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Article ; Online: Psychotropics drugs with cationic amphiphilic properties may afford some protection against SARS-CoV-2: A mechanistic hypothesis.

Vaugeois, Jean-Marie

2020 Volume 291, Page(s) 113220

MeSH term(s)	Amiodarone ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
Chemical Substances	Amiodarone (N3RQ532IUT)
Keywords	covid19
Language	English
Publishing date	2020-06-10
Publishing country	Ireland
Document type	Letter ; Comment
ZDB-ID	445361-x
ISSN	1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
ISSN (online)	1872-7123 ; 1872-7506
ISSN	0925-4927 ; 0165-1781
DOI	10.1016/j.psychres.2020.113220
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Article: Psychotropics drugs with cationic amphiphilic properties may afford some protection against SARS-CoV-2: A mechanistic hypothesis

Vaugeois, Jean-Marie

Psychiatry Res

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #592116
Database	COVID19

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Article ; Online: Psychotropics drugs with cationic amphiphilic properties may afford some protection against SARS-CoV-2

Vaugeois, Jean-Marie

Psychiatry Research

A mechanistic hypothesis

2020 Volume 291, Page(s) 113220

Keywords	Biological Psychiatry ; Psychiatry and Mental health ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	445361-x
ISSN	1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
ISSN (online)	1872-7123 ; 1872-7506
ISSN	0925-4927 ; 0165-1781
DOI	10.1016/j.psychres.2020.113220
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Antidepressant-like effect of low dose of scopolamine in the H/Rouen genetic mouse model of depression.

El Yacoubi, Malika / Vaugeois, Jean-Marie / Jamain, Stéphane

Fundamental & clinical pharmacology

2020 Volume 35, Issue 4, Page(s) 645–649

Abstract: Rodent models of depression are useful for the investigation of cellular and neuronal mechanisms of antidepressant drugs and for the discovery of potential new targets. In this study, we examined the antidepressant-like effect of scopolamine, a non- ... ...

Abstract	Rodent models of depression are useful for the investigation of cellular and neuronal mechanisms of antidepressant drugs and for the discovery of potential new targets. In this study, we examined the antidepressant-like effect of scopolamine, a non-selective muscarinic antagonist, in a genetic mouse model of depression obtained through a selective breeding strategy and called H/Rouen. In this model, we observed that scopolamine was active both in males and females at a lower dose (0.03 mg/kg) in the tail suspension test, 30 min following its administration, than observed in CD-1 mice. In addition, we showed this antidepressant-like effect was partly inhibited by an injection of 10 mg/kg of the AMPA receptor antagonist NBQX in both males and females, suggesting the antidepressant-like effect of scopolamine was mainly driven by AMPA receptors in the H/Rouen mouse line. Altogether, our results showed the high sensitivity of the H/Rouen mouse model of depression to study the antidepressant-like effects of pharmacological compounds.
MeSH term(s)	Animals ; Antidepressive Agents/administration & dosage ; Antidepressive Agents/pharmacology ; Disease Models, Animal ; Female ; Hindlimb Suspension ; Male ; Mice ; Mice, Inbred Strains ; Scopolamine/administration & dosage ; Scopolamine/pharmacology ; Swimming
Chemical Substances	Antidepressive Agents ; Scopolamine (DL48G20X8X)
Language	English
Publishing date	2020-12-26
Publishing country	England
Document type	Journal Article
ZDB-ID	639134-5
ISSN	1472-8206 ; 0767-3981
ISSN (online)	1472-8206
ISSN	0767-3981
DOI	10.1111/fcp.12639
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Article ; Online: Two polygenic mouse models of major depressive disorders identify TMEM161B as a potential biomarker of disease in humans.

El Yacoubi, Malika / Altersitz, Claire / Latapie, Violaine / Rizkallah, Elari / Arthaud, Sébastien / Bougarel, Laure / Pereira, Marcela / Wierinckx, Anne / El-Hage, Wissam / Belzeaux, Raoul / Turecki, Gustavo / Svenningsson, Per / Martin, Benoît / Lachuer, Joël / Vaugeois, Jean-Marie / Jamain, Stéphane

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

2024

Abstract: Treatments are only partially effective in major depressive disorders (MDD) but no biomarker exists to predict symptom improvement in patients. Animal models are essential tools in the development of antidepressant medications, but while recent genetic ... ...

Abstract	Treatments are only partially effective in major depressive disorders (MDD) but no biomarker exists to predict symptom improvement in patients. Animal models are essential tools in the development of antidepressant medications, but while recent genetic studies have demonstrated the polygenic contribution to MDD, current models are limited to either mimic the effect of a single gene or environmental factor. We developed in the past a model of depressive-like behaviors in mice (H/Rouen), using selective breeding based on behavioral reaction after an acute mild stress in the tail suspension test. Here, we propose a new mouse model of depression (H-TST) generated from a more complex genetic background and based on the same selection process. We first demonstrated that H/Rouen and H-TST mice had similar phenotypes and were more sensitive to glutamate-related antidepressant medications than selective serotonin reuptake inhibitors. We then conducted an exome sequencing on the two mouse models and showed that they had damaging variants in 174 identical genes, which have also been associated with MDD in humans. Among these genes, we showed a higher expression level of Tmem161b in brain and blood of our two mouse models. Changes in TMEM161B expression level was also observed in blood of MDD patients when compared with controls, and after 8-week treatment with duloxetine, mainly in good responders to treatment. Altogether, our results introduce H/Rouen and H-TST as the two first polygenic animal models of MDD and demonstrate their ability to identify biomarkers of the disease and to develop rapid and effective antidepressant medications.
Language	English
Publishing date	2024-02-07
Publishing country	England
Document type	Journal Article
ZDB-ID	639471-1
ISSN	1740-634X ; 0893-133X
ISSN (online)	1740-634X
ISSN	0893-133X
DOI	10.1038/s41386-024-01811-8
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Article ; Online: Validation of a Fast and Simple HPLC-UV Method for the Quantification of Adenosine Phosphates in Human Bronchial Epithelial Cells.

Juarez-Facio, Ana Teresa / Martin de Lagarde, Violaine / Monteil, Christelle / Vaugeois, Jean-Marie / Corbiere, Cécile / Rogez-Florent, Tiphaine

Molecules (Basel, Switzerland)

2021 Volume 26, Issue 20

Abstract: A new HPLC method for the simultaneous quantitative analysis of adenosine triphosphate (ATP), adenosine diphosphate (ADP), and adenosine monophosphate (AMP) was developed and validated. ATP, ADP, and AMP were extracted from human bronchial epithelial ... ...

Abstract	A new HPLC method for the simultaneous quantitative analysis of adenosine triphosphate (ATP), adenosine diphosphate (ADP), and adenosine monophosphate (AMP) was developed and validated. ATP, ADP, and AMP were extracted from human bronchial epithelial cells with a rapid extraction procedure and separated with a C18 column (3 × 150 mm, 2.7 µm) using isocratic elution with a mobile phase consisting of 50 mM of potassium hydrogen phosphate (pH 6.80). The absorbance was monitored at 254 nm. The calibration curves were linear in 0.2 to 10 µM, selective, precise, and accurate. This method allowed us to quantify the nucleotides from two cell models: differentiated NHBE primary cells grown at the air-liquid interface (ALI) and BEAS-2B cell line. Our study highlighted the development of a sensitive, simple, and green analytical method that is faster and less expensive than other existing methods to measure ATP, ADP, and AMP and can be carried out on 2D and 3D cell models.
MeSH term(s)	Adenine Nucleotides/metabolism ; Bronchi/metabolism ; Cell Line ; Chromatography, High Pressure Liquid/methods ; Epithelial Cells/metabolism ; Humans ; Indicators and Reagents/metabolism
Chemical Substances	Adenine Nucleotides ; Indicators and Reagents
Language	English
Publishing date	2021-10-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules26206324
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Article ; Online: Validation of a Fast and Simple HPLC-UV Method for the Quantification of Adenosine Phosphates in Human Bronchial Epithelial Cells

Ana Teresa Juarez-Facio / Violaine Martin de Lagarde / Christelle Monteil / Jean-Marie Vaugeois / Cécile Corbiere / Tiphaine Rogez-Florent

Molecules, Vol 26, Iss 6324, p

2021 Volume 6324

Abstract	A new HPLC method for the simultaneous quantitative analysis of adenosine triphosphate (ATP), adenosine diphosphate (ADP), and adenosine monophosphate (AMP) was developed and validated. ATP, ADP, and AMP were extracted from human bronchial epithelial cells with a rapid extraction procedure and separated with a C18 column (3 × 150 mm, 2.7 µm) using isocratic elution with a mobile phase consisting of 50 mM of potassium hydrogen phosphate (pH 6.80). The absorbance was monitored at 254 nm. The calibration curves were linear in 0.2 to 10 µM, selective, precise, and accurate. This method allowed us to quantify the nucleotides from two cell models: differentiated NHBE primary cells grown at the air–liquid interface (ALI) and BEAS-2B cell line. Our study highlighted the development of a sensitive, simple, and green analytical method that is faster and less expensive than other existing methods to measure ATP, ADP, and AMP and can be carried out on 2D and 3D cell models.
Keywords	HPLC-UV ; BEAS-2B cells ; NHBE cells ; adenosine phosphates ; cellular extraction ; Organic chemistry ; QD241-441
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Desloratadine, an FDA-approved cationic amphiphilic drug, inhibits SARS-CoV-2 infection in cell culture and primary human nasal epithelial cells by blocking viral entry.

Morin-Dewaele, Margot / Bartier, Sophie / Berry, François / Brillet, Rozenn / López-Molina, Dennis Salomón / Nguyễn, Công Trung / Maille, Pascale / Sereno, Kevin / Nevers, Quentin / Softic, Laurent / Vaugeois, Jean-Marie / Louis, Bruno / Bequignon, Emilie / Bruscella, Patrice / Coste, André / Pawlotsky, Jean-Michel / Jamain, Stéphane / Ahmed-Belkacem, Abdelhakim

Scientific reports

2022 Volume 12, Issue 1, Page(s) 21053

Abstract: The 2019 global coronavirus (COVID-19) pandemic has brought the world to a grinding halt, highlighting the urgent need for therapeutic and preventive solutions to slow the spread of emerging viruses. The objective of this study was to assess the anti- ... ...

Abstract	The 2019 global coronavirus (COVID-19) pandemic has brought the world to a grinding halt, highlighting the urgent need for therapeutic and preventive solutions to slow the spread of emerging viruses. The objective of this study was to assess the anti-SARS-CoV-2 effectiveness of 8 FDA-approved cationic amphiphilic drugs (CADs). SARS-CoV-2-infected Vero cells, Calu-3 cells and primary Human Nasal Epithelial Cells (HNEC) were used to investigate the effects of CADs and revealed their antiviral mode of action. Among the CADs tested, desloratadine, a commonly used antiallergic, well-tolerated with no major side effects, potently reduced the production of SARS-CoV-2 RNA in Vero-E6 cells. Interestingly, desloratadine was also effective against HCoV-229E and HCoV-OC43 showing that it possessed broad-spectrum anti-coronavirus activity. Investigation of its mode of action revealed that it targeted an early step of virus lifecycle and blocked SARS-CoV-2 entry through the endosomal pathway. Finally, the ex vivo kinetic of the antiviral effect of desloratadine was evaluated on primary Human Nasal Epithelial Cells (HNEC), showing a significant delay of viral RNA production with a maximal reduction reached after 72 h of treatment. Thus, this treatment could provide a substantial contribution to prophylaxis and systemic therapy of COVID-19 or other coronaviruses infections and requires further studies.
MeSH term(s)	Chlorocebus aethiops ; Animals ; Humans ; Virus Internalization ; COVID-19 ; SARS-CoV-2 ; Vero Cells ; RNA, Viral ; Cell Culture Techniques
Chemical Substances	RNA, Viral
Language	English
Publishing date	2022-12-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-25399-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Ultrafine Particles Issued from Gasoline-Fuels and Biofuel Surrogates Combustion: A Comparative Study of the Physicochemical and

Juárez-Facio, Ana Teresa / Rogez-Florent, Tiphaine / Méausoone, Clémence / Castilla, Clément / Mignot, Mélanie / Devouge-Boyer, Christine / Lavanant, Hélène / Afonso, Carlos / Morin, Christophe / Merlet-Machour, Nadine / Chevalier, Laurence / Ouf, François-Xavier / Corbière, Cécile / Yon, Jérôme / Vaugeois, Jean-Marie / Monteil, Christelle

Toxics

2022 Volume 11, Issue 1

Abstract: Gasoline emissions contain high levels of pollutants, including particulate matter (PM), which are associated with several health outcomes. Moreover, due to the depletion of fossil fuels, biofuels represent an attractive alternative, particularly second- ... ...

Abstract	Gasoline emissions contain high levels of pollutants, including particulate matter (PM), which are associated with several health outcomes. Moreover, due to the depletion of fossil fuels, biofuels represent an attractive alternative, particularly second-generation biofuels (B2G) derived from lignocellulosic biomass. Unfortunately, compared to the abundant literature on diesel and gasoline emissions, relatively few studies are devoted to alternative fuels and their health effects. This study aimed to compare the adverse effects of gasoline and B2G emissions on human bronchial epithelial cells. We characterized the emissions generated by propane combustion (CAST1), gasoline Surrogate, and B2G consisting of Surrogate blended with anisole (10%) (S+10A) or ethanol (10%) (S+10E). To study the cellular effects, BEAS-2B cells were cultured at air-liquid interface for seven days and exposed to different emissions. Cell viability, oxidative stress, inflammation, and xenobiotic metabolism were measured. mRNA expression analysis was significantly modified by the Surrogate S+10A and S+10E emissions, especially
Language	English
Publishing date	2022-12-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2733883-6
ISSN	2305-6304 ; 2305-6304
ISSN (online)	2305-6304
ISSN	2305-6304
DOI	10.3390/toxics11010021
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Development of a standardized in vitro approach to evaluate microphysical, chemical, and toxicological properties of combustion-derived fine and ultrafine particles.

Juarez-Facio, Ana Teresa / Castilla, Clément / Corbière, Cécile / Lavanant, Hélène / Afonso, Carlos / Morin, Christophe / Merlet-Machour, Nadine / Chevalier, Laurence / Vaugeois, Jean-Marie / Yon, Jérôme / Monteil, Christelle

Journal of environmental sciences (China)

2021 Volume 113, Page(s) 104–117

Abstract: Ultrafine particles represent a growing concern in the public health community but their precise role in many illnesses is still unknown. This lack of knowledge is related to the experimental difficulty in linking their biological effects to their ... ...

Abstract	Ultrafine particles represent a growing concern in the public health community but their precise role in many illnesses is still unknown. This lack of knowledge is related to the experimental difficulty in linking their biological effects to their multiple properties, which are important determinants of toxicity. Our aim is to propose an interdisciplinary approach to study fine (FP) and ultrafine (UFP) particles, generated in a controlled manner using a miniCAST (Combustion Aerosol Standard) soot generator used with two different operating conditions (CAST1 and CAST3). The chemical characterization was performed by an untargeted analysis using ultra-high resolution mass spectrometry. In conjunction with this approach, subsequent analysis by gas chromatography-mass spectrometry (GC-MS) was performed to identify polycyclic aromatic hydrocarbons (PAH). CAST1 enabled the generation of FP with a predominance of small PAH molecules, and CAST3 enabled the generation of UFP, which presented higher numbers of carbon atoms corresponding to larger PAH molecules. Healthy normal human bronchial epithelial (NHBE) cells differentiated at the air-liquid interface (ALI) were directly exposed to these freshly emitted FP and UFP. Expression of MUC5AC, FOXJ1, OCLN and ZOI as well as microscopic observation confirmed the ciliated pseudostratified epithelial phenotype. Study of the mass deposition efficiency revealed a difference between the two operating conditions, probably due to the morphological differences between the two categories of particles. We demonstrated that only NHBE cells exposed to CAST3 particles induced upregulation in the gene expression of IL-8 and NQO1. This approach offers new perspectives to study FP and UFP with stable and controlled properties.
MeSH term(s)	Aerosols ; Air Pollutants/analysis ; Air Pollutants/toxicity ; Epithelial Cells/chemistry ; Humans ; Particle Size ; Particulate Matter/analysis ; Particulate Matter/toxicity ; Polycyclic Aromatic Hydrocarbons/analysis ; Polycyclic Aromatic Hydrocarbons/toxicity ; Soot
Chemical Substances	Aerosols ; Air Pollutants ; Particulate Matter ; Polycyclic Aromatic Hydrocarbons ; Soot
Language	English
Publishing date	2021-06-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1092300-7
ISSN	1878-7320 ; 1001-0742
ISSN (online)	1878-7320
ISSN	1001-0742
DOI	10.1016/j.jes.2021.06.001
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