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  1. Article ; Online: Modified Hu-lu-ba-wan protects diabetic glomerular podocytes via promoting PKM2-mediated mitochondrial dynamic homeostasis.

    Gong, Minmin / Guo, Yujin / Dong, Hui / Wu, Fan / He, Qiongyao / Gong, Jing / Lu, Fuer

    Phytomedicine : international journal of phytotherapy and phytopharmacology

    2023  Volume 123, Page(s) 155247

    Abstract: ... induced apoptosis and improve renal injury in DKD. Modified Hu-lu-ba-wan (MHLBW) shows distinct clinical ...

    Abstract Background: Mitochondrial dysfunction is implicated in the progression of diabetic kidney disease (DKD). Damaged mitochondria produce excessive reactive oxygen species (ROS) that can cause apoptosis. Mitochondrial dynamics control the quality and function of mitochondria. Targeting mitochondrial dynamics may reduce ROS-induced apoptosis and improve renal injury in DKD. Modified Hu-lu-ba-wan (MHLBW) shows distinct clinical effects on DKD patients, which are related to its role in antioxidant stress modulation. However, the relevant mechanisms of MHLBW have not been clearly explored.
    Purpose: This study was aimed to evaluate the therapeutic effects of MHLBW on spontaneous DKD mice and clarify the potential mechanisms.
    Methods: The main components of MHLBW were identified by HPLC. Using db/db mice as DKD models, we evaluated the therapeutic effects of MHLBW on mice after an 8-week administration. We investigated the molecular mechanism of MHLBW in regulating mitochondrial dynamic homeostasis, podocyte apoptosis, and glomerular damage. After that, computational docking analysis and in vitro experiments were conducted for further mechanism verification.
    Results: Intragastric administration of MHLBW for 8 weeks in db/db mice significantly improved glucose metabolism, basement membrane thickening, mesangial expansion, glomerular fibrosis, and podocyte injury. MHLBW can reverse podocyte apoptosis via promoting mitochondrial dynamic homeostasis, which was related to regulating the PKM2/ PGC-1α/Opa1 pathway. Berberine (BBR), one of the components of MHLBW, exhibited preeminent affinity with PKM2 as reflected by computational docking analysis. In cultured podocytes, BBR can also prevent apoptosis by promoting PKM2-mediated mitochondrial dynamic homeostasis.
    Conclusion: Our study demonstrates that MHLBW can treat DKD by inhibiting glomerular damage and podocyte apoptosis through positive regulation of PKM2-mediated mitochondrial dynamic homeostasis. These results may provide a potential strategy against DKD.
    MeSH term(s) Humans ; Mice ; Animals ; Podocytes/metabolism ; Mitochondrial Dynamics ; Reactive Oxygen Species/metabolism ; Diabetic Nephropathies/metabolism ; Homeostasis ; Apoptosis ; Diabetes Mellitus
    Chemical Substances Reactive Oxygen Species
    Language English
    Publishing date 2023-12-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2023.155247
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4115: Show issues Location:
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  2. Article ; Online: Element effects in endohedral metal-metal-bonding fullerenes M2@C82 (M = Sc, Y, La, Lu).

    Shui, Yuan / Liu, Dong / Zhao, Pei / Zhao, Xiang / Ehara, Masahiro / Lu, Xing / Akasaka, Takeshi / Yang, Tao

    The Journal of chemical physics

    2023  Volume 159, Issue 24

    Abstract: ... Y, La, Lu). Multiple bonding analysis approaches unambiguously reveal the existence of one two ... center two-electron σ covalent metal-metal bond in M2@C82 (M = Sc, Y, Lu); however, the La-La bonding ... that the M-M bond length at room temperature follows the trend of Sc < Lu < Y. The statistical thermodynamics ...

    Abstract Endohedral metal-metal-bonding fullerenes have recently emerged, in which encapsulated metals form a metal-metal bond. However, the physical reasons why some metal elements prefer to form metal-metal bonds inside fullerene are still unclear. Herein, we reported first-principles calculations on electronic structures, bonding properties, dynamics, and thermodynamic stabilities of endohedral metallofullerenes M2@C82 (M = Sc, Y, La, Lu). Multiple bonding analysis approaches unambiguously reveal the existence of one two-center two-electron σ covalent metal-metal bond in M2@C82 (M = Sc, Y, Lu); however, the La-La bonding interaction in La2@C82 is weaker and could not be categorized as one metal-metal covalent bond. The energy decomposition analysis on bonding interactions between an encapsulated metal dimer and fullerene cages suggested that there exist two electron-sharing bonds between a metal dimer and fullerene cages. The reasons why La2 prefers to donate electrons to fullerene cages rather than form a standard σ covalent metal-metal bond are mainly attributed to two following facts: La2 has a lower ionization potential, while the hybridization of ns, (n - 1)d, and np atomic orbitals in La2 is higher. Ab initio molecular dynamic simulations reveal that the M-M bond length at room temperature follows the trend of Sc < Lu < Y. The statistical thermodynamics calculations at different temperatures reveal that the experimentally observed endohedral metal-metal-bonding fullerenes M2@C82 have high concentrations in the endohedral fullerene formation temperature range.
    Language English
    Publishing date 2023-12-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3113-6
    ISSN 1089-7690 ; 0021-9606
    ISSN (online) 1089-7690
    ISSN 0021-9606
    DOI 10.1063/5.0180309
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  3. Article: Protective Effects of Hu-Lu-Ba-Wan () against Oxidative Stress in Testis of Diabetic Rats through PKCα/NAPDH Oxidase Signaling Pathway.

    Jiang, Shu-Jun / Dong, Hui / Fang, Ke / Chen, Guang / Li, Jing-Bin / Xu, Li-Jun / Zou, Xin / Lu, Fu-Er

    Chinese journal of integrative medicine

    2021  Volume 27, Issue 6, Page(s) 432–439

    Abstract: Objective: To explore the protective effect and the underlying mechanism of Hu-Lu-Ba-Wan (, HLBW ...

    Abstract Objective: To explore the protective effect and the underlying mechanism of Hu-Lu-Ba-Wan (, HLBW) on the testis of diabetic rats.
    Methods: Twenty-four male Wistar rats (160-180 g) were randomly divided into 3 groups according to a random number table, including a control group (n=8), diabetic group (n=8), and HLBW group (n=8). Diabetic rat model was established by high-fat-diet administration and single intravenous injection of streptozotocin (26 mg/kg). Then HLBW granule was administrated for 12 weeks. Fasting blood glucose and insulin levels as well as serum total testosterone level and testicular testosterone content were examined. Oxidative stress markers in both serum and testis were tested. Meanwhile, testicular morphology was observed under hematoxylin and eosin (HE) and the ultrastructure of Leydig cell was observed by electron microscope. The superoxide anion level was detected by DHE, and TUNEL-positive cells of testis was evaluated by TUNEL assay. The gene and protein expression of protein kinase C (PKCα), phosphorylated PKCα (P-PKCα) and P47phox in testicular tissues were determined by quantitative RT-PCR analysis and Western bolt analysis.
    Results: Compared with the diabetic group, HLBW treatment significantly reduced the fasting glucose levels and increased the levels of fasting insulin and testosterone in serum (P<0.01). HLBW administration also reduced the levels of reactive oxygen species (ROS) in plasma and alleviated the damage of oxidative stress in the testis of diabetic rats. Additionally, HLBW down-regulated the protein and mRNA levels of PKCα, P-PKCα and P47phox in testicular tissues.
    Conclusion: HLBW may attenuate the oxidative stress in the testis of diabetic rats via PKCα /NAPDH oxidase signaling pathway.
    MeSH term(s) Animals ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Drugs, Chinese Herbal ; Male ; NADPH Oxidases ; Oxidative Stress ; Oxidoreductases/metabolism ; Protein Kinase C-alpha ; Rats ; Rats, Wistar ; Signal Transduction ; Testis/metabolism
    Chemical Substances Drugs, Chinese Herbal ; Oxidoreductases (EC 1.-) ; NADPH Oxidases (EC 1.6.3.-) ; Protein Kinase C-alpha (EC 2.7.11.13)
    Language English
    Publishing date 2021-01-15
    Publishing country China
    Document type Journal Article
    ZDB-ID 2171254-2
    ISSN 1993-0402 ; 1672-0415
    ISSN (online) 1993-0402
    ISSN 1672-0415
    DOI 10.1007/s11655-021-2863-2
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    Zs.A 5823: Show issues Location:
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  4. Article ; Online: Absent in melanoma 2 protein in systemic lupus erythematosus: friend or foe? Comment on the article by Lu et al.

    Xu, Wang-Dong / Huang, An-Fang

    Arthritis & rheumatology (Hoboken, N.J.)

    2022  Volume 74, Issue 6, Page(s) 1093–1094

    MeSH term(s) Humans ; Lupus Erythematosus, Systemic ; Melanoma
    Language English
    Publishing date 2022-04-26
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2756371-6
    ISSN 2326-5205 ; 2326-5191
    ISSN (online) 2326-5205
    ISSN 2326-5191
    DOI 10.1002/art.42084
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: First Report of Southern Blight of Dendrobium huoshanense Caused by Sclerotium rolfsii in Lu’an, China

    Cheng, Andong / Li, Ping / Liu, Dong

    Plant Disease. 2023 Feb. 01, v. 107, no. 2 p.560-

    2023  

    Abstract: ... Sclerotium rolfsii Sacc. occurred during June to September from 2017 to 2020 in Huoshan, Lu’an, China. The yield and ... this is the first report of S. rolfsii causing southern blight on D. huoshanense in Lu’an. Confirmation ...

    Abstract Dendrobium, the second largest genus of Orchidaceae, is mainly distributed in Asia, Oceania, and Europe (Ding et al. 2008). An emerging disease on D. huoshanense with symptoms resembling southern blight Sclerotium rolfsii Sacc. occurred during June to September from 2017 to 2020 in Huoshan, Lu’an, China. The yield and quality of D. huoshanense were seriously affected especially under greenhouse conditions in July, with a disease incidence of 42%. Early symptoms consisted of water-soaked lesions on the lower stem tissue. Leaves turned pale green and withered, and a dense white mycelial mat formed on the lower stem along with 1- to 2-mm-diameter, white, round sclerotia. Subsequently, infected stems collapsed with the whole stem yellow and withered, and with many dark brown sclerotia on withered stems. Sclerotia from five diseased plants were disinfected in 1% mercury bichloride for 10 s, rinsed in 75% ethanol for 30 s, rinsed four times with sterile water, dried, and transferred to potato dextrose agar (PDA) with a cross section of the diseased and healthy parts and incubated at 27°C in darkness. Mycelia were selected from the edge of the colony and transferred to new PDA plates for purification of cultures after 3 days. Fungal colonies with white mycelia and abundant sclerotia developed after 7 days of incubation. Isolate morphological characteristics confirmed the identity as S. rolfsii (Mordue 1974). To further confirm the identity of the causal fungus, the complete internal transcribed spacer (ITS) rDNA region, the elongation factor-1a gene (EF1a) and the large subunit (LSU) region of one representative isolate, MB-1, were amplified using the primers ITS1/ITS4 (White et al. 1990), EF1-983F/EF1-2218R (Rehner and Buckley 2005), and NL1/NL4 (O’Donnell et al. 1997), respectively. Sequences have been deposited in GenBank (accession nos. OM946593 for ITS, OL416131 for EF1a, and OL373917 for LSU). There was 100% sequence identity to Athelia rolfsii (S. rolfsii) with the sequences MN610008.1 (ITS) and MW322687.1 (EF1a), and 99.84% sequence identity to MT225781.1 (LSU). Pathogenicity tests were performed by wound inoculation with culture discs of mycelia (diameter = 5 mm) on the stem base of 10- to 12-cm tall plants (four stems per pot, one stem inoculated with one culture disc, four replicates). Four healthy stems of the plants served as a control. The test was conducted in an artificial climate incubator at 26 ± 1°C with a 16 h light/8 h dark photoperiod and plants were enclosed for 72 h in polyethylene bags (relative humidity = 90%). Two days postinoculation, white mycelia developed in the wound and the leaves at the upper and lower parts of the wound began to turn yellow. Then the stem softened and turned yellow. White sclerotia were formed by the sixth day. By 12 days postinoculation, stems were atrophied and collapsed, sclerotia were yellow brown, and most leaves showed yellow discoloration and fell off. S. rolfsii was reisolated from infected plants. Control plants remained healthy. To our knowledge, this is the first report of S. rolfsii causing southern blight on D. huoshanense in Lu’an. Confirmation of the causal agent provides a basis for management of S. rolfsii in cultivated D. huoshanense.
    Keywords Athelia rolfsii ; Dendrobium catenatum ; blight ; climate ; culture media ; discoloration ; disease incidence ; ethanol ; fungi ; genes ; greenhouses ; internal transcribed spacers ; mercuric chloride ; mycelium ; pathogenicity ; polyethylene ; relative humidity ; sclerotia ; sequence analysis ; China ; Europe ; Pacific Ocean Islands ; field crops ; other ; pathogen detection
    Language English
    Dates of publication 2023-0201
    Publishing place The American Phytopathological Society
    Document type Article ; Online
    ZDB-ID 754182-x
    ISSN 0191-2917
    ISSN 0191-2917
    DOI 10.1094/PDIS-03-22-0586-PDN
    Database NAL-Catalogue (AGRICOLA)

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    Z 2043: Show issues

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  6. Article ; Online: Application of machine learning to pretherapeutically estimate dosimetry in men with advanced prostate cancer treated with <sup>177</sup>Lu-PSMA I&T therapy.

    Xue, Song / Gafita, Andrei / Dong, Chao / Zhao, Yu / Tetteh, Giles / Menze, Bjoern H / Ziegler, Sibylle / Weber, Wolfgang / Afshar-Oromieh, Ali / Rominger, Axel / Eiber, Matthias / Shi, Kuangyu

    European journal of nuclear medicine and molecular imaging

    2022  Volume 49, Issue 12, Page(s) 4064–4072

    Abstract: ... with 177Lu-PSMA I&T RLT were included retrospectively. They had available pre-therapy 68 ... cycles of 177Lu-PSMA I&T RLT were applied. Organ-based standard uptake values (SUVs) were ...

    Abstract Purpose: Although treatment planning and individualized dose application for emerging prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) are generally recommended, it is still difficult to implement in practice at the moment. In this study, we aimed to prove the concept of pretherapeutic prediction of dosimetry based on imaging and laboratory measurements before the RLT treatment.
    Methods: Twenty-three patients with metastatic castration-resistant prostate cancer (mCRPC) treated with <sup>177</sup>Lu-PSMA I&T RLT were included retrospectively. They had available pre-therapy <sup>68</sup> Ga-PSMA-HEBD-CC PET/CT and at least 3 planar and 1 SPECT/CT imaging for dosimetry. Overall, 43 cycles of <sup>177</sup>Lu-PSMA I&T RLT were applied. Organ-based standard uptake values (SUVs) were obtained from pre-therapy PET/CT scans. Patient dosimetry was calculated for the kidney, liver, spleen, and salivary glands using Hermes Hybrid Dosimetry 4.0 from the planar and SPECT/CT images. Machine learning methods were explored for dose prediction from organ SUVs and laboratory measurements. The uncertainty of these dose predictions was compared with the population-based dosimetry estimates. Mean absolute percentage error (MAPE) was used to assess the prediction uncertainty of estimated dosimetry.
    Results: An optimal machine learning method achieved a dosimetry prediction MAPE of 15.8 ± 13.2% for the kidney, 29.6% ± 13.7% for the liver, 23.8% ± 13.1% for the salivary glands, and 32.1 ± 31.4% for the spleen. In contrast, the prediction based on literature population mean has significantly larger MAPE (p < 0.01), 25.5 ± 17.3% for the kidney, 139.1% ± 111.5% for the liver, 67.0 ± 58.3% for the salivary glands, and 54.1 ± 215.3% for the spleen.
    Conclusion: The preliminary results confirmed the feasibility of pretherapeutic estimation of treatment dosimetry and its added value to empirical population-based estimation. The exploration of dose prediction may support the implementation of treatment planning for RLT.
    MeSH term(s) Dipeptides/therapeutic use ; Heterocyclic Compounds, 1-Ring/therapeutic use ; Humans ; Lutetium/therapeutic use ; Machine Learning ; Male ; Positron Emission Tomography Computed Tomography/methods ; Prostate-Specific Antigen ; Prostatic Neoplasms, Castration-Resistant/diagnostic imaging ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; Prostatic Neoplasms, Castration-Resistant/radiotherapy ; Retrospective Studies ; Urea/analogs & derivatives
    Chemical Substances Dipeptides ; Heterocyclic Compounds, 1-Ring ; PSMA I&T ; Lutetium (5H0DOZ21UJ) ; Urea (8W8T17847W) ; Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2022-06-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-022-05883-w
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    Zs.A 1227: Show issues Location:
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  7. Article ; Online: Van Vleck paramagnetism in undoped and Lu-doped bulk ceria.

    Varenik, Maxim / Zhang, Xiao-Dong / Leitus, Gregory / Yavo, Nimrod / Carmieli, Raanan / Wachtel, Ellen / Guo, Xin / Lubomirsky, Igor

    Physical chemistry chemical physics : PCCP

    2018  Volume 20, Issue 42, Page(s) 27019–27024

    Abstract: ... susceptibility decreases linearly with Lu content, and becomes diamagnetic at 30 mol% Lu. The Curie-Weiss ... from Ce3+ could be detected. The fact that the magnetization decreases with Lu content, even ...

    Abstract The magnetic properties of undoped, bulk CeO2 are not fully understood. In contrast to nanocrystalline ceria that exhibits paramagnetism attributed to Ce3+ at grain surfaces, bulk ceria is weakly paramagnetic, despite the absence of magnetic ions. In the present work, the magnetic susceptibility of bulk ceria ceramics doped with Lu3+, which has neither spin nor orbital angular momentum, was measured in order to assess the relative contributions of the crystal lattice, residual Ce3+ and oxygen vacancies to the overall bulk magnetization. We observed a magnetic response consisting of two parts: temperature independent (5-300 K) magnetic susceptibility, and Curie-Weiss paramagnetism. The temperature independent susceptibility decreases linearly with Lu content, and becomes diamagnetic at 30 mol% Lu. The Curie-Weiss magnetism visible at low temperatures was identified as resulting from a few ppm of Fe contaminant. However, Fe contamination does not contribute to the temperature independent paramagnetism. No contribution from Ce3+ could be detected. The fact that the magnetization decreases with Lu content, even though the concentration of oxygen vacancies, and the lattice defects associated with them, increases, indicates that neither is coupled to the magnetic field. Weak, temperature-independent paramagnetism in non-metals is usually attributed to a second order, Van Vleck-type magnetization. However, Van Vleck paramagnetism requires that the population of the first excited state be constant within the range of temperatures investigated. We discuss possible modifications of the large band gap electronic structure of undoped ceria which could account for our observations.
    Language English
    Publishing date 2018-10-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/c8cp04953j
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  8. Article ; Online: Phanuromyia ricaniae Nam, Lee Talamas sp. n. (Hymenoptera: Scelionidae) reared from the eggs of Ricania shantungensis Chou Lu (Hemiptera: Ricaniidae) in Asia.

    Nam, Sanghyeok / Chen, Hua-Yan / Talamas, Elijah J / Lee, Gwan-Seok / Dong, Wei / Sun, Li-Juan / Lee, Seunghwan

    Zootaxa

    2020  Volume 4890, Issue 1, Page(s) zootaxa.4890.1.6

    Abstract: ... reared from the eggs of a planthopper, Ricania shantungensis Chou Lu (Hemiptera: Ricaniidae ...

    Abstract The genus Phanuromyia in the subfamily Telenominae (Hymenoptera: Scelionidae) consists of 60 described species, for which host records indicate they are egg parasitoids of lanternflies and planthoppers (Hemiptera: Auchenorrhyncha). In this study, we describe a new species of the genus, P. ricaniae sp. n., reared from the eggs of a planthopper, Ricania shantungensis Chou Lu (Hemiptera: Ricaniidae). This planthopper has been considered as a serious invasive pest in South Korean agriculture. Ricania shantungensis has a wide host range, including economically important crops such as apple, peach, and pear. Phanuromyia ricaniae therefore has the potential to be a biological control agent against ricaniid planthoppers.
    MeSH term(s) Animals ; Asia ; Hemiptera ; Host Specificity ; Hymenoptera
    Language English
    Publishing date 2020-12-01
    Publishing country New Zealand
    Document type Journal Article
    ISSN 1175-5334
    ISSN (online) 1175-5334
    DOI 10.11646/zootaxa.4890.1.6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book: Qun xiong zhu lu

    Zhao, Dong / Liu, Jinqi

    Di er ji

    2011  

    Title variant Qun xiong zhu lu : Di er ji ; Ch'ün-hsiung-chu-lu
    Author's details Zhao Dong, Liu Jinqi bianzhu
    Keywords Chinesisches Schach
    Language Chinese
    Size 387 S, graph. Darst.
    Publisher Jing ji guan li chu ban she
    Publishing place Beijing
    Document type Book
    Note In chines. Schr. ; Große Helden jagen Wild : 2. Sammlung
    ISBN 9787509616697 ; 7509616697
    Database Former special subject collection: coastal and deep sea fishing

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  10. Article: [Acupuncture at Chize (LU 5) for 23 cases of intractable hiccup].

    Fang, Xianiun / Dong, Li

    Zhongguo zhen jiu = Chinese acupuncture & moxibustion

    2015  Volume 35, Issue 10, Page(s) 1060

    MeSH term(s) Acupuncture Points/classification ; Acupuncture Therapy ; Adult ; Aged ; Female ; Hiccup/therapy ; Humans ; Male ; Middle Aged ; Treatment Outcome ; Young Adult
    Language Chinese
    Publishing date 2015-10
    Publishing country China
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 0255-2930
    ISSN 0255-2930
    Database MEDical Literature Analysis and Retrieval System OnLINE

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