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Article ; Online: Pictorial Review of Pleural Disease: Multimodality Imaging and Differential Diagnosis.

Yamada, Aya / Taiji, Ryosuke / Nishimoto, Yuko / Itoh, Takahiro / Marugami, Aki / Yamauchi, Satoshi / Minamiguchi, Kiyoyuki / Yanagawa, Masahiro / Tomiyama, Noriyuki / Tanaka, Toshihiro

Radiographics : a review publication of the Radiological Society of North America, Inc

2024 Volume 44, Issue 4, Page(s) e230079

Abstract: The pleura is a thin, smooth, soft-tissue structure that lines the pleural cavity and separates the lungs from the chest wall, consisting of the visceral and parietal pleurae and physiologic pleural fluid. There is a broad spectrum of normal variations ... ...

Abstract	The pleura is a thin, smooth, soft-tissue structure that lines the pleural cavity and separates the lungs from the chest wall, consisting of the visceral and parietal pleurae and physiologic pleural fluid. There is a broad spectrum of normal variations and abnormalities in the pleura, including pneumothorax, pleural effusion, and pleural thickening. Pneumothorax is associated with pulmonary diseases and is caused by iatrogenic or traumatic factors. Chest radiography and US help detect pneumothorax with various signs, and CT can also help assess the causes. Pleural effusion occurs in a wide spectrum of diseases, such as heart failure, cirrhosis, asbestos-related diseases, infections, chylothorax, and malignancies. Chest US allows detection of a small pleural effusion and evaluation of echogenicity or septa in pleural effusion. Pleural thickening may manifest as unilateral or bilateral and as focal, multifocal, or diffuse. Various diseases can demonstrate pleural thickening, such as asbestos-related diseases, neoplasms, and systemic diseases. CT, MRI, and fluorodeoxyglucose (FDG) PET/CT can help differentiate between benign and malignant lesions. Knowledge of these features can aid radiologists in suggesting diagnoses and recommending further examinations with other imaging modalities. The authors provide a comprehensive review of the clinical and multimodality imaging findings of pleural diseases and their differential diagnoses.
MeSH term(s)	Humans ; Diagnosis, Differential ; Pneumothorax/complications ; Positron Emission Tomography Computed Tomography ; Pleural Diseases/diagnostic imaging ; Pleural Effusion/complications ; Asbestos ; Pleural Neoplasms/complications
Chemical Substances	Asbestos (1332-21-4)
Language	English
Publishing date	2024-03-28
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	603172-9
ISSN	1527-1323 ; 0271-5333
ISSN (online)	1527-1323
ISSN	0271-5333
DOI	10.1148/rg.230079
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Zs.A 1751: Show issues

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Article ; Online: An evaluation method for developing abuse-deterrent opioid formulations with agonist and antagonist combinations using conditioned place preference.

Zhang, Xinjian / Kitaichi, Kiyoyuki / Mouri, Akihiro / Zhou, Xinzhu / Nabeshima, Toshitaka / Yamada, Kiyofumi / Nagai, Taku

Biochemical and biophysical research communications

2022 Volume 639, Page(s) 100–105

Abstract: Although opioids are useful narcotic analgesics in clinical settings, their misuse and addiction in the United States of America and other countries are rapidly increasing. Therefore, the development of abuse-deterrent formulations is an urgent issue. We ...

Abstract	Although opioids are useful narcotic analgesics in clinical settings, their misuse and addiction in the United States of America and other countries are rapidly increasing. Therefore, the development of abuse-deterrent formulations is an urgent issue. We herein investigated how to select the ratio of an opioid and the opioid receptor antagonist, naloxone in abuse-deterrent formulations for mice. The conditioned place preference (CPP) test was used to evaluate the rewarding effects of abused drugs. The opioids morphine (30 μmol/kg), oxycodone (3 μmol/kg), fentanyl (0.4 μmol/kg), and buprenorphine (0.5 μmol/kg) significantly induced place preference in mice. We also examined the optimal ratio of naloxone and opioids to inhibit the rewarding effects of the latter. Naloxone (3-5 μmol/kg) effectively inhibited place preference induced by the opioids tested. We calculated theoretical drug doses that exerted the same pharmacodynamic effects based on two parameters: μ-opioid receptor binding affinity and blood-brain barrier (BBB) permeability. Theoretical doses were very close to the drug doses at which mice showed place preference. Therefore, the CPP test is useful as a behavioral method for evaluating abuse-deterrent formulations of opioids mixed with an antagonist. The ratio of naloxone with opioids, at which mice did not show place preference, may be an effective index for developing abuse-deterrent formulations. Ratios may be calculated for other opioids based on μ-opioid receptor binding affinity and BBB permeability.
MeSH term(s)	Mice ; United States ; Animals ; Analgesics, Opioid/pharmacology ; Opioid-Related Disorders/prevention & control ; Abuse-Deterrent Formulations ; Naloxone ; Narcotic Antagonists/pharmacology ; Narcotic Antagonists/therapeutic use
Chemical Substances	Analgesics, Opioid ; Abuse-Deterrent Formulations ; Naloxone (36B82AMQ7N) ; Narcotic Antagonists
Language	English
Publishing date	2022-11-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2022.11.072
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Zs.A 116: Show issues

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Article ; Online: Simplified daptomycin dosing regimen for adult patients with methicillin-resistant Staphylococcus aureus infections based on population pharmacokinetic analysis.

Yamada, Takaaki / Soda, Midori / Nishida, Ruriko / Miyake, Noriko / Maeshiro, Yasutaka / Oida, Yasuhisa / Yamashita, Yuji / Egashira, Nobuaki / Shimono, Nobuyuki / Kitaichi, Kiyoyuki / Ieiri, Ichiro

Drug metabolism and pharmacokinetics

2022 Volume 44, Page(s) 100444

Abstract: Daptomycin is used to treat methicillin-resistant Staphylococcus aureus (MRSA) infections. Current guidelines recommend higher daptomycin doses (8-10 mg/kg) for severe infections; however, pharmacokinetic (PK) and pharmacodynamic-based dosing strategies ... ...

Abstract	Daptomycin is used to treat methicillin-resistant Staphylococcus aureus (MRSA) infections. Current guidelines recommend higher daptomycin doses (8-10 mg/kg) for severe infections; however, pharmacokinetic (PK) and pharmacodynamic-based dosing strategies are still limited. Therefore, we designed a new optimal daptomycin dosing regimen for patients with MRSA infections using a population PK modeling approach. A total of 110 plasma concentrations from 47 adult patients who received daptomycin in general wards were enrolled for population PK modeling. The target area under the concentration-time curve/minimum inhibitory concentration (MIC) ratio, target peak/MIC ratio, and threshold of the trough concentration for safety were set to >666, >60, and 24.3 mg/L, respectively. Renal function was indicated as a significant covariate for daptomycin clearance. The simulated probability of target attainment was more than 90% at MIC values of 0.25 and 0.5 mg/L in all patients at the standard dose (6 mg/kg). In contrast, comprehensive simulation assessments recommended 10 mg/kg every 24 h in patients with creatinine clearance >60 mL/min for MIC values of 1.0 mg/L. We propose a new simplified daptomycin dosing regimen stratified by renal function and MIC values based on PK model-based simulation analyses. The proposed regimen is expected to maximize clinical efficacy and minimize adverse events.
MeSH term(s)	Adult ; Anti-Bacterial Agents ; Daptomycin/pharmacology ; Daptomycin/therapeutic use ; Humans ; Methicillin-Resistant Staphylococcus aureus ; Microbial Sensitivity Tests
Chemical Substances	Anti-Bacterial Agents ; Daptomycin (NWQ5N31VKK)
Language	English
Publishing date	2022-01-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2095748-8
ISSN	1880-0920 ; 1347-4367 ; 0916-1139
ISSN (online)	1880-0920
ISSN	1347-4367 ; 0916-1139
DOI	10.1016/j.dmpk.2022.100444
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Zs.A 3734: Show issues

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Article ; Online: Cytotoxic substances from two species of Japanese sea hares: chemistry and bioactivity.

Yamada, Kiyoyuki / Ojika, Makoto / Kigoshi, Hideo / Suenaga, Kiyotake

Proceedings of the Japan Academy. Series B, Physical and biological sciences

2010 Volume 86, Issue 3, Page(s) 176–189

Abstract: From the sea hares belonging to two genera, Aplysia and Dolabella, a variety of new cytotoxic substances were isolated as minute constituents: their chemical structures were determined and their cytotoxicity was evaluated. Regarding the highly cytotoxic ... ...

Abstract	From the sea hares belonging to two genera, Aplysia and Dolabella, a variety of new cytotoxic substances were isolated as minute constituents: their chemical structures were determined and their cytotoxicity was evaluated. Regarding the highly cytotoxic substances, further chemical and biological studies were performed that included their asymmetric chemical synthesis and elucidation of biological characteristics such as antitumor activity.
MeSH term(s)	Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Aplysia/chemistry ; Cell Death/drug effects ; Drug Screening Assays, Antitumor ; Japan ; Peptides/chemistry ; Peptides/isolation & purification ; Peptides/pharmacology ; Structure-Activity Relationship ; Toxins, Biological/chemistry ; Toxins, Biological/isolation & purification ; Toxins, Biological/pharmacology ; Toxins, Biological/toxicity
Chemical Substances	Antineoplastic Agents ; Peptides ; Toxins, Biological
Language	English
Publishing date	2010-03-15
Publishing country	Japan
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	161781-3
ISSN	1349-2896 ; 0386-2208
ISSN (online)	1349-2896
ISSN	0386-2208
DOI	10.2183/pjab.86.176
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Article ; Online: Mitral valve repair during acute phase infective endocarditis with extensive destruction of the anterior leaflet rough zone and cerebral infarction.

Hisatomi, Kazuki / Yamada, Takafumi / Odate, Tomohiro / Yamashita, Kizuku / Eishi, Kiyoyuki

General thoracic and cardiovascular surgery

2012 Volume 60, Issue 8, Page(s) 507–510

Abstract: Some reports suggest that mitral valve repair has good outcomes and may, therefore, be the preferred surgical approach in patients with active infective endocarditis (Doukas et al. in Heart 92(3):361-363, 2006); Ruttmann et al. in J Thorac Cardiovasc ... ...

Abstract	Some reports suggest that mitral valve repair has good outcomes and may, therefore, be the preferred surgical approach in patients with active infective endocarditis (Doukas et al. in Heart 92(3):361-363, 2006); Ruttmann et al. in J Thorac Cardiovasc Surg 130(3):765-771, 2005; Sternik et al. in J Heart Valve Dis 11(1):91-97, 2002). However, in cases of active infective endocarditis of the mitral valve, extensive destruction of valvular tissue may make reliable valve repair difficult. Moreover, the timing of valve repair for active infective endocarditis remains controversial, especially in patients having cerebral complications. We present a case of a 34-year-old woman who had active infective endocarditis of the mitral valve complicated by multiple acute cerebral infarctions from septic embolisation. We could successfully carry out mitral valve repair 36 h after the diagnosis of active infective endocarditis and cerebral infarction was made. Her postoperative course was uneventful, and the patient remained in good health without recurrence of infective endocarditis and neurological complications.
MeSH term(s)	Adult ; Anti-Bacterial Agents/therapeutic use ; Cerebral Infarction/diagnosis ; Cerebral Infarction/microbiology ; Echocardiography, Doppler ; Endocarditis, Bacterial/diagnosis ; Endocarditis, Bacterial/drug therapy ; Endocarditis, Bacterial/microbiology ; Female ; Heart Valve Prosthesis Implantation/instrumentation ; Humans ; Magnetic Resonance Imaging ; Mitral Valve/microbiology ; Mitral Valve/surgery ; Mitral Valve Annuloplasty/instrumentation ; Streptococcal Infections/complications ; Streptococcal Infections/diagnosis ; Streptococcal Infections/drug therapy ; Streptococcal Infections/microbiology ; Streptococcus/isolation & purification ; Time Factors ; Treatment Outcome
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2012-05-19
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	2376888-5
ISSN	1863-6713 ; 1863-6705
ISSN (online)	1863-6713
ISSN	1863-6705
DOI	10.1007/s11748-012-0036-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1173: Show issues

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Article: Aplyronine A, a potent antitumour macrolide of marine origin, and the congeners aplyronines B-H: chemistry and biology.

Yamada, Kiyoyuki / Ojika, Makoto / Kigoshi, Hideo / Suenaga, Kiyotake

Natural product reports

2009 Volume 26, Issue 1, Page(s) 27–43

Abstract: Aplyronines A-H are cytotoxic macrolides isolated from the sea hare Aplysia kurodai. Aplyronine A is the major constituent among the aplyronines, and this review concentrates on the results of chemical and biological research into this natural product. ... ...

Abstract	Aplyronines A-H are cytotoxic macrolides isolated from the sea hare Aplysia kurodai. Aplyronine A is the major constituent among the aplyronines, and this review concentrates on the results of chemical and biological research into this natural product. The isolation, determination of stereostructure and enantioselective total synthesis of the aplyronines are covered, together with discussion of their antitumour activity and structure-activity relationships, and the three-dimensional X-ray structure of the actin-aplyronine A complex.
MeSH term(s)	Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/isolation & purification ; Antineoplastic Agents/pharmacology ; Aplysia/chemistry ; Crystallography, X-Ray ; Lactones/chemistry ; Lactones/isolation & purification ; Lactones/pharmacology ; Macrolides/chemical synthesis ; Macrolides/chemistry ; Macrolides/pharmacology ; Marine Biology ; Marine Toxins/chemistry ; Marine Toxins/metabolism ; Molecular Conformation ; Molecular Structure ; Serine/analogs & derivatives ; Serine/chemistry ; Serine/isolation & purification ; Serine/pharmacology ; Stereoisomerism ; Structure-Activity Relationship
Chemical Substances	Antineoplastic Agents ; Lactones ; Macrolides ; Marine Toxins ; aplyronine A (151923-84-1) ; Serine (452VLY9402)
Language	English
Publishing date	2009-04-15
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2002546-4
ISSN	1460-4752 ; 0265-0568
ISSN (online)	1460-4752
ISSN	0265-0568
DOI	10.1039/b800263k
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Ptaquiloside, the major toxin of bracken, and related terpene glycosides: chemistry, biology and ecology.

Yamada, Kiyoyuki / Ojika, Makoto / Kigoshi, Hideo

Natural product reports

2007 Volume 24, Issue 4, Page(s) 798–813

Abstract: Bracken (Pteridium spp.) is a ubiquitous fern which has been described as one of the five most common plants on the earth. The toxic effects of bracken on livestock have been recorded since the end of the 19th century, and extensive and intensive ... ...

Abstract	Bracken (Pteridium spp.) is a ubiquitous fern which has been described as one of the five most common plants on the earth. The toxic effects of bracken on livestock have been recorded since the end of the 19th century, and extensive and intensive investigations for the bracken toxin(s) led to the isolation of ptaquiloside in 1983 as the major, but unstable, toxin of bracken. This review concentrates mainly on the results of the scientific investigations into ptaquiloside, and cites 133 references.
MeSH term(s)	Ecology ; Ferns/chemistry ; Glycosides/chemistry ; Glycosides/isolation & purification ; Glycosides/toxicity ; Indans/chemistry ; Indans/isolation & purification ; Indans/toxicity ; Molecular Structure ; Plants, Toxic/chemistry ; Sesquiterpenes/chemistry ; Sesquiterpenes/isolation & purification ; Sesquiterpenes/toxicity
Chemical Substances	Glycosides ; Indans ; Sesquiterpenes ; ptaquiloside (F0MN9S5699)
Language	English
Publishing date	2007-08
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2002546-4
ISSN	1460-4752 ; 0265-0568
ISSN (online)	1460-4752
ISSN	0265-0568
DOI	10.1039/b614160a
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Article: Aplyronine A, a potent antitumour macrolide of marine origin, and the congeners aplyronines B–H: chemistry and biology

Yamada, Kiyoyuki / Ojika, Makoto / Kigoshi, Hideo / Suenaga, Kiyotake

Natural product reports. 2008 Dec. 18, v. 26, no. 1

2008

Abstract: Aplyronines A–H are cytotoxic macrolides isolated from the sea hare Aplysia kurodai. Aplyronine A is the major constituent among the aplyronines, and this review concentrates on the results of chemical and biological research into this natural product. ... ...

Abstract	Aplyronines A–H are cytotoxic macrolides isolated from the sea hare Aplysia kurodai. Aplyronine A is the major constituent among the aplyronines, and this review concentrates on the results of chemical and biological research into this natural product. The isolation, determination of stereostructure and enantioselective total synthesis of the aplyronines are covered, together with discussion of their antitumour activity and structure–activity relationships, and the three-dimensional X-ray structure of the actin–aplyronine A complex.
Keywords	Aplysia ; X-radiation ; antineoplastic activity ; cytotoxicity ; enantioselectivity ; macrolides
Language	English
Dates of publication	2008-1218
Size	p. 27-43.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2002546-4
ISSN	1460-4752 ; 0265-0568
ISSN (online)	1460-4752
ISSN	0265-0568
DOI	10.1039/b800263k
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Custom-made titanium devices as membranes for bone augmentation in implant treatment: Modeling accuracy of titanium products constructed with selective laser melting.

Otawa, Naruto / Sumida, Tomoki / Kitagaki, Hisashi / Sasaki, Kiyoyuki / Fujibayashi, Shunsuke / Takemoto, Mitsuru / Nakamura, Takashi / Yamada, Tomohiro / Mori, Yoshihide / Matsushita, Tomiharu

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery

2015 Volume 43, Issue 7, Page(s) 1289–1295

Abstract: Objective: The purpose of this study was to verify the modeling accuracy of various products, and to produce custom-made devices for bone augmentation in individual patients requiring implantation.: Materials and methods: Two-(2D) and three- ... ...

Abstract	Objective: The purpose of this study was to verify the modeling accuracy of various products, and to produce custom-made devices for bone augmentation in individual patients requiring implantation. Materials and methods: Two-(2D) and three-dimensional (3D) specimens and custom-made devices that were designed as membranes for guided bone regeneration (GBR) were produced using a computer-aided design (CAD) and rapid prototyping (RP) method. The CAD design was produced using a 3D printing machine and selective laser melting (SLM) with pure titanium (Ti) powder. The modeling accuracy was evaluated with regard to: the dimensional accuracy of the 2D and 3D specimens; the accuracy of pore structure of the 2D specimens; the accuracy of porosity of the 3D specimens; and the error between CAD design and the scanned real product by overlapped images. Results: The accuracy of the 2D and 3D specimens indicated precise results in various parameters, which were tolerant in ISO 2768-1. The error of overlapped images between the CAD and scanned data indicated that accuracy was sufficient for GBR. In integrating area of all devices, the maximum and average error were 292 and 139 μm, respectively. Conclusions: High modeling accuracy can be achieved in various products using the CAD/RP-SLM method. These results suggest the possibility of clinical applications.
MeSH term(s)	Computer-Aided Design/instrumentation ; Female ; Humans ; Lasers ; Male ; Prostheses and Implants ; Titanium/chemistry ; Titanium/therapeutic use
Chemical Substances	Titanium (D1JT611TNE)
Language	English
Publishing date	2015-09
Publishing country	Scotland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	91267-0
ISSN	1878-4119 ; 1010-5182 ; 0301-0503
ISSN (online)	1878-4119
ISSN	1010-5182 ; 0301-0503
DOI	10.1016/j.jcms.2015.05.006
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Zs.A 882: Show issues

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Article: Ptaquiloside, the major toxin of bracken, and related terpene glycosides: chemistry, biology and ecology

Yamada, Kiyoyuki / Ojika, Makoto / Kigoshi, Hideo

Natural product reports. 2007 July 25, v. 24, no. 4

2007

Abstract	Bracken (Pteridium spp.) is a ubiquitous fern which has been described as one of the five most common plants on the earth. The toxic effects of bracken on livestock have been recorded since the end of the 19th century, and extensive and intensive investigations for the bracken toxin(s) led to the isolation of ptaquiloside in 1983 as the major, but unstable, toxin of bracken. This review concentrates mainly on the results of the scientific investigations into ptaquiloside, and cites 133 references.
Keywords	Pteridium ; chemistry ; ecology ; ferns and fern allies ; glycosides ; livestock ; ptaquiloside ; toxicity ; toxins
Language	English
Dates of publication	2007-0725
Size	p. 798-813.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2002546-4
ISSN	1460-4752 ; 0265-0568
ISSN (online)	1460-4752
ISSN	0265-0568
DOI	10.1039/b614160a
Database	NAL-Catalogue (AGRICOLA)

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