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  1. Article ; Online: Silence in the Noise: Journey With Hearing Loss Across 2 Worlds.

    Sher, Taimur

    Mayo Clinic proceedings

    2021  Volume 96, Issue 5, Page(s) 1132–1134

    MeSH term(s) Bullying ; Hearing Aids ; Hearing Loss/diagnosis ; Hearing Loss/etiology ; Hearing Loss/psychology ; Hearing Loss/therapy ; Humans ; Noise/adverse effects ; Pakistan ; Physicians/psychology ; Quality of Life ; Risk Factors ; Social Environment ; United States
    Language English
    Publishing date 2021-04-09
    Publishing country England
    Document type Journal Article ; Personal Narrative
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2021.02.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.183: Show issues Location:
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  2. Article ; Online: Public Health Crises and the Human Subjects of Biomedical Research: A Focus on COVID-19.

    Sher, Taimur / Wright, R Scott

    Mayo Clinic proceedings

    2020  Volume 95, Issue 6, Page(s) 1130–1131

    MeSH term(s) Betacoronavirus/isolation & purification ; Biomedical Research/ethics ; Biomedical Research/methods ; Biomedical Research/standards ; COVID-19 ; Clinical Trials as Topic/ethics ; Clinical Trials as Topic/organization & administration ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Ethics, Research ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; Public Health/methods ; Public Health/standards ; Research Subjects ; SARS-CoV-2 ; Stakeholder Participation ; United States ; United States Food and Drug Administration
    Keywords covid19
    Language English
    Publishing date 2020-04-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2020.04.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Algorithms and Bioethics.

    Sher, Taimur / Sharp, Richard / Wright, R Scott

    Mayo Clinic proceedings

    2020  Volume 95, Issue 5, Page(s) 843–844

    MeSH term(s) Algorithms ; Artificial Intelligence ; Bioethics ; Cardiology
    Language English
    Publishing date 2020-08-31
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2020.03.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Anti-B Cell Maturation Antigen Chimeric Antigen Receptor T Cell Therapy for the Treatment of AL Amyloidosis and Concurrent Relapsed/Refractory Multiple Myeloma: Preliminary Efficacy and Safety.

    Das, Saurav / Ailawadhi, Sikander / Sher, Taimur / Roy, Vivek / Fernandez, Andre / Parrondo, Ricardo D

    Current oncology (Toronto, Ont.)

    2023  Volume 30, Issue 11, Page(s) 9627–9633

    Abstract: While immunotherapies, such as CAR T therapy and bi-specific antibodies, have revolutionized the treatment of multiple myeloma (MM), patients with AL amyloidosis have been excluded from trials with these agents due to concerns of underlying autonomic, ... ...

    Abstract While immunotherapies, such as CAR T therapy and bi-specific antibodies, have revolutionized the treatment of multiple myeloma (MM), patients with AL amyloidosis have been excluded from trials with these agents due to concerns of underlying autonomic, cardiac, and renal dysfunction, leading to potentially fatal toxicities from these therapies. In this communication, we described the outcomes of two patients with AL amyloidosis and concurrent MM with underlying cardiac and/or renal dysfunction who underwent anti-BCMA CAR T cell therapy with ide-cel or cilta-cel, received cytokine release syndrome prophylaxis, and tolerated therapy well with manageable toxicities and achieved a MRD-negative state. We described the preliminary efficacy and safety of CAR T in patients with AL amyloidosis and highlighted the importance of patient selection and medical optimization of cardiac and renal function prior to CAR T.
    MeSH term(s) Humans ; Multiple Myeloma/therapy ; Multiple Myeloma/drug therapy ; Immunotherapy, Adoptive/adverse effects ; Receptors, Chimeric Antigen/therapeutic use ; Immunoglobulin Light-chain Amyloidosis/complications ; Immunoglobulin Light-chain Amyloidosis/therapy ; B-Cell Maturation Antigen/therapeutic use ; Cell- and Tissue-Based Therapy ; Kidney Diseases/etiology
    Chemical Substances Receptors, Chimeric Antigen ; B-Cell Maturation Antigen
    Language English
    Publishing date 2023-10-31
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 1236972-x
    ISSN 1718-7729 ; 1198-0052
    ISSN (online) 1718-7729
    ISSN 1198-0052
    DOI 10.3390/curroncol30110697
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Kidney Transplantation and Monoclonal Gammopathy of Undetermined Significance.

    Aslam, Nabeel / Trautman, Christopher L / Sher, Taimur

    Transplantation direct

    2021  Volume 7, Issue 8, Page(s) e723

    Abstract: Plasma cell disorders are one of the most common hematologic malignancies. Monoclonal gammopathy of undetermined significance (MGUS) is defined by a serum monoclonal protein <3 g/dL, bone marrow plasma cell infiltration <10%, and most importantly absence ...

    Abstract Plasma cell disorders are one of the most common hematologic malignancies. Monoclonal gammopathy of undetermined significance (MGUS) is defined by a serum monoclonal protein <3 g/dL, bone marrow plasma cell infiltration <10%, and most importantly absence of end-organ damage. The prevalence of MGUS in general population is estimated to be 1%-4% and its frequency increases with age with 3% among people above 50 y of age. The risk of progression to clinically significant plasma cell dyscrasia is estimated to be 1% per year. With aging population and increasing use of transplantation for the management of kidney disease in older adults, MGUS is being identified during the evaluation for kidney transplant candidacy or during the postkidney transplant follow-up. MGUS in patients with end-stage renal disease (ESRD) undergoing evaluation for kidney transplant can pose a complex management dilemma. In this article, we review the current state of knowledge about the prevalence of MGUS in ESRD population and the impact of kidney transplantation on the progression of MGUS to clinically significant plasma cell disorder. We make recommendations for the screening of ESRD patients undergoing kidney transplant evaluation and the management of MGUS after renal transplant.
    Language English
    Publishing date 2021-07-09
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2373-8731
    ISSN 2373-8731
    DOI 10.1097/TXD.0000000000001176
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Trends in participant race and sex reporting in lung cancer phase III clinical trials.

    Aslam, Faaiq N / Manochakian, Rami / Lou, Yanyan / Colon-Otero, Gerardo / Sher, Taimur

    Cancer reports (Hoboken, N.J.)

    2023  Volume 6 Suppl 1, Page(s) e1856

    Abstract: Background: Clinical trials are an essential part of advancing care for cancer patients. Historically, however, racial minorities and females have been underrepresented in these trials. Efforts like the National Institute of Health Revitalization Act ... ...

    Abstract Background: Clinical trials are an essential part of advancing care for cancer patients. Historically, however, racial minorities and females have been underrepresented in these trials. Efforts like the National Institute of Health Revitalization Act attempted to mitigate these disparities, but despite these efforts, they continue to exist. These disparities can subsequently lead to minorities and females receiving suboptimal care.
    Aims: The purpose of our study was to understand the changing trends in reporting of participant race and sex as a demographic variable in phase III lung cancer clinical trials published over the last 35 years given these consequences of poor representation.
    Methods and results: A total of 426 articles reporting the results of phase III lung cancer clinical trials published from 1984 to 2019 were identified in PubMed. From these articles, data on participant sex and race were collected from the demographic tables to construct the database for this study. This database was subsequently used to determine the rate of reporting of demographic factors like race and sex and the participation trends over the time of minority and female participation in lung cancer phase III clinical trials. The SciPy Stats package for Python was used to calculate descriptive statistics, 95% confidence intervals, two sample t-test, one-way analysis of variance test, and Pearson's correlation coefficients. The Matplotlib package for Python was used for figure generation. Only 137 (32.2%) of the 426 studies analyzed reported the race of participants. Among those studies, we found that the mean participation rate of White participants was significantly higher (82.65%; p < .001). We found a decrease in African American participants and an increase in Asian participants over time. When looking at sex, we found that although the rate of male participation (69.02%) was significantly higher than that of female participation (30.98%), female participation has improved with time at a rate of 0.65% per year.
    Conclusion: We found that the reporting and participation of minority races continue to lag that of other demographic factors like sex in phase III clinical trials in lung cancer. Based on our analysis, we note a decline in participation of African Americans in lung cancer phase III clinical trials despite the rising incidence of lung cancer.
    MeSH term(s) Female ; Humans ; Male ; Black or African American ; Lung Neoplasms/epidemiology ; Lung Neoplasms/ethnology ; Lung Neoplasms/therapy ; Minority Groups ; Patient Acceptance of Health Care ; Biomedical Research ; Sex Factors
    Language English
    Publishing date 2023-07-08
    Publishing country United States
    Document type Clinical Trial, Phase III ; Journal Article
    ISSN 2573-8348
    ISSN (online) 2573-8348
    DOI 10.1002/cnr2.1856
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Public Health Crises and the Human Subjects of Biomedical Research

    Sher, Taimur / Wright, R. Scott

    Mayo Clinic Proceedings

    A Focus on COVID-19

    2020  Volume 95, Issue 6, Page(s) 1130–1131

    Keywords General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2020.04.016
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: COVID-19 and Vulnerable Population With Communication Disorders.

    Sher, Taimur / Stamper, Greta C / Lundy, Larry B

    Mayo Clinic proceedings

    2020  Volume 95, Issue 9, Page(s) 1845–1847

    MeSH term(s) Adult ; Betacoronavirus ; COVID-19 ; Child ; Communication Disorders/complications ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Hearing Loss/complications ; Humans ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; SARS-CoV-2 ; Vulnerable Populations
    Keywords covid19
    Language English
    Publishing date 2020-06-29
    Publishing country England
    Document type Journal Article ; Video-Audio Media
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2020.06.034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Immunotherapy beyond cellular therapy in follicular lymphoma: A case of complete remission after failure of two CAR-T.

    Kase, Adam M / Kharfan-Dabaja, Mohamed A / Donaldson, Andrew / Elliott, Jamie / Sher, Taimur

    Clinical case reports

    2022  Volume 10, Issue 4, Page(s) e05572

    Abstract: Patients with relapsed follicular lymphoma who do not respond to CAR-T have a poor outcome. We present a case of refractory follicular lymphoma who relapsed after two CAR-T infusions and achieved a complete remission after treatment with obinutuzumab and ...

    Abstract Patients with relapsed follicular lymphoma who do not respond to CAR-T have a poor outcome. We present a case of refractory follicular lymphoma who relapsed after two CAR-T infusions and achieved a complete remission after treatment with obinutuzumab and lenalidomide. This represents a promising treatment option in the post-CAR-T setting.
    Language English
    Publishing date 2022-04-08
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.5572
    Database MEDical Literature Analysis and Retrieval System OnLINE

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