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  1. Article ; Online: The migration behavior of human glioblastoma cells is influenced by the redox-sensitive human macrophage capping protein CAPG.

    Prescher, Nina / Hänsch, Sebastian / Knobbe-Thomsen, Christiane B / Stühler, Kai / Poschmann, Gereon

    Free radical biology & medicine

    2021  Volume 167, Page(s) 81–93

    Abstract: The macrophage capping protein CAPG belongs to the gelsolin superfamily which modulates actin dynamics by capping the growing end of actin filaments in a ... ...

    Abstract The macrophage capping protein CAPG belongs to the gelsolin superfamily which modulates actin dynamics by capping the growing end of actin filaments in a Ca
    MeSH term(s) Actins/genetics ; Actins/metabolism ; Cell Line, Tumor ; Cell Movement ; Glioblastoma/genetics ; Humans ; Macrophages/metabolism ; Microfilament Proteins ; Nuclear Proteins ; Oxidation-Reduction
    Chemical Substances Actins ; Microfilament Proteins ; Nuclear Proteins ; CAPG protein, human (148412-71-9)
    Language English
    Publishing date 2021-03-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 807032-5
    ISSN 1873-4596 ; 0891-5849
    ISSN (online) 1873-4596
    ISSN 0891-5849
    DOI 10.1016/j.freeradbiomed.2021.02.038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2109: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: Correction: EGFR Cooperates with EGFRvIII to Recruit Macrophages in Glioblastoma.

    An, Zhenyi / Knobbe-Thomsen, Christiane B / Wan, Xiaohua / Fan, Qi Wen / Reifenberger, Guido / Weiss, William A

    Cancer research

    2019  Volume 79, Issue 21, Page(s) 5681

    Language English
    Publishing date 2019-11-01
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-19-2800
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Advances in the molecular genetics of gliomas - implications for classification and therapy.

    Reifenberger, Guido / Wirsching, Hans-Georg / Knobbe-Thomsen, Christiane B / Weller, Michael

    Nature reviews. Clinical oncology

    2017  Volume 14, Issue 7, Page(s) 434–452

    Abstract: Genome-wide molecular-profiling studies have revealed the characteristic genetic alterations and epigenetic profiles associated with different types of gliomas. These molecular characteristics can be used to refine glioma classification, to improve ... ...

    Abstract Genome-wide molecular-profiling studies have revealed the characteristic genetic alterations and epigenetic profiles associated with different types of gliomas. These molecular characteristics can be used to refine glioma classification, to improve prediction of patient outcomes, and to guide individualized treatment. Thus, the WHO Classification of Tumours of the Central Nervous System was revised in 2016 to incorporate molecular biomarkers - together with classic histological features - in an integrated diagnosis, in order to define distinct glioma entities as precisely as possible. This paradigm shift is markedly changing how glioma is diagnosed, and has important implications for future clinical trials and patient management in daily practice. Herein, we highlight the developments in our understanding of the molecular genetics of gliomas, and review the current landscape of clinically relevant molecular biomarkers for use in classification of the disease subtypes. Novel approaches to the genetic characterization of gliomas based on large-scale DNA-methylation profiling and next-generation sequencing are also discussed. In addition, we illustrate how advances in the molecular genetics of gliomas can promote the development and clinical translation of novel pathogenesis-based therapeutic approaches, thereby paving the way towards precision medicine in neuro-oncology.
    MeSH term(s) Central Nervous System Neoplasms/classification ; Central Nervous System Neoplasms/genetics ; Central Nervous System Neoplasms/pathology ; Central Nervous System Neoplasms/therapy ; Glioma/classification ; Glioma/genetics ; Glioma/pathology ; Glioma/therapy ; Humans ; Molecular Biology ; Practice Guidelines as Topic ; World Health Organization
    Language English
    Publishing date 2017-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2491410-1
    ISSN 1759-4782 ; 1759-4774
    ISSN (online) 1759-4782
    ISSN 1759-4774
    DOI 10.1038/nrclinonc.2016.204
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6029: Show issues Location:
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    Zs.MG 103: Show issues

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  4. Conference proceedings: Characterization of the Endocannabinoid System in Gliomas and its Implication for novel Treatment Concepts

    Eifer, Anna Henriette / Knobbe-Thomsen, Christiane B. / Reifenberger, Guido

    2016  , Page(s) 16dgnnP42

    Event/congress Joint-Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN) and the Scandinavian Neuropathological Society (SNS); Hamburg; ; Scandinavian Neuropathological Society; 2016
    Keywords Medizin, Gesundheit
    Publishing date 2016-09-14
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/16dgnn44
    Database German Medical Science

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  5. Conference proceedings: Molecular and functional characterization of SMOC1 in IDH1 wild type and IDH1 mutant gliomas

    Weber, Marc Maximilian / Kaisers, Wolfgang / Reifenberger, Guido / Knobbe-Thomsen, Christiane B.

    2016  , Page(s) 16dgnnP39

    Event/congress Joint-Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN) and the Scandinavian Neuropathological Society (SNS); Hamburg; ; Scandinavian Neuropathological Society; 2016
    Keywords Medizin, Gesundheit
    Publishing date 2016-09-14
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/16dgnn42
    Database German Medical Science

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  6. Article ; Online: EGFR Cooperates with EGFRvIII to Recruit Macrophages in Glioblastoma.

    An, Zhenyi / Knobbe-Thomsen, Christiane B / Wan, Xiaohua / Fan, Qi Wen / Reifenberger, Guido / Weiss, William A

    Cancer research

    2018  Volume 78, Issue 24, Page(s) 6785–6794

    Abstract: Amplification of ... ...

    Abstract : Amplification of the
    MeSH term(s) Animals ; Brain Neoplasms/metabolism ; Cell Line, Tumor ; Cell Movement ; Chemokine CCL2/metabolism ; Cytokines/metabolism ; ErbB Receptors/metabolism ; Female ; Gene Expression Regulation, Neoplastic ; Glioblastoma/metabolism ; Humans ; Macrophages/metabolism ; Mice ; Microglia/metabolism ; Neoplasm Transplantation ; Phosphorylation ; Proto-Oncogene Proteins p21(ras)/metabolism ; RNA, Small Interfering/metabolism ; Signal Transduction ; Tumor Microenvironment ; Up-Regulation
    Chemical Substances CCL2 protein, human ; Chemokine CCL2 ; Cytokines ; KRAS protein, human ; RNA, Small Interfering ; epidermal growth factor receptor VIII ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1) ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2)
    Language English
    Publishing date 2018-11-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-17-3551
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.135/5: Show issues Location:
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  7. Article ; Online: A sensitive and simple targeted proteomics approach to quantify transcription factor and membrane proteins of the unfolded protein response pathway in glioblastoma cells.

    Nguyen, Chi D L / Malchow, Sebastian / Reich, Stefan / Steltgens, Sascha / Shuvaev, Konstantin V / Loroch, Stefan / Lorenz, Christin / Sickmann, Albert / Knobbe-Thomsen, Christiane B / Tews, Björn / Medenbach, Jan / Ahrends, Robert

    Scientific reports

    2019  Volume 9, Issue 1, Page(s) 8836

    Abstract: Many cellular events are driven by changes in protein expression, measurable by mass spectrometry or antibody-based assays. However, using conventional technology, the analysis of transcription factor or membrane receptor expression is often limited by ... ...

    Abstract Many cellular events are driven by changes in protein expression, measurable by mass spectrometry or antibody-based assays. However, using conventional technology, the analysis of transcription factor or membrane receptor expression is often limited by an insufficient sensitivity and specificity. To overcome this limitation, we have developed a high-resolution targeted proteomics strategy, which allows quantification down to the lower attomol range in a straightforward way without any prior enrichment or fractionation approaches. The method applies isotope-labeled peptide standards for quantification of the protein of interest. As proof of principle, we applied the improved workflow to proteins of the unfolded protein response (UPR), a signaling pathway of great clinical importance, and could for the first time detect and quantify all major UPR receptors, transducers and effectors that are not readily detectable via antibody-based-, SRM- or conventional PRM assays. As transcription and translation is central to the regulation of UPR, quantification and determination of protein copy numbers in the cell is important for our understanding of the signaling process as well as how pharmacologic modulation of these pathways impacts on the signaling. These questions can be answered using our newly established workflow as exemplified in an experiment using UPR perturbation in a glioblastoma cell lines.
    MeSH term(s) Cell Line, Tumor ; Gene Dosage ; Glioblastoma/chemistry ; Glioblastoma/metabolism ; Glioblastoma/pathology ; Humans ; Isotope Labeling ; Membrane Proteins/analysis ; Membrane Proteins/metabolism ; Membrane Proteins/standards ; Peptides/standards ; Proteomics/methods ; Proteomics/standards ; Transcription Factors/analysis ; Transcription Factors/metabolism ; Transcription Factors/standards ; Unfolded Protein Response
    Chemical Substances Membrane Proteins ; Peptides ; Transcription Factors
    Language English
    Publishing date 2019-06-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-019-45237-5
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  8. Article ; Online: A multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites.

    Reich, Stefan / Nguyen, Chi D L / Has, Canan / Steltgens, Sascha / Soni, Himanshu / Coman, Cristina / Freyberg, Moritz / Bichler, Anna / Seifert, Nicole / Conrad, Dominik / Knobbe-Thomsen, Christiane B / Tews, Björn / Toedt, Grischa / Ahrends, Robert / Medenbach, Jan

    Nature communications

    2020  Volume 11, Issue 1, Page(s) 2936

    Abstract: Stress response pathways are critical for cellular homeostasis, promoting survival through adaptive changes in gene expression and metabolism. They play key roles in numerous diseases and are implicated in cancer progression and chemoresistance. However, ...

    Abstract Stress response pathways are critical for cellular homeostasis, promoting survival through adaptive changes in gene expression and metabolism. They play key roles in numerous diseases and are implicated in cancer progression and chemoresistance. However, the underlying mechanisms are only poorly understood. We have employed a multi-omics approach to monitor changes to gene expression after induction of a stress response pathway, the unfolded protein response (UPR), probing in parallel the transcriptome, the proteome, and changes to translation. Stringent filtering reveals the induction of 267 genes, many of which have not previously been implicated in stress response pathways. We experimentally demonstrate that UPR-mediated translational control induces the expression of enzymes involved in a pathway that diverts intermediate metabolites from glycolysis to fuel mitochondrial one-carbon metabolism. Concomitantly, the cells become resistant to the folate-based antimetabolites Methotrexate and Pemetrexed, establishing a direct link between UPR-driven changes to gene expression and resistance to pharmacological treatment.
    MeSH term(s) Animals ; Antimetabolites/pharmacology ; Endoplasmic Reticulum/drug effects ; Endoplasmic Reticulum/metabolism ; Folic Acid/pharmacology ; Humans ; Methotrexate/pharmacology ; Pemetrexed/pharmacology ; Proteome/drug effects ; Proteome/genetics ; Regulon/drug effects ; Regulon/genetics ; Signal Transduction/drug effects ; Transcriptome/drug effects ; Transcriptome/genetics ; Unfolded Protein Response/drug effects ; Unfolded Protein Response/genetics
    Chemical Substances Antimetabolites ; Proteome ; Pemetrexed (04Q9AIZ7NO) ; Folic Acid (935E97BOY8) ; Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2020-06-10
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-020-16747-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: USP8

    Ballmann, Cora / Thiel, Anne / Korah, Hannah E / Reis, Anna-Carinna / Saeger, Wolfgang / Stepanow, Stefanie / Köhrer, Karl / Reifenberger, Guido / Knobbe-Thomsen, Christiane B / Knappe, Ulrich J / Scholl, Ute I

    Journal of the Endocrine Society

    2018  Volume 2, Issue 3, Page(s) 266–278

    Abstract: Gain-of-function somatic mutations in the ubiquitin specific protease 8 ( ...

    Abstract Gain-of-function somatic mutations in the ubiquitin specific protease 8 (
    Language English
    Publishing date 2018-02-19
    Publishing country United States
    Document type Journal Article
    ISSN 2472-1972
    ISSN (online) 2472-1972
    DOI 10.1210/js.2017-00364
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  10. Conference proceedings: Identification of interaction networks of mutant and wild-type IDH1 in glioma cell lines

    Overbeck, Nina / Stefanski, Anja / Knühmann, Miriam / Knobbe-Thomsen, Christiane B. / Stühler, Kai

    2016  , Page(s) 16dgnnP37

    Event/congress Joint-Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN) and the Scandinavian Neuropathological Society (SNS); Hamburg; ; Scandinavian Neuropathological Society; 2016
    Keywords Medizin, Gesundheit
    Publishing date 2016-09-14
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/16dgnn40
    Database German Medical Science

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