cognitive Battery. We estimated Bayesian networks using directed acyclic graph structures to examine directional dependencies among the variables. Study results: After accounting for negative symptoms and demographic variables, including age and sex, all nonsocial cognitive variables depended on processing speed. More specifically, attention, verbal memory, and reasoning and problem solving solely depended on processing speed, while a causal chain emerged between processing speed and visual memory (processing speed → attention → working memory → visual memory). Social processing variables within social cognition, including emotion in biological motion and empathic accuracy, depended on facial affect identification. Conclusions: These results suggest that processing speed and facial affect identification are fundamental domains of nonsocial and social cognition, respectively. We outline how these findings could potentially help guide specific interventions that aim to improve social and nonsocial cognition in people with schizophrenia.
MeSH term(s)	Male ; Humans ; Female ; Schizophrenia/complications ; Schizophrenia/diagnosis ; Bayes Theorem ; Cognition ; Problem Solving ; Memory, Short-Term ; Neuropsychological Tests
Language	English
Publishing date	2023-02-14
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	439173-1
ISSN	1745-1701 ; 0586-7614
ISSN (online)	1745-1701
ISSN	0586-7614
DOI	10.1093/schbul/sbad012
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Article ; Online: Effort-based decision-making as a determinant of supported employment outcomes in psychotic disorders.

Le, Thanh P / Green, Michael F / Wynn, Jonathan K / Iglesias, Julio E / Franco, Richard L / Kopelowicz, Alex / Kern, Robert S

Schizophrenia research

2023 Volume 262, Page(s) 149–155

Abstract: Schizophrenia is associated with a heavy economic burden in the United States that is partly due to the high rates of chronic unemployment. Individual Placement and Support (IPS) is an evidenced-based type of supported employment that can improve job ... ...

Abstract	Schizophrenia is associated with a heavy economic burden in the United States that is partly due to the high rates of chronic unemployment. Individual Placement and Support (IPS) is an evidenced-based type of supported employment that can improve job obtainment and work outcomes in psychotic disorders. Outcomes vary widely and a persistent challenge for IPS is low levels of engagement in the initial job search phase. Past studies have focused on interview-based motivation deficits as a key determinant of poor treatment engagement and work outcomes in schizophrenia. New validated performance-based measures of motivation, including effort-based decision-making (EBDM) tasks, may explain supported employment outcomes and provide insights into individual differences in IPS outcomes. This study investigated the degree to which IPS engagement (i.e., number of sessions attended during the first four months of service delivery) was related to baseline interview-based motivation deficits and performance on three EBDM tasks - two tasks of physical effort and one of cognitive effort (i.e., Balloon Task, Effort Expenditure for Rewards Task, Deck Choice Effort Task) - in a sample (N = 47) of people with a psychotic disorder. Results indicated that the level of EBDM performance, specifically on the Balloon Task, predicted IPS engagement, accounting for an additional 17 % of the variance above and beyond interview-based motivation deficits (total R
MeSH term(s)	Humans ; Employment, Supported ; Psychotic Disorders/complications ; Schizophrenia/complications ; Motivation ; Problem Behavior
Language	English
Publishing date	2023-11-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	639422-x
ISSN	1573-2509 ; 0920-9964
ISSN (online)	1573-2509
ISSN	0920-9964
DOI	10.1016/j.schres.2023.11.003
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Article ; Online: Sinus inflammation and chronic rhinosinusitis are associated with a diagnosis of new onset asthma in the following year.

Schwartz, Brian S / Pollak, Jonathan S / Bandeen-Roche, Karen / Hirsch, Annemarie G / Lehmann, Ashton E / Kern, Robert C / Tan, Bruce K / Kato, Atsushi / Schleimer, Robert P / Peters, Anju T

Allergy

2023 Volume 78, Issue 10, Page(s) 2659–2668

Abstract: Background: Chronic rhinosinusitis (CRS) and asthma commonly co-occur. No studies have leveraged large samples needed to formally address whether preexisting CRS is associated with new onset asthma over time.: Methods: We evaluated whether prevalent ... ...

Abstract	Background: Chronic rhinosinusitis (CRS) and asthma commonly co-occur. No studies have leveraged large samples needed to formally address whether preexisting CRS is associated with new onset asthma over time. Methods: We evaluated whether prevalent CRS [identified in two ways: validated text algorithm applied to sinus computerized tomography (CT) scan or two diagnoses] was associated with new onset adult asthma in the following year. We used electronic health record data from Geisinger from 2008 to 2019. For each year we removed persons with any evidence of asthma through the end of the year, then identified those with new diagnosis of asthma in the following year. Complementary log-log regression was used to adjust for confounding variables (e.g., sociodemographic, contact with the health system, comorbidities), and hazard ratios (HRs) and 95% confidence intervals (CI) were calculated. Results: A total of 35,441 persons were diagnosed with new onset asthma and were compared to 890,956 persons who did not develop asthma. Persons with new onset asthma tended to be female (69.6%) and younger (mean [SD] age 45.9 [17.0] years). Both CRS definitions were associated (HR, 95% CI) with new onset asthma, with 2.21 (1.93, 2.54) and 1.48 (1.38, 1.59) for CRS based on sinus CT scan and two diagnoses, respectively. New onset asthma was uncommonly observed in persons with a history of sinus surgery. Conclusion: Prevalent CRS identified with two complementary approaches was associated with a diagnosis of new onset asthma in the following year. The findings may have clinical implications for the prevention of asthma.
MeSH term(s)	Adult ; Humans ; Female ; Middle Aged ; Rhinitis/diagnosis ; Rhinitis/epidemiology ; Rhinitis/complications ; Sinusitis/diagnosis ; Sinusitis/epidemiology ; Sinusitis/complications ; Asthma/diagnosis ; Asthma/epidemiology ; Asthma/complications ; Paranasal Sinuses ; Chronic Disease ; Inflammation/complications
Language	English
Publishing date	2023-05-23
Publishing country	Denmark
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	391933-x
ISSN	1398-9995 ; 0105-4538
ISSN (online)	1398-9995
ISSN	0105-4538
DOI	10.1111/all.15771
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Article ; Online: Collaborative team dynamics and scholarly outcomes of multidisciplinary research teams: A mixed-methods approach.

Slade, Emily / Kern, Philip A / Kegebein, Robert L / Liu, Chang / Thompson, Joel C / Kelly, Thomas H / King, Victoria L / DiPaola, Robert S / Surratt, Hilary L

Journal of clinical and translational science

2023 Volume 7, Issue 1, Page(s) e59

Abstract: Introduction: Impactful, transdisciplinary scientific discoveries are created by teams of researchers spanning multiple disciplines, but collaboration across disciplines can be challenging. We examined how team dynamics and collaboration are related to ... ...

Abstract	Introduction: Impactful, transdisciplinary scientific discoveries are created by teams of researchers spanning multiple disciplines, but collaboration across disciplines can be challenging. We examined how team dynamics and collaboration are related to successes and barriers faced by teams of researchers from multiple disciplines. Methods: A mixed-methods approach was used to examine 12 research teams granted multidisciplinary pilot awards. Team members were surveyed to assess their team dynamics and individual views about transdisciplinary research. Forty-seven researchers (59.5%) responded, including two to eight members from each funded team. Associations were examined between collaborative dynamics and scholarly product outcomes, including manuscripts, grant proposals, and awarded grants. One member from each team was selected for an in-depth interview to contextualize and extend information about collaborative processes, successes, and barriers to performing transdisciplinary research. Results: Quality of team interactions was positively associated with achievement of scholarly products ( Conclusions: Both the quantitative and qualitative study results indicate that effective collaboration is critical to multidisciplinary research team success. Development and/or promotion of team science-based trainings for researchers would promote these collaborative skills.
Language	English
Publishing date	2023-02-03
Publishing country	England
Document type	Journal Article
ISSN	2059-8661
ISSN (online)	2059-8661
DOI	10.1017/cts.2023.9
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Article ; Online: Risk of new-onset and prevalent disease in chronic rhinosinusitis: A prospective cohort study.

Hirsch, Annemarie G / Schwartz, Brian S / Nordberg, Cara / Tan, Bruce K / Schleimer, Robert P / Kern, Robert C / Peters, Anju T / Bandeen-Roche, Karen / Lehmann, Ashton E

International forum of allergy & rhinology

2023 Volume 13, Issue 9, Page(s) 1715–1725

Abstract: Background: Chronic rhinosinusitis (CRS) is accompanied by burdensome comorbid conditions. Understanding the relative timing of the onset of these conditions could inform disease prevention, detection, and management.: Objective: To evaluate the ... ...

Abstract	Background: Chronic rhinosinusitis (CRS) is accompanied by burdensome comorbid conditions. Understanding the relative timing of the onset of these conditions could inform disease prevention, detection, and management. Objective: To evaluate the association between CRS and new-onset and prevalent asthma, noncystic fibrosis bronchiectasis (NCFBE), chronic obstructive pulmonary disease (COPD), gastroesophageal reflux disease (GERD), and obstructive sleep apnea (OSA). Methods: We conducted a prospective cohort study among primary care patients using a detailed medical and symptom questionnaire in 2014 and again in 2020. We used questionnaire and electronic health record (EHR) data to determine CRS status: CRS Results: There were 7847 and 4445 respondents to the 2014 and 2020 questionnaires, respectively. CRS Conclusion: The findings from the study support further exploration of CRS as a target for the prevention and detection of asthma, NCFBE, COPD, GERD, and OSA.
MeSH term(s)	Humans ; Prospective Studies ; Chronic Disease ; Gastroesophageal Reflux/epidemiology ; Pulmonary Disease, Chronic Obstructive/complications ; Asthma/epidemiology ; Sleep Apnea, Obstructive/epidemiology ; Bronchiectasis ; Sinusitis/epidemiology ; Sinusitis/complications
Language	English
Publishing date	2023-02-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2625826-2
ISSN	2042-6984 ; 2042-6976
ISSN (online)	2042-6984
ISSN	2042-6976
DOI	10.1002/alr.23136
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Article ; Online: Optimizing team science in an academic medical center

Hilary L. Surratt / Janet K. Otachi / Emily Slade / Philip A. Kern / Victoria King / Thomas H. Kelly / Robert S. DiPaola

Journal of Clinical and Translational Science, Vol

A qualitative examination of investigator perspectives

2023 Volume 7

Abstract: Abstract Introduction: Optimizing the effectiveness of a team-based approach to unite multiple disciplines in advancing specific translational areas of research is foundational to improving clinical practice. The current study was undertaken to examine ... ...

Abstract	Abstract Introduction: Optimizing the effectiveness of a team-based approach to unite multiple disciplines in advancing specific translational areas of research is foundational to improving clinical practice. The current study was undertaken to examine investigators’ experiences of participation in transdisciplinary team science initiatives, with a focus on challenges and recommendations for improving effectiveness. Methods: Qualitative interviews were conducted with investigators from twelve multidisciplinary teams awarded pilot research funding by the University of Kentucky College of Medicine to better understand the barriers and facilitators to effective team science within an academic medical center. An experienced qualitative researcher facilitated one-on-one interviews, which lasted about one hour. Structured consensus coding and thematic analysis were conducted. Results: The sample was balanced by gender, career stage (five were assistant professor at the time of the award, seven were senior faculty), and training (six were PhDs; six were MD physicians). Key themes at the team-level centered on the tension between clinical commitments and research pursuits and the limitations for effective team functioning. Access to tangible support from home departments and key university centers was identified as a critical organizational facilitator of successful project completion. Organizational barriers centered on operationalizing protected time for physicians, gaps in effective mentoring, and limitations in operational support. Conclusions: Prioritizing tailored mentoring and career development support for early career faculty, and particularly physician faculty, emerged as a key recommendation for improving team science in academic medical centers. The findings contribute to establishing best practices and policies for team science in academic medical centers.
Keywords	Team science ; career development ; program evaluation ; pilot programs ; physician scientist ; Medicine ; R
Subject code	001
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Cambridge University Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Comparing the severity of chronic rhinosinusitis symptoms before versus during the COVID-19 pandemic.

Lin, Jasmine S / Tan, Bruce / Yeh, Chen / Kern, Robert / Conley, David / Welch, Kevin / Peters, Anju / Smith, Stephanie

Laryngoscope investigative otolaryngology

2022 Volume 7, Issue 6, Page(s) 1704–1711

Abstract: Background: COVID-19 measures such as masking, social distancing, and staying indoors may mitigate chronic rhinosinusitis (CRS) symptoms. We evaluate whether these measures correlated with improved symptoms in patients with CRS.: Methods: This ... ...

Abstract	Background: COVID-19 measures such as masking, social distancing, and staying indoors may mitigate chronic rhinosinusitis (CRS) symptoms. We evaluate whether these measures correlated with improved symptoms in patients with CRS. Methods: This retrospective study compared SNOT-22 survey data from the Northwestern CRS Registry at the time of enrollment and at years 1-5 of follow-up. The final sample consisted of 1826 SNOT-22 surveys for 598 patients. April 10, 2020 to December 31, 2021 was considered "during the pandemic" and prior to March 11, 2020 was considered "pre-pandemic." Wilcoxon test was used to compare SNOT22 at enrollment pre-pandemic versus during pandemic. Separate linear mixed models were performed to estimate SNOT22 at 1 to 5 years after enrollment pre-pandemic versus during pandemic. Results: Subjects enrolled during the pandemic had worse SNOT22 scores than those enrolled pre-pandemic (53 vs. 42, Conclusions: Patients with CRS experience a greater reduction in symptom severity in their first year of treatment during the pandemic than before the pandemic, plausibly from measures such as masking and staying indoors. Level of evidence: 4.
Language	English
Publishing date	2022-10-25
Publishing country	United States
Document type	Journal Article
ISSN	2378-8038
ISSN	2378-8038
DOI	10.1002/lio2.935
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