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  1. Article: Public Policy and Constitutional Rights in Times of Crisis

    Macfarlane, Emmett

    Canadian Journal of Political Science Revue Canadienne De Science Politique

    Abstract: Federal and provincial policy responses to the COVID-19 pandemic raise a host of constitutional issues that decision makers must pay heed to or risk serious violations of individual rights under the Charter of Rights and Freedoms This research note will ... ...

    Abstract Federal and provincial policy responses to the COVID-19 pandemic raise a host of constitutional issues that decision makers must pay heed to or risk serious violations of individual rights under the Charter of Rights and Freedoms This research note will examine a number of policy challenges as they relate to mobility rights (s 6), legal rights (ss 7 through 14), and equality rights (s 15) and will articulate the factors that policy makers should consider in design and implementation Other important constitutional questions, such as those relating to the division of powers, emergency powers and the relationship between the executive and Parliament, have also emerged in Canada but are beyond the scope of this note
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #828132
    Database COVID19

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  2. Article ; Online: Public Policy and Constitutional Rights in Times of Crisis

    Macfarlane, Emmett

    Canadian Journal of Political Science

    2020  Volume 53, Issue 2, Page(s) 299–303

    Abstract: Federal and provincial policy responses to the COVID-19 pandemic raise a host of constitutional issues that decision makers must pay heed to or risk serious violations of individual rights under the Charter of Rights and Freedoms. This research note will ...

    Abstract Federal and provincial policy responses to the COVID-19 pandemic raise a host of constitutional issues that decision makers must pay heed to or risk serious violations of individual rights under the Charter of Rights and Freedoms. This research note will examine a number of policy challenges as they relate to mobility rights (s. 6), legal rights (ss. 7 through 14), and equality rights (s. 15) and will articulate the factors that policy makers should consider in design and implementation. Other important constitutional questions, such as those relating to the division of powers, emergency powers and the relationship between the executive and Parliament, have also emerged in Canada but are beyond the scope of this note.
    Keywords Sociology and Political Science ; covid19
    Language English
    Publisher Cambridge University Press (CUP)
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 2066084-4
    ISSN 1744-9324 ; 0008-4239
    ISSN (online) 1744-9324
    ISSN 0008-4239
    DOI 10.1017/s0008423920000256
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Acute toxicity from the synthetic cathinone

    Blanco, Georgina / Vidler, Dan / Roper, Clair / Wood, David M / Dargan, Paul I / Keating, Liza / Macfarlane, Rebecca / Emmett, Stevan / Johnson, Graham / Eddleston, Michael / Hill, Simon L / Thomas, Simon H L

    Clinical toxicology (Philadelphia, Pa.)

    2021  Volume 59, Issue 12, Page(s) 1270–1273

    Abstract: Introduction: Acute toxicity caused by New Psychoactive Substances (NPS) has created a significant burden for Emergency Departments (EDs). Here we report characteristics of people presenting with toxicity after exposure to the synthetic cathinone : ... ...

    Abstract Introduction: Acute toxicity caused by New Psychoactive Substances (NPS) has created a significant burden for Emergency Departments (EDs). Here we report characteristics of people presenting with toxicity after exposure to the synthetic cathinone
    Methods: Adults presenting to hospital with severe acute toxicity after suspected NPS use were recruited between March 2015 and October 2020. Clinical features were recorded using consistent methodology and biological samples analysed using liquid chromatography-tandem mass-spectrometry.
    Results: NEP was detected in at least one sample from 9 of 893 patients recruited during the period of study, all presenting between 2016 and 2019 and 8 presenting in southern England. Commonly reported clinical features included tachycardia (6), agitation (6), confusion (6), mydriasis (5), hallucinations (4), acidosis (3) and elevated creatine kinase (3). Co-used drugs, detected in 6 patients, may have contributed to these features, but agitation and hallucinations were also reported in all 3 patients without analytical evidence of co-use.
    Conclusions: NEP was detected infrequently in episodes of drug toxicity in the UK between 2016 and 2019, especially in southern England. Clinical characteristics of toxicity are similar to those of other cathinones, although co-use of other drugs is common and may contribute to the features observed.
    MeSH term(s) Adult ; Alkaloids ; Benzodioxoles ; Butylamines ; Humans ; Psychotropic Drugs/toxicity ; United Kingdom/epidemiology
    Chemical Substances Alkaloids ; Benzodioxoles ; Butylamines ; N-ethylpentylone ; Psychotropic Drugs ; cathinone (540EI4406J)
    Language English
    Publishing date 2021-04-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 204476-6
    ISSN 1556-9519 ; 0009-9309 ; 0731-3810 ; 1556-3650
    ISSN (online) 1556-9519
    ISSN 0009-9309 ; 0731-3810 ; 1556-3650
    DOI 10.1080/15563650.2021.1909730
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 419: Show issues Location:
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  4. Article ; Online: Bile acids modulate glucocorticoid metabolism and the hypothalamic-pituitary-adrenal axis in obstructive jaundice.

    McNeilly, Alison D / Macfarlane, David P / O'Flaherty, Emmett / Livingstone, Dawn E / Mitić, Tijana / McConnell, Kirsty M / McKenzie, Scott M / Davies, Eleanor / Reynolds, Rebecca M / Thiesson, Helle C / Skøtt, Ole / Walker, Brian R / Andrew, Ruth

    Journal of hepatology

    2010  Volume 52, Issue 5, Page(s) 705–711

    Abstract: Background & aims: Suppression of the hypothalamic-pituitary-adrenal axis occurs in cirrhosis and cholestasis and is associated with increased concentrations of bile acids. We investigated whether this was mediated through bile acids acting to impair ... ...

    Abstract Background & aims: Suppression of the hypothalamic-pituitary-adrenal axis occurs in cirrhosis and cholestasis and is associated with increased concentrations of bile acids. We investigated whether this was mediated through bile acids acting to impair steroid clearance by inhibiting glucocorticoid metabolism by 5beta-reductase.
    Methods: The effect of bile acids on glucocorticoid metabolism was studied in vitro in hepatic subcellular fractions and hepatoma cells, allowing quantitation of the kinetics and transcript abundance of 5beta-reductase. Metabolism was subsequently examined in vivo in rats following dietary manipulation or bile duct ligation. Finally, glucocorticoid metabolism was assessed in humans with obstructive jaundice.
    Results: In rat hepatic cytosol, chenodeoxycholic acid competitively inhibited 5beta-reductase (K(i) 9.19+/-0.40 microM) and reduced its transcript abundance (in H4iiE cells) and promoter activity (reporter system, HepG2 cells). In Wistar rats, dietary chenodeoxycholic acid (1% w/w chow) inhibited hepatic 5beta-reductase activity, reduced urinary excretion of 3alpha,5beta-tetrahydrocorticosterone and reduced adrenal weight. Conversely, a fat-free diet suppressed bile acid levels and increased hepatic 5beta-reductase activity, supplementation of the fat-free diet with CDCA reduced 5beta-reductase activity, and urinary 3alpha,5beta-reduced corticosterone. Cholestasis in rats suppressed hepatic 5beta-reductase activity and transcript abundance. In eight women with obstructive jaundice, relative urinary excretion of 3alpha,5beta-tetrahydrocortisol was significantly lower than in healthy controls.
    Conclusion: These data suggest a novel role for bile acids in inhibiting hepatic glucocorticoid clearance, of sufficient magnitude to suppress hypothalamic-pituitary-adrenal axis activity. Elevated hepatic bile acids may account for adrenal insufficiency in liver disease.
    MeSH term(s) 3-Hydroxysteroid Dehydrogenases/genetics ; Animals ; Base Sequence ; Bile Acids and Salts/pharmacology ; Bile Acids and Salts/therapeutic use ; Bile Ducts/physiology ; Cytosol/enzymology ; Female ; Glucocorticoids/metabolism ; Humans ; Hydrocortisone/metabolism ; Hypothalamo-Hypophyseal System/drug effects ; Hypothalamo-Hypophyseal System/physiology ; Jaundice, Obstructive/drug therapy ; Jaundice, Obstructive/metabolism ; Jaundice, Obstructive/urine ; Kinetics ; Ligation ; Liver/enzymology ; Male ; Pituitary-Adrenal System/drug effects ; Pituitary-Adrenal System/physiology ; Promoter Regions, Genetic/drug effects ; Promoter Regions, Genetic/genetics ; Rats ; Rats, Wistar ; Tetrahydrocortisol/urine ; Transcription, Genetic/drug effects
    Chemical Substances Bile Acids and Salts ; Glucocorticoids ; Tetrahydrocortisol (7P2O6MFN8O) ; 3-Hydroxysteroid Dehydrogenases (EC 1.1.-) ; 3 alpha-hydroxysteroid-5 beta-oxidoreductase (EC 1.1.1-) ; Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2010-03-04
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2009.10.037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2027: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: Data and Tools Integration in the Canadian Open Neuroscience Platform.

    Poline, Jean-Baptiste / Das, Samir / Glatard, Tristan / Madjar, Cécile / Dickie, Erin W / Lecours, Xavier / Beaudry, Thomas / Beck, Natacha / Behan, Brendan / Brown, Shawn T / Bujold, David / Beauvais, Michael / Caron, Bryan / Czech, Candice / Dharsee, Moyez / Dugré, Mathieu / Evans, Ken / Gee, Tom / Ippoliti, Giulia /
    Kiar, Gregory / Knoppers, Bartha Maria / Kuehn, Tristan / Le, Diana / Lo, Derek / Mazaheri, Mandana / MacFarlane, Dave / Muja, Naser / O'Brien, Emmet A / O'Callaghan, Liam / Paiva, Santiago / Park, Patrick / Quesnel, Darcy / Rabelais, Henri / Rioux, Pierre / Legault, Mélanie / Tremblay-Mercier, Jennifer / Rotenberg, David / Stone, Jessica / Strauss, Ted / Zaytseva, Ksenia / Zhou, Joey / Duchesne, Simon / Khan, Ali R / Hill, Sean / Evans, Alan C

    Scientific data

    2023  Volume 10, Issue 1, Page(s) 189

    Abstract: We present the Canadian Open Neuroscience Platform (CONP) portal to answer the research community's need for flexible data sharing resources and provide advanced tools for search and processing infrastructure capacity. This portal differs from previous ... ...

    Abstract We present the Canadian Open Neuroscience Platform (CONP) portal to answer the research community's need for flexible data sharing resources and provide advanced tools for search and processing infrastructure capacity. This portal differs from previous data sharing projects as it integrates datasets originating from a number of already existing platforms or databases through DataLad, a file level data integrity and access layer. The portal is also an entry point for searching and accessing a large number of standardized and containerized software and links to a computing infrastructure. It leverages community standards to help document and facilitate reuse of both datasets and tools, and already shows a growing community adoption giving access to more than 60 neuroscience datasets and over 70 tools. The CONP portal demonstrates the feasibility and offers a model of a distributed data and tool management system across 17 institutions throughout Canada.
    MeSH term(s) Canada ; Databases, Factual ; Information Dissemination ; Software
    Language English
    Publishing date 2023-04-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2775191-0
    ISSN 2052-4463 ; 2052-4463
    ISSN (online) 2052-4463
    ISSN 2052-4463
    DOI 10.1038/s41597-023-01946-1
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  6. Article ; Online: Data and Tools Integration in the Canadian Open Neuroscience Platform

    Jean-Baptiste Poline / Samir Das / Tristan Glatard / Cécile Madjar / Erin W. Dickie / Xavier Lecours / Thomas Beaudry / Natacha Beck / Brendan Behan / Shawn T. Brown / David Bujold / Michael Beauvais / Bryan Caron / Candice Czech / Moyez Dharsee / Mathieu Dugré / Ken Evans / Tom Gee / Giulia Ippoliti /
    Gregory Kiar / Bartha Maria Knoppers / Tristan Kuehn / Diana Le / Derek Lo / Mandana Mazaheri / Dave MacFarlane / Naser Muja / Emmet A. O’Brien / Liam O’Callaghan / Santiago Paiva / Patrick Park / Darcy Quesnel / Henri Rabelais / Pierre Rioux / Mélanie Legault / Jennifer Tremblay-Mercier / David Rotenberg / Jessica Stone / Ted Strauss / Ksenia Zaytseva / Joey Zhou / Simon Duchesne / Ali R. Khan / Sean Hill / Alan C. Evans

    Scientific Data, Vol 10, Iss 1, Pp 1-

    2023  Volume 11

    Abstract: Measurement(s) Digital Data Repository Technology Type(s) Digital Data ... ...

    Abstract Measurement(s) Digital Data Repository Technology Type(s) Digital Data Repository
    Keywords Science ; Q
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
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