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  1. Article: Ask the doctor. The other night I work up at about 2 a.m., and my heart was pumping hard and my lower jaw ached. It lasted about an hour, even though I took an aspirin. Then I fell asleep. In the morning everything was fine. Was that a heart attack?

    Komaroff, Anthony L

    Harvard health letter

    2015  Volume 40, Issue 7, Page(s) 2

    MeSH term(s) Anticoagulants/therapeutic use ; Aspirin/therapeutic use ; Heart ; Heart Rate ; Humans ; Jaw ; Myocardial Infarction/diagnosis ; Pain/etiology
    Chemical Substances Anticoagulants ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2015-07-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1220053-0
    ISSN 1052-1577
    ISSN 1052-1577
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: By the way, doctor. I'm 86, and someone told me that I"m no longer in danger of getting Alzheimer's disease. My memory isn't quite what it was, though. Would Alzheimer's medicines help?

    Komaroff, Anthony L

    Harvard health letter

    2005  Volume 30, Issue 6, Page(s) 8

    MeSH term(s) Age Factors ; Aged ; Aged, 80 and over ; Alzheimer Disease/etiology ; Alzheimer Disease/prevention & control ; Humans ; Memory Disorders/etiology
    Language English
    Publishing date 2005-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1220053-0
    ISSN 1052-1577
    ISSN 1052-1577
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: For Researchers on Obesity: Historical Review of Extra Body Weight Definitions.

    Komaroff, Marina

    Journal of obesity

    2016  Volume 2016, Page(s) 2460285

    Abstract: Rationale. The concept of obesity has been known since ancient world; however, the current standard definition of obesity was endorsed only about a decade ago. There is a need for researches to understand multiple approaches to defining obesity and how ... ...

    Abstract Rationale. The concept of obesity has been known since ancient world; however, the current standard definition of obesity was endorsed only about a decade ago. There is a need for researches to understand multiple approaches to defining obesity and how and why the standard definition was developed. The review will help to grasp the complexity of the problem and can lead to novel hypotheses in obesity research. Objective. This paper focuses on the objective to understand historical background on the development of "reference and standard tables" of weight as a platform for normal versus abnormal body weight definition. Methods. A systematic literature review was performed to chronologically summarize the definition of body weight from time of Hippocrates till the year of 2010. Conclusion. This paper presents the historical background on the development of "reference and standard tables" of weight as a platform for normal versus abnormal body weight definition. Knowledge of historical approaches to the concept of obesity can motivate researchers to find new hypotheses and utilize the appropriate obesity assessments to address their objectives.
    MeSH term(s) Body Weight ; History, 19th Century ; History, 20th Century ; History, 21st Century ; History, Ancient ; Humans ; Obesity/history ; Reference Standards ; Research Design ; Terminology as Topic
    Language English
    Publishing date 2016-05-30
    Publishing country United States
    Document type Historical Article ; Journal Article ; Review
    ZDB-ID 2573566-4
    ISSN 2090-0716 ; 2090-0708
    ISSN (online) 2090-0716
    ISSN 2090-0708
    DOI 10.1155/2016/2460285
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Weight Fluctuation and Postmenopausal Breast Cancer in the National Health and Nutrition Examination Survey I Epidemiologic Follow-Up Study.

    Komaroff, Marina

    Journal of obesity

    2016  Volume 2016, Page(s) 7168734

    Abstract: Objective: The aim of this study is to investigate if weight fluctuation is an independent risk factor for postmenopausal breast cancer (PBC) among women who gained weight in adult years.: Methods: NHANES I Epidemiologic Follow-Up Study (NHEFS) ... ...

    Abstract Objective: The aim of this study is to investigate if weight fluctuation is an independent risk factor for postmenopausal breast cancer (PBC) among women who gained weight in adult years.
    Methods: NHANES I Epidemiologic Follow-Up Study (NHEFS) database was used in the study. Women that were cancers-free at enrollment and diagnosed for the first time with breast cancer at age 50 or greater were considered cases. Controls were chosen from the subset of cancers-free women and matched to cases by years of follow-up and status of body mass index (BMI) at 25 years of age. Weight fluctuation was measured by the root-mean-square-error (RMSE) from a simple linear regression model for each woman with their body mass index (BMI) regressed on age (started at 25 years) while women with the positive slope from this regression were defined as weight gainers. Data were analyzed using conditional logistic regression models.
    Results: A total of 158 women were included into the study. The conditional logistic regression adjusted for weight gain demonstrated positive association between weight fluctuation in adult years and postmenopausal breast cancers (odds ratio/OR = 1.67; 95% confidence interval/CI: 1.06-2.66).
    Conclusions: The data suggested that long-term weight fluctuation was significant risk factor for PBC among women who gained weight in adult years. This finding underscores the importance of maintaining lost weight and avoiding weight fluctuation.
    MeSH term(s) Adipose Tissue/pathology ; Adult ; Aged ; Breast Neoplasms/epidemiology ; Breast Neoplasms/etiology ; Breast Neoplasms/pathology ; Female ; Follow-Up Studies ; Humans ; Middle Aged ; Nutrition Surveys ; Odds Ratio ; Postmenopause/physiology ; Risk Factors ; United States/epidemiology ; Weight Gain ; Weight Loss
    Language English
    Publishing date 2016-02-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2573566-4
    ISSN 2090-0716 ; 2090-0708
    ISSN (online) 2090-0716
    ISSN 2090-0708
    DOI 10.1155/2016/7168734
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Efficacy of HP-3070, A Once-Daily Asenapine Transdermal System, in the Treatment of Adults with Schizophrenia: A PANSS Five-Factor Analysis.

    Citrome, Leslie / Castelli, Mariacristina / Hasebe, Masami / Terahara, Takaaki / Faden, Justin / Komaroff, Marina

    Neuropsychiatric disease and treatment

    2024  Volume 20, Page(s) 755–764

    Abstract: Introduction: HP-3070, a once-daily asenapine transdermal system, is the first antipsychotic "patch" formulation FDA approved for adults with schizophrenia. Positive and Negative Syndrome Scale (PANSS) score items can be grouped into a five-factor ... ...

    Abstract Introduction: HP-3070, a once-daily asenapine transdermal system, is the first antipsychotic "patch" formulation FDA approved for adults with schizophrenia. Positive and Negative Syndrome Scale (PANSS) score items can be grouped into a five-factor structure to describe specific schizophrenia symptom domains. This post hoc analysis of data from a pivotal study evaluated HP-3070's efficacy by examining these factors.
    Methods: In a phase 3 study, adults with an acute exacerbation of schizophrenia were randomized to six weeks of treatment with HP-3070 3.8mg/24h, 7.6mg/24h, or placebo. An analysis was performed using the five PANSS factor domains (negative symptoms, positive symptoms, disorganized thought, uncontrolled hostility/excitement, anxiety/depression). Mixed-model repeated-measures (MMRM) analysis included change from baseline (CFB) in PANSS factor score as the repeated dependent variable, with country, treatment, visit, treatment by visit interaction, and baseline PANSS score as covariates.
    Results: The analysis included 607 patients. Treatment with HP-3070 3.8mg/24h resulted in a statistically significant LS mean CFB (improvement) vs placebo at Weeks 4-6 for all domains except for anxiety/depression, where a numerical difference was observed in favor of active treatments. Among the domains, the positive symptom factor demonstrated the numerically greatest LS mean (SE) difference from placebo in CFB, which for HP-3070 7.6mg/24h was -2.0 [0.57] and for HP-3070 3.8mg/24h was -2.3 [0.57];
    Discussion: Post hoc analysis using a PANSS five-factor model suggests that HP-3070 may address a broad range of symptoms in people with schizophrenia.
    Language English
    Publishing date 2024-03-29
    Publishing country New Zealand
    Document type Case Reports ; Clinical Trial
    ZDB-ID 2186503-6
    ISSN 1178-2021 ; 1176-6328
    ISSN (online) 1178-2021
    ISSN 1176-6328
    DOI 10.2147/NDT.S439712
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Use of a novel study insight analytics (SIA) methodology to improve PANSS data quality and signal detection in a global clinical trial in schizophrenia.

    Opler, M / Negash, S / Tatsumi, K / Liu, C / Komaroff, M / Capodilupo, G / Hasebe, M / Echevarria, B / Blattner, R / Citrome, L

    Schizophrenia research

    2024  Volume 267, Page(s) 239–246

    Language English
    Publishing date 2024-04-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 639422-x
    ISSN 1573-2509 ; 0920-9964
    ISSN (online) 1573-2509
    ISSN 0920-9964
    DOI 10.1016/j.schres.2024.03.052
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  7. Article ; Online: Public Health Policies and Global COVID-19 Outbreak

    Komaroff, M / Belhouchet, A A

    European Journal of Public Health

    2020  Volume 30, Issue Supplement_5

    Abstract: Abstract Background Was the world prepared to face the pandemic with a standard strategy? Objectives To evaluate the association between public health interventions against the COVID-19 outbreak and the outcome. Methods The observational study included ... ...

    Abstract Abstract Background Was the world prepared to face the pandemic with a standard strategy? Objectives To evaluate the association between public health interventions against the COVID-19 outbreak and the outcome. Methods The observational study included data on incidence of confirmed COVID-19 cases (outcome) and public health non-pharmaceutical interventions (exposure) from five countries: France, Italy, Japan, South Korea, and the USA, December 31, 2019 through April 12, 2020. The public health measures were grouped into five categories: lockdown, movement restrictions, public health measures, social (including social distancing) and economic measures, and use of facial mask. The multiple linear regressions were utilized to test the hypothesis that implementation of some public health measures was associated with the change in the incident number of COVID-19 cases, 2-sided, α = 0.05. Results The incidence of COVID-19 would be significantly greater without lockdown (1.89 times, p-value <.0001), public health and economic measures (25.17, p-value <.0001), and using masks (11.93, p-value=0.002), assuming that all other public health policies are the same. The effectiveness increases with earlier time of implementation. Among considered countries, South Korea was the most efficacious, where all measures were statistically significantly efficacious (p-value <0.05). Conclusions The findings demonstrate an association between public health measures and the outcome. The experience from South Korea should be studied further as the most effective non-pharmacological approach to fight the disease. This paper is the first step to develop the standardized approach utilizing the public health interventions to be applied effectively to the globe population. Key messages the most effective measures to control the COVID-19, and future outbreaks. The effect of particular measure varied by country and time of implementation.
    Keywords Public Health, Environmental and Occupational Health ; covid19
    Language English
    Publisher Oxford University Press (OUP)
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 1129243-x
    ISSN 1464-360X ; 1101-1262
    ISSN (online) 1464-360X
    ISSN 1101-1262
    DOI 10.1093/eurpub/ckaa165.428
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Zs.A 3499: Show issues Location:
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  8. Article ; Online: Efficacy of HP-3070, an Asenapine Transdermal System, on Symptoms of Hostility in Adults With Schizophrenia: A Post Hoc Analysis of a 6-Week Phase 3 Study.

    Citrome, Leslie / Komaroff, Marina / Starling, Brittney / Byreddy, Sandeep / Terahara, Takaaki / Hasebe, Masami

    The Journal of clinical psychiatry

    2022  Volume 83, Issue 4

    Abstract: Objective:: Methods:: Results:: Conclusions:: Clinical Trials Registration: ...

    Abstract Objective:
    Methods:
    Results:
    Conclusions:
    Clinical Trials Registration:
    MeSH term(s) Adult ; Antipsychotic Agents/adverse effects ; Dibenzocycloheptenes ; Double-Blind Method ; Hostility ; Humans ; Psychomotor Agitation/drug therapy ; Schizophrenia/diagnosis ; Treatment Outcome
    Chemical Substances Antipsychotic Agents ; Dibenzocycloheptenes ; asenapine (JKZ19V908O)
    Language English
    Publishing date 2022-06-06
    Publishing country United States
    Document type Clinical Trial, Phase III ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 716287-x
    ISSN 1555-2101 ; 0160-6689
    ISSN (online) 1555-2101
    ISSN 0160-6689
    DOI 10.4088/JCP.21m14355
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: d-Amphetamine Transdermal System in Treatment of Children and Adolescents with Attention-Deficit/Hyperactivity Disorder: Secondary Endpoint Results and

    Cutler, Andrew J / Suzuki, Katsumi / Starling, Brittney / Balakrishnan, Kanan / Komaroff, Marina / Meeves, Suzanne / Castelli, Mariacristina / Childress, Ann

    Journal of child and adolescent psychopharmacology

    2023  Volume 33, Issue 5, Page(s) 176–182

    Abstract: Objectives: ...

    Abstract Objectives:
    MeSH term(s) Humans ; Adolescent ; Child ; Attention Deficit Disorder with Hyperactivity/drug therapy ; Central Nervous System Stimulants/adverse effects ; Treatment Outcome ; Dose-Response Relationship, Drug ; Dextroamphetamine/adverse effects
    Chemical Substances Central Nervous System Stimulants ; Dextroamphetamine (TZ47U051FI)
    Language English
    Publishing date 2023-06-20
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1055410-5
    ISSN 1557-8992 ; 1044-5463
    ISSN (online) 1557-8992
    ISSN 1044-5463
    DOI 10.1089/cap.2023.0005
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  10. Article ; Online: Summary of the 11th International Conference on Human Herpesviruses-6A, -6B, and -7.

    Komaroff, Anthony L / Zerr, Danielle M / Flamand, Louis

    Journal of medical virology

    2019  Volume 92, Issue 1, Page(s) 4–10

    Abstract: The 11th International Conference on Human Herpesviruses (HHV)-6A, -6B, and -7 was held in Quebec City, from 23 to 26 June 2019. It attracted 144 basic, translational, and clinical scientists from 20 countries. Important new information was presented ... ...

    Abstract The 11th International Conference on Human Herpesviruses (HHV)-6A, -6B, and -7 was held in Quebec City, from 23 to 26 June 2019. It attracted 144 basic, translational, and clinical scientists from 20 countries. Important new information was presented regarding: the mechanisms of chromosomal integration for HHV-6A and -6B; the biology of inherited chromosomally integrated HHV-6A and -6B; animal models for, and animal viruses with similarities to, HHV-6A, -6B, and -7; established and possible disease associations, including provocative new information suggesting these viruses may be one trigger of Alzheimer's disease, and new treatment strategies. In this review, we summarize presentations that were of particular interest. The full text of the Abstracts cited in the manuscript is available in the online Supporting Information Materials.
    MeSH term(s) Animals ; Congresses as Topic ; DNA, Viral/genetics ; Herpesviridae/classification ; Herpesviridae Infections/complications ; Herpesviridae Infections/drug therapy ; Humans ; Quebec ; Research
    Chemical Substances DNA, Viral
    Language English
    Publishing date 2019-09-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.25576
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