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  1. Book ; Online: Sabrina

    Arleo, Alessio / Tsigkanos, Christos / Jia, Chao / Leite, Roger A. / Murturi, Ilir / Klaffenboeck, Manfred / Dustdar, Schahram / Wimmer, Michael / Miksch, Silvia / Sorger, Johannes

    Modeling and Visualization of Economy Data with Incremental Domain Knowledge

    2019  

    Abstract: ... analysts to understand the big picture. In this paper, we present Sabrina, a financial data analysis and ... with (incremental) domain knowledge on general macroscopic aspects of the economy. Sabrina unites ... study with three domain experts, we illustrate the usefulness of Sabrina, which eases their analysis ...

    Abstract Investment planning requires knowledge of the financial landscape on a large scale, both in terms of geo-spatial and industry sector distribution. There is plenty of data available, but it is scattered across heterogeneous sources (newspapers, open data, etc.), which makes it difficult for financial analysts to understand the big picture. In this paper, we present Sabrina, a financial data analysis and visualization approach that incorporates a pipeline for the generation of firm-to-firm financial transaction networks. The pipeline is capable of fusing the ground truth on individual firms in a region with (incremental) domain knowledge on general macroscopic aspects of the economy. Sabrina unites these heterogeneous data sources within a uniform visual interface that enables the visual analysis process. In a user study with three domain experts, we illustrate the usefulness of Sabrina, which eases their analysis process.
    Keywords Quantitative Finance - General Finance ; Computer Science - Human-Computer Interaction
    Subject code 004
    Publishing date 2019-08-05
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Information gaps in England's independent healthcare sector.

    Anderson, Michael / Gutacker, Nils / Wimmer, Sabrina / Mossialos, Elias

    BMJ (Clinical research ed.)

    2024  Volume 384, Page(s) e079261

    MeSH term(s) Humans ; Health Care Sector ; State Medicine ; England
    Language English
    Publishing date 2024-03-19
    Publishing country England
    Document type Editorial
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj-2024-079261
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.10: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Public Risk-Taking and Rewards During the COVID-19 Pandemic - A Case Study of Remdesivir in the Context of Global Health Equity.

    Wimmer, Sabrina / Keestra, Sarai M

    International journal of health policy and management

    2022  Volume 11, Issue 5, Page(s) 567–578

    Abstract: Public investment, through both research grants and university funding, plays a crucial role in the research and development (R&D) of novel health technologies, including diagnostics, therapies, and vaccines, to address the coronavirus disease 2019 ( ... ...

    Abstract Public investment, through both research grants and university funding, plays a crucial role in the research and development (R&D) of novel health technologies, including diagnostics, therapies, and vaccines, to address the coronavirus disease 2019 (COVID-19) pandemic. Using the example of remdesivir, one of the most promising COVID-19 treatments, this paper traces back public contributions to different stages of the innovation process. Applying the Risk-Reward Nexus framework to the R&D of remdesivir, we analyse the role of the public in risk-taking and reward and address inequities in the biomedical innovation system. We discuss the collective, cumulative and uncertain characteristics of innovation, highlighting the lack of transparency in the biomedical R&D system, the need for public investment in the innovation process, and the "time-lag" between risk-taking and reward. Despite the significant public transnational contributions to the R&D of remdesivir, the rewards are extracted by few actors and the return to the public in the form of equitable access and affordable pricing is limited. Beyond the necessity to treat remdesivir as a global public good, we argue that biomedical innovation needs to be viewed in the broader concept of public value to prevent the same equity issues currently seen in the COVID-19 pandemic. This requires the state to take a market-shaping rather than market-fixing role, thereby steering innovation, ensuring that patents do not hinder global equitable access and affordable pricing and safeguarding a global medicines supply.
    MeSH term(s) Adenosine Monophosphate/analogs & derivatives ; Alanine/analogs & derivatives ; COVID-19/drug therapy ; Global Health ; Humans ; Pandemics ; Reward ; Risk-Taking
    Chemical Substances remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Alanine (OF5P57N2ZX)
    Keywords covid19
    Language English
    Publishing date 2022-05-01
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2724317-5
    ISSN 2322-5939 ; 2322-5939
    ISSN (online) 2322-5939
    ISSN 2322-5939
    DOI 10.34172/ijhpm.2020.166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Conference proceedings: Ärztliche Empathie und psychosozialer Stress bei Medizinstudierenden in schwierigen Gesprächssituationen mit Simulationspatient*innen

    Wimmer, Sabrina / Hladschik-Kermer, Birgit

    2022  , Page(s) V2.6

    Event/congress 15. Internationales SkillsLab Symposium 2021; sine loco [digital]; 2021
    Keywords Medizin, Gesundheit
    Publishing date 2022-03-11
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/21isls29
    Database German Medical Science

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  5. Article ; Online: University patenting and licensing practices in the United Kingdom during the first year of the COVID-19 pandemic.

    Keestra, Sarai / Rodgers, Florence / Osborne, Rhiannon / Wimmer, Sabrina

    Global public health

    2022  Volume 17, Issue 5, Page(s) 641–651

    Abstract: Universities' decisions during technology transfer may affect affordability, accessibility, and availability of COVID-19 health technologies downstream. We investigated measures taken by the top 35 publicly funded UK universities to ensure global ... ...

    Abstract Universities' decisions during technology transfer may affect affordability, accessibility, and availability of COVID-19 health technologies downstream. We investigated measures taken by the top 35 publicly funded UK universities to ensure global equitable access to COVID-19 health technologies between January and end of October 2020. We sent Freedom Of Information (FOI) requests and analysed universities' websites, to (i) assess institutional strategies on the patenting and licensing of COVID-19-related health technologies, (ii) identify all COVID-19-related health technologies licensed or patented and (iii) record whether universities engaged with the Open COVID pledge, COVID-19 Technology Access Pool (C-TAP), or Association of University Technology Managers (AUTM) COVID-19 licensing guidelines during the time period assessed. Except for the Universities of Oxford and Edinburgh, UK universities did not update their institutional strategies during the first year of the pandemic. Nine universities licensed 22 COVID-19 health technologies. Imperial College London disclosed ten patents relevant to COVID-19. No UK universities participated in the Open COVID Pledge or C-TAP, but discussions were ongoing in autumn 2020. The University of Bristol endorsed the AUTM guidelines. Despite important COVID-19 health technologies being developed by UK universities, our findings suggest minimal engagement with measures that may promote equitable access downstream. We suggest universities review their technology transfer policies and implement global equitable access strategies for COVID-19 health technologies. We furthermore propose that public and charitable funders can play a larger role in encouraging universities to adopt such practices by making access and transparency clauses a mandatory condition for receiving public funds for research.
    MeSH term(s) COVID-19/epidemiology ; Humans ; Pandemics ; Policy ; United Kingdom/epidemiology ; Universities
    Language English
    Publishing date 2022-03-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2234129-8
    ISSN 1744-1706 ; 1744-1692
    ISSN (online) 1744-1706
    ISSN 1744-1692
    DOI 10.1080/17441692.2022.2049842
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Conference proceedings: Evaluation der 10%-Methode zur Anpassung von CI Sprachprozessoren bei Erwachsenen

    Böck, Katja / Veloso de Oliveira, Julia / Regele, Sabrina / Wirth, Markus / Wollenberg, Barbara / Weiss, Nora / Wimmer, Wilhelm

    2024  , Page(s) 51

    Event/congress 26. Jahrestagung der Deutschen Gesellschaft für Audiologie; Aalen; Deutsche Gesellschaft für Audiologie e.V.; 2024
    Keywords Medizin, Gesundheit
    Publishing date 2024-03-05
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/24dga051
    Database German Medical Science

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  7. Article: Public Risk-Taking and Rewards During the COVID-19 Pandemic - A Case Study of Remdesivir in the Context of Global Health Equity

    Wimmer, Sabrina / Keestra, Sarai M

    Int. j. health policy manag

    Abstract: Public investment, through both research grants and university funding, plays a crucial role in the research and development (R&D) of novel health technologies, including diagnostics, therapies, and vaccines, to address the coronavirus disease 2019 ( ... ...

    Abstract Public investment, through both research grants and university funding, plays a crucial role in the research and development (R&D) of novel health technologies, including diagnostics, therapies, and vaccines, to address the coronavirus disease 2019 (COVID-19) pandemic. Using the example of remdesivir, one of the most promising COVID-19 treatments, this paper traces back public contributions to different stages of the innovation process. Applying the Risk-Reward Nexus framework to the R&D of remdesivir, we analyse the role of the public in risk-taking and reward and address inequities in the biomedical innovation system. We discuss the collective, cumulative and uncertain characteristics of innovation, highlighting the lack of transparency in the biomedical R&D system, the need for public investment in the innovation process, and the "time-lag" between risk-taking and reward. Despite the significant public transnational contributions to the R&D of remdesivir, the rewards are extracted by few actors and the return to the public in the form of equitable access and affordable pricing is limited. Beyond the necessity to treat remdesivir as a global public good, we argue that biomedical innovation needs to be viewed in the broader concept of public value to prevent the same equity issues currently seen in the COVID-19 pandemic. This requires the state to take a market-shaping rather than market-fixing role, thereby steering innovation, ensuring that patents do not hinder global equitable access and affordable pricing and safeguarding a global medicines supply.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #782687
    Database COVID19

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  8. Article ; Online: Public Risk-Taking and Rewards During the COVID-19 Pandemic - A Case Study of Remdesivir in the Context of Global Health Equity

    Wimmer, Sabrina / Keestra, Sarai M.

    International Journal of Health Policy and Management ; ISSN 2322-5939

    2020  

    Abstract: Public investment, through both research grants and university funding, plays a crucial role in the research and development (R&D) of novel health technologies, including diagnostics, therapies, and vaccines, to address the coronavirus disease 2019 ( ... ...

    Abstract Public investment, through both research grants and university funding, plays a crucial role in the research and development (R&D) of novel health technologies, including diagnostics, therapies, and vaccines, to address the coronavirus disease 2019 (COVID-19) pandemic. Using the example of remdesivir, one of the most promising COVID-19 treatments, this paper traces back public contributions to different stages of the innovation process. Applying the Risk-Reward Nexus framework to the R&D of remdesivir, we analyse the role of the public in risk-taking and reward and address inequities in the biomedical innovation system. We discuss the collective, cumulative and uncertain characteristics of innovation, highlighting the lack of transparency in the biomedical R&D system, the need for public investment in the innovation process, and the "time-lag" between risk-taking and reward. Despite the significant public transnational contributions to the R&D of remdesivir, the rewards are extracted by few actors and the return to the public in the form of equitable access and affordable pricing is limited. Beyond the necessity to treat remdesivir as a global public good, we argue that biomedical innovation needs to be viewed in the broader concept of public value to prevent the same equity issues currently seen in the COVID-19 pandemic. This requires the state to take a market-shaping rather than market-fixing role, thereby steering innovation, ensuring that patents do not hinder global equitable access and affordable pricing and safeguarding a global medicines supply.
    Keywords covid19
    Language English
    Publisher Maad Rayan Publishing Company
    Publishing country de
    Document type Article ; Online
    DOI 10.34172/ijhpm.2020.166
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Enzymatic Conversion of Lignosulfonate into Wood Adhesives: A Next Step towards Fully Biobased Composite Materials.

    Hellmayr, Raphaela / Bischof, Sabrina / Wühl, Jasmin / Guebitz, Georg M / Nyanhongo, Gibson S / Schwaiger, Nikolaus / Liebner, Falk / Wimmer, Rupert

    Polymers

    2022  Volume 14, Issue 2

    Abstract: This study investigates the effect of the enzymatic polymerization of lignosulfonate for the formulation of a lignosulfonate-based adhesive. For this, beech lamellas were glued together and tested according to the EN 302-1 standard. The results showed ... ...

    Abstract This study investigates the effect of the enzymatic polymerization of lignosulfonate for the formulation of a lignosulfonate-based adhesive. For this, beech lamellas were glued together and tested according to the EN 302-1 standard. The results showed that the laccase-polymerized lignosulfonate-based wood adhesives (LS-p) had similar mechanical properties as a standard carpenter's glue (PVAc-based D3 class white glue), as no significant difference in tensile shear strength between these two adhesive types was found. However, carpenter's glue showed almost 100% wood failure, while with the lignosulfonate-based wood glue, the samples failed, mainly in the glueline. Pre-polymerization of LS-p is the most critical factor to achieve the required viscosity, which is also connected to the wetting properties and the resulting tensile shear strength. The longer the pre-polymerization, the higher the viscosity of the LS-p adhesive, with the tensile shear strength reaching a plateau. The presented data show the potential of using enzymatically pre-polymerized lignosulfonate as a well-performing wood adhesive. Further development and optimization of the pre-polymerization process is required, which is also important to push towards upscaling and practical applications.
    Language English
    Publishing date 2022-01-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym14020259
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Viral Mimicry to Usurp Ubiquitin and SUMO Host Pathways.

    Wimmer, Peter / Schreiner, Sabrina

    Viruses

    2015  Volume 7, Issue 9, Page(s) 4854–4872

    Abstract: Posttranslational modifications (PTMs) of proteins include enzymatic changes by covalent addition of cellular regulatory determinants such as ubiquitin (Ub) and small ubiquitin-like modifier (SUMO) moieties. These modifications are widely used by ... ...

    Abstract Posttranslational modifications (PTMs) of proteins include enzymatic changes by covalent addition of cellular regulatory determinants such as ubiquitin (Ub) and small ubiquitin-like modifier (SUMO) moieties. These modifications are widely used by eukaryotic cells to control the functional repertoire of proteins. Over the last decade, it became apparent that the repertoire of ubiquitiylation and SUMOylation regulating various biological functions is not restricted to eukaryotic cells, but is also a feature of human virus families, used to extensively exploit complex host-cell networks and homeostasis. Intriguingly, besides binding to host SUMO/Ub control proteins and interfering with the respective enzymatic cascade, many viral proteins mimic key regulatory factors to usurp this host machinery and promote efficient viral outcomes. Advanced detection methods and functional studies of ubiquitiylation and SUMOylation during virus-host interplay have revealed that human viruses have evolved a large arsenal of strategies to exploit these specific PTM processes. In this review, we highlight the known viral analogs orchestrating ubiquitin and SUMO conjugation events to subvert and utilize basic enzymatic pathways.
    MeSH term(s) Host-Pathogen Interactions ; Small Ubiquitin-Related Modifier Proteins/metabolism ; Sumoylation ; Ubiquitin/metabolism ; Ubiquitination ; Viruses/growth & development
    Chemical Substances Small Ubiquitin-Related Modifier Proteins ; Ubiquitin
    Keywords covid19
    Language English
    Publishing date 2015-08-28
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v7092849
    Database MEDical Literature Analysis and Retrieval System OnLINE

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